Activity and subcellular distribution of cathepsins in primary human monocytes

Journal of Leukocyte Biology

Volumn 73, Issue 2, 2003, Pages 235-242

  Greiner, Andrea ^b   Lautwein, Alfred ^b   Overkleeft, Herman S ^b   Weber, Ekkehard ^b   Driessen, Christoph ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b NONE

Author keywords

Antigen presentation; Endocytic compartments; Endocytic proteases; Human APC; MHC class II

Indexed keywords

CATHEPSIN; CATHEPSIN B; CATHEPSIN H; CATHEPSIN L; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; LYSOSOME; MAJOR HISTOCOMPATIBILITY COMPLEX; MONOCYTE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION;

ANTIGENS, DIFFERENTIATION, B-LYMPHOCYTE; CATHEPSINS; CELL LINE; ENDOCYTOSIS; HEMATOPOIETIC STEM CELLS; HISTOCOMPATIBILITY ANTIGENS CLASS II; HUMANS; MONOCYTES;

FELIS CATUS;

EID: 0037308679     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.0802398     Document Type: Article

References (37)

1. Chapman, H. A., Riese, R. J., Shi, G. P. (1997) Emerging roles for cysteine proteases in human biology. Annu. Rev. Physiol. 59, 63-88.
2. Villadangos, J. A., Ploegh, H. L. (2000) Proteolysis in MHC class II antigen presentation: who's in charge? Immunity 12, 233-239.
3. Punturieri, A., Filippov, S., Allen, E., Caras, I., Murray, R., Reddy, V., Weiss, S. J. (2000) Regulation of elastinolytic cysteine proteinase activity in normal and cathepsin K-deficient human macrophages. J. Exp. Med. 192, 789-799.
4. Reddy, V. Y., Zhang, Q. Y., Weiss, S. J. (1995) Pericellular mobilization of the tissue-destructive cysteine proteinases, cathepsins B, L, and S, by human monocyte-derived macrophages. Proc. Natl. Acad. Sci. USA 92, 3849-3853.
5. Chapman, H. A. (1998) Endosomal proteolysis and MHC class II function. Curr. Opin. Immunol. 10, 93-102.
6. Riese, R. J., Mitchell, R. N., Villadangos, J. A., Shi, G. P., Palmer, J. T., Karp, E. R., De Sanctis, G. T., Ploegh, H. L., Chapman, H. A. (1998) Cathepsin S activity regulates antigen presentation and immunity. J. Clin. Invest. 101, 2351-2363.
7. Driessen, C., Lennon-Dumenil, A. M., Ploegh, H. L. (2001) Individual cathepsins degrade immune complexes internalized by antigen-presenting cells via Fcgamma receptors. Eur. J. Immunol. 31, 1592-1601.
8. Pluger, E. B., Boes, M., Alfonso, C., Schroter, C. J., Kalbacher, H., Ploegh, H. L., Driessen, C. (2002) Specific role for cathepsin S in the generation of antigenic peptides in vivo. Eur. J. Immunol. 32, 467-476.
9. Driessen, C., Bryant, R. A., Lennon-Dumenil, A. M., Villadangos, J. A., Bryant, P. W., Shi, G. P., Chapman, H. A., Ploegh, H. L. (1999) Cathepsin S controls the trafficking and maturation of MHC class II molecules in dendritic cells. J. Cell Biol. 147, 775-790.
10. Pierre, P., Mellman, I. (1998) Developmental regulation of invariant chain proteolysis controls MHC class II trafficking in mouse dendritic cells. Cell 93, 1135-1145.
11. Bakke, O., Dobberstein, B. (1990) MHC class II-associated invariant chain contains a sorting signal for endosomal compartments. Cell 63, 707-716.
12. Villadangos, J. A., Riese, R. J., Peters, C., Chapman, H. A., Ploegh, H. L. (1997) Degradation of mouse invariant chain: roles of cathepsins S and D and the influence of major histocompatibility complex polymorphism. J. Exp. Med. 186, 549-560.
13. Deussing, J., Roth, W., Saftig, P., Peters, C., Ploegh, H. L., Villadangos, J. A. (1998) Cathepsins B and D are dispensable for major histocompatibility complex class II-mediated antigen presentation. Proc. Natl. Acad. Sci. USA 95, 4516-4521.
14. Nakagawa, T., Roth, W., Wong, P., Nelson, A., Farr, A., Deussing, J., Villadangos, J. A., Ploegh, H., Peters, C., Rudensky, A. Y. (1998) Cathepsin L: critical role in Ii degradation and CD4 T cell selection in the thymus. Science 280, 450-453.
15. Riese, R. J., Chapman, H. A. (2000) Cathepsins and compartmentalization in antigen presentation. Curr. Opin. Immunol. 12, 107-113.
16. Hsieh, C. S., deRoos, P., Honey, K., Beers, C., Rudensky, A. Y. (2002) A role for cathepsin L and cathepsin S in peptide generation for MHC class II presentation. J. Immunol. 168, 2618-2625.
17. Claus, V., Jahraus, A., Tjelle, T., Berg, T., Kirschke, H., Faulstich, H., Griffiths, G. (1998) Lysosomal enzyme trafficking between phagosomes, endosomes, and lysosomes in J774 macrophages. Enrichment of cathepsin H in early endosomes. J. Biol. Chem. 273, 9842-9851.
