Pharmacologically regulated induction of silent mutations (PRISM): Combined pharmacological and genetic approaches for learning and memory

Neuroscientist

Volumn 9, Issue 2, 2003, Pages 104-109

  Frankland, Paul W ^a   Ohno, Masuo ^a   Takahashi, Eiki ^a   Chen, Adele R ^a   Costa, Rui M ^a   Kushner, Steven A ^a   Silva, Alcino J ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UCLA MEDICAL CENTER   (United States)

Author keywords

Fear conditioning; Knock out; LTP; Memory; Mutant

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PROTEIN KINASE (CALCIUM,CALMODULIN) II; RAS PROTEIN;

GENE CONTROL; GENE DELETION; GENE INDUCTION; GENE MUTATION; GENE TARGETING; GENETIC MANIPULATION; KNOCKOUT MOUSE; LEARNING; MEMORY; MOLECULAR GENETICS; MOLECULAR INTERACTION; MOUSE MUTANT; NERVE CELL PLASTICITY; NONHUMAN; PHARMACOGENETICS; PRIORITY JOURNAL; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION; TECHNIQUE; TRANSGENIC MOUSE;

ANIMALS; GENES, RAS; LEARNING; MEMORY; MITOGEN-ACTIVATED PROTEIN KINASES; MOLECULAR BIOLOGY; MUTATION; NEURONAL PLASTICITY; PHARMACOLOGY;

EID: 0037378007     PISSN: 10738584     EISSN: None     Source Type: Journal    
DOI: 10.1177/1073858403252225     Document Type: Review

References (32)

1. Adams JP, Sweatt JD. 2002. Molecular psychology: roles for the ERK MAP kinase cascade in memory. Annu Rev Pharmacol Toxicol 42:135-63.
2. Berman DE, Dudai Y. 2001. Memory extinction, learning anew, and learning the new: dissociations in the molecular machinery of learning in cortex. Science 291:2417-9.
3. Brambilla R, Gnesutta N, Minichiello L, White G, Roylance AJ, Herron CE, and others. 1997. A role for the Ras signalling pathway in synaptic transmission and long-term memory. Nature 390:281-6.
4. Cho YH, Giese KP, Tanila H, Silva AJ, Eichenbaum H. 1998. Abnormal hippocampal spatial representations in alphaCaMKIIT286A and CREBalphaDelta-mice. Science 279:867-9.
5. Costa RM, Yang T, Huynh DP, Pulst SM, Viskochil DH, Silva AJ, and others. 2001. Learning deficits, but normal development and tumor predisposition, in mice lacking exon 23a of Nf1. Nature Genetics 27:399-405.
6. Cullen PJ, Lockyer PJ. 2002. Integration of calcium and Ras signalling. Nat Rev Mol Cell Biol 3:339-48.
7. Dudai Y. 2002. Molecular bases of long-term memories: a question of persistence. Curr Opin Neurobiol 12:211-6.
8. Elgersma Y, Silva AJ. 1999. Molecular mechanisms of synaptic plasticity and memory. Curr Opin Neurobiol 9:209-13.
9. Fanselow MS. 2000. Contextual fear, gestalt memories, and the hippocampus. Behav Brain Res 110: 73-81.
10. Feil R, Brocard J, Mascrez B, LeMeur M, Metzger D, Chambon P. 1996. Ligand-activated site specific recombination in mice. Proc Natl Acad Sci U S A 93:10887-90.
11. Fink CC, Meyer T 2002. Molecular mechanisms of CaMKII activation in neuronal plasticity. Curr Opin Neurobiol 12:293-9.
12. Giese KP, Fedorov NB, Filipkowski RK, Silva AJ. 1998. Autophosphorylation at Thr286 of the a calcium-calmodulin kinase II in LTP and learning. Science 279:870-3.
13. Giese KP, Friedman E, Telliez JB, Fedorov NB, Wines M, Feig LA, and others. 2001. Hippocampus-dependent learning and memory is impaired in mice lacking the Ras-guanine-nucleotide releasing factor 1 (Ras-GRF1). Neuropharmacology 41:791-800.
14. Kida S, Josselyn S, Ortiz S, Kogan J, Chevere I, Masushige S, and others. 2002. CREB required for the stability of new and reactivated fear memories. Nature Neuroscience 5:348-55.
15. Lisman J, Schulman H, Cline H. 2002. The molecular basis of CaMKII function in synaptic and behavioural memory. Nat Rev Neurosci 3:175-90.
16. Logie C, Stewart AF. 1995. Ligand-regulated site-specific recombination. Proc Natl Acad Sci U S A 92:5940-4.
17. Lowes VL, Ip NY, Wong YH. 2002. Integration of signals from receptor tyrosine kinases and g protein-coupled receptors. Neurosignals 11:5-19.
18. Mansuy IM, Winder DG, Moallem TM, Osman M, Mayford M, Hawkins RD, and others. 1998. Inducible and reversible gene expression with the rtTA system for the study of memory. Neuron 21:257-65.
19. Mayford M, Bach ME, Huang YY, Wang L, Hawkins RD, Kandel ER. 1996. Control of memory formation through regulated expression of a CaMKII transgene. Science 274:1678-83.
20. Mayford M, Kandel ER. 1999. Genetic approaches to memory storage. Trends Genet 15:463-70.
21. Nader K, Schafe GE, Le Doux JE. 2000. Fear memories require protein synthesis in the amygdala for reconsolidation after retrieval. Nature (London) 406:722-6.
22. Ohno M, Frankland PW, Chen AP, Costa RM, Silva AJ. 2001. Inducible, pharmacogenetic approaches to the study of learning and memory. Nat Neurosci 4:1238-43.
23. Ohno M, Frankland PW, Silva AJ. 2002. A pharmacogenetic inducible approach to the study of NMDA/alphaCaMKII signaling in synaptic plasticity. Current Biology 12:654-6.
24. Otmakhov N, Griffith LC, Lisman JE. 1997. Postsynaptic inhibitors of calcium/calmodulin-dependent protein kinase type II block induction but not maintenance of pairing-induced long-term potentiation. J Neurosci 17:5357-65.
25. Roses AD. 2000. Pharmacogenetics and the practice of medicine. Nature 405:857-65.
26. Sanes JR, Lichtman JW. 1999. Can molecules explain long-term potentiation? Nat Neurosci 2:597-604.
27. Silva AJ, Frankland PW, Marowitz Z, Friedmann E, Lazlo G, Cioffi D, and others. 1997. A mouse model for the learning and memory deficits associated with neurofibromatosis type I. Nature Genetics 15:281-4.
28. Silva AJ, Paylor R, Wehner JM, Tonegawa S. 1992a. Impaired spatial learning in alpha-calcium-calmodulin kinase II mutant mice. Science 257:206-11.
29. Silva AJ, Wang Y, Paylor R, Wehner JM, Stevens CF, Tonegawa S. 1992b. Alpha calcium/calmodulin kinase II mutant mice: deficient long-term potentiation and impaired spatial learning. Cold Spring Harb Symp Quant Biol 57:527-39.
30. Sweatt JD. 2001. The neuronal MAP kinase cascade: a biochemical signal integration system subserving synaptic plasticity and memory. J Neurochem 76: 1-10.
31. Tsien JZ. 2000. Linking Hebb's coincidence-detection to memory formation. Curr Opin Neurobiol 10:266-73.
32. Villarreal DM, Do V, Haddad E, Derrick BE. 2002. NMDA receptor antagonists sustain LTP and spatial memory: active processes mediate LTP decay. Nat Neurosci 5:48-52.