Inhibition and activation of the human liver microsomal and human cytochrome P450 3A4 metabolism of testosterone by deployment-related chemicals

Drug Metabolism and Disposition

Volumn 31, Issue 4, 2003, Pages 384-391

  Usmani, Khawja A ^a   Rose, Randy L ^a   Hodgson, Ernest ^a  

^a NORTH CAROLINA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHLORPYRIFOS; CYTOCHROME P450 3A4; ESTRADIOL; FONOFOS; ORGANOPHOSPHORUS COMPOUND; PHORATE; TESTOSTERONE;

ARTICLE; CATALYSIS; DRUG ACTIVATION; DRUG INHIBITION; DRUG METABOLISM; DRUG POTENCY; ENDOCRINE FUNCTION; ENZYME SUBSTRATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HORMONE METABOLISM; HUMAN; HUMAN CELL; HYDROXYLATION; LIVER MICROSOME; MUSCLE STRENGTH; PRIORITY JOURNAL; SPERMATOGENESIS; XENOBIOTIC METABOLISM;

CHLORPYRIFOS; CHOLINESTERASE INHIBITORS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 ENZYME SYSTEM; DOSE-RESPONSE RELATIONSHIP, DRUG; GONADAL STEROID HORMONES; HUMANS; ISOENZYMES; KINETICS; MICROSOMES, LIVER; STEROID HYDROXYLASES; TESTOSTERONE;

EID: 0037377937     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: 10.1124/dmd.31.4.384     Document Type: Article

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