Folate: A Key to Optimizing Health and Reducing Disease Risk in the Elderly

Journal of the American College of Nutrition

Volumn 22, Issue 1, 2003, Pages 1-8

  Rampersaud, Gail C ^a,b   Kauwell, Gail P A ^a   Bailey, Lynn B ^a  

^a UNIVERSITY OF FLORIDA   (United States)

^b UNIVERSITY OF FLORIDA   (United States)

Author keywords

Aged; Chronic disease; Folate; Folic acid; Homocysteine; Vitamin B 12

Indexed keywords

CYANOCOBALAMIN; FOLIC ACID; HOMOCYSTEINE;

AGING; ALZHEIMER DISEASE; BIOAVAILABILITY; CHRONIC DISEASE; COGNITIVE DEFECT; CYANOCOBALAMIN DEFICIENCY; DEMENTIA; DIET SUPPLEMENTATION; DIETARY INTAKE; ELDERLY CARE; GENETIC POLYMORPHISM; HEALTH HAZARD; HUMAN; HYPERHOMOCYSTEINEMIA; POPULATION RESEARCH; REVIEW; RISK FACTOR;

AGED; BIOLOGICAL AVAILABILITY; CARDIOVASCULAR DISEASES; COGNITION DISORDERS; DIETARY SUPPLEMENTS; FEMALE; FOLIC ACID; FOLIC ACID DEFICIENCY; FOOD, FORTIFIED; HUMANS; MALE; NEOPLASMS; NUTRITION POLICY; RISK FACTORS; UNITED STATES; VEGETABLES; VITAMIN B 12; VITAMIN B 12 DEFICIENCY;

ASPARAGUS;

EID: 0037309722     PISSN: 07315724     EISSN: 15411087     Source Type: Journal    
DOI: 10.1080/07315724.2003.10719270     Document Type: Article

References (88)

