Th1 and Th2 cells

Current Opinion in Hematology

Volumn 8, Issue 1, 2001, Pages 47-51

  Dong, Chen ^a   Flavell, Richard A ^b  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CHEMOKINE; CYTOKINE; TRANSCRIPTION FACTOR;

CYTOKINE PRODUCTION; EFFECTOR CELL; GENE EXPRESSION REGULATION; IMMUNE RESPONSE; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE HOMING; PRIORITY JOURNAL; REVIEW; SIGNAL PROCESSING; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION; TH1 CELL; TH2 CELL;

ANIMALS; GENE EXPRESSION REGULATION; HUMANS; LYMPHOCYTE ACTIVATION; SIGNAL TRANSDUCTION; TH1 CELLS; TH2 CELLS;

EID: 0035169579     PISSN: 10656251     EISSN: None     Source Type: Journal    
DOI: 10.1097/00062752-200101000-00009     Document Type: Review

References (46)

1. TH1 and TH2 cells: Different patterns of lymphokine secretion lead to different functional properties
2. CD28/B7 system of T cell costimulation
3. Studies using antigen-presenting cells lacking expression of both B7-1 (CD80) and B7-2 (CD86) show distinct requirements for B7 molecules during priming versus restimulation of Th2 but not Th1 cytokine production
4. CD28-mediated costimulation of interleukin 2 (IL-2) production plays a critical role in T cell priming for IL-4 and interferon gamma production
5. Helper T cell differentiation is controlled by the cell cycle
6. Costimulatory regulation of T cell function
7. ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28
8. T-cell co-stimulation through B7RP-1 and ICOS
9. The CD28-related molecule ICOS is required for effective T cell-dependent immune responses
10. Inducible costimulator protein (ICOS) controls T helper cell subset polarization after virus and parasite infection
11. CD40 and CD154 in cell-mediated immunity
12. TRANCE-RANK, a new signal pathway involved in lymphocyte development and T cell activation
13. TRANCE, a tumor necrosis factor family member critical for CD40 ligand-indenpendent T helper cell activation
14. OX40-deficient mice are defective in Th cell proliferation but are competent in generating B cell and CTL responses after virus infection
15. Ox40-ligand has a critical costimulatory role in dendritic cell:T cell interactions
16. The biology of chemokines and their receptors
17. The role of chemokine receptors in primary, effector, and memory immune responses
18. The role of CCR7 in TH1 and TH2 cell localization and delivery of B cell help in vivo
19. Effect of C-C chemokine receptor 2 (CCR2) knockout on type-2 (schistosomal antigen-elicited) pulmonary granuloma formation: Analysis of cellular recruitment and cytokine responses
20. CC chemokine receptor (CCR)2 is required for langerhans cell migration and localization of T helper cell type 1 (Th1)-inducing dendritic cells. Absence of ccr2 shifts the leishmania major-resistant phenotype to a susceptible state dominated by th2 cytokines, b cell outgrowth, and sustained neutrophilic inflammation
21. Control of TH2 polarization by the chemokine monocyte chemoattractant protein-1
22. Modulation of chromatin structure regulates cytokine gene expression during T cell differentiation
23. Th2-specific DNase I-hypersensitive sites in the murine IL-13 and IL-4 intergenic region
24. Identification of a coordinate regulator of interleukins 4, 13, and 5 by cross-species sequence comparisons
25. The transcription factor GATA-3 is necessary and sufficient for Th2 gene expression in CD4+ T cells
26. Transcriptional factor GATA-3 is differentially expressed in murine Th1 and Th2 cells and controls Th2-specific expression of the interleukin-5 gene
27. Inhibition of Th1 development mediated by GATA-3 through an IL-4- independent mechanism
28. Inhibition of allergic inflammation in a murine model of asthma by expression of a dominant-negative mutant of GATA-3
29. Stat6-independent GATA-3 autoactivation directs IL-4-independent Th2 development and commitment
30. Regulation of T helper cell differentiation by the transcription factor JunB
31. The proto-oncogene c-maf is responsible for tissue-specific expression of interleukin-4
32. c-maf promotes T helper cell type 2 (Th2) and attenuates Th1 differentiation by both interleukin 4-dependent and -independent mechanisms
33. The transcription factor c-Maf controls the production of interleukin-4 but not other Th2 cytokines
34. A novel transcription factor, T-bet, directs Th1 lineage commitment
35. Interferon-γ expression by Th1 · effector T cells mediated by the p38 MAP kinase signaling pathway
36. Defective IL-12 production in mitogen-activated protein (MAP) kinase kinase 3 (Mkk3)-deficient mice
37. Two essential regulatory elements in the human interferon gamma promoter confer activation specific expression in T cells
38. The proximal regulatory element of the interferon-γ promoter mediates selective expression in T cells
39. Regulation of the activity of IFN-γ promoter elements during Th cell differentiation
40. Memory and effector, but not naive t cells, express transcriptional activity under the control of two IFN-γ promoter elements
41. Regulation of c-Jun NH(2)-terminal kinase (Jnk) gene expression during T cell activation
42. Differentiation of CD4+ T cells to Th1 cells requires MAP kinase JNK2
43. Defective t cell differentiation in the absence of Jnk1
44. JNK is required for effector T-cell function but not for T-cell activation
45. JNK inhibits targeting of protein phosphatase calcineurin to NFATc1
46. Role of the guanosine triphosphatase Rac2 in T helper 1 cell differentiation