Macrophage signalling upon mycobacterial infection: The MAP kinases lead the way

Cellular Microbiology

Volumn 5, Issue 3, 2003, Pages 133-142

  Schorey, Jeffrey S ^a   Cooper, Andrea M ^b  

^a UNIVERSITY OF NOTRE DAME   (United States)

^b TRUDEAU INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL RECEPTOR; CHEMOKINE; CYTOKINE; MITOGEN ACTIVATED PROTEIN KINASE; REACTIVE NITROGEN SPECIES;

ANTIBACTERIAL ACTIVITY; BACTERIAL VIRULENCE; CELL INVASION; CYTOKINE PRODUCTION; EFFECTOR CELL; ENZYME ACTIVATION; ENZYME ACTIVITY; HOST CELL; INFECTION CONTROL; MACROPHAGE; MACROPHAGE ACTIVATION; MYCOBACTERIOSIS; MYCOBACTERIUM AVIUM; MYCOBACTERIUM BOVIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PATHOGENESIS; PHAGOCYTOSIS; PRIORITY JOURNAL; SHORT SURVEY; SIGNAL TRANSDUCTION; SPECIES DIFFERENCE;

ANIMALS; ENZYME ACTIVATION; LIPOPOLYSACCHARIDES; MACROPHAGES; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASES; MODELS, IMMUNOLOGICAL; MYCOBACTERIUM; MYCOBACTERIUM INFECTIONS;

BACTERIA (MICROORGANISMS); CORYNEBACTERINEAE; MYCOBACTERIUM; MYCOBACTERIUM AVIUM; MYCOBACTERIUM BOVIS; MYCOBACTERIUM TUBERCULOSIS;

EID: 0037346775     PISSN: 14625814     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1462-5822.2003.00263.x     Document Type: Short Survey

References (77)