1. United States Census Bureau: "Table NP-T3-D. Projections of the Total Resident Population by 5-Year Age Groups, and Sex with Special Age Categories: Middle Series, 2011 to 2015." US Census Bureau Website. http://www.census.gov/population/www/projections/popproj.html Accessed December 3, 2002.
2. Wahlqvist ML, Savige GS: Interventions aimed at dietary and lifestyle changes to promote healthy aging. Eur J Clin Nutr 54: S148-S156, 2000.
3. Gregory JF: Bioavailability of folate. Eur J Clin Nutr 51(1):S54-S59, 1997.
4. Food Standards: "Amendment of the Standards of Identity for Enriched Grain Products to Require Addition of Folic Acid. Final Rule." (Codified at 21 CFR Part 136, 137, and 139) 61 Federal Register 8781-8807, 1996.
5. Sauberlich HE, Kretsch MJ, Skala JH, Johnson HL, Taylor PC: Folate requirement and metabolism in nonpregnant women. Am J Clin Nutr 46:1016-1028, 1987.
6. Pfeiffer CM, Rogers LM, Bailey LB, Gregory JF: Absorption of folate from fortified cereal-grain products and of supplemental folate consumed with or without food determined by using a dual-label stable-isotope protocol. Am J Clin Nutr 66:1388-1397, 1997.
7. Institute of Medicine, Food and Nutrition Board: "Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline." Washington, DC: National Academy Press, 1998.
8. Suitor CW, Bailey LB: Dietary folate equivalents: Interpretation and application. J Am Diet Assoc 100:88-94, 2000.
9. Bailey LB, Moyers S, Gregory JF: Folate. In Bowman BA, Russell RM (eds): "Present Knowledge in Nutrition," 8th ed. Washington, DC: ILSI Press, pp 214-229, 2001.
10. Momparler RL, Bovenzi V: DNA methylation and cancer. J Cell Physiol 183:145-154, 2000.
11. Kang S-S, Zou J, Wong PWK, Kowalisyn J, Strokosch G: Intermediate homocysteinemia: A thermolabile variant of methylenetetrahydrofolate reductase. Am J Hum Genet 43:414-421, 1988.
12. Bailey LB, Gregory 3rd JF: Polymorphisms of methylenetetrahydrofolate reductase and other enzymes: Metabolic significance, risks and impact on folate requirement. J Nutr 129:919-922, 1999.
13. Jacques PF, Bostom AG, Williams RR, Ellison RC, Eckfeldt JH, Rosenberg IH, Selhub J, Rozen R: Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations. Circulation 93:7-9, 1996.
14. Kauwell GPA, Wilsky CE, Cerda JJ, Herrlinger-Garcia K, Hutson AD, Theriaque DW, Boddie A, Rampersaud GC, Bailey LB: Methylenetetrahydrofolate reductase mutation (677C3T) negatively influences plasma homocysteine response to marginal folate intake in elderly women. Metabolism 49:1440-1443, 2000.
15. Rosenberg IH, Rosenberg LE: The implications of genetic diversity for nutrient requirements: The case of folate. Nutr Rev 56: S47-S53, 1998.
16. Botto LD, Yang Q: 5,10-methylenetetrahydrofolate reductase gene variants and congenital anomalies: A HuGE review. Am J Epidemiol 151:862-877, 2000.
17. Kauwell GPA, Lippert BL, Wilsky CE, Herrlinger-Garcia K, Hutson AD, Theriaque DW, Rampersaud GC, Cerda JJ, Bailey LB: Folate status of elderly women following moderate folate depletion responds only to a higher folate intake. J Nutr 130:1584-1590, 2000.
18. Food and Nutrition Board: "Recommended Dietary Allowances," 10th ed. Washington, DC: National Academy of Science, 1989.
19. Ho C, Kauwell GPA, Bailey LB: Practitioners' guide to meeting the vitamin B-12 Recommended Dietary Allowance for people aged 51 years and older. J Am Diet Assoc 99:725-727, 1999.
20. Baik HW, Russell RM: Vitamin B12 deficiency in the elderly. Annu Rev Nutr 19:357-377, 1999.
21. Rothenberg SP: Increasing the dietary intake of folate: Pros and cons. Semin Hematol 36:65-74, 1999.
22. Mills JL: Fortification of foods with folic acid-how much is enough? N Eng J Med 342:1442-1445, 2000.
23. Food Standards: amendment of the standards of identity for enriched grain products to require addition of folic acid. Fed Regist 58(197):53305-53312, 1993.
24. Jacques PF, Selhub J, Bostom AG, Wilson PWF, Rosenberg IH: The effect of folic acid fortification on plasma folate and total homocysteine concentrations. N Engl J Med 340:1449-1454, 1999.
