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Volumn 13, Issue 1, 2003, Pages 90-96

Chemotherapy response and resistance

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT;

EID: 0037309193     PISSN: 0959437X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-437X(02)00014-X     Document Type: Review
Times cited : (49)

References (54)
  • 1
    • 0037169358 scopus 로고    scopus 로고
    • Apoptosis: A link between cancer genetics and chemotherapy
    • Johnstone R.W., Ruefli A.A., Lowe S.W. Apoptosis: a link between cancer genetics and chemotherapy. Cell. 108:2002;153-164.
    • (2002) Cell , vol.108 , pp. 153-164
    • Johnstone, R.W.1    Ruefli, A.A.2    Lowe, S.W.3
  • 2
    • 0036531901 scopus 로고    scopus 로고
    • A unified view of the DNA-damage checkpoint
    • Melo J., Toczyski D. A unified view of the DNA-damage checkpoint. Curr. Opin. Cell. Biol. 14:2002;237-245.
    • (2002) Curr. Opin. Cell. Biol. , vol.14 , pp. 237-245
    • Melo, J.1    Toczyski, D.2
  • 3
    • 85047694961 scopus 로고    scopus 로고
    • Bax expression correlates with cellular drug sensitivity to doxorubicin, cyclophosphamide and chlorambucil but not fludarabine, cladribine or corticosteroids in B cell chronic lymphocytic leukemia
    • Bosanquet A.G., Sturm I., Wieder T., Essmann F., Bosanquet M.I., Head D.J., Dorken B., Daniel P.T. Bax expression correlates with cellular drug sensitivity to doxorubicin, cyclophosphamide and chlorambucil but not fludarabine, cladribine or corticosteroids in B cell chronic lymphocytic leukemia. Leukemia. 16:2002;1035-1044.
    • (2002) Leukemia , vol.16 , pp. 1035-1044
    • Bosanquet, A.G.1    Sturm, I.2    Wieder, T.3    Essmann, F.4    Bosanquet, M.I.5    Head, D.J.6    Dorken, B.7    Daniel, P.T.8
  • 4
    • 0029935682 scopus 로고    scopus 로고
    • Involvement of the CD95 (APO-1/FAS) receptor/ligand system in drug-induced apoptosis in leukemia cells
    • Friesen C., Herr I., Krammer P.H., Debatin K.M. Involvement of the CD95 (APO-1/FAS) receptor/ligand system in drug-induced apoptosis in leukemia cells. Nat. Med. 2:1996;574-577.
    • (1996) Nat. Med. , vol.2 , pp. 574-577
    • Friesen, C.1    Herr, I.2    Krammer, P.H.3    Debatin, K.M.4
  • 6
    • 0032508414 scopus 로고    scopus 로고
    • NF-κB antiapoptosis: Induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation
    • Wang C.Y., Mayo M.W., Korneluk R.G., Goeddel D.V., Baldwin A.S. Jr. NF-κB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation. Science. 281:1998;1680-1683.
    • (1998) Science , vol.281 , pp. 1680-1683
    • Wang, C.Y.1    Mayo, M.W.2    Korneluk, R.G.3    Goeddel, D.V.4    Baldwin A.S., Jr.5
  • 7
    • 0036238817 scopus 로고    scopus 로고
    • The Raf/MEK/ERK signal transduction cascade as a target for chemotherapeutic intervention in leukemia
    • Lee J.T. Jr., McCubrey J.A. The Raf/MEK/ERK signal transduction cascade as a target for chemotherapeutic intervention in leukemia. Leukemia. 16:2002;486-507.
    • (2002) Leukemia , vol.16 , pp. 486-507
    • Lee J.T., Jr.1    McCubrey, J.A.2
  • 8
    • 0032485213 scopus 로고    scopus 로고
    • Agents that cause DNA double strand breaks lead to p16INK4a enrichment and the premature senescence of normal fibroblasts
    • Robles S.J., Adami G.R. Agents that cause DNA double strand breaks lead to p16INK4a enrichment and the premature senescence of normal fibroblasts. Oncogene. 16:1998;1113-1123.
