Role of mononuclear phagocytes in M tuberculosis pathogenesis

Journal of Investigative Medicine

Volumn 44, Issue 6, 1996, Pages 312-323

  Schlesinger, Larry S ^a,b  

^a UNIVERSITY OF IOWA   (United States)

^b UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENT RECEPTOR;

ANIMAL; HUMAN; IMMUNOLOGY; LUNG ALVEOLUS MACROPHAGE; MYCOBACTERIUM TUBERCULOSIS; PATHOPHYSIOLOGY; PHAGOCYTE; PHAGOCYTOSIS; PHYSIOLOGY; REVIEW; TUBERCULOSIS;

ANIMALS; HUMANS; MACROPHAGES, ALVEOLAR; MYCOBACTERIUM TUBERCULOSIS; PHAGOCYTES; PHAGOCYTOSIS; RECEPTORS, COMPLEMENT; TUBERCULOSIS;

EID: 0030210318     PISSN: 17088267     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (161)

1. Snider DE Jr, La Montagne JR. The neglected global tuberculosis problem: a report of the 1992 world congress on tuberculosis. J Infect Dis 1994;169:1189-96.
2. Raviglione MC, Snider, DE Jr, Kochi A. Global epidemiology of tuberculosis: morbidity and mortality of a worldwide epidemic. JAMA 1995;273:220-6.
3. Chan J, Kaufmann SHE. Immune mechanisms of protection. In: Bloom BR, ed. Tuberculosis: pathogenesis, protection, and control. Washington, DC: ASM Press, 1994:389-415.
4. Youmans GP. Tuberculosis. Philadelphia: WB Saunders Co, 1979.
5. Johnson WD Jr, Mei B, Cohn ZA. The separation, long-term cultivation, and maturation of the human moiocyte. J Exp Med 1977;146:1613-26.
6. Nakagawara A, Nathan CF, Cohn ZA. Hydrogen peroxide metabolism in human monocytes during differentiation in vitro. J Clin Invest 1981;68:1243-52.
7. Newman SL, Musson RA, Henson PM. Development of functional complement receptors during in vitro maturation of human monocytes into macrophages. J Immunol 1980;125:2236-44.
8. Wright S D, Silverstein SC. Tumor-promoting phorbol esters stimulate C3b and C3b′ receptor-mediated phagocytosis in cultured human monocytes. J Exp Med 1982;156:1149-64.
9. Speert DP, Silverstein SC. Phagocytosis of unopsonized zymosan by human monocyte-derived macrophages: maturation and inhibition by mannan. J Leukoc Biol 1985;38:655-8.
10. Myones BL, Dalzell JG, Hogg N, Ross GD. Neutrophil and monocyte cell surface pi 50,955 has iC3b-receptoi (CR4) activity resembling CR3. J Clin Invest 1988;82:640-51.
11. Hogg NL, Takacs DG, Palmer Selvendran Y, Allen C. The p150,95 molecule is a marker of human mononuclear phagocytes: comparison with expression of class II molecules. Eur J Immunol 1986;16:240-8.
12. Schlesinger LS, Horwitz MA. Phagocytosis of Mycobacterium leprae by human monocyte-derived macrophages is mediated by complement receptors CR1(CD35), CR3(CD11b/CD18), and CR4(CD11c/CD18) and interferon γ activation inhibits complement receptor function and phagocytosis of this bacterium. J Immunol 1991;147:1983-94.
13. Fels A, Cohn ZA. The alveolar macrophage. J Appl Physiol 1986;60:353-69.
14. Tenner A J, Robinson SL, Borchelt J, Wright JR. Human pulmonary surfactant protein (SP-A), a protein structurally homologous to C1q, can enhance FcR- and CR1-mediated phagocytosis. J Biol Chem 1989;264:13923-8.
15. Schlesinger LS, Bellinger-Kawahara CG, Payne NR, Horwitz MA. Phagocytosis of Mycobacterium tuberculosis is mediated by human monocyte complement receptors and complement component C3. J Immunol 1990;144:2771-80.
16. Horwitz MA. Intracellular parasitism. Curr Opin Immunol 1988;1:41-6.
17. Wright SD. Receptors for complement and the biology of phagocytosis. In: Gallin JI, Goldstein LM, Snyderman R, eds. Inflammation: basic principles and clinical correlates. New York: Raven Press, Ltd. 1992:477-95.
18. Ross GD. Opsonization and membrane complement receptors. In: Ross GD, ed. Immunobiology of the complement system. Orlando: Academic Press, Inc. 1986:87-114.
