Analysis of the stimulatory effect of splicing on mRNA production and utilization in mammalian cells

RNA

Volumn 9, Issue 5, 2003, Pages 618-630

  Lu, Shihua ^a   Cullen, Bryan R ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Nuclear mRNA export; Polyadenylation; Splicing; Translation

Indexed keywords

BETA GLOBIN; MESSENGER RNA;

ANIMAL CELL; ARTICLE; GENE EXPRESSION; HUMAN; HUMAN CELL; INTRON; MAMMAL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA PROCESSING; RNA SPLICING; RNA TRANSLATION; VIRUS REPLICATION;

3T3 CELLS; ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; CELL LINE; GENE EXPRESSION; GLOBINS; HEPATITIS B VIRUS; HUMANS; INTRONS; MICE; PROINSULIN; PROTEIN BIOSYNTHESIS; PROTEIN PRECURSORS; QUAIL; RATS; RNA PROCESSING, POST-TRANSCRIPTIONAL; RNA SPLICING; RNA, MESSENGER;

ANIMALIA; INSERTION SEQUENCES; MAMMALIA; VERTEBRATA;

EID: 0037407941     PISSN: 13558382     EISSN: None     Source Type: Journal    
DOI: 10.1261/rna.5260303     Document Type: Article

References (53)