    • (1998) Oncogene , vol.16 , pp. 1113-1123
    • Robles, S.J.1    Adami, G.R.2
  • 10
    • 0035219571 scopus 로고    scopus 로고
    • Radiation-induced senescence-like growth arrest requires TP53 function but not telomere shortening
    • Suzuki K., Mori I., Nakayama Y., Miyakoda M., Kodama S., Watanabe M. Radiation-induced senescence-like growth arrest requires TP53 function but not telomere shortening. Radiat. Res. 155:2001;248-253.
    • (2001) Radiat. Res. , vol.155 , pp. 248-253
    • Suzuki, K.1    Mori, I.2    Nakayama, Y.3    Miyakoda, M.4    Kodama, S.5    Watanabe, M.6
  • 12
    • 0037013154 scopus 로고    scopus 로고
    • A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy
    • INK4a control drug-induced senescence, and defects at the INK4a/ARF locus as a byproduct of ARF loss or selection against p53 during tumor development may provide the basis for compromised drug responses
    • INK4a control drug-induced senescence, and defects at the INK4a/ARF locus as a byproduct of ARF loss or selection against p53 during tumor development may provide the basis for compromised drug responses.
    • (2002) Cell , vol.109 , pp. 335-346
    • Schmitt, C.1    Fridman, J.S.2    Yang, M.3    Lee, S.4    Baranov, E.5    Hoffman, R.M.6    Lowe, S.W.7
  • 13
    • 0030944985 scopus 로고    scopus 로고
    • Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
    • Serrano M., Lin A.W., McCurrach M.E., Beach D., Lowe S.W. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell. 88:1997;593-602.
    • (1997) Cell , vol.88 , pp. 593-602
    • Serrano, M.1    Lin, A.W.2    McCurrach, M.E.3    Beach, D.4    Lowe, S.W.5
  • 14
    • 0036237039 scopus 로고    scopus 로고
    • Oncogenic ras and p53 cooperate to induce cellular senescence
    • Introduction of oncogenic Ras cooperates with p53 to induce premature senescence in the presence of ARF. Activation of a temperature-sensitive p53 allele alone or the mere stabilization of p53 via ARF is insufficient to induce senescence, but contributes to the senescent phenotype in concert with qualitative changes mediated by oncogenic Ras
    • Ferbeyre G., de Stanchina E., Querido E., McCurrach M.E., Hannon G., Lowe S.W. Oncogenic ras and p53 cooperate to induce cellular senescence. Mol. Cell. Biol. 22:2002;3497-3508 Introduction of oncogenic Ras cooperates with p53 to induce premature senescence in the presence of ARF. Activation of a temperature-sensitive p53 allele alone or the mere stabilization of p53 via ARF is insufficient to induce senescence, but contributes to the senescent phenotype in concert with qualitative changes mediated by oncogenic Ras.
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 3497-3508
    • Ferbeyre, G.1    De Stanchina, E.2    Querido, E.3    McCurrach, M.E.4    Hannon, G.5    Lowe, S.W.6
  • 16
    • 0033816629 scopus 로고    scopus 로고
    • Uncoupling between phenotypic senescence and cell cycle arrest in aging p21-deficient fibroblasts
    • Dulic V., Beney G.E., Frebourg G., Drullinger L.F., Stein G.H. Uncoupling between phenotypic senescence and cell cycle arrest in aging p21-deficient fibroblasts. Mol. Cell. Biol. 20:2000;6741-6754.
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 6741-6754
    • Dulic, V.1    Beney, G.E.2    Frebourg, G.3    Drullinger, L.F.4    Stein, G.H.5
  • 18
    • 0037013147 scopus 로고    scopus 로고
    • Suppression of Myc-induced apoptosis in beta cells exposes multiple oncogenic properties of Myc and triggers carcinogenic progression
    • L allows rapid Myc-driven tumor formation, thereby supporting the concept of oncogenic action and cellular failsafe reaction
    • L allows rapid Myc-driven tumor formation, thereby supporting the concept of oncogenic action and cellular failsafe reaction.
