Low-dose folic acid supplementation decreases plasma homocysteine concentrations: A randomized trial

American Journal of Clinical Nutrition

Volumn 69, Issue 1, 1999, Pages 99-104

  Brouwer, Ingeborg A ^a   Van Dusseldorp, Marijke ^b   Thomas, Chris M G ^b   Duran, Marinus ^b   Hautvast, Joseph G A J ^b   Eskes, Tom K A B ^b   Steegers Theunissen, Régine P M ^b  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b NONE

Author keywords

Cardiovascular disease; Folate; Folic acid; Homocysteine; Humans; Neural tube defects; Supplements; Women

Indexed keywords

FOLIC ACID; HOMOCYSTEINE;

ADULT; ARTICLE; BLOOD LEVEL; CARDIOVASCULAR DISEASE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIET SUPPLEMENTATION; FEMALE; HUMAN; MALE; NEURAL TUBE DEFECT; NORMAL HUMAN; RANDOMIZED CONTROLLED TRIAL;

EID: 0032921011     PISSN: 00029165     EISSN: None     Source Type: Journal    
DOI: 10.1093/ajcn/69.1.99     Document Type: Article

References (34)

1. MRC Vitamin Study Research Group, Prevention of neural tube defects: results of the Medical Research Council Vitamin Study. Lancet 1991;338:131-7.
2. Czeizel AE, Dudás I. Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation. N Engl J Med 1992;327:1832-5.
3. Kirke PN, Daly LE, Elwood JH. A randomized trial of low dose folic acid to prevent neural lube defects. Arch Dis Child 1992;67:1442-6.
4. Laurence KM, James N, Miller MH, Tennant GB, Campbell H. Double-blind randomised controlled trial of folate treatment before conception to prevent recurrence of neural-tube detects. Br Med J 1981;282:1509-11.
5. Smithells RW, Sheppard S, Schorah CJ, et al. Possible prevention of neural tube defects by periconceptional vitamin supplementation. Lancet 1980;1:339-40.
6. Steegers-Theunissen RPM, Boers GHJ, Trijbels JMF, Eskes TKAB. Neural-tube defects and derangement of homocysteine metabolism. N Engl J Med 1991;324:199-200 (letter).
7. Steegers-Theunissen RPM, Boers GHJ, Trijbels JMF, et al. Maternal hyperhomocysteinemia: a risk factor for neural tube defects? Metabolism 1994;43:1475-80.
8. Mills JL, McPartlin JM, Kirke PN, et al. Homocysteine metabolism in pregnancies complicated by neural-tube defects. Lancet 1995;345:149-51.
9. Pancharuniti N, Lewis CA, Sauberlich HE, et al. Plasma homocyst(e)ine, folate, and vitamin B-12 concentrations and risk for early-onset coronary artery disease. Am J Clin Nutr 1994; 59:940-8.
10. Stampfer MJ, Malinow MR, Willett WC, et al. A prospective study of plasma homocyst(e)ine and risk of myocardial infarction in US physicians. JAMA 1992;268:877-81.
11. Clarks R, Daly L, Robinson K, et al. Hyperhomocysteinemia: an independent risk factor for vascular disease. N Engl J Med 1991; 324:1149-55.
12. Selhub J, Jacques PF, Bostom AG, et al. Association between plasma homocysteine concentrations and extracranial carotidartery stenosis. N Engl J Med 1995;332:286-91.
13. Den Heijer M, Koster T, Blom HJ, et al. Hyperhomocysteinemia as a risk factor for deep-vein thrombosis. N Engl J Med 1996; 334:759-62.
14. Falcon CR, Cattaneo M, Panzeri D, Martinelli I, Mannucci PM. High prevalence of hyperhomocyst(e)inemia in patients with juvenile venous thrombosis. Arterioscler Thromb 1994;14:1080-3.
15. Giles WH, Kittner SJ, Anda RF, Croft JB, Casper ML. Serum folate and risk for ischemic stroke. Stroke 1995;26:1166-70.
