Folate status of elderly women following moderate folate depletion responds only to a higher folate intake

Journal of Nutrition

Volumn 130, Issue 6, 2000, Pages 1584-1590

  Kauwell, Gail P A ^e   Lippert, Bettina L ^a,e   Wilsky, Chad E ^e   Herrlinger Garcia, Kelli ^e   Hutson, Alan D ^b,e   Theriaque, Douglas W ^c,e   Rampersaud, Gail C ^e   Cerda, James J ^d,e   Bailey, Lynn B ^e  

^a Blake Medical Center   (United States)

^b University of Florida ^*  (United States)

^c UNIVERSITY OF FLORIDA   (United States)

^d UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^e UNIVERSITY OF FLORIDA   (United States)

Author keywords

Elderly; Folate; Homocysteine; Requirements; Women

Indexed keywords

FOLIC ACID; HOMOCYSTEINE;

AGED; ARTICLE; BIOAVAILABILITY; CLINICAL ARTICLE; CONTROLLED STUDY; DIETARY INTAKE; FEMALE; FOLIC ACID BLOOD LEVEL; FOLIC ACID DEFICIENCY; HUMAN; NUTRITIONAL STATUS; POSTMENOPAUSE;

EID: 0034117080     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/130.6.1584     Document Type: Article

References (35)

