Selegiline attenuates cardiac oxidative stress and apoptosis in heart failure: Association with improvement of cardiac function

European Journal of Pharmacology

Volumn 461, Issue 2-3, 2003, Pages 149-158

  Qin, Fuzhong ^a   Shite, Junya ^a   Mao, Weike ^a   Liang, Chang Seng ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

Apoptosis; Cardiac function; Heart failure; Oxidative stress; Selegiline

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; ANTIOXIDANT; MITOCHONDRIAL DNA; MONOCLONAL ANTIBODY; NORADRENALIN; PLACEBO; PROTEIN BAX; PROTEIN BCL 2; SELEGILINE; SINGLE STRANDED DNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; ECHOCARDIOGRAPHY; HEART FAILURE; HEART FUNCTION; HEART LEFT VENTRICLE; HEART LEFT VENTRICLE CONTRACTION; HEART MUSCLE CELL; HEART PACING; IMMUNOHISTOCHEMISTRY; NONHUMAN; NORADRENALIN BLOOD LEVEL; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RABBIT; WESTERN BLOTTING;

EID: 0037436065     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(03)01306-2     Document Type: Article

References (56)

1. Aoki H., Kang P.M., Hampe J., Yoshimura K., Noma T., Matsuzaki M., Izumo S. Direct activation of mitochondrial apoptosis machinery by c-Jun N-terminal kinase in adult cardiac myocytes. J. Biol. Chem. 277:2002;10244-10250.
2. Bialik S., Cryns V.L., Drincic A., Miyata S., Wollowick A.L., Srinivasan A., Kitsis R.N. The mitochondrial apoptotic pathway is activated by serum and glucose deprivation in cardiac myocytes. Circ. Res. 85:1999;403-414.
3. Birkmayer W., Riederer P., Youdim M.B., Linauer W. The potentiation of the anti-akinetic effect of L-dopa treatment by an inhibitor of MAO-B, deprenyl. J. Neural Transm. 36:1975;303-336.
4. Carrillo M.C., Kitani K., Kanai S., Sato Y., Miyasaka K., Ivy G.O. (-)Deprenyl increases activities of superoxide dismutase and catalase in certain brain regions in old male mice. Life Sci. 54:1994;975-981.
5. Carrillo M.C., Kitani K., Kanai S., Sato Y., Ivy G.O., Miyasaka K. Long term treatment with (-)deprenyl reduces the optimal dose as well as the effective dose range for increasing antioxidant enzyme activity in old mouse brain. Life Sci. 59:1996;1047-1057.
6. Carrillo M.C., Kanai S., Kitani K., Ivy G.O. A high dose of long term treatment with deprenyl loses its effect on antioxidant enzyme activities as well as on survivals of Fischer-344 rats. Life Sci. 67:2000;2539-2548.
7. Castro P.F., Diaz-Araya G., Nettle D., Corbalan R., Perez O., Nazzal C., Larrain G., Lavandero S. Effects of early decrease in oxidative stress after medical therapy in patients with class IV congestive heart failure. Am. J. Cardiol. 89:2002;236-239.
8. Cesselli D., Jakoniuk I., Barlucchi L., Beltrami A.P., Hintze T.H., Nadal-Ginard B., Kajstura J., Leri A., Anversa P. Oxidative stress-mediated cardiac cell death is a major determinant of ventricular dysfunction and failure in dog dilated cardiomyopathy. Circ. Res. 89:2001;279-286.
9. Cohen R.M., Campbell I.C., Yamaguchi I., Pickar D., Kopin I.J., Murphy D.L. Cardiovascular changes in response to selective monoamine oxidase inhibition in the rat. Eur. J. Pharmacol. 80:1982;155-160.
