Molecular mechanisms and Th1/Th2 pathways in corticosteroid regulation of cytokine production

Journal of Neuroimmunology

Volumn 109, Issue 1, 2000, Pages 23-29

  Kovalovsky, Damián ^a,b   Refojo, Damián ^a,b   Holsboer, Florian ^c   Arzt, Eduardo ^a,b  

^a INSTITUTO DE FISIOLOGÍA   (Argentina)

^b Facultad de Ciencias Naturales e Instituto M Lillo   (Argentina)

^c MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

Author keywords

Cytokines; Glucocorticoids; IL 1; IL 1ra; Th1; Th2

Indexed keywords

CYTOKINE; GAMMA INTERFERON; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; HYDROCORTISONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; LIPOPOLYSACCHARIDE; LYMPHOTOXIN; STAT PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR GATA 3; TRANSFORMING GROWTH FACTOR BETA;

ARTICLE; GENETIC TRANSCRIPTION; HORMONAL REGULATION; HUMAN; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; IMMUNE RESPONSE; IMMUNE SYSTEM; INFLAMMATION; PRIORITY JOURNAL;

ANIMALS; GLUCOCORTICOIDS; HUMANS; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; INTERLEUKIN 1 RECEPTOR ANTAGONIST PROTEIN; INTERLEUKIN-1; PITUITARY-ADRENAL SYSTEM; SIALOGLYCOPROTEINS; SIGNAL TRANSDUCTION; TH1 CELLS; TH2 CELLS; TRANSCRIPTION, GENETIC;

EID: 0034284355     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-5728(00)00298-8     Document Type: Article

References (30)