19. Kishimoto TK, Larson RS, Corbi AL, Dustin ML, Staunton DE, Springer TA. The leukocyte integrins. Adv Immunol 1989;46:149-82.
20. Stewart M, Thiel M, Hogg N. Leukocyte integrins. Curr Opin Cell Biol 1995;7:690-6.
21. Van Kooyk Y, Figdor CG. Lymphocyte adhesion mediated by integrins. Res Immunol 1993;144:709-22.
22. Thornton BP, Vetvicka V, Pitman M, Goldman RC, Ross GD. Analysis of the sugar specificity and molecular location of the β-glucan-binding lectin site of complement receptor type 3 (CD11b/CD18). J Immunol 1996;156:1235-46.
23. Shepherd VL, Campbell EJ, Senior RM, Stahl PD. Characterization of the mannose/fucose receptor on human mononuclear phagocytes. Journal of the Reticuloendothelial Society 1982;32:423-31.
24. Stahl PD. The mannose receptor and other macrophage lectins. Curr Opin Immunol 1992;4:49-52.
25. Taylor ME. Recognition of complex carbohydrates by the macrophage mannose receptor. Biochem Soc Trans 1993;21:468-73.
26. Joiner KA, Fuhrman SA, Miettinen HM, Kasper LH, Mellman I. Toxoplasma gondii: fusion competence of parasitophorous vacuoles in Fc receptor-transfected fibroblasts. Science 1990;249:641-6.
27. Mosser DM, Edelson PJ. The third component of complement (C3) is responsible for the intracellular survival of Leishmania major. Nature 1987;327:329-31.
28. Drevets DA, Canono BP, Campbell PA. Listericidal and nonlistericidal mouse macrophages differ in complement receptor type 3-mediated phagocytosis of L monocytogenes and in preventing escape of the bacteria into the cytoplasm. J Leukoc Biol 1992;52:70-9.
29. Hoepelman AIM, Tuomanen EI. Consequences of microbial attachment: directing host cell functions with adhesins. Infect Immun 1992;60:1729-33.
30. Hieny S, Da Silva RP, Sher A. Complement enhances the survival of metacyclic trypomastigotes of Trypanosoma cruzi in mouse peritoneal macrophages [abstract]. FASEB J 1992;2:A678.
31. Simon RH, Paine R III. Participation of pulmonary alveolar epithelial cells in lung inflammation. J Lab Clin Med 1995;126:108-18.
32. Ramanathan VD, Curtis J, Turk JL. Activation of the alternative pathway of complement by mycobacteria and cord factor. Infect Immun 1980;29:30-5.
33. Rourke FJ, Fan SS, Wilder MS. Anticomplementary activity of tuberculin: relationship to platelet aggregation and lytic response. Infect Immun 1979;23:160-7.
34. Schlesinger LS. Macrophage phagocytosis of virulent but not attenuated strains of Mycobacterium tuberculosis is mediated by mannose receptors in addition to complement receptors. J Immunol 1993;150:2920-30.
35. Hirsch CS, Ellner JJ, Russell DG, Rich EA. Complement receptor-mediated uptake and tumor necrosis factor-α-mediated growth inhibition of Mycobacterium tuberculosis by human alveolar macrophages. J Immunol 1994;152:743-53.
36. Czop JK, Kay J. Isolation and characterization of β-glucan receptors on human mononuclear phagocytes. J Exp Med 1991;173:1511-20.
37. Wozencraft AD, Sayers G, Blackwell JM. Macrophage type 3 complement receptors mediate serum-independent binding of Leishmania donovani: detection of macrophage-derived complement on the parasite surface by immunoelectron microscopy. J Exp Med 1986;164:1332-7.
38. Ezekowitz RAB, Sim RB, Hill M, Gordon S. Local opsonization by secreted macrophage complement components: role of preceptors for complement in uptake of zymosan. J Exp Med 1983;159:244-60.
39. Stokes RW, Haidl ID, Jefferies WA, Speert DP. Mycobacteria-macrophage interactions: macrophage phenotype determines the nonopsonic binding of Mycobacterium tuberculosis to murine macrophages. J Immunol 1993151:7067-76.
40. Hetland G, Wiker HG. Antigen 85C on Mycobacterium bovis, BCG and M tuberculosis promotes monocyte-CR3-mediated uptake of microbeads coated with mycobacterial products. Immunology 1994;82:445-9.
41. Brennan PJ, Nikaido H. The envelope of mycobacteria. Annu Rev Biochem 1995;64:29-63.
42. Chatterjee D, Hunter SW, McNeil M, Brennan PJ. Lipoarabinomannan. Multiglycosylated form of the mycobacterial mannosylphosphatidylinositols. J Biol Chem 1992;267:6228-33.
