Physiologically-based pharmacokinetic model for trichloroethylene considering enterohepatic recirculation of major metabolites

Risk Analysis

Volumn 18, Issue 3, 1998, Pages 261-269

  Stenner, Robert D ^a   Merdink, James L ^b   Fisher, Jeffery W ^c   Bull, Richard J ^a  

^a PACIFIC NORTHWEST NATIONAL LABORATORY   (United States)

^b WASHINGTON STATE UNIVERSITY   (United States)

^c AIR FORCE RESEARCH LABORATORY   (United States)

Author keywords

Enterohepatic recirculation; PBPK models; Toxicokinetics; Trichloroethylene

Indexed keywords

ENTEROHEPATIC RECIRCULATION; TOXICOKINETICS; TRICHLOROETHYLENE;

CHLORINE COMPOUNDS; HEMODYNAMICS; MATHEMATICAL MODELS; METABOLISM; METABOLITES; PHYSIOLOGY;

PHARMACOKINETICS;

TRICHLOROACETIC ACID; TRICHLOROETHANOL; TRICHLOROETHANOL GLUCURONIDE; TRICHLOROETHYLENE; UNCLASSIFIED DRUG;

ARTICLE; DOSE CALCULATION; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG METABOLISM; ENTEROHEPATIC CIRCULATION; HUMAN; HUMAN TISSUE; LIVER CARCINOGENESIS; PREDICTION; PROTEIN BINDING; QUANTITATIVE DIAGNOSIS;

ANIMALS; BLOOD PROTEINS; CARCINOGENS; ENTEROHEPATIC CIRCULATION; ENVIRONMENTAL POLLUTANTS; LIVER NEOPLASMS, EXPERIMENTAL; MICE; MODELS, BIOLOGICAL; PROTEIN BINDING; RATS; RATS, INBRED F344; RISK; TRICHLOROACETIC ACID; TRICHLOROETHYLENE;

EID: 0032102017     PISSN: 02724332     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1539-6924.1998.tb01293.x     Document Type: Article

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