    • (2002) Cell , vol.109 , pp. 321-334
    • Pelengaris, S.1    Khan, M.2    Evan, G.I.3
  • 19
    • 0030667376 scopus 로고    scopus 로고
    • Requirement for the CD95 receptor-ligand pathway in c-Myc-induced apoptosis
    • Hueber A.O., Zornig M., Lyon D., Suda T., Nagata S., Evan G.I. Requirement for the CD95 receptor-ligand pathway in c-Myc-induced apoptosis. Science. 278:1997;1305-1309.
    • (1997) Science , vol.278 , pp. 1305-1309
    • Hueber, A.O.1    Zornig, M.2    Lyon, D.3    Suda, T.4    Nagata, S.5    Evan, G.I.6
  • 20
    • 0032504784 scopus 로고    scopus 로고
    • P19ARF links the tumor suppressor p53 to Ras
    • Palmero I., Pantoja C., Serrano M. p19ARF links the tumor suppressor p53 to Ras. Nature. 395:1998;125-126.
    • (1998) Nature , vol.395 , pp. 125-126
    • Palmero, I.1    Pantoja, C.2    Serrano, M.3
  • 23
    • 0037076326 scopus 로고    scopus 로고
    • Cyclin D3 activates Caspase 2, connecting cell proliferation with cell death
    • Mendelsohn A.R., Hamer J.D., Wang Z.B., Brent R. Cyclin D3 activates Caspase 2, connecting cell proliferation with cell death. Proc. Natl. Acad. Sci. USA. 99:2002;6871-6876.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 6871-6876
    • Mendelsohn, A.R.1    Hamer, J.D.2    Wang, Z.B.3    Brent, R.4
  • 27
    • 0036653392 scopus 로고    scopus 로고
    • E2F transcriptional repressor complexes are critical downstream targets of p19(ARF)/p53-induced proliferative arrest
    • De-repression, not activation, is the predominant mechanism increasing the expression of E2F target genes. This de-repression also renders mouse embryo fibroblasts resistant to the pro-senescent capabilities of ARF, p53 or oncogenic Ras, which identifies E2F transcriptional repressor complexes as downstream effectors of anti-proliferative ARF/p53 signaling
    • Rowland B.D., Denissov S.G., Douma S., Stunnenberg H.G., Bernards R., Peeper D.S. E2F transcriptional repressor complexes are critical downstream targets of p19(ARF)/p53-induced proliferative arrest. Cancer Cell. 2:2002;55-65 De-repression, not activation, is the predominant mechanism increasing the expression of E2F target genes. This de-repression also renders mouse embryo fibroblasts resistant to the pro-senescent capabilities of ARF, p53 or oncogenic Ras, which identifies E2F transcriptional repressor complexes as downstream effectors of anti-proliferative ARF/p53 signaling.
    • (2002) Cancer Cell , vol.2 , pp. 55-65
    • Rowland, B.D.1    Denissov, S.G.2    Douma, S.3    Stunnenberg, H.G.4    Bernards, R.5    Peeper, D.S.6
  • 28
    • 0035110959 scopus 로고    scopus 로고
    • Dual antitumor effects of 5-fluorouracil on the cell cycle in colorectal carcinoma cells: A novel target mechanism concept for pharmacokinetic modulating chemotherapy
    • Yoshikawa R., Kusunoki M., Yanagi H., Noda M., Furuyama J.I., Yamamura T., Hashimoto-Tamaoki T. Dual antitumor effects of 5-fluorouracil on the cell cycle in colorectal carcinoma cells: a novel target mechanism concept for pharmacokinetic modulating chemotherapy. Cancer Res. 61:2001;1029-1037.
    • (2001) Cancer Res. , vol.61 , pp. 1029-1037
    • Yoshikawa, R.1    Kusunoki, M.2    Yanagi, H.3    Noda, M.4    Furuyama, J.I.5    Yamamura, T.6    Hashimoto-Tamaoki, T.7
  • 29
    • 0033826530 scopus 로고    scopus 로고
    • Genetic analysis of chemoresistance in primary murine lymphomas
    • Schmitt C.A., Rosenthal C.T., Lowe S.W. Genetic analysis of chemoresistance in primary murine lymphomas. Nat. Med. 6:2000;1029-1035.