1. Brinster, R.L., Allen, J.M., Behringer, R.R., Gelinas, R.E., and Palmiter, R.D. 1988. Introns increase transcriptional efficiency in transgenic mice. Proc. Natl. Acad. Sci. 85: 836-840.
2. Brodsky, A.S. and Silver, P.A. 2000. Pre-mRNA processing factors are required for nuclear export. RNA 6: 1737-1749.
3. Buchman, A.R. and Berg, P. 1988. Comparison of intron-dependent and intron-independent gene expression. Mol. Cell. Biol. 8: 4395-4405.
4. Chang, D.D. and Sharp, P.A. 1989. Regulation by HIV Rev depends upon recognition of splice sites. Cell 59: 789-795.
5. Cho, E.J., Takagi, T., Moore, C.R., and Buratowski, S. 1997. mRNA capping enzyme is recruited to the transcription complex by phosphorylation of the RNA polymerase II carboxy-terminal domain. Genes & Dev. 11: 3319-3326.
6. Custodio, N., Carmo-Fonseca, M., Geraghty, F., Pereira, H.S., Grosveld, F., and Antonion, M. 1999. Inefficient processing impairs release of RNA from the site of transcription. EMBO J. 18: 2855-2866.
7. Deng, T., Li, Y., and Johnson, L.F. 1989. Thymidylate synthase gene expression is stimulated by some (but not all) introns. Nucleic Acids Res. 17: 645-658.
8. Dower, K. and Rosbash, M. 2002. T7 RNA polymerase-directed transcripts are processed in yeast and link 3′ end formation to mRNA export. RNA 8: 686-697.
9. Eckner, R., Ellmeier, W., and Birnstiel, M.L. 1991. Mature messenger RNA 3; End formation stimulates RNA export from the nucleus. EMBO J. 10: 3513-3522.
10. Fornerod, M., Ohno, M., Yoshida, M., and Mattaj, I.W. 1997. CRM1 is an export receptor for leucine-rich nuclear export signals. Cell 90: 1051-1060.
11. Furger, A., O'Sullivan, J.M., Binnie, A., Lee, B.A., and Proudfoot, N.J. 2002. Promoter proximal splice sites enhance transcription. Genes & Dev. 16: 2792-2799.
12. Gatfield, D. and Izaurralde, E. 2002. REF1/Aly and the additional exon junction complex proteins are dispensable for nuclear mRNA export. J. Cell Biol. 159: 579-588.
13. Grüter, P., Tabernero, C., von Kobbe, C., Schmitt, C., Saavedra, C., Bachi, A., Wilm, M., Felber, B.K., and Izaurralde, E. 1998. TAP, the human homolog of Mex67p, mediates CTE-dependent RNA export from the nucleus. Mol. Cell 1: 649-659.
14. Hattori, K., Angel, P., Beau, M.M.L., and Karin, M. 1988. Structure and chromosomal localization of the functional intronless human JUN protooncogene. Proc. Natl. Acad. Sci. 85: 9148-9152.
15. Hentschel, C.C. and Birnstiel, M.X. 1981. The organization and expression of histone gene families. Cell 25: 301-313.
16. Hilleren, P., McCarthy, T., Rosbash, M., Parker, R. and Jensen, T.H. 2001. Quality control of mRNA 3′-end processing is linked to the nuclear exosome. Nature 413: 538-542.
17. Huang, J. and Liang, T.J. 1993. A novel hepatitis B virus (HBV) genetic element with Rev response element-like properties that is essential for expression of HBV gene products. Mol. Cell. Biol. 13: 7476-7486.
18. Huang, M.T.-F. and Gorman, C.M. 1990. Intervening sequences increase efficiency and accumulation of cytoplasmic RNA. Nucleic Acids Res. 18: 937-947.
19. Huang, Y. and Carmichael, G.G. 1996. Role of polyadenylation in nucleocytoplasmic transport of mRNA. Mol. Cell. Biol. 16: 1534-1542.
20. Huang, Y., Wimler, K.M., and Carmichael, G.G. 1999. Intronless mRNA transport elements may affect multiple steps of pre-mRNA processing. EMBO J. 18: 1642-1652.
21. Huang, Z.-M. and Yen, T.S.B. 1995. Role of the hepatitis B virus posttranscriptional regulatory element in export of intronless transcripts. Mol. Cell. Biol. 5: 3864-3869.
22. Jonsson, J.J., Goresman, M.D., Wilson, N., and McIvor, R.S. 1992. Intron requirement for expression of the human purine nucleoside phosphorylase gene. Nucleic Acids Res. 20: 3191-3198.
23. Kang, Y. and Cullen, B.R. 1999. The human Tap protein is a nuclear mRNA export factor that contains novel RNA-binding and nucleocytoplasmic transport sequences. Genes & Dev. 13: 1126-1139.
24. Kataoka, N., Diem, M.D., Kim, V.N., Yong, J., and Dreyfuss, G. 2001. Magoh, a human homolog of Drosophila magno nashi protein, is a component of the splicing-dependent exon-exon junction complex. EMBO J. 20: 6424-6433.
25. Kataoka, N., Yong, J., Kim, V.N., Velazquez, F., Perkinson, R.A., Wang, F., and Dreyfuss, G. 2000. Pre-mRNA splicing imprints mRNA in the nucleus with a novel RNA-binding protein that persists in the cytoplasm. Mol. Cell 6: 673-682.
26. Kim, V.N., Yong, J., Kataoka, N., Abel, L., Diem, M.D., and Dreyfuss, G. 2001. The Y14 protein communicates to the cytoplasm the position of exon-exon junctions. EMBO J. 20: 2062-2066.
27. Le Hir, H., Gatfield, D., Braun, I.C., Forler, D., and Izaurralde, E. 2001a. The protein Mago provides a link between splicing and mRNA localization. EMBO Rep. 21: 41119-1124.