1. Arzt E., Sauer J., Pollmacher T., Labeur M., Holsboer F., Reul J.M.H.M., Stalla G.K. Glucocorticoids suppress interleukin-1 receptor antagonist synthesis following induction by endotoxin. Endocrinology. 134:1994;672-677.
2. Bauerle P.A., Baltimore D. NF-kB: ten years after. Cell. 87:1996;13-20.
3. Barber A.E., Coyle S.M., Fischer E., Smith C., Poll T., Shires T., Lowry S.F. Influence of hypercortisolemia on soluble tumor necrosis factor receptor II and interleukin-1 receptor antagonist responses to endotoxin in human beings. Surgery. 118:1995;406-411.
4. Beato M., Chavez S., Truss M. Transcriptional regulation by steroid hormones. Steroids. 61:1996;240-251.
5. Brown E.A., Dare H.A., Marsh C.B., Wewers M.D. The combination of endotoxin and dexamethasone induces type II interleukin 1 receptor in monocytes: an comparison to interleukin 1 beta (IL-1 beta) and interleukin 1 receptor antagonist (IL-1ra). Cytokine. 8:1996;828-836.
6. Colotta F., Saccani S., Giri J.G., Dower S.K., Sims J.E., Introna M., Mantovani A. Regulated expression and release of the IL-1 decoy receptor in human mononuclear phagocytes. J. Immunol. 156:1996;2534-2541.
7. Costas M., Trapp T., Paez Pereda M., Sauer J., Rupprecht R., Nahmod V.E., Reul J.M.H.M., Holsboer F., Arzt E. Molecular and functional evidence for in vitro cytokine enhancement of human and murine target cell sensitivity to glucocorticoids. J. Clin. Invest. 98:1996;1409-1416.
8. Dinarello C.A. The interleukin-1 family: 10 years of discovery. FASEB J. 8:1994;1314-1325.
9. Fenton M.J., Buras J.A., Donnelly R.P. IL-4 reciprocally regulates IL-1 and IL-1 receptor antagonist expression in human monocytes. J. Immunol. 149:1992;1283-1288.
10. Franchimont D., Martens H., Hagelstein M.T., Louis E., Dewe W., Chrousos G.P., Belaiche J., Geenen V. Tumor necrosis factor alpha decreases, and Interleukin-10 increases, the sensitivity of human monocytes to dexamethasone: potential regulation of the glucocorticoid receptor. J. Clin. Endocrinol. Metab. 84:1999;2834-2839.
11. Ho I.C., Hodge M.R., Rooney J.W., Glimcher L.H. The proto-oncogene c-maf is responsible for tissue-specific expression of interleukin-4. Cell. 85:1996;973-983.
12. Joyce D.A., Steer J.H., Kloda A. Dexamethasone antagonizes IL-4 and IL-10-induced release of IL-1ra by monocytes but augments IL-4, IL-10, and TGF-β-induced suppression of TNF-α release. J. Interferon Cytokine Res. 16:1996;511-517.
13. Karin M., Liu Z., Zandi E. AP-1 function and regulation. Curr. Opin. Cell Biol. 9:1997;240-246.
14. Kovalovsky D., Paez Pereda M., Sauer J., Perez Castro C., Nahmod V.E., Stalla G.K., Holsboer F., Arzt E. The Th1 and Th2 cytokines IFN-γ and IL-4 antagonize the inhibition of monocyte IL-1 receptor antagonist by glucocorticoids: involvement of IL-1. Eur. J. Immunol. 28:1998;2075-2085.
15. Kovalovsky D., Paez Pereda M., Stalla G.K., Holsboer F., Arzt E. Differential regulation of interleukin-1 receptor antagonist by proopiomelanocortin peptides adrenocorticotropic hormone and β-endorphin. Neuroimmunomodulation. 6:1999;367-372.
16. Lee S.W., Tsou A.P., Chan H., Thomas J., Petrie K., Eugui E.M., Allison A.C. Glucocorticoids selectively inhibit the transcription of the interleukin 1 β gene and decrease the stability of interleukin 1β mRNA. Proc. Natl. Acad. Sci. USA. 85:1988;1204-1208.
17. Oriss T.B., McCarthy S.A., Morel B.F., Campana M.A., Morel P.A. Crossregulation between T helper cell (Th) 1 and Th2: inhibition of Th2 proliferation by IFN-gamma involves interference with IL-1. J. Immunol. 158:1997;3666-3672.
18. Paez Pereda M., Perez Castro C., Costas M., Nahmod V.E., Stalla G.K., Holsboer F., Arzt E. Glucocorticoid inhibit the autoregulatory induction of interleukin-1 in monocytes after endotoxin stimulation. Neuroimmunomodulation. 3:1996;227-232.
19. Paez Pereda M., Sauer J., Perez Castro C., Finkielman S., Stalla G.K., Holsboer F., Arzt E. Corticotropin-Releasing hormone differentially modulates the interleukin-1 system according to the level of monocyte activation by endotoxin. Endocrinology. 136:1995;5504-5510.
20. Ramirez F., Fowell D.J., Puklavec M., Simmonds S., Mason D. Glucocorticoids promote a Th2 cytokine response by CD4+Tcells in vitro. J. Immunol. 156:1996;2406-2412.
21. Ranger A.M., Hodge M.R., Gravallese E.M., Oukka M., Davidson L., Alt F.W., de la Grousse F.C., Hoey T., Grusby M., Glimcher L.H. Delayed lymphoid repopulation with defects in IL-4-driven responses produced by inactivation of NF-ATc. Immunity. 8:1998;125-134.
22. Santos A.A., Scheltinga M.R., Lynch E., Brown E.F., Lawton F., Chambers E., Browning J., Dinarello C.A., Wollf S.M., Wilmore D.W. Elaboration of interleukin-1 receptor antagonist is not attenuated by glucocorticoids after endotoxemia. Arch. Surg. 128:1993;138-144.
23. Sauer J., Castrén M., Hopfner U., Holsboer F., Stalla G.K., Arzt E. Inhibition of lipopolysaccharide-induced monocyte interleukin-1 receptor antagonist synthesis by cortisol: involvement of the mineralocorticoid receptor. J. Clin. Endocrinol. Metab. 81:1996;72-79.
24. Scheinman R.I., Cogswell F.C., Lofquist A.K., Baldwin A.S. Jr. Role of transcriptional activation of IkB in mediation of immunosuppression by glucocorticoids. Science. 270:1995;283-286.
25. Scheinman R.I., Gualberto A., Jewel C.M., Cidlowski J.A., Baldwin A.S. Jr. Characterization of mechanisms involved in transrepression of NF-kB by activated glucocorticoid receptors. Mol. Cell. Biol. 15:1995;943-953.
26. Szabo S.J., Glimcher L.H., Ho I. Genes that regulate interleukin-4 expression in T cells. Curr. Opin. Immunol. 9:1997;776-781.
27. Thierfelder W.E., van Deursen J.M., Yamamoto K., Tripp R.A., Sarawar S.R., Carson R.T., Sangster M.Y., Vignali D.A., Doherty P.C., Grosveld G.C., Ihle J.N. Requirement for Stat4 in interleukin-12 mediated responses of natural killer and T cells. Nature. 382:1996;171-174.
28. Ulich T.R., Guo K., Yin S., del Castillo J., Yi E., Thompson R.C., Eisenberg S.P. Endotoxin-induced cytokine gene expression in vivo.IV. Expression of interleukin α/β and interleukin 1 receptor antagonist mRNA during endotoxemia and during endotoxin-initiated local acute inflammation. Am. J. Pathol. 141:1992;61-68.
29. Vacca A., Felli M.P., Farina A.R., Martinotti S., Maroder M., Screpanti I., Meco D., Petrangeli E., Frati L., Gulino A. Glucocorticoid receptor-mediated suppression of the interleukin 2 gene expression through impairment of the cooperativity between nuclear factor of activated T cells and AP-1 enhancer elements. J. Exp. Med. 175:1992;637-646.
30. Zheng W., Flavell R.A. The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. Cell. 89:1997;587-596.