-
1
-
-
0034722901
-
Small molecule modulators of cyclin-dependent kinases for cancer therapy
-
Senderowicz, A. M. Small molecule modulators of cyclin-dependent kinases for cancer therapy. Oncogene. 19: 6600-6606, 2000.
-
(2000)
Oncogene
, vol.19
, pp. 6600-6606
-
-
Senderowicz, A.M.1
-
2
-
-
0033375469
-
Flavopiridol: The first cyclin-dependent kinase inhibitor in human clinical trials
-
Senderowicz, A. M. Flavopiridol: the first cyclin-dependent kinase inhibitor in human clinical trials. Invest. New Drugs, 17: 313-320, 1999.
-
(1999)
Invest. New Drugs
, vol.17
, pp. 313-320
-
-
Senderowicz, A.M.1
-
4
-
-
0029665778
-
Flavopiridol induces G1 arrest with inhibition of cyclin-dependent kinase (CDK) 2 and CDK4 in human breast carcinoma cells
-
Carlson, B. A., Dubay, M. M., Sausville, E. A., Brizuela, L., and Worland. P. J. Flavopiridol induces G1 arrest with inhibition of cyclin-dependent kinase (CDK) 2 and CDK4 in human breast carcinoma cells. Cancer Res., 56: 2973-2978, 1996.
-
(1996)
Cancer Res.
, vol.56
, pp. 2973-2978
-
-
Carlson, B.A.1
Dubay, M.M.2
Sausville, E.A.3
Brizuela, L.4
Worland, P.J.5
-
5
-
-
0032212885
-
Flavopiridol, a novel cyclin-dependent kinase inhibitor, suppresses the growth of head and neck squamous cell carcinomas by inducing apoptosis
-
Patel, V., Senderowicz, A. M., Pinto, D., Igishi, T., Raffeld, M., Quintanilla-Martinez, L., Ensley, J. F., Sausville, E. A., and Gutkind, J. S. Flavopiridol, a novel cyclin-dependent kinase inhibitor, suppresses the growth of head and neck squamous cell carcinomas by inducing apoptosis. J. Clin. Investig., 102: 1674-1681, 1998.
-
(1998)
J. Clin. Investig.
, vol.102
, pp. 1674-1681
-
-
Patel, V.1
Senderowicz, A.M.2
Pinto, D.3
Igishi, T.4
Raffeld, M.5
Quintanilla-Martinez, L.6
Ensley, J.F.7
Sausville, E.A.8
Gutkind, J.S.9
-
6
-
-
0031963058
-
Early induction of apoptosis in hematopoietic cell lines after exposure to flavopiridol
-
Parker, B., Kaur, G., Nieves-Neira, W., Taimi, M., Kolhagen, G., Shimizu, T., Pommier, Y., Sausville, E., and Senderowicz, A. M. Early induction of apoptosis in hematopoietic cell lines after exposure to flavopiridol. Blood, 91: 458-465, 1998.
-
(1998)
Blood
, vol.91
, pp. 458-465
-
-
Parker, B.1
Kaur, G.2
Nieves-Neira, W.3
Taimi, M.4
Kolhagen, G.5
Shimizu, T.6
Pommier, Y.7
Sausville, E.8
Senderowicz, A.M.9
-
7
-
-
0033568521
-
Downregulation of cyclin D1 by transcriptional repression in MCF-7 human breast carcinoma cells induced by flavopiridol
-
Carlson, B., Lahusen, T., Singh, S., Loaiza-Perez, A., Worland, P. J., Pestell, R., Albanese, C., Sausville, E. A., and Senderowicz, A. M. Downregulation of cyclin D1 by transcriptional repression in MCF-7 human breast carcinoma cells induced by flavopiridol. Cancer Res., 59: 4634-4641, 1999.
-
(1999)
Cancer Res.
, vol.59
, pp. 4634-4641
-
-
Carlson, B.1
Lahusen, T.2
Singh, S.3
Loaiza-Perez, A.4
Worland, P.J.5
Pestell, R.6
Albanese, C.7
Sausville, E.A.8
Senderowicz, A.M.9
-
8
-
-
0033231301
-
Flavopiridol, a protein kinase inhibitor, down-regulates hypoxic induction of vascular endothelial growth factor expression in human monocytes
-
Melillo, G., Sausville, E. A., Cloud, K., Lahusen, T., Varesio, L., and Senderowicz, A. M. Flavopiridol, a protein kinase inhibitor, down-regulates hypoxic induction of vascular endothelial growth factor expression in human monocytes. Cancer Res., 59: 5433-5437, 1999.