10. Condorelli G., Roncarati R., Ross J., Pisani A., Stassi G., Todaro M., Trocha S., Drusco A., Gu Y., Russo M.A., Frati G., Jones S.P., Lefer D.J., Napoli C., Croce C.M. Heart-targeted overexpression of caspase 3 in mice increases infarct size and depresses cardiac function. Proc. Natl. Acad. Sci. U. S. A. 98:2001;9977-9982.
11. De la Asuncion J.G., Millan A., Pla R., Bruseghini L., Esteras A., Pallardo F.V., Sastre J., Vina J. Mitochondrial glutathione oxidation correlates with age-associated oxidative damage to mitochondrial DNA. FASEB J. 10:1996;333-338.
12. Duez P., Helson M., Some T.I., Dubois J., Hanocq M. Chromatographic determination of 8-oxo-7,8-dihydro-2′-deoxyguanosine in cellular DNA: a validation study. Free Radic. Res. 33:2000;243-260.
13. Ebadi M., Srinivasan S.K., Baxi M.D. Oxidative stress and antioxidant therapy in Parkinson's disease. Prog. Neurobiol. 48:1996;1-19.
14. Ellis G.R., Anderson R.A., Lang D., Blackman D.J., Morris R.H.K., Morris-Thurgood J., McDowell I.F.W., Jackson S.K., Lewis M.J., Frenneaux M.P. Neutrophil superoxide anion-generating capacity, endothelial function and oxidative stress in chronic heart failure: effects of short- and long-term vitamin C therapy. J. Am. Coll. Cardiol. 36:2000;1474-1482.
15. Ferdinandy P., Danial H., Ambrus I., Rothery R.A., Schulz R. Peroxynitrite is a major contributor to cytokine-induced myocardial contractile failure. Circ. Res. 87:2000;241-247.
16. Feuerstein G.Z., Young P.R. Apoptosis in cardiac diseases: stress- and mitogen-activated signaling pathways. Cardiovasc. Res. 45:2000;560-569.
17. Frustaci A., Chimenti C., Setoguchi M., Guerra S., Corsello S., Crea F., Leri A., Kajstura J., Anversa P., Maseri A. Cell death in acromegalic cardiomyopathy. Circulation. 99:1999;1426-1434.
18. Hare J.M. Oxidative stress and apoptosis in heart failure progression. Circ. Res. 89:2001;198-200.
19. Hockenbery D.M., Oltvai Z.N., Yin X.M., Milliman C.L., Korsmeyer S.J. Bcl-2 functions in an antioxidant pathway to prevent apoptosis. Cell. 75:1993;241-251.
20. Ide T., Tsutsui H., Hayashidani S., Kang D., Suematsu N., Nakamura K., Utsumi H., Hamasaki N., Takeshita A. Mitochondrial DNA damage and dysfunction associated with oxidative stress in failing hearts after myocardial infarction. Circ. Res. 88:2001;529-535.
21. Kawai H., Mohan A., Hagen J., Dong E., Armstrong J., Stevens S.Y., Liang C.-S. Alterations in cardiac adrenergic terminal function and β-adrenoceptor density in pacing-induced heart failure. Am. J. Physiol., Heart Circ. Physiol. 278:2000;H1708-H1716.
22. Khaldy H., Escames G., Leon J., Vives F., Luna J.D., Acuna-Castroviejo D. Comparative effects of melatonin, L-deprenyl, trolox and ascorbate in the suppression of hydroxyl radical formation during dopamine autoxidation in vitro. J. Pineal Res. 29:2000;100-107.
23. Kinugawa S., Tsutsui H., Hayashidani S., Ide T., Suematsu N., Satoh S., Utsumi H., Takeshita A. Treatment with dimethylthiourea prevents left ventricular remodeling and failure after experimental myocardial infarction in mice: role of oxidative stress. Circ. Res. 87:2000;392-398.
24. Kitani K., Miyasaka K., Kanai S., Carrillo M.C., Ivy G.O. Upregulation of antioxidant enzyme activities by deprenyl. Implications for life span extension. Ann. N.Y. Acad. Sci. 15:1996;391-409.