43. Hunter SW, Brennan PJ. Evidence for the presence of a phosphatidylinositol anchor on the lipoarabinomannan and lipomannan of Mycobacterium tuberculosis. J Biol Chem 1990;265:9272-9.
44. Chatterjee D, Lowell K, Rivoire B, McNeil MR, Brennan PJ. Lipoarabinomannan of Mycobacterium tuberculosis. Capping with mannosyl residues in some strains. J Biol Chem 1992;267:6234-9.
45. Chatterjee D, Khoo K-H, McNeil MR, Dell A, Morris HR, Brennan PJ. Structural definition of the non-reducing termini of mannosecapped LAM from Mycobacterium tuberculosis through selective enzymatic degradation and fast atom bombardment-mass spectrometry. Glycobiology 1993;3:497-506.
46. Chatterjee D, Roberts AD, Lowell K, Brennan PJ, Orme IM. Structural basis of capacity of lipoarabinomannan to induce secretion of tumor necrosis factor. Infect Immun 1992;60:1249-53.
47. Roach TIA, Barton CH, Chatterjee D, Blackwell JM. Macrophage activation: lipoarabinomannan from avirulent and virulent strains of Mycobacterium tuberculosis differentially induces the early genes c-fos, KC, JE, and tumor necrosis factor-α. J Immunol 1993;150:1886-96.
48. Sieling PA, Chatterjee D, Porcelli SA, Prigozy TI, Mazzaccaro RJ, Soriano T, Bloom BR, Brenner MB, Kronenberg M, Brennan PJ, Modlin RL. CD1-restricted T cell recognition of microbial lipoglycan antigens. Science 1995;269:227-30.
49. Schlesinger LS, Hull SR, Kaufman TM. Binding of the terminal mannosyl units of lipoarabinomannan from a virulent strain of Mycobacterium tuberculosis to human macrophages. J Immunol 1994;152:4070-9.
50. Taylor ME, Bezouska K, Drickamer K. Contribution to ligand binding by multiple carbohydrate-recognition domains in the macrophage mannose receptor. J Biol Chem 1992;267:1719-26.
51. Prinzis S, Chatterjee D, Brennan PJ. Structure and antigenicity of lipoarabinomannan from Mycobacterium bovis BCG. J Gen Microbiol 1993;139:2649-58.
52. Khoo K-H, Dell A, Morris HR, Brennan PJ, Chatterjee D. Inositol phosphate capping of the nonreducing termini of lipoarabinomannan from rapidly growing strains of mycobacterium. J Biol Chem 1995;270:12380-9.
53. Venisse A, Berjeaud J-M, Chaurand P, Gilleron M, Puzo G. Structural features of lipoarabinomannan from Mycobacterium bovis BCG. Determination of molecular mass by laser desorption mass spectrometry. J Biol Chem 1993;268:12401-11.
54. Schlesinger LS, Kaufman TM, Kang BK, Marchiando LK. Host and bacterial determinants that mediate phagocytosis of M tuberculosis. J Cell Biochem 1995;19B:60.
55. Stokes RW, Speert DP. Lipoarabinomannan inhibits nonopsonic binding of Mycobacterium tuberculosis to murine macrophages. J Immunol 1995;155:1361-9.
56. Ilangumaran, S, Arni S, Poincelet M, Theler J-M, Brennan PJ, Din N, Hoessli DC. Integration of mycobacterial lipoarabinomannans into glycosylphosphatidylinositol-rich domains of lymphomonocytic cell plasma membranes. J Immunol 1995;155:1334-42.
57. Venisse A, Fournié J-J, Puzo G. Mannosylated lipoarabinomannan interacts with phagocytes. Eur J Biochem 1995;231:440-7.
58. Pugin J, Heumann D. Tomasz A, Kravchenko VV, Akamatsu Y, Nishijima, Glauser MP, Tobias PS, Ulevitch RJ. CD14 is a pattern recognition receptor. Immunity 1994;1:509-16.
59. Zhang Y, Doerfler M, Lee TC, Guillemin B, Rom WN. Mechanisms of stimulation of interleukin-1α and tumor necrosis factor-α by Mycobacterium tuberculosis components. J Clin Invest 1993;91:2076-83.
60. Goswami S, Sarkar S, Basu J, Kundu M, Chakrabarti P. Mycotin: a lectin involved in the adherence of mycobacteria to macrophages. FEBS Lett 1994;355:183-6.
61. Ortalo-Magné A, Dupont M-A, Lemassu A, Andersen AB, Gounon P, Daffé M. Molecular composition of the outermost capsular material of the tubercle bacillus. Microbiology 1995;141:1609-20.