-
(1999)
Cancer Res.
, vol.59
, pp. 5433-5437
-
-
Melillo, G.1
Sausville, E.A.2
Cloud, K.3
Lahusen, T.4
Varesio, L.5
Senderowicz, A.M.6
-
9
-
-
0032563315
-
Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors
-
Gray, N. S., Wodicka, L., Thunnissen, A. M., Norman, T. C., Kwon, S., Espinoza, F. H., Morgan, D. O., Barnes, G., LeClerc, S., Meijer, L., Kim, S. H., Lockhart, D. J., and Schultz, P. G. Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors. Science, 281: 533-538, 1998.
-
(1998)
Science
, vol.281
, pp. 533-538
-
-
Gray, N.S.1
Wodicka, L.2
Thunnissen, A.M.3
Norman, T.C.4
Kwon, S.5
Espinoza, F.H.6
Morgan, D.O.7
Barnes, G.8
LeClerc, S.9
Meijer, L.10
Kim, S.H.11
Lockhart, D.J.12
Schultz, P.G.13
-
10
-
-
0034665961
-
Flavopiridol inhibits P-TEFb and blocks HIV-1 replication
-
Chao, S. H., Fujinaga, K., Marion, J. E., Taube, R., Sausville, E. A., Senderowicz, A. M., Peterlin, B. M., and Price, D. H. Flavopiridol inhibits P-TEFb and blocks HIV-1 replication. J. Biol. Chem., 275: 28345-28348, 2000.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 28345-28348
-
-
Chao, S.H.1
Fujinaga, K.2
Marion, J.E.3
Taube, R.4
Sausville, E.A.5
Senderowicz, A.M.6
Peterlin, B.M.7
Price, D.H.8
-
11
-
-
0005751758
-
Clinical trials referral resource. Clinical trials of flavopiridol
-
Wright, J., Blamer, G. L., and Cheson, B. D. Clinical trials referral resource. Clinical trials of flavopiridol. Oncology (Huntingt), 12: 1018, 1023-1024, 1998.
-
(1998)
Oncology (Huntingt)
, vol.12
, Issue.1018
, pp. 1023-1024
-
-
Wright, J.1
Blamer, G.L.2
Cheson, B.D.3
-
12
-
-
0033955395
-
Flavopiridol, a novel cyclin-dependent kinase inhibitor, in metastatic renal cancer: A University of Chicago Phase II consortium study
-
Stadler, W. M., Vogelzang, N. J., Amato, R., Sosman, J., Taber, D., Liebowitz, D., and Vokes, E. E. Flavopiridol, a novel cyclin-dependent kinase inhibitor, in metastatic renal cancer: a University of Chicago Phase II consortium study. J. Clin. Oncol., 18: 371-375, 2000.
-
(2000)
J. Clin. Oncol.
, vol.18
, pp. 371-375
-
-
Stadler, W.M.1
Vogelzang, N.J.2
Amato, R.3
Sosman, J.4
Taber, D.5
Liebowitz, D.6
Vokes, E.E.7
-
13
-
-
0031670668
-
Phase I trial of continuous infusion flavopiridol, a novel cyclin-dependent kinase inhibitor, in patients with refractory neoplasms
-
Senderowicz, A. M., Headlee, D., Stinson, S. F., Lush, R. M., Kalil, N., Villalba, L., Hill, K., Steinberg, S. M., Figg, W. D., Tompkins, A., Arbuck, S. G., and Sausville, E. A. Phase I trial of continuous infusion flavopiridol, a novel cyclin-dependent kinase inhibitor, in patients with refractory neoplasms. J. Clin. Oncol., 16: 2986-2999, 1998.
-
(1998)
J. Clin. Oncol.
, vol.16
, pp. 2986-2999
-
-
Senderowicz, A.M.1
Headlee, D.2
Stinson, S.F.3
Lush, R.M.4
Kalil, N.5
Villalba, L.6
Hill, K.7
Steinberg, S.M.8
Figg, W.D.9
Tompkins, A.10
Arbuck, S.G.11
Sausville, E.A.12
-
14
-
-
0012029032
-
Phase I clinical and pharmacokinetic trial of flavopiridol
-
Thomas, J., Cleary, J., Tutsch, K., Arzoomanian, R., Alberti, D., Simon, K., Feierabend, D., Morgan, K., and Wilding, G. Phase I clinical and pharmacokinetic trial of flavopiridol, San Diego: Proc. Eightieth Annual Meeting of the American Association of Cancer Res., 1997.