1. Aderem, A., and Underhill, D.M. (1999) Mechanisms of phagocytosis in macrophages. Annu Rev Immunol 17: 593-623.
2. Astarie-Dequeker, C., N'Diaye, E.N., Le Cabec, V., Rittig, M.G., Prandi, J., and Maridonneau-Parini, I. (1999) The mannose receptor mediates uptake of pathogenic and non-pathogenic mycobacteria and bypasses bactericidal responses in human macrophages. Infect Immun 67: 469-477.
3. Avruch, J., Khokhlatchev, A., Kyriakis, J.M., Luo, Z., Tzivion, G., Vavvas, D., and Zhang, X.F. (2001) Ras activation of the Raf kinase: tyrosine kinase recruitment of the MAP kinase cascade. Recent Prog Horm Res 56: 127-155.
4. Balcewicz-Sablinska, M.K., Keane, J., Kornfeld, H., and Remold, H.G. (1998) Pathogenic Mycobacterium tuberculosis evades apoptosis of host macrophages by release of TNF-R2, resulting in inactivation of TNF-alpha. J Immunol 161: 2636-2641.
5. Baldassare, J.J., Bi, Y., and Bellone, C.J. (1999) The role of p38 mitogen-activated protein kinase in IL-1 beta transcription. J Immunol 162: 5367-5373.
6. Barker, L.P., George, K.M., Falkow, S., and Small, P.L. (1997) Differential trafficking of live and dead Mycobacterium marinum organisms in macrophages. Infect Immun 65: 1497-1504.
7. Bellmann, K., Burkart, V., Bruckhoff, J., Kolb, H., and Landry, J. (2000) p38-dependent enhancement of cytokine-induced nitric-oxide synthase gene expression by heat shock protein 70. J Biol Chem 275: 18172-18179.
8. Beltan, E., Horgen, L., and Rastogi, N. (2000) Secretion of cytokines by human macrophages upon infection by pathogenic and non-pathogenic mycobacteria. Microb Pathog 28: 313-318.
9. Bernardo, J., Billingslea, A.M., Blumenthal, R.L., Seetoo, K.F., Simons, E.R., and Fenton, M.J. (1998) Differential responses of human mononuclear phagocytes to mycobacterial lipoarabinomannans: role of CD14 and the mannose receptor. Infect Immun 66: 28-35.
10. Bhattacharyya, A., Pathak, S., Kundu, M., and Basu, J. (2002) Mitogen-activated protein kinases regulate Mycobacterium avium-induced tumor necrosis factor-alpha release from macrophages. FEMS Immunol Med Microbiol 34: 73.
11. Blumenthal, A., Ehlers, S., Ernst, M., Flad, H.D., and Reiling, N. (2002) Control of mycobacterial replication in human macrophages: roles of extracellular signal-regulated kinases 1 and 2 and p38 mitogen- activated protein kinase pathways. Infect Immun 70: 4961-4967.
12. Chan, E.D., Winston, B.W., Uh, S.T., Remigio, L.K., and Riches, D.W. (1999) Systematic evaluation of the mitogen-activated protein kinases in the induction of iNOS by tumor necrosis factor-alpha and interferon-gamma. Chest 116: 91S-92S.
13. Chan, E.D., Chan, J., and Schluger, N.W. (2001a) What is the role of nitric oxide in murine and human host defense against tuberculosis? Current knowledge. Am J Respir Cell Mol Biol 25: 606-612.
14. Chan, E.D., Morris, K.R., Belisle, J.T., Hill, P., Remigio, L.K., Brennan, P.J., and Riches, D.W. (2001b) Induction of inducible nitric oxide synthase-NO* by lipoarabinomannan of Mycobacterium tuberculosis is mediated by MEK1-ERK, MKK7-JNK, and NF- kappaB signalling pathways. Infect Immun 69: 2001-2010.
15. Chan, J., Fan, X.D., Hunter, S.W., Brennan, P.J., and Bloom, B.R. (1991) Lipoarabinomannan, a possible virulence factor involved in persistence of Mycobacterium tuberculosis within macrophages. Infect Immun 59: 1755-1761.
16. Chatterjee, D., and Khoo, K.H. (1998) Mycobacterial lipoarabinomannan: an extraordinary lipoheteroglycan with profound physiological effects. Glycobiology 8: 113-120.
17. Chatterjee, D., and Khoo, K.H. (2001) The surface glycopeptidolipids of mycobacteria: structures and biological properties. Cell Mol Life Sci 58: 2018-2042.
18. Chatterjee, D., Roberts, A.D., Lowell, K., Brennan, P.J., and Orme, I.M. (1992) Structural basis of capacity of lipoarabinomannan to induce secretion of tumor necrosis factor. Infect Immun 60: 1249-1253.
19. Chen, C., Chen, Y.H., and Lin, W.W. (1999) Involvement of p38 mitogen-activated protein kinase in lipopolysaccharide-induced iNOS and COX-2 expression in J774 macrophages. Immunology 97: 124-129.