16. Morrison HI, Schaukel D, Desmeules M, Wigle DT. Serum folate and risk of fatal coronary heart disease. JAMA 1996;275:1893-6.
17. Ubbink JB. The role of vitamins in the pathogenesis and treatment of hyperhomocyst(e)inaemia. J Inherit Metab Dis 1997;20:316-25.
18. Jacob RA, Wu M-M, Henning SM, Swenseid ME. Homocysteine increases as folate decreases in plasma of healthy men during short-term dietary folate and methyl group restriction. J Nutr 1994;124:1072-80.
19. O'Keefe CA, Bailey LB, Thomas EA, et al. Controlled dietary folate affects folate status in nonpregnant women. J Nutr 1995;125:2717-25.
20. Guttormsen AB, Ueland PM, Nesthus I, et al. Determinants and vitamin responsiveness of intermediate hyperhomocysteinemia (> or = 40 micromol/liter). The Hordaland Homocysteine Study. J Clin Invest 1996;98:2174-83.
21. Ward M, McNulty H, McPartlin J, Strain JJ, Weir DG, Scott JM. Plasma homocysteine, a risk factor for cardiovascular disease, is lowered by physiological doses of folic acid. Q J Med 1997; 90:519-24.
22. Den Heijer M, Brouwer IA, Bos GMJ, et al. Vitamin supplementation reduces blood homocysteine levels. A controlled trial in patients with venous thrombosis and healthy volunteers. Arterioscler Thromb Vasc Biol 1998;18:356-61.
23. Araki A, Sako Y. Determination of free and total homocysteine in human plasma by high performance liquid chromatography with fluorescence detection. J Chromatogr 1987;422:43-52.
24. Dierkes J. Vitamin requirements for the reduction of homocysteine in healthy young women. Giessen, Germany: Wissenschaftlichen Fachverlag Dr Fleck. 1995.
25. Ubbink JB, Vermaak WJH, van der Merwe A, Becker PJ, Delport R, Potgieter HC. Vitamin requirements for the treatment of hyperhomocysteinemia in humans. J Nutr 1994;124:1927-33.
26. Stites TE, Bailey LB, Scott KC, Toth JP, Fisher WP, Gregory JF III. Kinetic modeling of folate metabolism through use of chronic administration of deuterium-labeled folic acid in men. Am J Clin Nutr 1997;65:53-60.
27. Zettner A, Boss GR, Seegmiller JE. A long-term study of the absorption of large oral doses of folic acid. Ann Clin Lab Sci 1981;11:516-24.
28. Shane B. Folate chemistry and metabolism. In: Bailey LB, ed. Folate in health and disease. New York: Marcel Dekker, Inc, 1995:1-22.
29. Boushey CJ, Bereford SAA, Omenn GS, Motulsky AG. A quantitative assessment of plasma homocysteine as a risk factor for cardiovascular disease. JAMA 1995;274:1049-57.
30. Kelly P, McPartlin J, Goggins M, Weir DG, Scott JM. Unmetabolized folic acid in serum: acute studies in subjects consuming fortified food and supplements. Am J Clin Nutr 1997;65:1790-5.
31. Savage DG, Lindenbaum J. Folate-cobalamin interactions. In: Bailey LB, ed. Folate in health and disease. New York: Marcel Dekker, Inc. 1995:237-83.
32. Campbell NRC. How safe are folic acid supplements? Arch Intern Med 1996;156:1638-44.
33. Tamura T. Nutrient interaction of folate and zinc. In: Bailey LB, ed. Folate in health and disease. New York: Marcel Dekker, Inc, 1995: 287-312.
34. Wei M-M, Bailey LB, Toth JP, Gregory JF III. Bioavailability for humans of deuterium-labeled monoglutamyl and polyglutamyl folates is affected by selected foods. J Nutr 1997;126:3100-8.