-
(1997)
San Diego: Proc. Eightieth Annual Meeting of the American Association of Cancer Res.
-
-
Thomas, J.1
Cleary, J.2
Tutsch, K.3
Arzoomanian, R.4
Alberti, D.5
Simon, K.6
Feierabend, D.7
Morgan, K.8
Wilding, G.9
-
15
-
-
0033545342
-
Acute-phase proteins and other systemic responses to inflammation
-
Published erratum in N. Engl. J. Med., 340: 1376, 1999
-
Gabay, C., and Kushner, I, Acute-phase proteins and other systemic responses to inflammation (Published erratum in N. Engl. J. Med., 340: 1376, 1999). N. Engl. J. Med., 340: 448-454, 1999.
-
(1999)
N. Engl. J. Med.
, vol.340
, pp. 448-454
-
-
Gabay, C.1
Kushner, I.2
-
16
-
-
0028095919
-
The acute phase response
-
Baumann, H., and Gauldie, J. The acute phase response. Immunol. Today, 15: 74-80, 1994.
-
(1994)
Immunol. Today
, vol.15
, pp. 74-80
-
-
Baumann, H.1
Gauldie, J.2
-
17
-
-
0030589152
-
Initiation of acute phase response and synthesis of cytokines
-
Koj, A. Initiation of acute phase response and synthesis of cytokines. Biochim. Biophys. Acta, 1317: 84-94, 1996.
-
(1996)
Biochim. Biophys. Acta
, vol.1317
, pp. 84-94
-
-
Koj, A.1
-
18
-
-
0029593490
-
The acute phase response and the hematopoietic system: The role of cytokines
-
Trey, J. E., and Kushner, I. The acute phase response and the hematopoietic system: the role of cytokines. Crit. Rev. Oncol. Hematol., 21: 1-18, 1995.
-
(1995)
Crit. Rev. Oncol. Hematol.
, vol.21
, pp. 1-18
-
-
Trey, J.E.1
Kushner, I.2
-
20
-
-
0032104274
-
Recent advances in cytokines, cytokine receptors and signal transduction
-
Rubinstein, M., Dinarello, C. A., Oppenheim, J. J., and Hertzog, P. Recent advances in cytokines, cytokine receptors and signal transduction. Cytokine Growth Factor Rev., 9: 175-181, 1998.
-
(1998)
Cytokine Growth Factor Rev.
, vol.9
, pp. 175-181
-
-
Rubinstein, M.1
Dinarello, C.A.2
Oppenheim, J.J.3
Hertzog, P.4
-
21
-
-
0033105768
-
Resolving conflicting signals: Cross inhibition of cytokine signaling pathways
-
Begley, C. G., and Nicola, N. A. Resolving conflicting signals: cross inhibition of cytokine signaling pathways. Blood, 93: 1443-1447, 1999.
-
(1999)
Blood
, vol.93
, pp. 1443-1447
-
-
Begley, C.G.1
Nicola, N.A.2
-
22
-
-
0032922288
-
Molecular regulation of cytokine gene expression during the immune response
-
Viola, J. P., and Rao, A. Molecular regulation of cytokine gene expression during the immune response. J. Clin. Immunol., 19: 98-108, 1999.
-
(1999)
J. Clin. Immunol.
, vol.19
, pp. 98-108
-
-
Viola, J.P.1
Rao, A.2
-
23
-
-
0033874108
-
Proinflammatory cytokines
-
Dinarello, C. A. Proinflammatory cytokines. Chest, 118: 503-508, 2000.
-
(2000)
Chest
, vol.118
, pp. 503-508
-
-
Dinarello, C.A.1
-
24
-
-
0032055497
-
Flavopiridol induces apoptosis of normal lymphoid cells, causes immunosuppresion, and has potent antitumor activity in vivo against human and leukemia xenografts
-
Arguello, F., Alexander, M., Sterry, J., Tudor, G., Smith, E., Kalavar, N., Greene, J., Koss, W., Morgan, D., Stinson, S., Siford, T., Alvord, W., Labansky, R., and Sausville, E. Flavopiridol induces apoptosis of normal lymphoid cells, causes immunosuppresion, and has potent antitumor activity in vivo against human and leukemia xenografts. Blood, 91: 2482-2490, 1998.
