Bioavailability of recombinant tumor necrosis factor determines its lethality in mice

European Journal of Immunology

Volumn 32, Issue 10, 2002, Pages 2759-2765

  Ameloot, Paul ^a   Takahashi, Nozomi ^a   Everaerdt, Bart ^a   Hostens, Jeroen ^a   Eugster, Hans Pietro ^b   Fiers, Walter ^a   Brouckaert, Peter ^a,c  

^a DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^b UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^c GHENT UNIVERSITY   (Belgium)

Author keywords

Clearance; Lethality; Mutein; Pharmacokinetics; Therapy

Indexed keywords

INTERLEUKIN 6; LIGAND; PROTEIN P55; RECOMBINANT TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR RECEPTOR;

ANIMAL EXPERIMENT; ARTICLE; BIOAVAILABILITY; CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG EXPOSURE; DRUG HALF LIFE; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG SELECTIVITY; FEMALE; FRACTIONATION; KNOCKOUT MOUSE; LETHALITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; WILD TYPE;

ANIMALS; ANTIGENS, CD; BIOLOGICAL AVAILABILITY; FEMALE; HUMANS; LETHAL DOSE 50; MICE; MICE, INBRED C57BL; RECEPTORS, TUMOR NECROSIS FACTOR; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE I; RECOMBINANT PROTEINS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0036772312     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(2002010)32:10<2759::AID-IMMU2759>3.0.CO;2-L     Document Type: Article

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