    • (2000) Nat. Med. , vol.6 , pp. 1029-1035
    • Schmitt, C.A.1    Rosenthal, C.T.2    Lowe, S.W.3
  • 31
    • 0036118319 scopus 로고    scopus 로고
    • Apoptosis and chemoresistance in transgenic cancer models
    • Schmitt C.A., Lowe S.W. Apoptosis and chemoresistance in transgenic cancer models. J. Mol. Med. 80:2002;137-146.
    • (2002) J. Mol. Med. , vol.80 , pp. 137-146
    • Schmitt, C.A.1    Lowe, S.W.2
  • 32
    • 0033569423 scopus 로고    scopus 로고
    • INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53
    • Schmitt C.A., McCurrach M.E., de Stanchina E., Wallace-Brodeur R.R., Lowe S.W. INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53. Genes Dev. 13:1999;2670-2677.
    • (1999) Genes Dev. , vol.13 , pp. 2670-2677
    • Schmitt, C.A.1    McCurrach, M.E.2    De Stanchina, E.3    Wallace-Brodeur, R.R.4    Lowe, S.W.5
  • 33
    • 18244409933 scopus 로고    scopus 로고
    • Diffuse large B-cell lymphoma outcome prediction by gene-expression profiling and supervised machine learning
    • On the basis of a combined microarray technology and a supervised learning approach to investigating primary tumor samples from untreated patients, this study demonstrates that the status of a small number of genes, including genes controlling apoptosis, is sufficient to predict treatment outcome in diffuse large-B-cell lymphoma. This study underlines by genetic means the role of drug-induced apoptosis as a pivotal program not only for acute anti-tumor activity, but also for long-term prognosis in patients
    • Shipp M.A., Ross K.N., Tamayo P., Weng A.P., Kutok J.L., Aguiar R.C., Gaasenbeek M., Angelo M., Reich M., Pinkus G.S.et al. Diffuse large B-cell lymphoma outcome prediction by gene-expression profiling and supervised machine learning. Nat. Med. 8:2002;68-74 On the basis of a combined microarray technology and a supervised learning approach to investigating primary tumor samples from untreated patients, this study demonstrates that the status of a small number of genes, including genes controlling apoptosis, is sufficient to predict treatment outcome in diffuse large-B-cell lymphoma. This study underlines by genetic means the role of drug-induced apoptosis as a pivotal program not only for acute anti-tumor activity, but also for long-term prognosis in patients.
    • (2002) Nat. Med. , vol.8 , pp. 68-74
    • Shipp, M.A.1    Ross, K.N.2    Tamayo, P.3    Weng, A.P.4    Kutok, J.L.5    Aguiar, R.C.6    Gaasenbeek, M.7    Angelo, M.8    Reich, M.9    Pinkus, G.S.10
  • 36
    • 0033606852 scopus 로고    scopus 로고
    • Role of p53 and p21waf1/cip1 in senescence-like terminal proliferation arrest induced in human tumor cells by chemotherapeutic drugs
    • Chang B.D., Xuan Y., Broude E.V., Zhu H., Schott B., Fang J., Roninson I.B. Role of p53 and p21waf1/cip1 in senescence-like terminal proliferation arrest induced in human tumor cells by chemotherapeutic drugs. Oncogene. 18:1999;4808-4818.
    • (1999) Oncogene , vol.18 , pp. 4808-4818
    • Chang, B.D.1    Xuan, Y.2    Broude, E.V.3    Zhu, H.4    Schott, B.5    Fang, J.6    Roninson, I.B.7
  • 37
    • 0037039381 scopus 로고    scopus 로고
    • Molecular determinants of terminal growth arrest induced in tumor cells by a chemotherapeutic agent
    • A gene-expression comparison between the senescent and the proliferating fractions of a drug-treated human colon cancer cell line demonstrates that drug-induced senescence is associated with reduced expression of genes involved in proliferation, and with increased expression of genes encoding intracellular and secreted growth inhibitors, suggesting that paracrine effects might be important in drug-induced senescence
    • Chang B.D., Swift M.E., Shen M., Fang J., Broude E.V., Roninson I.B. Molecular determinants of terminal growth arrest induced in tumor cells by a chemotherapeutic agent. Proc. Natl. Acad. Sci. USA. 99:2002;389-394 A gene-expression comparison between the senescent and the proliferating fractions of a drug-treated human colon cancer cell line demonstrates that drug-induced senescence is associated with reduced expression of genes involved in proliferation, and with increased expression of genes encoding intracellular and secreted growth inhibitors, suggesting that paracrine effects might be important in drug-induced senescence.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 389-394
    • Chang, B.D.1    Swift, M.E.2    Shen, M.3    Fang, J.4    Broude, E.V.5    Roninson, I.B.6
  • 38
    • 0029013310 scopus 로고
    • Absence of p53 allows direct immortalization of hematopoietic cells by the myc and raf oncogenes
    • Metz T., Harris A.W., Adams J.M. Absence of p53 allows direct immortalization of hematopoietic cells by the myc and raf oncogenes. Cell. 82:1995;29-36.