-
(1998)
Blood
, vol.91
, pp. 2482-2490
-
-
Arguello, F.1
Alexander, M.2
Sterry, J.3
Tudor, G.4
Smith, E.5
Kalavar, N.6
Greene, J.7
Koss, W.8
Morgan, D.9
Stinson, S.10
Siford, T.11
Alvord, W.12
Labansky, R.13
Sausville, E.14
-
25
-
-
0029904810
-
Flavopiridol: A cytotoxic flavone that induces cell death in noncycling A549 human lung carcinoma cells
-
Bible, K. C., and Kaufmann, S. H. Flavopiridol: a cytotoxic flavone that induces cell death in noncycling A549 human lung carcinoma cells. Cancer Res., 56: 4856-4861, 1996.
-
(1996)
Cancer Res.
, vol.56
, pp. 4856-4861
-
-
Bible, K.C.1
Kaufmann, S.H.2
-
26
-
-
0032533599
-
Flavopiridol induces apoptosis in chronic lymphocytic leukemia cells via activation of caspase-3 without evidence of bcl-2 modulation or dependence on functional p53
-
Byrd, J. C., Shinn, C., Waselenko, J. K., Fuchs, E. J., Lehman, T. A., Nguyen, P. L., Flinn, I. W., Diehl, L. F., Sausville, E., and Grever, M. R. Flavopiridol induces apoptosis in chronic lymphocytic leukemia cells via activation of caspase-3 without evidence of bcl-2 modulation or dependence on functional p53. Blood, 92: 3804-3816, 1998.
-
(1998)
Blood
, vol.92
, pp. 3804-3816
-
-
Byrd, J.C.1
Shinn, C.2
Waselenko, J.K.3
Fuchs, E.J.4
Lehman, T.A.5
Nguyen, P.L.6
Flinn, I.W.7
Diehl, L.F.8
Sausville, E.9
Grever, M.R.10
-
27
-
-
0029993339
-
Structural basis for specificity and potency of a flavonoid inhibitor of human CDK2, a cell cycle kinase
-
De Azevedo, W. F., Jr., Mueller-Dieckmann, H. J., Schulze-Gahmen, U., Worland, P. J., Sausville, E., and Kim, S. H. Structural basis for specificity and potency of a flavonoid inhibitor of human CDK2, a cell cycle kinase. Proc. Natl. Acad. Sci. USA, 93: 2735-2740, 1996.
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 2735-2740
-
-
De Azevedo W.F., Jr.1
Mueller-Dieckmann, H.J.2
Schulze-Gahmen, U.3
Worland, P.J.4
Sausville, E.5
Kim, S.H.6
-
28
-
-
0026452974
-
Growth inhibition with reversible cell cycle arrest of carcinoma cells by flavone L86-8275
-
Kaur, G., Stetler-Stevenson, M., Sebers, S., Worland, P., Sedlacek, H., Myers, C., Czech, J., Naik, R., and Sausville, E. Growth inhibition with reversible cell cycle arrest of carcinoma cells by flavone L86-8275. J. Natl. Cancer Inst. (Bethesda), 84: 1736-1740, 1992.
-
(1992)
J. Natl. Cancer Inst. (Bethesda)
, vol.84
, pp. 1736-1740
-
-
Kaur, G.1
Stetler-Stevenson, M.2
Sebers, S.3
Worland, P.4
Sedlacek, H.5
Myers, C.6
Czech, J.7
Naik, R.8
Sausville, E.9
-
29
-
-
0033960068
-
Induction of apoptosis and inhibition of c-erbB-2 in breast cancer cells by flavopiridol
-
Li, Y., Bhuiyan, M., Alhasan, S., Senderowicz, A. M., and Sarkar, F. H. Induction of apoptosis and inhibition of c-erbB-2 in breast cancer cells by flavopiridol. Clin. Cancer Res., 6: 223-229, 2000.
-
(2000)
Clin. Cancer Res.