25. Kitani K., Kanai S., Ivy G.O., Garrillo M.C. Assessing the effects of deprenyl on longevity and antioxidant defenses in different animal models. Ann. N.Y. Acad. Sci. 854:1998;291-306.
26. Kitani K., Kanai S., Ivy G.O., Carrillo M.C. Pharmacological modifications of endogenous antioxidant enzymes with special reference to the effects of deprenyl: a possible antioxidant strategy. Mech. Ageing Dev. 111:1999;211-221.
27. Laugwitz K.L., Moretti A., Weig H.J., Gillitzer A., Pinkernell K., Ott T., Pragst I., Stadele C., Seyfarth M., Schomig A., Ungerer M. Blocking caspase-activated apoptosis improves contractility in failing myocardium. Hum. Gene Ther. 12:2001;2051-2063.
28. +)-induced apoptosis independent of MAO-B inhibition. Neurosci. Lett. 224:1997;197-200.
29. Mak S., Newton G.E. The oxidative stress hypothesis of congestive heart failure. Chest. 120:2001;2035-2046.
30. Maruyama W., Yamamoto T., Kitani K., Carrillo M.C., Youdim M., Naoi M. Mechanism underlying anti-apoptotic activity of a (-)deprenyl-related propargylamine, rasagiline. Mech. Ageing Dev. 116:2000;181-191.
31. Mytilineou C., Leonardi E.K., Radcliffe P., Heinonen E.H., Han S.K., Werner P., Cohen G., Olanow C.W. Deprenyl and desmethylselegiline protect mesencephalic neurons from toxicity induced by glutathione depletion. J. Pharmacol. Exp. Ther. 284:1998;700-706.
32. Nakamura K., Kusano K., Nakamura Y., Kakishita M., Ohta K., Nagase S., Yamamoto M., Miyaji K., Saito H., Morita H., Emori T., Matsubara H., Toyokuni S., Ohe T. Carvedilol decreases elevated oxidative stress in human failing myocardium. Circulation. 105:2002;2867-2871.
33. Oltvai Z.N., Milliman C.L., Korsmeyer S.J. Bcl-2 heterodimerizes in vivo with a conserved homology, bax, that accelerates programmed cell death. Cell. 74:1993;609-619.
34. Oskarsson H.J., Coppey L., Weiss R.M., Li W.G. Antioxidants attenuate myocyte apoptosis in the remote non-infarcted myocardium following large myocardial infarction. Cardiovasc. Res. 45:2000;679-687.
35. Qin F., Rounds N.K., Mao W., Kawai K., Liang C.-S. Antioxidant vitamins prevent cardiomyocyte apoptosis produced by norepinephrine infusion in ferrets. Cardiovasc. Res. 51:2001;736-748.
36. Sabbah H.N. Apoptotic cell death in heart failure. Cardiovasc. Res. 45:2000;704-712.
37. Salo P.T., Tatton W.G. Deprenyl reduces the death of motoneurons caused by axotomy. J. Neurosci. Res. 31:1992;394-400.
38. Scheinin M., Illi A., Koulu M., Ojala-Karlsson P. Norepinephrine metabolites in plasma as indicators of pharmacological inhibition of monoamine oxidase and catechol O-methyltransferase. Adv. Pharmacol. 42:1998;367-370.
39. Semkova I., Wolz P., Schilling M., Krieglstein J. Selegiline enhances NGF synthesis and protects central nervous system neurons from excitotoxic and ischemic damage. Eur. J. Pharmacol. 315:1996;19-30.
40. Shigenaga M.K., Aboujaoude E.N., Chen Q., Ames B.N. Assays of oxidative DNA damage biomarkers 8-oxo-2′-deoxyguanosine and 8-oxoguanine in nuclear DNA and biological fluids by high-performance liquid chromatography with electrochemical detection. Methods Enzymol. 234:1994;16-33.
41. Shite J., Dong E., Kawai H., Stevens S.Y., Liang C.-S. Selegiline improves cardiac sympathetic terminal function and β-adrenergic responsiveness in heart failure. Am. J. Physiol., Heart Circ. Physiol. 279:2000;H1283-H1290.