1. Boushey, C. J., Beresford, A.A.A., Omenn, G. S. & Motulsky, A. G. (1995) A quantitative assessment of plasma homocysteine as a risk factor for vascular disease: probable benefits of increasing folic acid intakes. J. Am. Med. Assoc. 274: 1049-1057.
2. Brattstrom, L., Hultbert, B. L. & Hardebo, J. E. (1985) Folic acid responsive postmenopausal homocysteinemia. Metabolism 34: 1073-1077.
3. Brouwer, I. A., van Dusseldorp, M., West, C. E., Meyboom, S., Thomas, C.M.G., Duran, M., van het Hot, K. H., Eskes, T.K.A.B., Hautvast, J.G.A.J. & Steegers-Theunissen, R.P.M. (1999) Dietary folate from vegetables and citrus fruit decreases plasma homocysteine concentrations in humans in a dietary controlled trial. J. Nutr. 129: 1135-1139.
4. Caudill, M. A., Cruz, A. C., Gregory, J. F., III, Hutson, A. D. & Bailey, L. B. (1997) Folate status response to controlled folate intake in pregnant women. J. Nutr. 127: 2363-2370.
5. Cox, D. R. & Stuart, A. (1955) Some quick sign tests for trend in location and dispersion. Biometrika 42: 80-95.
6. Cuskelly, G. J., McNulty, H. & Scott, J. M. (1996) Effect of increasing dietary folate on red-cell folate: implications for prevention of neural tube defects. Lancet 347: 657-659.
7. Food and Nutrition Board (1980) Recommended Dietary Allowances, 9th ed. National Academy of Science, Washington, DC.
8. Food and Nutrition Board (1989) Recommended Dietary Allowances, 10th ed. National Academy of Science, Washington, DC.
9. Garry, P. J., Goodwin, J. S., Hunt, W. C., Hooper, E. M. & Leonard, A. G. (1982) Nutritional status in a healthy elderly population: dietary and supplemental intakes. Am. J. Clin. Nutr. 36: 319-331.
10. Gregory, J. F., III. (1997) Bioavailability of folate. Eur. J. Clin. Nutr. 51 (suppl. 1): S54-S59.
11. Herbert, V. (1962) Experimental nutritional folate deficiency in man. Trans. Assoc. Am. Physicians 75: 307-320.
12. Herbert, V. (1963) A palatable diet for producing experimental folate deficiency in man. Am. J. Clin. Nutr. 12: 17-20.
13. Herbert, V. (1987) Making sense of laboratory tests of folate status: folate requirements to sustain normality. Am. J. Hematol. 26: 199-207.
14. Home, D.W. & Patterson, D. (1988) Lactobacillus casei microbiological assay of folic acid derivatives in 96-well microtiter plates. Clin. Chem. 34: 2357-2359.
15. 12, Pantothenic Acid, Biotin, and Choline, pp. 8-1 to 8-59. National Academy Press, Washington, DC.
16. Jacob, R. A., Gretz, D. M., Taylor, P. C., James, S. J., Pogribny, I. P., Miller, B. J., Henning, S. M. & Swendseid, M. E. (1998) Moderate folate depletion increases plasma homocysteine and decreases lymphocyte DNA methylation in postmenopausal women. J. Nutr. 128: 1204-1212.
17. Jacob, R. A., Wu, M.-M., Henning, S. M. & Swendseid, M. E. (1994) Homocysteine increases as folate decreases in plasma of healthy men during short-term dietary folate and methyl group restriction. J. Nutr. 124: 1072-1080.
18. Kang, S.-S., Wong, P.W.K. & Norusis, M. (1987) Homocysteinemia due to folate deficiency. Metabolism 36: 458-462.
19. Koehler, K. M., Pareo-Tubbeh, S. L., Romero, L. J., Baumgartner, R. N. & Garry, P. J. (1997) Folate nutrition and older adults: challenges and opportunities. J. Am. Diet. Assoc. 97: 167-173.
20. Koehler, K. M., Romero, L. J., Stauber, P. M., Pareo-Tubbeh, S. L., Liang, H. C., Baumgartner, R. N., Garry, P. J., Allen, R. H. & Stabler, S. P. (1996) Vitamin supplementation and other variables affecting serum homocysteine and methylmalonic acid concentrations in elderly men and women. J. Am. Coll. Nutr. 15: 364-376.
21. Martin, J. I., Landen, W. O., Soliman, A.-G.M. & Eitenmiller, R. R. (1990) Application of tri-enzyme extraction for total folate determination in foods. J. Assoc. Off. Anal. Chem. 73: 805-808.
22. O'Keefe, C. A., Bailey, L. B., Thomas, E. A., Hofler, S. A., Davis, B. A., Cerda, J. J. & Gregory, J. F., III. (1995) Controlled dietary folate affects folate status in nonpregnant women. J. Nutr. 125: 2717-2725.
23. Pfeiffer, C. M., Rogers, L. M., Bailey, L. B. & Gregory, J. F. (1997) Absorption of folate from fortified cereal-grain products and of supplemental folate consumed with or without food determined by using a dual-label stable-isotope protocol. Am. J. Clin. Nutr. 66: 1388-1397.
24. Popkin, B. M., Haines, P. S. & Patterson, R. E. (1992) Dietary changes in older Americans, 1977-1987. Am. J. Clin. Nutr. 55: 823-830.
25. Rowe, J. W., Andres, R., & Tobin, J. D. (1976) Age-adjusted standards for creatinine clearance. Ann. Intern. Med. 84: 567-569.
26. Sauberlich, H. E., Kretsch, M. J., Skala, J. H., Johnson, H. L. & Taylor, P. C. (1987) Folate requirement and metabolism in nonpregnant women. Am. J. Clin. Nutr. 46: 1016-1028.
27. Selhub, J., Jacques, P. F., Wilson, P.W.F., Rush, D. & Rosenberg, I. H. (1993) Vitamin status and intake as primary determinants of homocysteinemia in an elderly population. J. Am. Med. Assoc. 270: 2693-2698.
28. Shane, B. (1995) Folate chemistry and metabolism. In: Folate In Health and Disease (Bailey, L.B., ed.), vol. 1, pp. 1-22. Marcel Dekker, New York, NY.
29. Subar, A. F., Block, G. & James, L. D. (1989) Folate intake and food sources in the US population. Am. J. Clin. Nutr. 50: 508-516.
30. Suitor, C. W. & Bailey, L. B. (2000) Dietary folate equivalents: interpretation and application. J. Am. Diet. Assoc. 100: 88-94.
31. Tamura, T. (1990) Microbiological assay of folates. In: Folic Acid Metabolism in Health and Disease. Contemporary Issues in Clinical Nutrition(Picciano, M. F., Stokstad, E.L.R. & Gregory, J. F., III, eds.), Wiley-Liss, New York. NY.
32. Tucker, K. L., Selhub, J, Wilson, P.W.F. & Rosenberg, I. H. (1996) Dietary intake pattern relates to plasma folate and homocysteine concentrations in the Framingham heart study. J. Nutr. 126: 3025-3031.
33. Vester, B. & Rasmussen, K. (1991) High performance liquid chromatography method for rapid and accurate determination of homocysteine in plasma and serum. Eur. J. Clin. Chem. Clin. Biochem. 29: 549.
34. Wei, M.-M., Bailey, L. B., Toth, J. P. & Gregory, J. F., III (1996) Bioavailability for humans of deuterium-labeled monoglutamyl and polyglutamyl folates is affected by selected foods. J. Nutr. 126: 3100-3108.
35. Wouters, M.G.A.J., Moorrees, M.Th.E.C., Mooren, M.J.V.D., Blom, H. J., Boers, G.H.J., Schellekens, L. A., Thomas, C.M.G. & Eskes, T.K.A.B. (1995) Plasma homocysteine and menopausal status. Eur. J. Clin. Investig. 25: 801-805.