, vol.6
, pp. 223-229
-
-
Li, Y.1
Bhuiyan, M.2
Alhasan, S.3
Senderowicz, A.M.4
Sarkar, F.H.5
-
30
-
-
0000441622
-
A Phase I trial of 1 hour infusion of flavopiridol (Fla), a novel cyclin-dependent kinase inhibitor, in patients with advanced neoplasms
-
Senderowicz, A. M., Messmann, R., Arbuck, S., Headlee, D., Zhai, S., Murgo, A., Melillo, G., Figg, W., and Sausville, E. A Phase I trial of 1 hour infusion of flavopiridol (Fla), a novel cyclin-dependent kinase inhibitor, in patients with advanced neoplasms. New Orleans: Proc. Ann. Meet. Am. Soc. Clin. Oncol., 2000.
-
(2000)
New Orleans: Proc. Ann. Meet. Am. Soc. Clin. Oncol.
-
-
Senderowicz, A.M.1
Messmann, R.2
Arbuck, S.3
Headlee, D.4
Zhai, S.5
Murgo, A.6
Melillo, G.7
Figg, W.8
Sausville, E.9
-
31
-
-
0002504382
-
Preclinical and clinical development of Protein serine-threonine Kinase inhibitors
-
Senderowicz, A., Murgo, A., and Kalil, N. Preclinical and clinical development of Protein serine-threonine Kinase inhibitors. South American Journal of Cancer, 3: 95-112, 2000.
-
(2000)
South American Journal of Cancer
, vol.3
, pp. 95-112
-
-
Senderowicz, A.1
Murgo, A.2
Kalil, N.3
-
32
-
-
0036789539
-
Phase I clinical and pharmacokinetic study of flavopiridol administered as a daily 1-hour infusion in patients with advanced neoplasms
-
Tan, A., Headlee, D., Messmann, R., Sausville, E. A., Arbuck, S., Murgo, A., Melillo, G., Zhai, S., Figg, W., Swain, S., and Senderowicz, A. M. Phase I clinical and pharmacokinetic study of flavopiridol administered as a daily 1-hour infusion in patients with advanced neoplasms. J. Clin. Oncol., 20: 4074-4082, 2002.
-
(2002)
J. Clin. Oncol.
, vol.20
, pp. 4074-4082
-
-
Tan, A.1
Headlee, D.2
Messmann, R.3
Sausville, E.A.4
Arbuck, S.5
Murgo, A.6
Melillo, G.7
Zhai, S.8
Figg, W.9
Swain, S.10
Senderowicz, A.M.11
-
33
-
-
0030890718
-
Gp130 and the interleukin-6 family of cytokines
-
Taga, T., and Kishimoto, T. Gp130 and the interleukin-6 family of cytokines. Annu. Rev. Immunol., 15: 797-819, 1997.
-
(1997)
Annu. Rev. Immunol.
, vol.15
, pp. 797-819
-
-
Taga, T.1
Kishimoto, T.2
-
34
-
-
0027421831
-
Interleukin-6 in biology and medicine
-
Akira, S., Taga, T., and Kishimoto, T. Interleukin-6 in biology and medicine. Adv. Immunol., 54: 1-78, 1993.
-
(1993)
Adv. Immunol.
, vol.54
, pp. 1-78
-
-
Akira, S.1
Taga, T.2
Kishimoto, T.3
-
35
-
-
0027978341
-
Effects of recombinant human interleukin-6 in cancer patients: A phase I-II study
-
van Gameren, M. M., Willemse, P. H., Mulder, N. H., Limburg, P. C., Groen, H. J., Vellenga, E., and de Vries, E. G. Effects of recombinant human interleukin-6 in cancer patients: a phase I-II study. Blood, 84: 1434-1441, 1994.
-
(1994)
Blood
, vol.84
, pp. 1434-1441
-
-
Van Gameren, M.M.1
Willemse, P.H.2
Mulder, N.H.3
Limburg, P.C.4
Groen, H.J.5
Vellenga, E.6
De Vries, E.G.7
-
36
-
-
0029147155
-
Toxicity and efficacy of escalating dosages of recombinant human interleukin-6 after chemotherapy in patients with breast cancer or non-small-cell lung cancer
-
Veldhuis, G. J., Willemse, P. H., Sleijfer, D. T., van der Graaf, W. T., Groen, H. J., Limburg, P. C., Mulder, N. H., and de Vries, E. G. Toxicity and efficacy of escalating dosages of recombinant human interleukin-6 after chemotherapy in patients with breast cancer or non-small-cell lung cancer, J. Clin. Oncol., 13: 2585-2593, 1995.