42. Simon L., Szilagyi G., Bori Z., Orbay P., Nagy Z. (-)-D-Deprenyl attenuates apoptosis in experimental brain ischaemia. Eur. J. Pharmacol. 430:2001;235-241.
43. Suuronen T., Kolehmainen P., Salminen A. Protective effect of L-deprenyl against apoptosis induced by okadaic acid in cultured neuronal cells. Biochem. Pharmacol. 59:2000;1589-1595.
44. Suzuki K., Kostin S., Person V., Elsasser A., Schaper J. Time course of the apoptotic cascade and effects of caspase inhibitors in adult rat ventricular cardiomyocytes. J. Mol. Cell. Cardiol. 33:2001;983-994.
45. Tatton W.G., Chalmers-Redman R.M. Modulation of gene expression rather than monoamine oxidase inhibition: (-)-deprenyl-related compounds in controlling neurodegeneration. Neurology. 47:1996;S171-S183.
46. Tatton W.G., Ju W.Y., Holland D.P., Tai C., Kwan M. (-)-Deprenyl reduces PC12 cell apoptosis by inducing new protein synthesis. J. Neurochem. 63:1994;1572-1575.
47. Tatton W.G., Wadia J.S., Ju W.Y., Chalmers-Redman R.M., Tatton N.A. (-)-Deprenyl reduces neuronal apoptosis and facilitates neuronal outgrowth by altering protein synthesis without inhibiting monoamine oxidase. Neural Transm., Suppl. 48:1996;45-59.
48. Tatton W.G., Chalmers-Redman R.M., Ju W.J., Mammen M., Carlile G.W., Pong A.W., Tatton N.A. Progarylamines induce antiapoptotic new protein synthesis in serum- and nerve growth factor (NGF)-withdrawn, NGF-differentiated PC-12 cells. J. Pharmacol. Exp. Ther. 301:2002;753-764.
49. ThyagaRajan S., Madden K.S., Stevens S.Y., Felten D.L. Restoration of splenic noradrenergic nerve fibers and immune reactivity in old F344 rats: a comparison between L-deprenyl and L-desmethyldeprenyl. Int. J. Immunopharmacol. 22:2000;523-536.
50. Turkka J., Suominen K., Tolonen U., Sotaniemi K., Myllyla V.V. Selegiline diminishes cardiovascular autonomic responses in Parkinson's disease. Neurology. 48:1997;662-667.
51. 2+ uptake coupled to electron transport in rat heart mitochondria. J. Biol. Chem. 253:1978;6379-6385.
52. Wadia J.S., Chalmers-Redman R.M., Ju W.J., Carlile G.W., Phillips J.L., Fraser A.D., Tatton W.G. Mitochondrial membrane potential and nuclear changes in apoptosis caused by serum and nerve growth factor withdrawal: time course and modification by (-)-deprenyl. J. Neurosci. 18:1998;932-947.
53. Watanabe I., Toyoda M., Okuda J., Tenjo T., Tanaka K., Yamamoto T., Kawasaki H., Sugiyama T., Kawarada Y., Tanigawa N. Detection of apoptotic cells in human colorectal cancer by two different in situ methods: antibody against single-stranded DNA and terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end-labeling (TUNEL) methods. Jpn. J. Cancer Res. 90:1999;188-193.
54. Wu R.M., Mohanakumar K.P., Murphy D.L., Chiueh C.C. Antioxidant mechanism and protection of nigral neurons against MPP+ toxicity by deprenyl (selegiline). Ann. N.Y. Acad. Sci. 738:1994;214-221.
55. Xu L., Ma J.F., Seigel G.M., Ma J.X. L-Deprenyl, blocking apoptosis and regulating gene expression in cultured retinal neurons. Biochem. Pharmacol. 58:1999;1183-1190.
56. Zhao Z.Q., Nakamura M., Wang N.P., Wilcox J.N., Shearer S., Ronson R.S., Guyton R.A., Vinten-Johansen J. Reperfusion induces myocardial apoptotic cell death. Cardiovasc. Res. 45:2000;651-660.