Multiple mechanisms of vascular smooth muscle relaxation by the activation of proteinase-activated receptor 2 in mouse mesenteric arterioles

British Journal of Pharmacology

Volumn 135, Issue 1, 2002, Pages 155-169

  McGuire, John J ^a,b   Hollenberg, Morley D ^a,b   Andrade Gordon, Patricia ^c   Triggle, Chris R ^a,b  

^a UNIVERSITY OF CALGARY   (Canada)

^b UNIVERSITY OF CALGARY   (Canada)

^c R W JOHNSON PHARMACEUTICAL RES I   (United States)

Author keywords

Endothelium dependent hyperpolarizing factor; Endothelium dependent relaxing factors; Mesentery artery; Nitric oxide synthase; Proteinase activated receptor 2

Indexed keywords

17 OCTADECYNOIC ACID; 4 AMINOPYRIDINE; 7 NITROINDAZOLE; 9 (TETRAHYDRO 2 FURYL)ADENINE; APAMIN; ARACHIDONYL TRIFLUOROMETHYL KETONE; CARBENOXOLONE; CARBOXY 2 PHENYL 4,4,5,5 TETRAMETHYL IMIDAZOLINE 1 OXYL 3 OXIDE; CHARYBDOTOXIN; GLIBENCLAMIDE; IBERIOTOXIN; INDOMETACIN; LEIUROTOXIN I; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; NOLPITANTIUM; OUABAIN; POTASSIUM CHANNEL; PROPRANOLOL; PROTEINASE ACTIVATED RECEPTOR 2; PROTEINASE ACTIVATED RECEPTOR 2 AGONIST; SAREDUTANT; TETRODOTOXIN; TETRYLAMMONIUM; UNCLASSIFIED DRUG; VASODILATOR AGENT;

ANIMAL TISSUE; ARTERIOLE; ARTICLE; DRUG EFFECT; DRUG MECHANISM; DRUG POTENCY; INTESTINE BLOOD FLOW; MALE; MESENTERIC ARTERY; MOUSE; NONHUMAN; PRIORITY JOURNAL; SMOOTH MUSCLE RELAXATION; VASCULAR SMOOTH MUSCLE; VASODILATATION;

ACETYLCHOLINE; ANIMALS; BIOLOGICAL FACTORS; CYCLIC GMP; CYCLOOXYGENASE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; GUANYLATE CYCLASE; MALE; MEMBRANE POTENTIALS; MESENTERIC ARTERIES; MICE; MICE, INBRED C57BL; MUSCLE RELAXATION; MUSCLE, SMOOTH, VASCULAR; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE DONORS; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; NITRIC OXIDE SYNTHASE TYPE III; OLIGOPEPTIDES; POTASSIUM; POTASSIUM CHANNEL BLOCKERS; RECEPTOR, PAR-2; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, THROMBIN;

EID: 0036152776     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0704469     Document Type: Article

References (77)