-
(1995)
J. Clin. Oncol.
, vol.13
, pp. 2585-2593
-
-
Veldhuis, G.J.1
Willemse, P.H.2
Sleijfer, D.T.3
Van der Graaf, W.T.4
Groen, H.J.5
Limburg, P.C.6
Mulder, N.H.7
De Vries, E.G.8
-
37
-
-
0027489606
-
Phase I study of bryostatin 1: Assessment of interleukin 6 and tumor necrosis factor alpha induction in vivo, The Cancer Res. Campaign Phase I Committee
-
Philip, P. A., Rea, D., Thavasu, P., Carmichael, J., Stuart, N. S., Rockett, H., Talbot, D. C., Ganesan, T., Pettit, G. R., Balkwill, F. et al. Phase I study of bryostatin 1: assessment of interleukin 6 and tumor necrosis factor alpha induction in vivo, The Cancer Res. Campaign Phase I Committee. J. Natl. Cancer Inst. (Bethesda), 85: 1812-1818, 1993.
-
(1993)
J. Natl. Cancer Inst. (Bethesda)
, vol.85
, pp. 1812-1818
-
-
Philip, P.A.1
Rea, D.2
Thavasu, P.3
Carmichael, J.4
Stuart, N.S.5
Rockett, H.6
Talbot, D.C.7
Ganesan, T.8
Pettit, G.R.9
Balkwill, F.10
-
38
-
-
0029084804
-
A phase I trial of bryostatin 1 in patients with advanced malignancy using a 24 hour intravenous infusion
-
Jayson, G. C., Crowther, D., Prendiville, J., McGown, A. T., Scheid, C., Stern, P., Young, R., Brenchley, P., Chang, J., Owens, S. et al. A phase I trial of bryostatin 1 in patients with advanced malignancy using a 24 hour intravenous infusion. Br. J. Cancer, 72: 461-468, 1995.
-
(1995)
Br. J. Cancer
, vol.72
, pp. 461-468
-
-
Jayson, G.C.1
Crowther, D.2
Prendiville, J.3
McGown, A.T.4
Scheid, C.5
Stern, P.6
Young, R.7
Brenchley, P.8
Chang, J.9
Owens, S.10
-
39
-
-
0033386539
-
Protein kinase C targeting in antineo-plastic treatment strategies
-
Jarvis, W. D., and Grant, S. Protein kinase C targeting in antineo-plastic treatment strategies. Investig. New Drugs, 17: 227-240, 1999.
-
(1999)
Investig. New Drugs
, vol.17
, pp. 227-240
-
-
Jarvis, W.D.1
Grant, S.2
-
40
-
-
0031042926
-
Concurrent phase I trials of intravenous interleukin 6 in solid tumor patients: Reversible dose-limiting neurological toxicity
-
Sosman, J. A., Aronson, F. R., Sznol, M., Atkins, M. B., Dutcher, J. P., Weiss, G. R., Isaacs, R. E., Margolin, K, A., Fisher, R. I., Ernest, M. L., Mier, J., Oleksowicz, L., Eckhardt, J. R., Levitt, D., and Doro-show, J. H. Concurrent phase I trials of intravenous interleukin 6 in solid tumor patients: reversible dose-limiting neurological toxicity. Clin. Cancer Res., 3: 39-46, 1997.
-
(1997)
Clin. Cancer Res.
, vol.3
, pp. 39-46
-
-
Sosman, J.A.1
Aronson, F.R.2
Sznol, M.3
Atkins, M.B.4
Dutcher, J.P.5
Weiss, G.R.6
Isaacs, R.E.7
Margolin, K.A.8
Fisher, R.I.9
Ernest, M.L.10
Mier, J.11
Oleksowicz, L.12
Eckhardt, J.R.13
Levitt, D.14
Doro-Show, J.H.15
-
41
-
-
0028364587
-
A phase I trial of intravenous interleukin-6 in patients with advanced cancer
-
Weber, J., Gunn, H., Yang, J., Parkinson, D., Topalian, S., Schwartzentruber, D., Ettinghausen, S., Levitt, D., and Rosenberg, S. A. A phase I trial of intravenous interleukin-6 in patients with advanced cancer. J. Immunother. Emphas. Tumor Immunol., 15: 292-302, 1994.