    • (1995) Cell , vol.82 , pp. 29-36
    • Metz, T.1    Harris, A.W.2    Adams, J.M.3
  • 39
    • 0033562997 scopus 로고    scopus 로고
    • Loss of the ARF tumor suppressor reverses premature replicative arrest but not radiation hypersensitivity arising from disabled atm function
    • Kamijo T., van de Kamp E., Chong M.J., Zindy F., Diehl J.A., Sherr C.J., McKinnon P.J. Loss of the ARF tumor suppressor reverses premature replicative arrest but not radiation hypersensitivity arising from disabled atm function. Cancer Res. 59:1999;2464-2469.
    • (1999) Cancer Res. , vol.59 , pp. 2464-2469
    • Kamijo, T.1    Van de Kamp, E.2    Chong, M.J.3    Zindy, F.4    Diehl, J.A.5    Sherr, C.J.6    McKinnon, P.J.7
  • 41
    • 0029134878 scopus 로고
    • Evidence that c-myc mediated apoptosis does not require wild-type p53 during lymphomagenesis
    • Hsu B., Marin M.C., el-Naggar A.K., Stephens L.C., Brisbay S., McDonnell T.J. Evidence that c-myc mediated apoptosis does not require wild-type p53 during lymphomagenesis. Oncogene. 11:1995;175-179.
    • (1995) Oncogene , vol.11 , pp. 175-179
    • Hsu, B.1    Marin, M.C.2    El-Naggar, A.K.3    Stephens, L.C.4    Brisbay, S.5    McDonnell, T.J.6
  • 43
    • 0035942177 scopus 로고    scopus 로고
    • Oncogenic ras activates the ARF-p53 pathway to suppress epithelial cell transformation
    • Lin A.W., Lowe S.W. Oncogenic ras activates the ARF-p53 pathway to suppress epithelial cell transformation. Proc. Natl. Acad. Sci. USA. 98:2001;5025-5030.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 5025-5030
    • Lin, A.W.1    Lowe, S.W.2
  • 44
    • 0025251664 scopus 로고
    • Novel primitive lymphoid tumors induced in transgenic mice by cooperation between myc and bcl-2
    • Strasser A., Harris A.W., Bath M.L., Cory S. Novel primitive lymphoid tumors induced in transgenic mice by cooperation between myc and bcl-2. Nature. 348:1990;331-333.
    • (1990) Nature , vol.348 , pp. 331-333
    • Strasser, A.1    Harris, A.W.2    Bath, M.L.3    Cory, S.4
  • 45
    • 0033569422 scopus 로고    scopus 로고
    • Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis
    • Eischen C.M., Weber J.D., Roussel M.F., Sherr C.J., Cleveland J.L. Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis. Genes Dev. 13:1999;2658-2669.
    • (1999) Genes Dev. , vol.13 , pp. 2658-2669
    • Eischen, C.M.1    Weber, J.D.2    Roussel, M.F.3    Sherr, C.J.4    Cleveland, J.L.5
  • 46
    • 0036527761 scopus 로고    scopus 로고
    • Dissecting p53 tumor suppressor functions in vivo
    • +/- haematopoietic stem cells that are otherwise prone to p53 inactivation can prevent p53 loss, but results in lymphomas that are as aggressive as their p53-deficient counterparts, although the Bcl2-expressing group preserves other important p53 effector functions such as checkpoint control or chromosomal stability
    • +/- haematopoietic stem cells that are otherwise prone to p53 inactivation can prevent p53 loss, but results in lymphomas that are as aggressive as their p53-deficient counterparts, although the Bcl2-expressing group preserves other important p53 effector functions such as checkpoint control or chromosomal stability.