1. Varying extracellular [K+]: A functional approach to separating EDHF- and EDNO-related mechanisms in perfused rat mesenteric arterial bed
2. Detection of functional receptors for the proteinase-activated-receptor- 2-activating polypepfide, SLIGRL-NH2, in rat vascular and gastric smooth muscle
3. +ATPase on EDHF relaxations in the rat hepatic artery
4. Ligand cross-reactivity within the protease-activated receptor family
5. Nitric oxide directly activates calcium-dependent potassium channels in vascular smooth muscle
6. Antisense oligonucleotides against cytochrome P450 2C8 attenuate EDHF-mediated Ca(2+) changes and dilation in isolated resistance arteries
7. Nitrovasodilators relax mesenteric micro-vessels by cGMP-induced stimulation of Ca-activated K channels
8. Acetylcholine-induced relaxation in blood vessels from endothelial nitric oxide synthase knockout mice
9. Central role of heterocellular gap junctional communication in endothelium-dependent relaxations of rabbit arteries
10. Modulation of endothelium-dependent hyperpolarization and relaxation to acetylcholine in rat mesenteric artery by cytochrome P450 enzyme activity
11. Acetylcholine releases endothelium-derived hyperpolarizing factor and EDRF from rat blood vessels
12. Role of endothelial cells in relaxation of isolated arteries by bradykinin
13. Nitric oxide-sensitive and -insensitive contractions of the isolated rabbit iris sphincter muscle
14. Nitric oxide is the mediator of both endothelium-dependent relaxation and hyperpolarization of the rabbit carotid artery
15. Expression cloning and characterization of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation
16. Cardiovascular responses mediated by protease-activated receptor-2 (PAR2) and thrombin receptor (PAR-1) are distinguished in mice deficient in PAR-2 or PAR-1
17. Reversible inhibition of intercellular junctional communication by glycyrrhetinic acid
18. Endothelium-dependent inhibitory effects of acetylcholine, adenosine triphosphate, thrombin and arachidonic acid in the canine femoral artery
19. Potassium-and acetylcholine-induced vasorelaxation in mice lacking endothelial nitric oxide synthase
20. The other endothelium-derived relaxing factor: A review of recent findings concerning the nature and cellular actions of endothelium-derived hyperpolarizing factor (EDHF)
21. NO/PG12-independent vasorelaxation and the cytochrome P450 pathway in rabbit carotid artery
22. An indirect influence of phenylephrine on the release of endothelium- derived vasodilators in rat small mesenteric artery
23. Charybdotoxin and apamin block EDHF in rat mesenteric artery if selectively applied to the endothelium
24. K+ is an endothelium-derived hyperpolarizing factor in rat arteries
25. Role of gap junctions and EETs in endothelium-dependent hyperpolarization of porcine coronary artery
26. Vascular effects of proteinase-activated receptor 2 agonist peptide
27. Mechanism underlying substance P-induced relaxation in dog isolated superficial temporal arteries
28. Cytochrome P450 2C is an EDHF synthase in coronary arteries
29. Cytochrome P450-dependent effects of bradykinin in the rat heart
30. Pharmacological evaluation of an epoxide as the putative hyperpolarizing factor mediating the nitric oxide-independent vasodilator effect of bradykinin in the rat heart
31. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine
32. Endothelium-dependent hyperpolarization and relaxation resistance to N(G)-nitro-L-arginine and indomethacin in coronary circulation
33. Heterogeneous mechanisms of endothelium-dependent relaxation for thrombin and peptide activators of protease-activated receptor-1 in porcine isolated coronary artery
34. K + channels which contribute to the acetylcholine-induced hyperpolarization in smooth muscle of the guinea-pig submucosal arteriole
35. Endothelium-derived Hyperpolarization Factor - Fact or Fiction
36. Characterization of endothelium-derived hyperpolarizing factor as a cytochrome P450-derived arachidonic acid metabolite in mammals
37. Proteinase-activated receptors: Structural requirements for activity, receptor cross-reactivity, and receptor selectivity of receptor- activating peptides
38. Proteinase-activated receptor 4 (PAR4): Activation and inhibition of rat platelet aggregation by PAR4-derived peptides
39. Mechanisms of endothelium-dependent vascular smooth muscle relaxation elicited by bradykinin and VIP
40. Calmidazolium, a calmodulin inhibitor, inhibits endothelium-dependent relaxations resistant to nitro-L-arginine in the canine coronary artery
41. A dual thrombin receptor system for platelet activation
42. Evaluation of proteinase-activated receptor-1 (PAR1) agonists and antagonists using a cultured cell receptor desensitization assay: Activation of PAR2 by PAR1-targeted ligands
43. Evidence that mechanisms dependent and independent of nitric oxide mediate endothelium-dependent relaxation to bradykinin in human small resistance-like coronary arteries
44. Endothelium-derived relaxing factors: A focus on endothelium-derived hyperpolarization factor
45. Neuronal NOS-cGMP-dependent ACh-induced relaxation in pial arterioles of endothelial NOS knockout mice
46. Nitric oxide (NO)-induced activation of large conductance Ca2 + - Dependent K + channels (BK(Ca)) in smooth muscle cells isolated from the rat mesenteric artery
47. Endothelium-dependent and -independent responses to protease-activated receptor-2 (PAR-2) activation in mouse isolated renal arteries
48. Endothelial cell thrombin receptors and PAR-2. Two protease-activated receptors located in a single cellular environment
49. Apamin-sensitive K+ channels mediate an endothelium-dependent hyperpotarization in rabbit mesenteric arteries
50. Molecular cloning of a potential proteinase activated receptor
51. The mouse proteinase-activated receptor-2 eDNA and gene. Molecular cloning and functional expression
52. A transferable, beta-naphthoflavone-inducible, hyperpolarizing factor is synthesized by native and cultured porcine coronary endothelial cells
53. Endothelium-independent, ouabain-sensitive relaxation of bovine coronary arteries by EETs
54. Role of endothelial cell hyperpolarization in EDHF-mediated responses in the guinea-pig carotid artery
55. Is EDHF an epoxyeicosatrienoic acid?
56. Agonist-induced endothelium-dependent relaxation in rat thoracic aorta may be mediated through cGMP
57. cDNA cloning and expression of a hamster alpha-thrombin receptor coupled to Ca2+mobilization
58. Receptors for substance P. I. The pharmacological preparations
59. Dual endothelium-dependent vascular activities of proteinase-activated receptor-2-activating peptides: Evidence for receptor heterogeneity
60. Rat proteinase-activated receptor-2 (PAR-2): cDNA sequence and activity of receptor-derived peptides in gastric and vascular tissue
61. Endothelium-dependent contractile actions of proteinase-activated receptor-2-activating peptides in human umbilical vein: Release of a contracting factor via a novel receptor
62. Activation of protease-activated receptor-2 (PAR-2) elicits nitric oxide-dependent dilatation of the basilar artery in vivo
63. Evidence for selective effects of chronic hypertension on cerebral artery vasodilatation to protease-activated receptor-2 activation
64. Hyperpolarization and relaxation of arterial smooth muscle caused by nitric oxide derived from the endothelium
65. + channels, membrane potential and the release of vasoactive factors from the vascular endothelium
66. Influence of cytochrome P-450 inhibitors on endothelium-dependent nitro- L-arginineresistantrelaxation and cromakalim-induced relaxation in rat mesenteric arteries
67. Influence of some phospholipase A2 and cytochrome P450 inhibitors on rat arterial smooth muscle K+ currents
68. EDHF and residual NO: Different factors
69. Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation
70. Acetylcholine-induced relaxation of peripheral arteries isolated from mice lacking endothelial nitric oxide synthase
71. Effect of potassium channel blockers on L-NAME insensitive relaxations in rat small mesenteric artery
72. Role of EDHF in conduction of vasodilation along hamster cheek pouch arterioles in vivo
73. Cytochrome P-450 pathway in acetylcholine-induced canine coronary microvascular vasodilation in vivo
74. Cloning and characterization of human protease-activated receptor 4
75. Relation between cyclic GMP generation and cerebrovascular reactivity: Modulation by NPY and alpha-trinositol
76. Effects of cytochrome P450 inhibitors on EDHF-mediated relaxation in the rat hepatic artery
77. Role of potassium channels in endothelium-dependent relaxation resistant to nitroarginine in the rat hepatic artery