25. Choumenkovitch SF, Jacques PF, Nadeau MR, Wilson PWF, Rosenberg IH, Selhub J: Folic acid fortification increases red blood cell folate concentrations in the Framingham Study. J Nutr 131: 3277-3280, 2001.
26. Whittaker P, Tufaro PR, Rader JI: Iron and folate in fortified cereals. J Am Coll Nutr 20:247-254, 2001.
27. Tucker KL, Selhub J, Wilson PWF, Rosenberg IH: Dietary intake pattern relates to plasma folate and homocysteine concentrations in the Framingham Heart Study. J Nutr 126:3025-3031, 1996.
28. U.S. Department of Health and Human Services: "Use of Dietary Supplements in the United States, 1988-94." Series 11: Data from the National Health Examination Survey, the National Health and Nutrition Examination Surveys and the Hispanic Health and Nutrition Examination Survey No. 244. DHHS Publication No. 99-1694. Hyattsville, MD: National Center for Health Statistics, 1999.
29. Vitolins MZ, Quandt SA, Case LD, Bell RA, Arcury TA, Mc- Donald J: Vitamin and mineral supplement use by older rural adults. J Gerontol 55A:M613-M617, 2000.
30. Koehler KM, Baumgartner RN, Garry PJ, Allen RH, Stabler SP, Rimm EB: Association of folate intake and serum homocysteine in elderly persons according to vitamin supplementation and alcohol use. Am J Clin Nutr 73:628-637, 2001.
31. van Ede AE, Laan RFJM, Blom HJ, De Abreu RA, van de Putte LBA: Methotrexate in rheumatoid arthritis: An update with focus on mechanisms involved in toxicity. Semin Arthritis Rheum 27: 277-292, 1998.
32. Leeb BF, Witzmann G, Ogris E, Studnicka-Benke A, Andel I, Schweitzer H, Smolen JS: Folic acid and cyanocobalamin levels in serum and erythrocytes during low-dose methotrexate therapy of rheumatoid arthritis and psoriatic arthritis patients. Clin Exp Rheumatol 13:459-463, 1995.
33. Andersen LS, Hansen EL, Knudsen JB, Wester JU, Hansen GVO, Hansen TM: Prospectively measured red cell folate levels in methotrexate treated patients with rheumatoid arthritis: Relation to withdrawal and side effects. J Rheumatol 24:830-837, 1997.
34. Morgan SL, Baggott JE, Lee JY, Alarcon GS: Folic acid supplementation prevents deficient blood folate levels and hyperhomocysteinemia during longterm, low dose methotrexate therapy for rheumatoid arthritis: Implications for cardiovascular disease prevention. J Rheumatol 25:441-446, 1998.
35. Haagsma CJ, Blom HJ, van Riel PLCM, van't Hof MA, Giesendorf BAJ, van Oppenraaij-Emmerzaal D, van de Putte LBA: Influence of suphasalazine, methotrexate, and the combination of both on plasma homocysteine concentrations in patients with rheumatoid arthritis. Ann Rheum Dis 58:79-84, 1999.
36. Slot O: Changes in plasma homocysteine in arthritis patients starting treatment with low-dose methotrexate subsequently supplemented with folic acid. Scan J Rheumatol 30:305-307, 2001.
37. Ortiz Z, Shea B, Suarez-Almazor ME, Moher D, Wells GA, Tugwell P: The efficacy of folic acid and folinic acid in reducing methotrexate gastrointestinal toxicity in rheumatoid arthritis. A metaanalysis of randomized controlled trials. J Rheumatol 25:36- 43, 1998.
38. Van Ede AE, Laan RFJM, Rood MJ, Huizinga TWJ, van de Laar MAFJ, van Denderen CJ, Westgeest TAA, Romme TC, de Rooij DRAM, Jacobs MJM, de Boo TM, van der Wilt G-J, Severens JL, Hartman M, Krabbe PFM, Dijkmans BAC, Breedveld FC, van de Putte LBA: Effect of folic or folinic acid supplementation on the toxicity and efficacy of methotrexate in rheumatoid arthritis. Arthritis Rheum 44:1515-1524, 2001.
39. Halsted CH: Alcohol and folate interactions: Clinical implications. In Bailey LB (ed): "Folate in Health and Disease." New York: Marcel Dekker, pp 313-327, 1995.
40. Kane GC, Lipsky JJ: Drug-grapefruit juice interactions. Mayo Clin Proc 75:933-942, 2000.
41. Koehler KM, Pareo-Tubbeh SL, Romero LJ, Baumgartner RN, Garry PJ: Folate nutrition and older adults: Challenges and opportunities. J Am Diet Assoc 97:167-173, 1997.
42. Greenblatt DJ, Patki KC, von Moltke LL, Shader RI: Drug interactions with grapefruit juice: An update. J Clin Psychopharmacol 21:357-359, 2001.
43. Boushey CJ, Beresford SAA, Omenn GS, Motulsky AG: A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. JAMA 274:1049-1057, 1995.
44. Danesh J, Lewington S: Plasma homocysteine and coronary heart disease: Systematic review of published epidemiological studies. J Cardiovasc Risk 5:229-232, 1998.