62. Lemassu A, Daffé M. Structural features of the exocellular polysaccharides of Mycobacterium tuberculosis. Biochem J 1994297:351-7.
63. Arruda S, Bomfim G, Knights R, Huima-Byron T, Riley LW. Cloning of an M tuberculosis DNA fragment associated with entry and survival inside cells. Science 1993;261:1454-7.
64. Peterson PK, Gekker G, Hu S, Sheng WS, Anderson WR, Ulevitch RJ, Tobias PS, Gustafson KV, Molitor TW, Chao CC. CD14 receptor-mediated uptake of nonopsonized Mycobacterium tuberculosis by human microglia. Infect Immun 1995;63:1598-602.
65. Schlesinger LS. Roles of complement receptors, the mannosylfucosyl receptor, and pulmonary surfactant protein, SP-A in phagocytosis of Mycobacterium tuberculosis by human macrophages. Clin Res [abstract]. 1992;40:383A.
66. Hawgood S, Clements JA. Pulmonary surfactant and its apoproteins. J Clin Invest 1990;86:1-6.
67. Haagsman HP. Surfactant proteins A and D. Biochem Soc Trans 1994;22:100-6.
68. Gaynor CD, McCormack FX, Voelker DR, McGowan SE, Schlesinger LS. Pulmonary surfactant protein A mediates enhanced phagocytosis of Mycobacterium tuberculosis by a direct interaction with human macrophages. J Immunol 1995;155:5343-51.
69. Downing JF, Pasula R, Wright JR, Twigg HL III, Martin WJ II. Surfactant protein A promotes attachment of Mycobacterium tuberculosis to alveolar macrophages during infection with human immunodeficiency virus. Proc Natl Acad Sci USA 1995;92:4848-52.
70. Reyes JM, Putong PB. Association of pulmonary alveolar lipoproteinosis with mycobacterial infection. Am J Clin Pathol 1980;74:478-85.
71. Phelps DS, Rose RM. Increased recovery of surfactant protein A in AIDS-related pneumonia. Am Rev Respir Dis 1991;143:1072-5.
72. Aslanzadeh J, Brown EJ, Quillin SP, Ritchey JK, Ratliff TL. Characterization of soluble fibronectin binding to Bacille Calmette-Guérin. J Gen Microbiol 1989;135:2735-41.
73. 1 integrin on Mycobacterium avium-Mycobacterium intracellulare. Infect Immun 1992;60:3652-7.
74. Ratliff TL, McCarthy R, Telle WB, Brown EJ. Purification of a mycobacterial adhesion for fibronectin. Infect Immun 1993;61:1889-94.
75. Abou-Zeid C, Ratliff TL, Wiker HG, Harboe M, Bennedsen J, Rook GAW. Characterization of fibronectin-binding antigens released by Mycobacterium tuberculosis and Mycobacterium bovis BCG. Infect Immun 1988;56:3046-51.
76. Abou-Zeid C, Garbe T, Lathigra R, Wiker HG, Harboe M, Rook GAW, Young DB. Genetic and immunological analysis of Mycobacterium tuberculosis fibronectin-binding proteins. Infect Immun 1991;59:2712-8.
77. Thole JER, Schöningh R, Janson AAM, Garbe T, Y. E. Cornelisse T, Clark-Curtiss JE, Kolk AHJ, Ottenhoff THM, De Vries RRP, Abou-Zeid C. Molecular and immunological analysis of a fibronectin-binding protein antigen secreted by Mycobacterium leprae. Mol Microbiol 1992;6:153-63.
78. Bevilacque MP, Amrani D, Musesson MW, Bianco C. Receptors for cold-insoluble globulin (plasma fibronectin) on human monocytes. J Exp Med 1981;153:42-60.
79. Pommier CG, Inada S, Fries LF, Takahashi T, Frank MM, Brown EJ. Plasma fibronectin enhances phagocytosis of opsonized particles by human peripheral blood monocytes. J Exp Med 1983;157:1844-54.
80. Wright SD, Detmers PA, Jong MTC, Meyer BC. Inteferon-γ depresses binding of ligand by C3b and C3bi receptors on cultured human monocytes, an effect reversed by fibronectin. J Exp Med 1986;163:1245-59.
81. Mokoena T, Gordon S. Human macrophage activation: modulation of mannosyl, fucosyl receptor activity in vitro by lymphokines, γ and α interferons, and dexamethasone. J Clin Invest 1987;75:624-31.
82. Maródi L, Schreiber S, Anderson DC, MacDermott RP, Korchak HM, Johnston RB Jr. Enhancement of macrophage candidacidal activity by interferon-γ. Increased phagocytosis, killing, and calcium signal mediated by a decreased number of mannose receptors. J Clin Invest 1993;91:2596-601.
