A convenient in vitro screening method for predicting in vivo drug metabolic clearance using isolated hepatocytes suspended in serum

Drug Metabolism and Disposition

Volumn 28, Issue 12, 2000, Pages 1518-1523

  Shibata, Yoshihiro ^a   Takahashi, Hiroyuki ^a   Ishii, Yasuyuki ^a  

^a BANYU PHARMACEUTICAL CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

7 ETHOXYCOUMARIN; ALPRENOLOL; CAFFEINE; CHLORPROMAZINE; DIAZEPAM; DRUG; HEXOBARBITAL; IBUPROFEN; LIDOCAINE; PHENAZONE; PHENYTOIN; PROPRANOLOL; QUINIDINE; THEOPHYLLINE; TOLBUTAMIDE; VERAPAMIL; WARFARIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG METABOLISM; DRUG SCREENING; LIVER CELL; LIVER CLEARANCE; MODEL; NONHUMAN; PLASMA CLEARANCE; PRIORITY JOURNAL; RAT; SERUM; TECHNIQUE;

ALGORITHMS; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTIPYRINE; BIOLOGICAL AVAILABILITY; CULTURE MEDIA; HEPATOCYTES; LIVER; MALE; METABOLIC CLEARANCE RATE; PHARMACEUTICAL PREPARATIONS; RATS; RATS, SPRAGUE-DAWLEY;

ANIMALIA;

EID: 0033670103     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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