20. Chimini, G., and Chavrier, P. (2000) Function of Rho family proteins in actin dynamics during phagocytosis and engulfment. Nat Cell Biol 2: E191-E196.
21. Clemens, D.L., and Horwitz, M.A. (1996) The Mycobacterium tuberculosis phagosome interacts with early endosomes and is accessible to exogenously administered transferrin. J Exp Med 184: 1349-1355.
22. Cobb, M.H. (1999) MAP kinase pathways. Prog Biophys Mol Biol 71: 479-500.
23. Cross, T.G., Scheel-Toellner, D., Henriquez, N.V., Deacon, E., Salmon, M., and Lord, J.M. (2000) Serine/threonine protein kinases and apoptosis. Exp Cell Res 256: 34-41.
24. Dahl, K.E., Shiratsuchi, H., Hamilton, B.D., Ellner, J.J., and Toossi, Z. (1996) Selective induction of transforming growth factor beta in human monocytes by lipoarabinomannan of Mycobacterium tuberculosis. Infect Immun 64: 399-405.
25. Douvas, G.S., Looker, D.L., Vatter, A.E., and Crowle, A.J. (1985) Gamma interferon activates human macrophages to become tumoricidal and leishmanicidal but enhances replication of macrophage-associated mycobacteria. Infect Immun 50: 1-8.
26. Ernst, J.D. (1998) Macrophage receptors for Mycobacterium tuberculosis. Infect Immun 66: 1277-1281.
27. Falcone, V., Bassey, E.B., Toniolo, A., Conaldi, P.G., and Collins, F.M. (1994) Differential release of tumor necrosis factor-alpha from murine peritoneal macrophages stimulated with virulent and avirulent species of mycobacteria. FEMS Immunol Med Microbiol 8: 225-232.
28. Florido, M., Goncalves, A.S., Silva, R.A., Ehlers, S., Cooper, A.M., and Appelberg, R. (1999) Resistance of virulent Mycobacterium avium to gamma interferon-mediated anti-microbial activity suggests additional signals for induction of mycobacteriostasis. Infect Immun 67: 3610-3618.
29. Flynn, J.L., and Chan, J. (2001) Immunology of tuberculosis. Annu Rev Immunol 19: 93-129.
30. Fratti, R.A., Backer, J.M., Gruenberg, J., Corvera, S., and Deretic, V. (2001) Role of phosphatidylinositol 3-kinase and Rab5 effectors in phagosomal biogenesis and mycobacterial phagosome maturation arrest. J Cell Biol 154: 631-644.
31. Fratti, R.A., Chua, J., and Deretic, V. (2002) Cellubrevin alterations and Mycobacterium tuberculosis phagosome maturation arrest. J Biol Chem 277: 17320-17326.
32. Guay, J., Lambert, H., Gingras-Breton, G., Lavoie, J.N., Huot, J., and Landry, J. (1997) Regulation of actin filament dynamics by p38 map kinase-mediated phosphorylation of heat shock protein 27. J Cell Sci 110: 357-368.
33. Guha, M., and Mackman, N. (2001) LPS induction of gene expression in human monocytes. Cell Signal 13: 85-94.
34. Heldwein, K.A., and Fenton, M.J. (2002) The role of Toll-like receptors in immunity against mycobacterial infection. Microbes Infect 4: 937-944.
35. Ibata-Ombetta, S., Jouault, T., Trinel, P.A., and Poulain, D. (2001) Role of extracellular signal-regulated protein kinase cascade in macrophage killing of Candida albicans. J Leukoc Biol 70: 149-154.
36. Jones, B.W., Heldwein, K.A., Means, T.K., Saukkonen, J.J., and Fenton, M.J. (2001a) Differential roles of Toll-like receptors in the elicitation of proinflammatory responses by macrophages. Ann Rheum Dis 60 (Suppl. 3): iii6-12.
37. Jones, B.W., Means, T.K., Heldwein, K.A., Keen, M.A., Hill, P.J., Belisle, J.T., and Fenton, M.J. (2001b) Different Toll-like receptor agonists induce distinct macrophage responses. J Leukoc Biol 69: 1036-1044.
38. Juffermans, N.P., Verbon, A., Belisle, J.T., Hill, P.J., Speelman, P., van Deventer, S.J., and van der Poll, T. (2000) Mycobacterial lipoarabinomannan induces an inflammatory response in the mouse lung. A role for interleukin-1. Am J Respir Crit Care Med 162: 486-489.
39. Keane, J., Balcewicz-Sablinska, M.K., Remold, H.G., Chupp, G.L., Meek, B.B., Fenton, M.J., and Kornfeld, H. (1997) Infection by Mycobacterium tuberculosis promotes human alveolar macrophage apoptosis. Infect Immun 65: 298-304.