    • (2002) Cancer Cell , vol.1 , pp. 289-298
    • Schmitt, C.A.1    Yang, M.2    Fridman, J.S.3    Baranov, E.4    Hoffman, R.M.5    Lowe, S.W.6
  • 47
    • 0035817687 scopus 로고    scopus 로고
    • Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice
    • INK4a can act as tumor suppressors in mice, although this depends upon the genetic and cell-type context
    • INK4a can act as tumor suppressors in mice, although this depends upon the genetic and cell-type context.
    • (2001) Nature , vol.413 , pp. 83-86
    • Krimpenfort, P.1    Quon, K.C.2    Mooi, W.J.3    Loonstra, A.4    Berns, A.5
  • 48
    • 0035863837 scopus 로고    scopus 로고
    • Hemizygous p16(INK4A) deletion in pediatric acute lymphoblastic leukemia predicts independent risk of relapse
    • Carter T.L., Watt P.M., Kumar R., Burton P.R., Reaman G.H., Sather H.N., Baker D.L., Kees U.R. Hemizygous p16(INK4A) deletion in pediatric acute lymphoblastic leukemia predicts independent risk of relapse. Blood. 97:2001;572-574.
    • (2001) Blood , vol.97 , pp. 572-574
    • Carter, T.L.1    Watt, P.M.2    Kumar, R.3    Burton, P.R.4    Reaman, G.H.5    Sather, H.N.6    Baker, D.L.7    Kees, U.R.8
  • 49
    • 0037019830 scopus 로고    scopus 로고
    • Inactivation of p21WAF1 sensitizes cells to apoptosis via an increase of both p14ARF and p53 levels and an alteration of Bax/Bcl-2 ratio
    • Javelaud D., Besancon F. Inactivation of p21WAF1 sensitizes cells to apoptosis via an increase of both p14ARF and p53 levels and an alteration of Bax/Bcl-2 ratio. J. Biol. Chem. 277:2002;37949-37954.
    • (2002) J. Biol. Chem. , vol.277 , pp. 37949-37954
    • Javelaud, D.1    Besancon, F.2
  • 50
    • 0033601370 scopus 로고    scopus 로고
    • Pharmacological rescue of mutant p53 conformation and function
    • Foster B.A., Coffey H.A., Morin M.J., Rastinejad F. Pharmacological rescue of mutant p53 conformation and function. Science. 286:1999;2507-2510.
    • (1999) Science , vol.286 , pp. 2507-2510
    • Foster, B.A.1    Coffey, H.A.2    Morin, M.J.3    Rastinejad, F.4
  • 53
    • 0036341291 scopus 로고    scopus 로고
    • Smac agonists sensitize for Apo2L/TRAIL- or anticancer drug-induced apoptosis and induce regression of malignant glioma in vivo
    • Fulda S., Wick W., Weller M., Debatin K.M. Smac agonists sensitize for Apo2L/TRAIL- or anticancer drug-induced apoptosis and induce regression of malignant glioma in vivo. Nat. Med. 8:2002;808-815.
    • (2002) Nat. Med. , vol.8 , pp. 808-815
    • Fulda, S.1    Wick, W.2    Weller, M.3    Debatin, K.M.4
  • 54
    • 0037138454 scopus 로고    scopus 로고
    • Pifithrin-alpha, an inhibitor of p53, enhances the genetic instability induced by etoposide (VP16) in human lymphoblastoid cells treated in vitro
    • Bassi L., Carloni M., Fonti E., Palma de la Pena N., Meschini R., Palitti F. Pifithrin-alpha, an inhibitor of p53, enhances the genetic instability induced by etoposide (VP16) in human lymphoblastoid cells treated in vitro. Mutat. Res. 499:2002;163-176.
    • (2002) Mutat. Res. , vol.499 , pp. 163-176
    • Bassi, L.1    Carloni, M.2    Fonti, E.3    Palma de la Pena, N.4    Meschini, R.5    Palitti, F.6


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