28. Le Hir, H., Gatfield, D., Izaurralde, E., and Moore, M.J. 2001b. The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay. EMBO J. 20: 4987-4997.
29. Le Hir, H., Izaurralde, E., Maquat, L.E., and Moore, M.J. 2000. The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions. EMBO J. 19: 6860-6869.
30. Lei, E.P., Krebber, H., and Silver, P.A. 2001. Messenger RNAs are recruited for nuclear export during transcription. Genes & Dev. 15: 1771-1782.
31. Liu, X. and Mertz, J. 1995. HnRNP L binds a cis-acting RNA sequence element that enables intron-independent gene expression. Genes & Dev. 9: 1766-1780.
32. -. 1996. Sequence of the polypyrimidine tract of the 3′-terminal 3′ splicing signal can affect intron-dependent pre-mRNA processing in vivo. Nucleic Acids Res. 24: 1765-1773.
33. Lomedico, P., Rosenthal, N., Efstratiadis, A., Gilbert, W., Kolodner, R., and Tizard, R. 1979. The structure and evolution of the two non-allelic rat preproinsulin genes. Cell 18: 545-558.
34. Luo, M.-j., and Reed, R. 1999. Splicing is required for rapid and efficient mRNA export in metazoans. Proc. Natl. Acad. Sci. 96: 14937-14942.
35. Lykke-Andersen, J., Shu, M.-D., and Steitz, J.A. 2001. Communication of the position of exon-exon junctions to the mRNA surveillance machinery by the protein RNPS1. Science 293: 1836-1839.
36. Malim, M.H., Hauber, J., Fenrick, R., and Cullen, B.R. 1988. Immunodeficiency virus Rev trans-activator modulates the expression of the viral regulatory genes. Nature 335: 181-183.
37. Malim, M.H., Hauber, J., Le, S.-Y., Maizel, J.V., and Cullen, B.R. 1989. The HIV-1 Rev trans-activator acts through a structured target sequence to activate nuclear export of unspliced viral mRNA. Nature 338: 254-257.
38. Maniatis, T. and Reed, R. 2002. An extensive network of coupling among gene expression machines. Nature 416: 499-506.
39. Matsumoto, K., Wassarman, K.M., and Wolffe, A.P. 1998. Nuclear history of a pre-mRNA determines the translational activity of cytoplasmic mRNA. EMBO J. 17: 2107-2121.
40. McCracken, S., Fong, N., Yankulov, K., Ballantyne, S., Pan, G., Greenblatt, J., Patterson, S.D., Wickens, M., and Bentley, D.L. 1997. The C-terminal domain of RNA polymerase II couples mRNA processing to transcription. Nature 385: 357-361.
41. Nagata, S., Manlei, N., and Weissmann, C. 1980. The structure of one of the eight or more distinct chromosomal genes for human interferon-α. Nature 287: 401-408.
42. Niwa, M., Rose, S.D., and Berget, S.M. 1990. In vitro polyadenylation is stimulated by the presence of an upstream intron. Genes & Dev. 4: 1552-1559.
43. Nott, A., Meislin, S.H., and Moore, M.J. 2003. A quantitative analysis of intron effects on mammalian gene expression. RNA (this issue).
44. Ohno, M., Segref, A., Kuersten, S., and Mattaj, I. W. 2002. Identity elements used in export of mRNAs. Mol. Cell 9: 659-671.
45. Otero, G.C., Harris, M.E., Donello, J.E., and Hope, T.J. 1998. Leptomycin B inhibits equine infectious anemia virus Rev and feline immunodeficiency virus Rev function but not the function of the hepatitis B virus posttranscriptional regulatory element. J. Virol. 72: 7593-7597.
46. Pasleau, F., Leung, F., and Kopchick, J.J. 1987. A comparison of bovine growth hormone expression directed by bGH genomic or intronless DNA in transiently transfected eukaryotic cells. Gene 57: 47-52.
47. Rodrigues, J.P., Rode, M., Gatfield, D., Blencowe, B.J., Carmo-Fonseca, M., and Izaurralde, E. 2001. REF proteins mediate the export of spliced and unspliced mRNAs from the nucleus. Proc. Natl. Acad. Sci. 98: 1030-1035.
48. Ryu, W.-S. and Mertz, J.E. 1989. Simian virus 40 late transcripts lacking excisable intervening sequences are defective in both stability in the nucleus and transport to the cytoplasm. J. Virol. 63: 4386-4394.
49. Sträßer, K., Masuda, S., Mason, P., Pfannstiel, J., Oppizzl, M., Rodriguez-Navarro, S., Rondón, A.G., Agullera, A., Struhl, K., Reed, R., et al. 2002. TREX is a conserved complex coupling transcription with messenger RNA export. Nature 417: 304-307.
50. Vagner, S., Vagner, C., and Mattaj, I.W. 2000. The carboxyl terminus of vertebrate poly(A) polymerase interacts with U2AF 65 to couple 3′-end processing and splicing. Genes & Dev. 14: 403-413.
51. Yi, R., Bogerd, H.P., and Cullen, B.R. 2002. Recruitment of the Crm1 nuclear export factor is sufficient to induce cytoplasmic expression of incompletely spliced human immunodeficiency virus mRNAs. J. Virol. 76: 2036-2042.
52. Zenklusen, D., Vinciguerra, P., Wyss, J.-C., and Stutz, F. 2002. Stable mRNP formation and export require cotranscriptional recruitment of the mRNA export factors Yralp and Sub2p by Hprlp. Mol. Cell. Biol. 22: 8241-8253.
53. Zhou, Z., Luo, J.-j., Straesser, K., Katahira, J., Hurt, E., and Reed, R. 2000. The protein Aly links pre-messenger-RNA splicing to nuclear export in metazoans. Nature 407: 401-405.