45. Refsum H, Ueland PM, Nygard O, Vollset SE: Homocysteine and cardiovascular disease. Annu Rev Medicine 49:31-62, 1998.
46. Selhub J, Jacques PF, Wilson PWF, Rush D, Rosenberg IH: Vitamin status and intake as primary determinants of homocysteinemia in an elderly population. JAMA 270:2693-2698, 1993.
47. Durand P, Prost M, Loreau N, Lussier-Cacan S, Blache D: Impaired homocysteine metabolism and atherothrombotic disease. Lab Invest 81:645-672, 2001.
48. Homocysteine Lowering Trialists' Collaboration: Lowering blood homocysteine with folic acid based supplements: Meta-analysis of randomised trials. BMJ 316:894-898, 1998.
49. Brouwer IA, van Dusseldorp M, Thomas CMG, Duran M, Hautvast JGAJ, Eskes TKAB, Steegers-Theunissen RPM: Low-dose folic acid supplementation decreases plasma homocysteine concentrations: A randomized trial. Am J Clin Nutr 69:99-104, 1999.
50. Brattstrom L, Wilcken DEL, Ohrvik J, Brudin L: Common methylenetetrahydrofolate reductase gene mutation leads to hyperhomocysteinemia but not to vascular disease. The result of a metaanalysis. Circulation 98:2520-2526, 1998.
51. Gudnason V, Stansbie D, Scott J, Bowron A, Nicaud V, Humphries S: C677T (thermolabile alanine/valine) polymorphism in methylenetetrahydrofolate reductase (MTHFR): Its frequency and impact on plasma homocysteine concentration in different European populations. Atherosclerosis 136:347-354, 1998.
52. Eikelboom JW, Lonn E, Genest J, Hankey G, Yusuf S: Homocyst(e)ine and cardiovascular disease: A critical review of the epidemiologic evidence. Ann Intern Med 131:363-375, 1999.
53. Rampersaud GC, Bailey LB, Kauwell GPA: Folate: Relationship to colorectal and cervical cancer. Review and recommendations for practitioners. J Am Diet Assoc 102:1273-1282, 2002.
54. Choi S-W, Mason JB: Folate and carcinogenesis: An integrated scheme. J Nutr 130:129-132, 2000.
55. Jacob RA, Gretz DM, Taylor PC, James SJ, Pogribny IP, Miller BJ, Henning SM, Swendseid ME: Moderate folate depletion increases plasma homocysteine and decreases lymphocyte DNA methylation in postmenopausal women. J Nutr 128:1204-1212, 1998.
56. Rampersaud GC, Kauwell GPA, Hutson AD, Cerda JJ, Bailey LB: Genomic DNA methylation decreases in response to moderate folate depletion in elderly women. Am J Clin Nutr 72:998-1003, 2000.
57. Giovannucci E, Stampfer MJ, Colditz GA, Rimm EB, Trichopoulos D, Rosner BA, Speizer FE, Willett WC: Folate, methionine, and alcohol intake and risk of colorectal adenoma. J Natl Cancer Inst 85:875-884, 1993.
58. Giovannucci E, Stampfer MJ, Colditz GA, Hunter DJ, Fuchs C, Rosner BA, Speizer FE, Willett WC: Multivitamin use, folate, and colon cancer in women in the Nurses' Health Study. Ann Intern Med 129:517-524, 1998.
59. Su LJ, Arab L: Nutritional status of folate and colon cancer risk: Evidence from NHANES I Epidemiologic Follow-up Study. Ann Epidemiol 11:65-72, 2001.
60. Ma J, Stampfer MJ, Giovannucci E, Artigas C, Hunter DJ, Fuchs C, Willett WC, Selhub J, Hennekens CH, Rozen R: Methylenetetrahydrofolate reductase polymorphism, dietary interactions, and risk of colorectal cancer. Cancer Res 57:1098-1102, 1997.
61. Skibola CF, Smith MT, Kane E, Roman E, Rollinson S, Cartwright RA, Morgan G: Polymorphisms in the methylenetetrahydrofolate reductase gene are associated with susceptibility to acute leukemia in adults. PNAS 96:12810-12815, 1999.
62. Butterworth CE, Hatch KD, Macaluso M, Cole P, Sauberlich HE, Soong S-J, Borst M, Baker VV: Folate deficiency and cervical dysplasia. JAMA 267:528-533, 1992.
63. Kwasniewska A, Tukendorf A, Semczuk M: Folate deficiency and cervical intraepithelial neoplasia. Eur J Gynaec Oncol 18:526-530, 1997.
64. Zhang S, Hunter DJ, Hankinson SE, Giovannucci EL, Rosner BA, Colditz GA, Speizer FE, Willett WC: A prospective study of folate intake and the risk of breast cancer. JAMA 281:1632-1637, 1999.
65. Sellers TA, Kushi LH, Cerhan JR, Vierkant RA, Gapstur SM, Vachon CM, Olson JE, Therneau TM, Folsom AR: Dietary folate intake, alcohol, and risk of breast cancer in a prospective study of postmenopausal women. Epidemiology 12:420-428, 2001.