18. Wiederanders, B. (2000) The function of propeptide domains of cysteine proteinases. Adv. Exp. Med. Biol. 477, 261-270.
19. Greenbaum, D., Medzihradszky, K. F., Burlingame, A., Bogyo, M. (2000) Epoxide electrophiles as activity-dependent cysteine protease profiling and discovery tools. Chem. Biol. 7, 569-581.
20. Abrink, M., Gobl, A. E., Huang, R., Nilsson, K., Hellman, L. (1994) Human cell lines U-937, THP-1 and Mono Mac 6 represent relatively immature cells of the monocyte-macrophage cell lineage. Leukemia 8, 1579-1584.
21. Villadangos, J. A., Driessen, C., Shi, G. P., Chapman, H. A., Ploegh, H. L. (2000) Early endosomal maturation of MHC class II molecules independently of cysteine proteases and H-2DM. EMBO J. 19, 882-891.
22. Lennon-Dumenil, A. M., Roberts, R. A., Valentijn, K., Driessen, C., Overkleeft, H. S., Erickson, A., Peters, P. J., Bikoff, E., Ploegh, H. L., Wolf Bryant, P. (2001) The p41 isoform of invariant chain is a chaperone for cathepsin L. EMBO J. 20, 4055-4064.
23. Schroter, C. J., Braun, M., Englert, J., Beck, H., Schmid, H., Kalbacher, H. (1999) A rapid method to separate endosomes from lysosomal contents using differential centrifugation and hypotonic lysis of lysosomes. J. Immunol. Methods 227, 161-168.
24. Shi, G. P., Munger, J. S., Meara, J. P., Rich, D. H., Chapman, H. A. (1992) Molecular cloning and expression of human alveolar macrophage cathepsin S, an elastinolytic cysteine protease. J. Biol. Chem. 267, 7258-7262.
25. Palmer, J. T., Rasnick, D., Klaus, J. L., Bromme, D. (1995) Vinyl sulfones as mechanism-based cysteine protease inhibitors. J. Med. Chem. 38, 3193-3196.
26. Bogyo, M., Verhelst, S., Bellingard-Dubouchaud, V., Toba, S., Greenbaum, D. (2000) Selective targeting of lysosomal cysteine proteases with radiolabeled electrophilic substrate analogs. Chem. Biol. 7, 27-38.
27. Castellino, F., Germain, R. N. (1995) Extensive trafficking of MHC class II-invariant chain complexes in the endocytic pathway and appearance of peptide-loaded class II in multiple compartments. Immunity 2, 73-88.
28. Fiebiger, E., Meraner, P., Weber, E., Fang, I. F., Stingl, G., Ploegh, H., Maurer, D. (2001) Cytokines regulate proteolysis in major histocompatibility complex class II-dependent antigen presentation by dendritic cells. J. Exp. Med. 193, 881-892.
29. Riese, R. J., Shi, G. P., Villadangos, J., Stetson, D., Driessen, C., Lennon-Dumenil, A. M., Chu, C. L., Naumov, Y., Behar, S. M., Ploegh, H., Locksley, R., Champman, H. A. (2001) Regulation of CD1 function and NK1.1(+) T cell selection and maturation by cathepsin S. Immunity 15, 909-919.
30. Davidson, H. W., Watts, C. (1989) Epitope-directed processing of specific antigen by B lymphocytes. J. Cell Biol. 109, 85-92.
31. Turley, S. J., Inaba, K., Garrett, W. S., Ebersold, M., Unternaehrer, J., Steinman, R. M., Mellman, I. (2000) Transport of peptide-MHC class II complexes in developing dendritic cells. Science 288, 522-527.
32. Kleijmeer, M. J., Morkowski, S., Griffith, J. M., Rudensky, A. Y., Geuze, H. J. (1997) Major histocompatibility complex class II compartments in human and mouse B lymphoblasts represent conventional endocytic compartments. J. Cell Biol. 139, 639-649.
33. Kleijmeer, M., Ramm, G., Schuurhuis, D., Griffith, J., Rescigno, M., Ricciardi-Castagnoli, P., Rudensky, A. Y., Ossendorp, F., Melief, C. J., Stoorvogel, W., Geuze, H. J. (2001) Reorganization of multivesicular bodies regulates MHC class II antigen presentation by dendritic cells. J. Cell Biol. 155, 53-63.
34. Lennon-Dumenil, A. M., Bakker, A. H., Maehr, R., Fiebiger, E., Overkleeft, H. S., Rosemblatt, M., Ploegh, H. L., Lagaudriere-Gesbert, C. (2002) Analysis of protease activity in live antigen-presenting cells shows regulation of the phagosomal proteolytic contents during dendritic cell activation. J. Exp. Med. 196, 529-540.
35. Beck, H., Schwarz, G., Schroter, C. J., Deeg, M., Baier, D., Stevanovic, S., Weber, E., Driessen, C., Kalbacher, H. (2001) Cathepsin S and an asparagine-specific endoprotease dominate the proteolytic processing of human myelin basic protein in vitro. Eur. J. Immunol. 31, 3726-3736.
36. Villadangos, J. A., Cardoso, M., Steptoe, R. J., van Berkel, D., Pooley, J., Carbone, F. R., Shortman, K. (2001) MHC class II expression is regulated in dendritic cells independently of invariant chain degradation. Immunity 14, 739-749.
37. Mellman, I., Plutner, H. (1984) Internalization and of macrophage Fc receptors bound to polyvalent immune complexes. J. Cell Biol. 98, 1170-1177.