83. Toba H, Crowford JT, Ellner JJ. Pathogenicity of Mycobacterium avium for human monocytes: absence of macrophage activating factor activity of γ interferon. Infect Immun 1989;57:239-44.
84. Douvas GS, Looker DL, Vatter AE, Crowle AJ. Gamma interferon activates human macrophages to become tumoricidal and leishmanicidal but enhances replication of macrophage-associated mycobacteria. Infect Immun 1985;50:1-8.
85. Barnes P F, Modlin RL, Ellner JJ. T-cell responses and cytokines. In: Bloom BR, ed. Tuberculosis: pathogenesis, protection, and control. Washington, DC: ASM Press, 1994:417-35.
86. Schreiber S, Perkins SL, S. Teitelbaum L, Chappel J, Stahl PD, Blum JS. Regulation of mouse bone marrow macrophage mannose receptor expression and activation by prostaglandin E and IFN-γ. J Immunol 1993;151:4973-81.
87. Stein M, Keshav S, Harris N, Gordon S. Interleukin 4 potently enhances murine macrophage mannose receptor activity: a marker of alternative immunologic macrophage activation. J Exp Med 1992;176:287-92.
88. Abramson SL, Gallin JI. IL-4 inhibits superoxide production by human mononuclear phagocytes. J Immunol 1990;144:625-30.
89. Sampson LL, Heuser J, Brown EJ. Cytokine regulation of complement receptor-mediated ingestion by mouse peritoneal macrophages. J Immunol 1991;146:1005-13.
90. Hirsch CS, Yoneda T, Averill L, Ellner JJ, Toossi Z. Enhancement of intracellular growth of Mycobacterium tuberculosis in human monocytes by transforming growth factor-β1. J Infect Dis 1994;170:1229-37.
91. Bardana EJJ, McClatchy JK, Farr RS, Minden P. Universal occurrence of antibodies to tubercle bacilli in sera from non-tuberculous and tuberculous individuals. Clin Exp Immunol 1973;13:65-77.
92. Schlesinger LS, Horwitz MA. A role for natural antibody in the pathogenesis of leprosy: antibody in nonimmune serum mediates C3 fixation to the Mycobacterium leprae surface and hence phagocytosis by human mononuclear phagocytes. Infect Immun 1994;62:280-9.
93. Forget A, Benoit JC, Turcotte R, Gusew-Chartrand N. Enhanced activity of anti-mycobacterial sera in experimental Mycobacterium bovis (BCG) infection in mice. Infect Immun 1976;13:1301-6.
94. Armstrong JA, Hart PD. Phagosome-lysosome interactions in cultured macrophages infected with virulent tubercle bacilli: reversal of the usual nonfusion pattern and observations on bacterial survial. J Exp Med 1975;142:1-16.
95. De L.Costello AM, Kumar A, Narayan V, Akbar MS, Ahmed S, Abou-Zeid C, Rook GAW, Stanford J, Moreno C. Does antibody to mycobacterial antigens, including lipoarabinomannan, limit dissemination in childhood tuberculosis? Trans R Soc Trop Med Hyg 1992;86:686-92.
96. Blair AL, Cree IA, Beck JS, Grange JM, Kardjito T. Heat-stable opsonins in tuberculosis and leprosy. FEMS Immunol Med Microbiol 1993;7:197-204.
97. Stach J-L, Gros P, Forget A, Skamene E. Phenotypic expression of genetically-controlled natural resistance to Mycobacterium bovis (BCG). J Immunol 1984;132:888-92.
98. Radzioch D, Hudson T, Boule M, Barrera L. Urbance JW, Varesio L., Skamene E. Genetic resistance/susceptibility to mycobacteria: phenotypic expression in bone marrow derived macrophage lines. J Leukoc Biol 1991;50:263-72.
99. De Chastellier C, Fréhel C, Offredo C, Skamene E. Implication of phagosome-lysosome fusion in restriction of Mycobacterium avium growth in bone marrow macrophages from genetically resistant mice. Infect Immun 1993;61:3775-84.
100. Fallman M, Gullberg M, Hellberg C, Andersson T. Complement receptor-mediated phagocytosis is associated with accumulation of PC-derived DG in human PMN. J Biol Chem 1992;267:2656-63.
101. Kusner DJ, Hall CF, Schlesinger LS. Activation of macrophage phospholipase D is linked o the phagocytosis of M tuberculosis. Clin Res [abstract], 1995;43:356A.