-
(1994)
J. Immunother. Emphas. Tumor Immunol.
, vol.15
, pp. 292-302
-
-
Weber, J.1
Gunn, H.2
Yang, J.3
Parkinson, D.4
Topalian, S.5
Schwartzentruber, D.6
Ettinghausen, S.7
Levitt, D.8
Rosenberg, S.A.9
-
42
-
-
0027461967
-
Phase I trial of subcutaneous interleukin-6 in patients with advanced malignancies
-
Weber, J., Yang, J. C., Topalian, S. L., Parkinson, D. R., Schwartzentruber, D. S., Ettinghausen, S. E., Gunn, H., Mixon, A., Kim, H., Cole, D., et al. Phase I trial of subcutaneous interleukin-6 in patients with advanced malignancies. J. Clin. Oncol., 11: 499-506, 1993.
-
(1993)
J. Clin. Oncol.
, vol.11
, pp. 499-506
-
-
Weber, J.1
Yang, J.C.2
Topalian, S.L.3
Parkinson, D.R.4
Schwartzentruber, D.S.5
Ettinghausen, S.E.6
Gunn, H.7
Mixon, A.8
Kim, H.9
Cole, D.10
-
43
-
-
0029075385
-
A phase I trial of recombinant human interleukin-6 in patients with myelodysplastic syndromes and thrombocytopenia
-
Gordon, M. S., Nemunaitis, J., Hoffman, R., Paquette, R. L., Rosenfeld, C., Manfreda, S., Isaacs, R., and Nimer, S. D. A phase I trial of recombinant human interleukin-6 in patients with myelodysplastic syndromes and thrombocytopenia. Blood, 85: 3066-3076, 1995.
-
(1995)
Blood
, vol.85
, pp. 3066-3076
-
-
Gordon, M.S.1
Nemunaitis, J.2
Hoffman, R.3
Paquette, R.L.4
Rosenfeld, C.5
Manfreda, S.6
Isaacs, R.7
Nimer, S.D.8
-
44
-
-
0031183766
-
The role of nuclear factor-kappa B in cytokine gene regulation
-
Blackwell, T. S., and Christman, J. W. The role of nuclear factor-kappa B in cytokine gene regulation. Am. J. Respir. Cell Mol. Biol., 17: 3-9, 1997.
-
(1997)
Am. J. Respir. Cell Mol. Biol.
, vol.17
, pp. 3-9
-
-
Blackwell, T.S.1
Christman, J.W.2
-
45
-
-
0029874138
-
The NF-kappa B and I kappa B proteins: New discoveries and insights
-
Baldwin, A. S., Jr. The NF-kappa B and I kappa B proteins: new discoveries and insights. Annu. Rev. Immunol., 14: 649-683, 1996.
-
(1996)
Annu. Rev. Immunol.
, vol.14
, pp. 649-683
-
-
Baldwin A.S., Jr.1
-
46
-
-
0030614504
-
Regulation of NF-kappaB by cyclin-dependent kinases associated with the p300 coactivator
-
Perkins, N. D., Felzien, L. K., Betts, J. C., Leung, K., Beach, D. H., and Nabel, G. J. Regulation of NF-kappaB by cyclin-dependent kinases associated with the p300 coactivator. Science, 275: 523-527, 1997.
-
(1997)
Science
, vol.275
, pp. 523-527
-
-
Perkins, N.D.1
Felzien, L.K.2
Betts, J.C.3
Leung, K.4
Beach, D.H.5
Nabel, G.J.6
-
47
-
-
0030198344
-
Protein kinase cascades activated by stress and inflammatory cytokines
-
Kyriakis, J. M., and Avruch, J. Protein kinase cascades activated by stress and inflammatory cytokines. Bioessays, 18: 567-577, 1996.
-
(1996)
Bioessays
, vol.18
, pp. 567-577
-
-
Kyriakis, J.M.1
Avruch, J.2
-
48
-
-
0033616588
-
Requirement of mitogen-activated protein kinase kinase 3 (MKK3) for tumor necrosis factor-induced cytokine expression
-
Wysk, M., Yang, D. D., Lu, H. T., Flavell, R. A., and Davis, R. J. Requirement of mitogen-activated protein kinase kinase 3 (MKK3) for tumor necrosis factor-induced cytokine expression. Proc. Natl. Acad. Sci. USA, 96: 3763-3768, 1999.
