(-)-Deprenyl protection of 1-methyl-4 phenylpyridium ion (MPP+)-induced apoptosis independent of MAO-B inhibition

Neuroscience Letters

Volumn 224, Issue 3, 1997, Pages 197-200

  Le, Weidong ^a   Jankovic, Joseph ^a   Xie, Wenjie ^a   Kong, Rong ^a   Appel, Stanley H ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

( ) Deprenyl; 1 Methyl 4 phenylpyridinium ion; Apoptosis; Monoamine oxidase B; Parkinson's disease

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; MONOAMINE OXIDASE B INHIBITOR; N (2 AMINOETHYL) 4 CHLOROBENZAMIDE; NEUROPROTECTIVE AGENT; SELEGILINE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CULTURE; CELL LINE; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL;

1-METHYL-4-PHENYLPYRIDINIUM; ANIMALS; APOPTOSIS; CELLS, CULTURED; HYBRID CELLS; MONOAMINE OXIDASE; NEURONS; SELEGILINE;

EID: 0030891039     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(97)00170-5     Document Type: Article

References (17)

1. Birkmayer, W., Knoll, J., Riederer, P., Youdim, M.B.H., Hars, V. and Marton, J., Increased life expectancy resulting from addition of 1-deprenyl to Madopar treatment in Parkinson's disease: a long-term study, J. Neural Transm., 64 (1985) 113-127.
2. Bondiolotti, G.P., Galva, M.D., Villa, F., Sciaba, L. and Picotti, G.B., In vitro effects on monoamine uptake and release by the reversible monoamine oxidase-B inhibitors lazabemine and N-(2 aminoethyl)-p-chlorobenzamide: a comparison with L-deprenyl, Biochem. Pharmacol., 50 (1995) 97-102.
3. Burns, R.S., Chiueh, C.C., Markey, S.P., Ebert, M.H., Jacobowitz, D. and Kopin, I.J., A primate model of parkinsonism: selective destruc tion of dopaminergic neurons in the pars compacta of the substantia nigra by N-methy-4-phenyl-1,2,3,6-tetrahydropyridine, Proc. Natl. Acad. Sci. USA, 80 (1983) 4546-4550.
4. Crawford, G.D., Le, W.D., Smith, R.G., Xie, W.J. and Appel, S.H., A novel N18TG2 mesencephalon cell hybrid expresses properties which suggest a dopaminergic cell line of substantia nigra origin, J. Neurosci., 12 (1992) 3392-3396.
5. Dipasquale, B., Marini, M. and Youle, R.J., Apoptosis and DNA degradation by 1-metyl-4 phenylpyridium in neurons, Biochem. Biophys. Res. Commun., 181 (1991) 493-501.
6. Finnegan, K.T. and Skratt, J.J., Irwin, I, DeLanney, L.E. and Langston, J.W., Protection against DSP-4-induced neurotoxicity by deprenyl is not related to its inhibition of MAO-B, Eur. J. Pharmacol., 184 (1990) 119-126.
7. Kitani, K., Miyasaka, K., Kanai, S., Carrillo, M.C. and Ivy, G.O., Upregulation of antioxidant enzyme activities by deprenyl, Implications for lifespan extension, Ann. N.Y. Acad. Sci., 786 (1996) 391-409.
8. +): identification of a metabolite of MPTP, a toxin selective to the substantia nigra, Neurosci. Lett., 48 (1984) 87-92.
9. Le, W.D., Colom, L., Xie, W.J., Smith, R.G. and Appel, S.H., Cell death induced by β-amyloid 1-40 in hybrid clone: role of nitric oxide and NMDA-gated channel activation leading to apoptosis, Brain Res., 686 (1995) 49-60.
10. +) in ventral mesencephalic-striatal co-culture in rat, Neurosci. Lett., 170 (1994) 191-194.
11. Mytilineou, C. and Cohen, G., Deprenyl protects dopamine neurons from the neurotoxic effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridinium ion, J. Neurochem., 46 (1985) 1951-1953.
12. Oh, C., Murray, B., Hattacharya, N., Holland, D. and Tatton, W.G., (-)-Deprenyl alters the survival of adult facial motoneurons after axotomy: increases in vulnerable C57BL strain but decreases in motor neuron degeneration mutants, J. Neurosci. Res., 38 (1994) 64-74.
13. Olanow, C.W., Hauser, R.A., Gauger, L., Malapira, T., Koller, W., Hubble, J., Bushenbark, K., Lilienfield, D. and Esterlitz, J., The effect of deprenyl and levodopa on the progression of Parkinson's disease, Ann. Neurol., 38 (1995) 771-777.
14. +-induced hydroxyl radical formation in vivo without affecting dopamine efflux, Movement Disorders, 11 (Suppl.)(1996) 191.
15. Roy, E. and Bedard, P.J., Deprenyl increases survival of rat foetal nigral neurones in culture, NeuroReport, 4 (1993) 1183-1186.
16. Tatton, W.G., Ju, W.Y., Holland, D.P., Tai, C. and Kwan, M., (-)-Deprenyl reduces PC 12 cell apoptosis by inducing new protein synthesis, J. Neurochem., 63 (1994) 1572-1575.
17. Tatton, W.G. and Greenwood, C.E., Rescue of dying neurons: a new action for deprenyl in MPTP parkinsonism, J. Neurosci. Res., 30 (1991) 666-672.