Structure-activity studies of the inhibition of FabI, the enoyl reductase from Escherichia coli, by Triclosan: Kinetic analysis of mutant FabIs

Biochemistry

Volumn 42, Issue 15, 2003, Pages 4406-4413

  Sivaraman, Sharada ^a   Zwahlen, Jacque ^a   Bell, Alasdair F ^a   Hedstrom, Lizbeth ^b   Tonge, Peter J ^a  

^a STONY BROOK UNIVERSITY   (United States)

^b BRANDEIS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHESIS; ENZYME INHIBITION; ESCHERICHIA COLI; FATTY ACIDS;

STRUCTURE-ACTIVITY STUDIES;

BIOCHEMISTRY;

BACTERIAL ENZYME; MUTANT PROTEIN; OXIDOREDUCTASE; TRICLOSAN;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG PROTEIN BINDING; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME INHIBITION; ENZYME KINETICS; ENZYME STRUCTURE; ESCHERICHIA COLI; GENETIC SELECTION; INHIBITION KINETICS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SPECTROPHOTOMETRY; STRUCTURE ACTIVITY RELATION; WILD TYPE;

AMINO ACID SUBSTITUTION; CATALYTIC DOMAIN; ENOYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (NADH); ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; KINETICS; MUTATION; OXIDOREDUCTASES; STRUCTURE-ACTIVITY RELATIONSHIP; TRICLOSAN;

ACTINOBACTERIA (CLASS); BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; MYCOBACTERIUM; MYCOBACTERIUM TUBERCULOSIS; NEGIBACTERIA; UNCULTURED ACTINOMYCETE;

EID: 0037461276     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi0300229     Document Type: Article

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