66. Rohan TE, Jain MG, Howe GR, Miller AB: Dietary folate consumption and breast cancer risk. J Natl Cancer Inst 92:266-269, 2000.
67. Selhub J, Bagley LC, Miller J, Rosenberg IH: B vitamins, homocysteine, and neurocognitive function in the elderly. Am J Clin Nutr 71:614S-620S, 2000.
68. Goodwin JS, Goodwin JM, Garry PJ: Association between nutritional status and cognitive functioning in a healthy elderly population. JAMA 249:2917-2921, 1983.
69. Renvall MJ, Spindler AA, Ramsdell JW, Paskvan M: Nutritional status of free-living Alzheimer's patients. Am J Med Sci 298:20- 27, 1989.
70. Kristensen MO, Gulmann NC, Christensen JEJ, Ostergaard K, Rasmussen K: Serum cobalamin and methylmalonic acid in Alzheimer dementia. Acta Neurol Scand 87:475-481, 1993.
71. Nilsson K, Gustafson L, Faldt R, Andersson A, Brattstrom L, Lindgren A, Israelsson B, Hultberg B: Hyperhomocysteinaemia-a common finding in a psychogeriatric population. Eur J Clin Invest 26:853-859, 1996.
72. Ortega RM, Manas LR, Andres P, Gaspar MJ, Agudo FR, Jimenez A, Pascual T: Functional and psychic deterioration in elderly people may be aggravated by folate deficiency. J Nutr 126:1992-1999, 1996.
73. Riggs KM, Spiro 3rd A, Tucker K, Rush D: Relations of vitamin B-12, vitamin B-6, folate, and homocysteine to cognitive performance in the Normative Aging Study. Am J Clin Nutr 63:306-314, 1996.
74. La Rue A, Koehler KM, Wayne SJ, Chiulli SJ, Haaland KY, Garry PJ: Nutritional status and cognitive functioning in a normally aging sample: A 6-y reassessment. Am J Clin Nutr 65:20-29, 1997.
75. Joosten E, Lesaffre E, Riezler R, Ghekiere V, Dereymaeker L, Pelemans W, Dejaeger E: Is metabolic evidence for vitamin B-12 and folate deficiency more frequent in elderly patients with Alzheimer's disease? J Gerontol A Biol Sci Med Sci 52A:M76-M79, 1997.
76. Clarke R, Smith AD, Jobst KA, Refsum H, Sutton L, Ueland PM: Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease. Arch Neurol 55:1449-1455, 1998.
77. Lindenbaum J, Healton EB, Savage DG, Brust JCM, Garrett TJ, Podell ER, Marcell PD, Stabler SP, Allen RH: Neuropsychiatric disorders caused by cobalamin deficiency in the absence of anemia or macrocytosis. N Engl J Med 318:1720-1728, 1988.
78. Bell IR, Edman JS, Selhub J, Morrow FD, Marby DW, Kayne HL, Cole JO: Plasma homocysteine in vascular disease and in nonvascular dementia of depressed elderly people. Acta Psychiatr Scand 86:386-390, 1992.
79. Snowdon DA, Tully CL, Smith CD, Riley KP, Markesbery WR: Serum folate and the severity of atrophy of the neocortex in Alzheimer disease: Findings from the Nun Study. Am J Clin Nutr 71:993-998, 2000.
80. Seshadri S, Beiser A, Selhub J, Jacques PF, Rosenberg IH, D'Agostino RB, Wilson PWF, Wolf PA: Plasma homocysteine as a risk factor for dementia and alzheimer's disease. N Engl J Med 346:476-483, 2002.
81. Duthie SJ, Whalley LJ, Collins AR, Leaper S, Berger K, Deary IJ: Homocysteine, B vitamin status, and cognitive function in the elderly. Am J Clin Nutr 75:908-913, 2002.
82. Wang H-X, Wahlin A, Basun H, Fastbom J, Winblad B, Fratiglioni L: Vitamin B12 and folate in relation to the development of Alzhiemer's disease. Neurology 56:1188-1194, 2001.
83. Morris MS, Jacques PF, Rosenberg IH, Selhub J: Hyperhomocysteinemia associated with poor recall in the third National Health and Nutrition Examination Survey. Am J Clin Nutr 73:927-933, 2001.
84. Stabler SP, Lindenbaum J, Allen RH: Vitamin B-12 deficiency in the elderly: Current dilemmas. Am J Clin Nutr 66:741-749, 1997.
85. Steinmetz KA, Potter JD: Vegetables, fruit, and cancer prevention: A review. J Am Diet Assoc 96:1027-1039, 1996.
86. World Cancer Research Fund: "Food, Nutrition and the Prevention of Cancer: A global perspective." Washington, DC: American Institute for Cancer Research, 1997.
87. 5-A-Day for Better Health Program. National Cancer Institute, National Institutes of Health, Bethesda, MD. Available online at http://www.5aday.gov Accessed December 3, 2002.
88. US Department of Health and Human Services: "Dietary Guidelines for Americans," 5th ed. Home and Garden Bulletin No. Washington DC: US Department of Health and Human Services, 2000.