102. Ross GD, Cain JA, Lachmann PJ. Membrane complement receptor type three (CR3) has lectin-like properties analogous to bovine conglutinin and functions as a receptor for zymosan and rabbit erythrocytes as well as a receptor for iC3b. J Immunol 1985;134:3307-15.
103. Cain JA, Newman SL, Ross GD. Role of complement receptor type three and serum opsonins in the neutrophil response to yeast. Complement 4:75-86.
104. Elstad, MR, Parker CJ, Cowley FS, Wilcox LA, McIntyre TM, Prescott SM, Zimmerman GA. CD11b/CD18 integrin and a β-glucan receptor act in concert to induce the synthesis of platelet-activating factor by monocytes. J Immunol 1994;152:220-30.
105. Hoffman OA, Standing JE, Limper AH. Pneumocystis carinii stimulates tumor necrosis factor-α release from alveolar macrophages through a β-glucan-mediated mechanism. J Immunol 1993;150:3932-40.
106. May ME, Spagnuolo PJ. Evidence for activation of a respiratory burst in the interaction of human neutrophils with Mycobacterium tuberculosis. Infect Immun 1987;55:2304-7.
107. Douvas GS, Berger EM, Repine JE, Crowle AJ. Natural mycobacteriostatic activity in human monocyte-derived adherent cells. Am Rev Resp Dis 1986;134:44-8.
108. Wilson CB, Tsai V, Remington JS. Failure to trigger the oxidative metabolic burst by normal macrophages: possible mechanism for survival of intracellular pathogens. J Exp Med 1980;151:328-46.
109. Holzer TJ, Nelson KE, Schauf V, Crispen RG, Anderson BR. Mycobacterium leprae fails to stimulate phagocytic cell superoxide anion generation. Infect Immun 1986;51:514-20.
110. Gangadharam PRJ, Edwards CK III. Release of superoxide anion from resident and activated mouse peritoneal macrophages infected with Mycobacterium intracellulare. Am Rev Resp Dis 1984;130:834-8.
111. McCabe RE, Mullins BT. Failure of Trypanosoma cruzi to trigger the respiratory burst of activated macrophages. Mechanism for immune evasion and importance of oxygen-independent killing. J Immunol 1990;144:2384-8.
112. Jacobs RF, Locksley RM, Wilson CB, Haas IE, Klebanoff SJ. Interaction of primate alveolar macrophages and Legionella pneumophila. J Clin Invest 1984;73:1515-20.
113. Eissenberg LG, Goldman WE. Histoplasma capsulatum fails to trigger release of superoxide from macrophages. Infect Immun 1987;55:29-34.
114. Launois P, Blum L, Dieye A, Millan J, Sarthou JL, Bach MA. Phenolic glycolipid-1 from M leprae inhibits oxygen free radical production by human mononuclear cells. Res Immunol 1989;140:847-55.
115. Neill MA, Klebanoff SJ. The effect of phenolic glycolipid 1 from Mycobacterium leprae on the antimicrobial activity of human macrophages. J Exp Med 1988;167:30-42.
116. Chan J, Fujiwara T, Brennan P, McNeil M, Turco SJ, Sibille J-C, Snapper M, Aisen P, Bloom BR. Microbial glycolipids: possible virulence factors that scavenge oxygen radicals. Proc Natl Acad Sci USA 1989;86:2453-7.
117. Chan J, Fan X, Hunter SW, Brennan PJ, Bloom BR. Lipoarabinomannan, a possible virulence factor involved in persistence of Mycobacterium tuberculosis within macrophages. Infect Immun 1991;59:1755-61.
118. Vachula M, Holzer TJ, Anderson BR. Suppression of monocyte oxidative response by phenolic glycolipid 1 of Mycobacterium leprae. J Immunol 1989;142:1696-701.
119. Reiner NE. Altered cell signaling and mononuclear phagocyte deactivation during intracellular infection. Immunol Today 1994;15:374-81.
120. Brozna JP, Horan M, Rademacher JM, Pabst KA, Pabst MJ. Monocyte responses to sulfatide from Mycobacterium tuberculosis: inhibition of priming for enhanced release of superoxide, associated with increased secretion of interleukin-1 and tumor necrosis factor α, and altered protein phosphorylation. Infect Immun 1991;59:2542-8.
121. Pabst JJ, Gross JM, Prozna JP, Goren MB. Inhibition of macrophage priming by sulfatide from Mycobacterium tuberculosis. J Immunol 1988;140:634-40.
122. Brown MC, Taffet SM. Lipoarabinomannans derived from different strains of Mycobacterium tuberculosis differentially stimulate the activation of NF-β and KBF1 in murine macrophages. Infect Immun 1995;63:1960-8.