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 3763-3768
-
-
Wysk, M.1
Yang, D.D.2
Lu, H.T.3
Flavell, R.A.4
Davis, R.J.5
-
49
-
-
0028605318
-
A protein kinase involved in the regulation of inflammatory cytokine biosynthesis
-
Lee, J. C., Laydon, J. T., McDonnell, P. C., Gallagher, T. F., Kumar, S., Green, D., McNulty, D., Blumenthal, M. J., Heys, J. R., Landvatter, S. W., et al. A protein kinase involved in the regulation of inflammatory cytokine biosynthesis. Nature, 372: 739-746, 1994.
-
(1994)
Nature
, vol.372
, pp. 739-746
-
-
Lee, J.C.1
Laydon, J.T.2
McDonnell, P.C.3
Gallagher, T.F.4
Kumar, S.5
Green, D.6
McNulty, D.7
Blumenthal, M.J.8
Heys, J.R.9
Landvatter, S.W.10
-
50
-
-
0348032234
-
Flavopiridol-induced apoptosis is associated with p38 and MEK activation and is prevented by caspase and MAPK inhibitors
-
Lahusen, J., Loaiza-Perez, A., Sausville, E. A., and Senderowicz, A. M. Flavopiridol-induced apoptosis is associated with p38 and MEK activation and is prevented by caspase and MAPK inhibitors. San Francisco: Proc. Twentieth Ann. Meet. Am. Assoc. Cancer Res., 2000.
-
(2000)
San Francisco: Proc. Twentieth Ann. Meet. Am. Assoc. Cancer Res.
-
-
Lahusen, J.1
Loaiza-Perez, A.2
Sausville, E.A.3
Senderowicz, A.M.4
-
51
-
-
2842605597
-
Growth inhibition of human breast carcinoma and leukemia/lymphoma cell lines by recombinant interferon-beta 2
-
Chen, L., Mory, Y., Zilberstein, A., and Revel, M. Growth inhibition of human breast carcinoma and leukemia/lymphoma cell lines by recombinant interferon-beta 2. Proc. Natl. Acad. Sci. USA, 85: 8037-8041, 1988.
-
(1988)
Proc. Natl. Acad. Sci. USA
, vol.85
, pp. 8037-8041
-
-
Chen, L.1
Mory, Y.2
Zilberstein, A.3
Revel, M.4
-
52
-
-
0025321245
-
Antitumor activity of recombinant interleukin 6 in mice
-
Mule, J. J., McIntosh, J. K., Jablons, D. M., and Rosenberg, S. A. Antitumor activity of recombinant interleukin 6 in mice. J. Exp. Med., 171: 629-636, 1990.
-
(1990)
J. Exp. Med.
, vol.171
, pp. 629-636
-
-
Mule, J.J.1
McIntosh, J.K.2
Jablons, D.M.3
Rosenberg, S.A.4
-
53
-
-
0026760711
-
Interleukin-6 increases carcinoembryonic antigen and histocompatibility leukocyte antigen expression on the surface of human colorectal carcinoma cells
-
Ullmann, C. D., Schlom, J., and Greiner, J. W. Interleukin-6 increases carcinoembryonic antigen and histocompatibility leukocyte antigen expression on the surface of human colorectal carcinoma cells. J. Immunother., 12: 231-241, 1992.
-
(1992)
J. Immunother.
, vol.12
, pp. 231-241
-
-
Ullmann, C.D.1
Schlom, J.2
Greiner, J.W.3
-
54
-
-
0035045564
-
Multiple myeloma. Advances in disease biology: Therapeutic implications
-
Anderson, K. C. Multiple myeloma. Advances in disease biology: therapeutic implications. Semin. Hematol., 38: 6-10, 2001.
-
(2001)
Semin. Hematol.
, vol.38
, pp. 6-10
-
-
Anderson, K.C.1
-
55
-
-
0034123859
-
Malignancy: Identification of predictors of disease status and progression in patients with myeloma (MM)
-
Salem, M., Elbaz, O., Zahran, M., Elbaz, A., Elgamal, S., Eteba, S., and Mahmoud, L. A. Malignancy: identification of predictors of disease status and progression in patients with myeloma (MM). Hematology, 5: 41-45, 2000.
-
(2000)
Hematology
, vol.5
, pp. 41-45
-
-
Salem, M.1
Elbaz, O.2
Zahran, M.3
Elbaz, A.4
Elgamal, S.5
Eteba, S.6
Mahmoud, L.A.7
|