The Mycobacterium tuberculosis phagosome interacts with early endosomes and is accessible to exogenously administered transferrin

Journal of Experimental Medicine

Volumn 184, Issue 4, 1996, Pages 1349-1355

  Clemens, Daniel L ^a   Horwitz, Marcus A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL MARKER; TRANSFERRIN;

ARTICLE; BACTERICIDAL ACTIVITY; CELL MATURATION; ENDOSOME; IMMUNOGOLD STAINING; MYCOBACTERIUM TUBERCULOSIS; PHAGOCYTOSIS; PHAGOSOME; PRIORITY JOURNAL; TRANSFERRIN BLOOD LEVEL;

BIOLOGICAL TRANSPORT; CELL COMPARTMENTATION; ENDOCYTOSIS; ENDOSOMES; GOLD COLLOID; HUMANS; MACROPHAGES; MICROSCOPY, IMMUNOELECTRON; MYCOBACTERIUM TUBERCULOSIS; PHAGOSOMES; TRANSFERRIN;

EID: 0029905151     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.184.4.1349     Document Type: Article

References (16)

1. Armstrong, J.A., and P.D. Hart. 1971. Response of cultured macrophages to M. tuberculosis with observations on fusion of lysosomes with phagosomes. J. Exp. Med. 134:713-740.
2. Crowle, A., R. Dahl, E. Ross, and M. May. 1991. Evidence that vesicles containing living virulent M. tuberculosis or M. avium in cultured human macrophages are not acidic. Infect. Immun. 59:1823-1831.
3. Xu, S., A. Cooper, S. Sturgill-Koszycki, T. van Heyningen, D. Chatterjee, I. Orme, P. Allen, and D.G. Russell. 1994. Intracellular trafficking in Mycobacterium tuberculosis and Mycobacterium avium-infected macrophages. J. Immunol. 153:2568-2578.
4. Clemens, D.L., and M.A. Horwitz. 1995. Characterization of the Mycobacterium tuberculosis phagosome and evidence that phagosomal maturation is inhibited. J. Exp. Med. 181:257-270.
5. Horwitz, M.A. 1983. The Legionnaire's disease bacterium (L. pneumophila) inhibits phagosome-lysosome fusion in human monocytes. J. Exp. Med. 158:2108-2126.
6. Horwitz, M.A., and F.R. Maxfield. 1984. L. pneumophila inhibits acidification of its phagosome in human monocytes. J. Cell. Biol. 99: 1936-1943.
7. Clemens, D.L., and M.A. Horwitz. 1992. Membrane sorting during phagocytosis: selective exclusion of major histocompatibility complex molecules but not complement receptor CR3 during conventional and coiling phagocytosis. J. Exp. Med. 175:1317-1326.
8. Clemens, D.L., and M.A. Horwitz. 1993. Hypoexpression of MHC molecules on L. pneumophila phagosomes and phagolysosomes. Infect. Immun. 61:2803-2812.
9. van Renswoude, J., K. Bridges, J. Harford, and R. Klausner. 1982. Binding of apotransferrin to K562 cells: explanation of the transferrin cycle. Proc. Natl. Acad. Sci. USA. 79:6186-6190.
10. Dautry-Varsat, A., A. Ciechanover, and H. Lodish. 1983. pH and the recycling of transferrin during receptor-mediated endocytosis. Proc. Natl. Acad. Sci. USA. 80:2258-2262.
11. Frens, G. 1973. Controlled nucleation of the regulation of the particle size in monodisperse gold solutions. Nature (Lond.). Physical Science. 241:20-22.
12. Allison, A.C., and N.E. Byars. 1986. Adjuvant formulation for use in vaccines to elicit both cell-mediated and humoral immunity. J. Immunol. Methods. 95:157-168.
13. Rabinowitz, S., H. Horstmann, S. Gordon, and G. Griffiths. 1992. Immunocytochemical characterization of the endocytic and phagolysosomal compartments in peritoneal macrophages. J. Cell Biol. 116:95-112.
14. Sturgill-Koszycki, S., P. Schlesinger, P. Charkroborty, P. Haddix, H. Collins, A. Fok, R. Allen, S. Gluck, J. Heuser, and D. Russell. 1994. Lack of acidification in Mycobacterium phagosomes produced by exclusion of the vesicular proton-ATPase. Science (Wash. DC). 263:678-681.
15. Harth, G.H., B.-Y, Lee, J. Wang, D.L. Clemens, and M.A. Horwitz. 1996. Novel insights into the genetics, biochemistry, and immunocytochemistry of the 30 kDa major extracellular protein of Mycobacterium tuberculosis. Infect. Immun. 64:3038-3047.
16. de Chastellier, C., T. Lang, and L. Thilo. 1995. Phagocytic processing of the macrophage endoparasite, Mycobacterium avium, in comparison to phagosomes which contain Bacillus subtilis or latex beads. Eur. J. Cell Biol. 68:167-182.