123. Sibley LD, Hunter SW, Brennan PJ, Krahenbuhl JL. Mycobacterial lipoarabinomannan inhibits γ interferon-mediated activation of macrophages. Infect Immun 1988;56:1232-6.
124. Roach TIA, Chatterjee D, Blackwell JM. Induction of early-response genes KC and JE by mycobacterial lipoarabinomannans: regulation of KC expression in murine macrophages by Lsh/Ity/Bcg (candidate Nramp). Infect Immun 1994;62:1176-84.
125. Zhang Y, Broser M, Rom WN. Activation of the interleukin-6 gene by Mycobacterium tuberculosis or lipopolysaccharide is mediated by nuclear factors NF-IL6 and NF-κB. Proc Natl Acad Sci USA 1994;91:2225-9.
126. Armstrong JA, Hart PD. Response of cultured macrophages to Mycobacterium tuberculosis, with observations on fusion of lysosomes with phagosomes. J Exp Med 1971;134:713-40.
127. Rastogi N, Labrousse V, Paulo Carvalho de Sousa J. Mycobacterial growth and ultrastructure in mouse L-929 fibroblasts and bone marrow-derived macrophages: evidence that infected fibroblasts secrete mediators capable of modulating bacterial growth in macrophages. Curr Microbiol 1992;25:203-13.
128. Sturgill-Koszycki S, Schlesinger PH, Chakraborty P, Haddix P. L, Collins HL, Fok AK, Allen RD, Gluck SL, Heuser J, Russell DG. Lack of acidification in Mycobacterium phagosomes produced by exclusion of the vesicular proton-ATPase. Science 1994;263:678-81.
129. Xu S, Cooper A, Sturgill-Koszycki S, Van Heyningen T, Chatterjee D, Orme I, Allen P, Russell DG. Intracellular trafficking in Mycobacterium tuberculosis and Mycobacterium avium-infected macrophages. J Immunol 1994;153:2568-78.
130. Crowle AJ, Dahl R, Ross E, May MH. Evidence that Vesicles containing living, virulent Mycobacterium tuberculosis or Mycobacterium avium in cultured human macrophages are not acidic. Infect Immun 1991;59:1823-31.
131. Clemens DL, Horwitz MA. Characterization of the Mycobacterium tuberculosis phagosome and evidence that phagosomal maturation is inhibited. J Exp Med 1995;181:257-70.
132. Frehel C, Rastogi N. Mycobacterium leprae surface components intervene in the early phagosome-lysosome fusion inhibition event. Infect Immun 1987;55:2916-21.
133. Sibley LD, Franzblau SG, Krahenbuhl JL. Intracellular fate of Mycobacterium leprae in normal and activated mouse macrophages. Infect Immun 1987;55:680-5.
134. Frehel C, De Chastellier C, Lang T, Rastogi N. Evidence for inhibition of fusion of lysosomal and prelysosomal compartments with phagosomes in macrophages infected with pathogenic Mycobacterium avium. Infect Immun 1986;52:252-62.
135. Oh U-K, Straubinger RM. Intracellular fate of Mycobacterium avium: use of dual-label spectrofluorometry to investigate the influence of bacterial viability and opsonization on phagosomal pH and phagosomelysosome interaction. Infect Immun 1996;64:319-25.
136. Hart PD, Armstrong JA. Strain virulence and the lysosomal response in macrophages infected with Mycobacterium tuberculosis. Infect Immun 1974;10:742-6.
137. McDonough KA, Kress Y, Bloom BR. Pathogenesis of tuberculosis: interaction of Mycobacterium tuberculosis with macrophages. Infect Immun 1993;61:2763-73.
138. Myrvik QN, Leake ES, Wright MJ. Disruption of phagosomal membranes of normal alveolar macrophages by the H37Rv strain of Mycobacterium tuberculosis. A correlate of virulence. Am Rev Respir Dis 1984;129:322-8.
139. Goren MB, Hart PD, Young MR, Armstrong JA. Prevention of phagosome-lysosome fusion in cultured macrophages by sulfatides of Mycobacterium tuberculosis. Proc Natl Acad Sci USA 197673:2510-4.
140. Goren MB, Brokl O, Schaefer WB. Lipids of putative relevance to virulence in Mycobacterium tuberculosis: correlation of virulence with elaboration of sulfatides and strongly acidic lipids. Infect Immun 1974;9:142-9.
141. Crowe LM, Spargo BJ, Ioneda T, Beaman BL, Crowe JH. Interaction of cord factor (α,α′-trehalose-6,6′-dimycolate) with phospholipids. Biochim Biophys Acta Bio-Membr 1994;1194:53-60.