40. Knutson, K.L., Hmama, Z., Herrera-Velit, P., Rochford, R., and Reiner, N.E. (1998) Lipoarabinomannan of Mycobacterium tuberculosis promotes protein tyrosine dephosphorylation and inhibition of mitogen-activated protein kinase in human mononuclear phagocytes. Role of the Src homology 2 containing tyrosine phosphatase 1. J Biol Chem 273: 645-652.
41. Kong, A.N., Yu, R., Chen, C., Mandlekar, S., and Primiano, T. (2000) Signal transduction events elicited by natural products: role of MAPK and caspase pathways in homeostatic response and induction of apoptosis. Arch Pharm Res 23: 1-16.
42. Kovalovsky, D., Refojo, D., Holsboer, F., and Arzt, E. (2000) Molecular mechanisms and Th1/Th2 pathways in corticosteroid regulation of cytokine production. J Neuroimmunol 109: 23-29.
43. Landry, J., and Huot, J. (1995) Modulation of actin dynamics during stress and physiological stimulation by a signaling pathway involving p38 MAP kinase and heat-shock protein 27. Biochem Cell Biol 73: 703-707.
44. Maiti, D., Bhattacharyya, A., and Basu, J. (2001) Lipoarabinomannan from Mycobacterium tuberculosis promotes macrophage survival by phosphorylating Bad through a phosphatidylinositol 3-kinase/Akt pathway. J Biol Chem 276: 329-333.
45. Malik, Z.A., Denning, G.M., and Kusner, D.J. (2000) Inhibition of Ca (2+) signaling by Mycobacterium tuberculosis is associated with reduced phagosome-lysosome fusion and increased survival within human macrophages. J Exp Med 191: 287-302.
46. Mansour, S.J., Matten, W.T., Hermann, A.S., Candia, J.M., Rong, S., Fukasawa, K., et al. (1994) Transformation of mammalian cells by constitutively active MAP kinase kinase. Science 265: 966-970.
47. Martin-Blanco, E. (2000) p38 MAPK signalling cascades: ancient roles and new functions. Bioessays 22: 637-645.
48. Means, T.K., Wang, S., Lien, E., Yoshimura, A., Golenbock, D.T., and Fenton, M.J. (1999) Human toll-like receptors mediate cellular activation by Mycobacterium tuberculosis. J Immunol 163: 3920-3927.
49. Means, T.K., Jones, B.W., Schromm, A.B., Shurtleff, B.A., Smith, J.A., Keane, J., et al. (2001) Differential effects of a Toll-like receptor antagonist on Mycobacterium tuberculosis-induced macrophage responses. J Immunol 166: 4074-4082.
50. Mendez-Samperio, P., Palma, J., and Vazquez, A. (2001) Roles of intracellular calcium and NF-kappaB in the Bacillus Calmette- Guerin-induced secretion of interleukin-8 from human monocytes. Cell Immunol 211: 113-122.
51. Nandan, D., Lo, R., and Reiner, N. (1999) Activation of phosphotyrosine phosphatase activity attenuates mitogen-activated protein kinase signaling and inhibits c-FOS nitric oxide synthase expression in macrophagtes infected with Leishmania donovani. Infection Immunity 67: 4055-4063.
52. Nathan, C., and Shiloh, M.U. (2000) Reactive oxygen and nitrogen intermediates in the relationship between mammalian hosts and microbial pathogens. Proc Natl Acad Sci USA 97: 8841-8848.
53. Pages, G., Lenormand, P., L'Allemain, G., Chambard, J.C., Meloche, S., and Pouyssegur, J. (1993) Mitogen-activated protein kinases p42mapk and p44mapk are required for fibroblast proliferation. Proc Natl Acad Sci USA 90: 8319-8323.
54. Palmer, L.E., Pancetti, A.R., Greenberg, S., and Bliska, J.B. (1999) YopJ of Yersinia spp. is sufficient to cause downregulation of multiple mitogen-activated protein kinases in eukaryotic cells. Infect Immun 67: 708-716.
55. Peterson, P.K., Gekker, G., Hu, S., Sheng, W.S., Anderson, W.R., Ulevitch, R.J. et al. (1995) CD14 receptor-mediated uptake of nonopsonized Mycobacterium tuberculosis by human microglia. Infect Immun 63: 1598-1602.
56. Rao, K.M. (2001) MAP kinase activation in macrophages. J Leukoc Biol 69: 3-10.
57. Reiling, N., Blumenthal, A., Flad, H.D., Ernst, M., and Ehlers, S. (2001) Mycobacteria-induced tnf-alpha and il-10 formation by human macrophages is differentially regulated at the level of mitogen-activated protein kinase activity. J Immunol 167: 3339-3345.
58. Rivera-Marrero, C.A., Schuyler, W., Roser, S., and Roman, J. (2000) Induction of MMP-9 mediated gelatinolytic activity in human monocytic cells by cell wall components of Mycobacterium tuberculosis. Microb Pathog 29: 231-244.
