The contribution of somatic hypermutation to the diversity of serum immunoglobulin: Dramatic increase with age

Immunity

Volumn 13, Issue 3, 2000, Pages 409-417

  Williams, Gareth T ^a   Jolly, Christopher J ^a   Köhler, Jenny ^a   Neuberger, Michael S ^a  

^a MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M;

ANIMAL EXPERIMENT; ARTICLE; B LYMPHOCYTE; CONTROLLED STUDY; GENE REARRANGEMENT; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOGLOBULIN PRODUCTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SOMATIC MUTATION;

EID: 0033662327     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(00)00040-6     Document Type: Article

References (48)

1. Activation of memory and virgin B cell clones in hyperimmune animals
2. Maturation of the immune response in germinal centers
3. Passenger transgenes reveal intrinsic specificity of the antibody hypermutation mechanism: Clustering, polarity, and specific hot spots
4. Enhanced B-1 cell development, but impaired IgG antibody responses in mice deficient in secreted IgM
5. B cell repertoire in adult antigen-free and conventional neonatal BALB/c mice. II. Analysis of antigen binding capacities in relation to VH gene usage
6. Targeted gene disruption reveals a role for natural secretory IgM in the maturation of the primary immune response
7. Light chain germline genes and the immune response to 2-phenyloxazolone
8. Molecular characterization of anti-DNA antibodies induced in normal mice by immunization with bacterial DNA. Differences from spontaneous anti-DNA in the content and location of VH CDR3 arginines
9. Age-related decrease in the proportion of germinal center B cells from mouse Peyer's patches is accompanied by an accumulation of somatic mutations in their immunoglobulin genes
10. Modifying the sequence of an immunoglobulin V-gene alters the resulting pattern of hypermutation
11. Isolation of high affinity human antibodies directly from large synthetic repertoires
12. Most peripheral B cells in mice are ligand selected
13. The repertoire of serum IgM in normal mice is largely independent of external antigenic contact
14. Ageing and the immune system
15. Isotypes and specificities of immunoglobulins produced by germ-free mice fed chemically defined ultrafiltered 'antigen-free' diet
16. Frequency analysis of functional immunoglobulin C- and V-gene expression by mitogen-reactive B cells in germ-free mice fed chemically defined ultrafiltered 'antigen-free' diet
17. Immunoglobulin heavy chain gene expression in peripheral blood B lymphocytes
18. In situ studies of the primary immune response to (4-hydroxy-3-nitroprenyl)acetyl. II. A common clonal origin for periarteriolar lymphoid sheath associated foci and germinal centers
19. Intraclonal generation of antibody mutants in germinal centres
20. Rapid methods for the analysis of immunoglobulin gene hypermutation: Application to transgenic and gene-targeted mice
21. Functional analogues of the VκOx1 gene in different strains of mice: Evolutionary conservation but diversity based on V-J joining
22. Allelic forms of immunoglobulin V genes in different strains of mice
23. Targeted disruption of muchain membrane exon causes loss of heavy-chain allelic exclusion
24. Variable region gene analysis of B cell subsets derived from a 4-year-old child: Somatically mutated memory B cells accumulate in the peripheral blood already at young age
25. Evidence for a large compartment of IgM-expressing memory B cells in humans
26. Multiple sequences from downstream of the J kappa cluster can combine to recruit somatic hypermutation to a heterologous, upstream mutation domain
27. Mimicking somatic hypermutation: Affinity maturation of antibodies displayed on bacteriophage using a bacterial mutator strain
28. Antigen-driven selection of virgin and memory B cells
29. Mitogen-driven B cell proliferation and differentiation are not accompanied by hypermutation of immunoglobulin variable region genes
30. Lifetime of plasma cells in the bone marrow
31. Human cord blood antibody repertoire. Mixed population of VH gene segments and CDR3 distribution in the expressed C alpha and C gamma repertoires
32. Expression and regulation of immunoglobulin heavy-chain gene transfected into lymphoid cells
33. Monitoring and interpreting the intrinsic features of somatic hypermutation
34. Autonomous activation of B and T cells in antigen-free mice
35. Mutation and selection during the secondary response to 2-phenyloxazolone
36. In vitro triggering of somatic mutation in human naive B cells
37. Hypermutation generating the sheep immunoglobulin repertoire is an antigen-independent process
38. Somatic hypermutation of immunoglobulin genes in human neonates
39. Somatic hypermutagenesis in immunoglobulin genes. II. Influence of neighbouring base sequences on mutagenesis
40. Natural occurrence and origin of somatically mutated memory B cells in mice
41. Somatic hypermutation of immunoglobulin kappa may depend on sequences 3' of C-kappa and occurs on passenger transgenes
42. Analysis of somatic mutation and class switching in naive and memory B cells generating adoptive primary and secondary responses
43. Humoral immunity due to long-lived plasma cells
44. The extent of affinity maturation differs between the memory and antibody-forming cell compartments in the primary immune response
45. The variable genes and gene families of the mouse immunoglobulin kappa locus
46. Immunoglobulin switch transcript production in vivo related to the site and time of antigen-specific B cell activation
47. + B cell line in vitro: Definition of the requirements and modalities of hypermutation
48. Subtle differences in antibody responses and hypermutation of λ light chains in mice with a disrupted κ constant region