142. Spargo BJ, Crowe LM, Ioneda T, Beaman BL, Crowe JH. Cord factor (α,α-trehalose 6,6′-dimycolate) inhibits fusion between phospholipid vesicles. Proc Natl Acad Sci USA 1991;88:737-40.
143. Gordon AH, D'Arcy Hart P, Young MR. Ammonia inhibits phagosome-lysosome fusion in macrophages. Nature 1980;286:79-80.
144. Clemens DL, Lee BY, Horwitz MA. Purification, characterization, and genetic analysis of Mycobacterium tuberculosis urease, a potentially critical determinant of host-pathogen interaction. J Bacteriol 1995;177:5644-52.
145. Harth G, Clemens DL, Horwitz MA. Glutamine synthetase of Mycobacterium tuberculosis: extracellular release and characterization of its enzymatic activity. Proc Natl Acad Sci USA 1994;91:9342-6.
146. Nikaido H, Kim S-H, Rosenberg EY. Physical organization of lipids in the cell wall of Mycobacterium chelonae. Mol Microbiol 1993;8:1025-30.
147. Paul T R, Beveridge TJ. Reevaluation of envelope profiles and cytoplasmic ultrastructure of mycobacteria processed by conventional embedding and freeze-substitution protocols. J Bacteriol 1992;174:6508-17.
148. Rastogi N. Recent observations concerning structure and function relationships in the mycobacterial cell envelope: elaboration of a model in terms of mycobacterial pathogenicity, virulence and drug-resistance. Res Microbiol 1991;142:464-76.
149. Liu J, Rosenberg EY, Nikaido H. Fluidity of the lipid domain of cell wall from Mycobacterium chelonae. Proc Natl Acad Sci USA 1995;92:11254-8.
150. Keller R, Keist R, Joller P. Macrophage response to microbial pathogens: modulation of the expression of adhesion, CD14, and MHC class II molecules by viruses, bacteria, protozoa and fungi. Scand J Immunol 1995;42:337-44.
151. Pancholi P, Mirza A, Bhardwaj N, Steinman RM. Sequestration from immune CD4+ T cells of mycobacteria growing in human macrophages. Science 1993;260:984-6.
152. Gercken J, Pryjma J, Ernst M, Flad H-D. Defective antigen presentation by Mycobacterium tuberculosis-infected monocytes. Infect Immun 1994;62:3472-8.
153. Wadee AA, Kuschke RH, Dooms TG. The inhibitory effects of Mycobacterium tuberculosis on MHC class II expression by monocytes activated with riminophenazines and phagocyte stimulants. Clin Exp Immunol 1995;100:434-9.
154. Saha B, Das G, Vohra H, Ganguly NK, Mishra GC. Macrophage-T cell interaction in experimental mycobacterial infection. Selective regulation of co-stimulatory molecules on Mycobacterium-infected macrophages and its implication in the suppression of cell-mediated immune response. Eur J Immunol 1994;24:2618-24.
155. López Ramírez GM, Rom WN, Ciotoli C, Talbot A, Martiniuk F, Cronstein B, Reibman J. Mycobacterium tuberculosis alters expression of adhesion molecules on monocytic cells. Infect Immun 1994;62:2515-20.
156. Potts BC, Fogarty SJ, Yi H, Schlesinger LS. M tuberculosis within human macrophages is accompanied by altered levels of β2 integrin stead state mRNA and surface protein [abstract]. Thirtieth US-Japan Joint Conference on Tuberculosis and Leprosy, p. 46.
157. Birdi TJ, Mistry NF. Mahadevan PR, Antia NH. Alterations in the membrane of macrophages from leprosy patients. Infect Immun 1983;41:121-7.
158. Mariano M, Nikitin T, Malucelli BE. Phagocytic potential of macrophages from within delayed hypersensitivity-mediated granulomata. J Pathol 1977;123:27-33.
159. Kaye PM, Sims M, Feldmann M. Regulation of macrophage accessory cell activity by mycobacteria. II. In vitro inhibition of Ia expression by Mycobacterium microti. Clin Exp Immunol 1986;64:28-34.
160. Tsuyuguchi I, Kawasumi H, Takashima T, Tsuyuguchi T, Kishimoto S. Mycobacterium avium-Mycobaclerium intracellulare complex-induced suppression of T-cell proliferation in vitro by regulation of monocyte accessory cell activity. Infect Immun 1990;58:1369-78.
161. Mshana RN, Hastings RC, Krahenbuhl JL. Infection with live mycobacteria inhibits in vitro detection of la antigen on macrophages. Immunobiology 1988;177:40-54.