59. Roach, S.K., and Schorey, J.S. (2002) Differential regulation of the mitogen-activated protein kinases by pathogenic and nonpathogenic mycobacteria. Infect Immun 70: 3040-3052.
60. Roach, T.I., Barton, C.H., Chatterjee, D., and Blackwell, J.M. (1993) Macrophage activation: lipoarabinomannan from avirulent and virulent strains of Mycobacterium tuberculosis differentially induces the early genes c-fos, KC, JE, and tumor necrosis factor-alpha. J Immunol 150: 1886-1896.
61. 2+-dependent cell signaling. J Infect Dis 182: 240-251.
62. Rook, G.A., Steele, J., Ainsworth, M., and Champion, B.R. (1986) Activation of macrophages to inhibit proliferation of Mycobacterium tuberculosis: comparison of the effects of recombinant gamma-interferon on human monocytes and murine peritoneal macrophages. Immunology 59: 333-338.
63. Sangari, F.J., Parker, A., and Bermudez, L.E. (1999) Mycobacterium avium interaction with macrophages and intestinal epithelial cells. Front Biosci 4: D582-D588.
64. Schaible, U.E., Sturgill-Koszycki, S., Schlesinger, P.H., and Russell, D.G. (1998) Cytokine activation leads to acidification and increases maturation of Mycobacterium avium-containing phagosomes in murine macrophages. J Immunol 160: 1290-1296.
65. Schlesinger, L.S. (1996) Role of mononuclear phagocytes in M. tuberculosis pathogenesis. J Invest Med 44: 312-323.
66. Schlesinger, L.S., Kaufman, T.M., Iyer, S., Hull, S.R., and Marchiando, L.K. (1996) Differences in mannose receptor-mediated uptake of lipoarabinomannan from virulent and attenuated strains of Mycobacterium tuberculosis by human macrophages. J Immunol 157: 4568-4575.
67. Strohmeier, G.R., and Fenton, M.J. (1999) Roles of lipoarabinomannan in the pathogenesis of tuberculosis. Microbes Infect 1: 709-717.
68. Sturgill-Koszycki, S., Schlesinger, P.H., Chakraborty, P., Haddix, P.L., Collins, H.L., Fok, A.K., et al. (1994) Lack of acidification in Mycobacterium phagosomes produced by exclusion of the vesicular. Science 263: 678-681.
69. Sturgill-Koszycki, S., Schaible, U.E., and Russell, D.G. (1996) Mycobacterium-containing phagosomes are accessible to early endosomes and reflect a transitional state in normal phagosome biogenesis proton-ATPase. EMBO J 15: 6960-6968.
70. Sugawara, I., Mizuno, S., Yamada, H., Matsumoto, M., and Akira, S. (2001) Disruption of nuclear factor-interleukin-6, a transcription factor, results in severe mycobacterial infection. Am J Pathol 158: 361-366.
71. Ting, L.M., Kim, A.C., Cattamanchi, A., and Ernst, J.D. (1999) Mycobacterium tuberculosis inhibits IFN-gamma transcriptional responses without inhibiting activation of STAT1. J Immunol 163: 3898-3906.
72. Tse, H.M., Josephy, S.I., Chan, E.D., Fouts, D., and Cooper, A.M. (2002) Activation of the mitogen-activated protein kinase signaling pathway is instrumental in determining the ability of Mycobacterium avium to grow in murine macrophages. J Immunol 168: 825-833.
73. Via, L.E., Fratti, R.A., McFalone, M., Pagan-Ramos, E., Deretic, D., and Deretic, V. (1998) Effects of cytokines on mycobacterial phagosome maturation. J Cell Sci 111: 897-905.
74. Wang, T.H., Wang, H.S., and Soong, Y.K. (2000) Regulation and functions of c-Jun N-terminal kinase/stress-activated protein kinase. Chang Keng I Hsueh Tsa Chih 23: 57-72.
75. Widmann, C., Gibson, S., Jarpe, M.B., and Johnson, G.L. (1999) Mitogen-activated protein kinase: conservation of a three-kinase module from yeast to human. Physiol Rev 79: 143-180.
76. Zhang, Y., and Rom, W.N. (1993) Regulation of the interleukin-1 beta (IL-1 beta) gene by mycobacterial components and lipopolysaccharide is mediated by two nuclear factor-IL6 motifs. Mol Cell Biol 13: 3831-3837.
77. Zu, Y.L., Qi, J., Gilchrist, A., Fernandez, G.A., Vazquez-Abad, D., Kreutzer, D.L., et al. (1998) p38 mitogen-activated protein kinase activation is required for human neutrophil function triggered by TNF-alpha or FMLP stimulation. J Immunol 160: 1982-1989.