Specific role for cathepsin S in the generation of antigenic peptides in vivo

European Journal of Immunology

Volumn 32, Issue 2, 2002, Pages 467-476

  Plüger, Esther B E ^a   Boes, Marianne ^a   Alfonso, Christopher ^b   Schröter, Christian J ^c   Kalbacher, Hubert ^c   Ploegh, Hidde L ^a   Driessen, Christoph ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b R W JOHNSON PHARMACEUTICAL RES I   (United States)

^c UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Antigen presentation; Antigen processing; Cathepsin; HEL

Indexed keywords

ANTIGEN; B LYMPHOCYTE RECEPTOR; CATHEPSIN B; CATHEPSIN D; CATHEPSIN L; CATHEPSIN S; CYSTEINE PROTEINASE; EPITOPE; LYSOZYME; MAJOR HISTOCOMPATIBILITY ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; PROTEINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN PRESENTING CELL; ARTICLE; B LYMPHOCYTE; CONTROLLED STUDY; CORRELATION FUNCTION; DOG; EGG; ENZYME SPECIFICITY; HEN; IN VITRO STUDY; IN VIVO STUDY; MASS SPECTROMETRY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PROCESSING; RABBIT; SEQUENCE ANALYSIS; T LYMPHOCYTE; TRANSGENIC MOUSE;

ANIMALS; ANTIGEN PRESENTATION; CATHEPSIN B; CATHEPSINS; CHICKENS; CYSTEINE ENDOPEPTIDASES; EPITOPES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; MURAMIDASE; PEPTIDE FRAGMENTS; PROTEIN BIOSYNTHESIS; PROTEIN PROCESSING, POST-TRANSLATIONAL; RECEPTORS, ANTIGEN, B-CELL;

EID: 0036177422     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(200202)32:2<467::AID-IMMU467>3.0.CO;2-Y     Document Type: Article

References (36)

1. Endosomal proteolysis and MHC class II function
2. Capture and processing of exogenous antigens for presentation on MHC molecules
3. How MHC class II molecules acquire peptide cargo: Biosynthesis and trafficking through the endocytic pathway
4. Processing and reactivity of T cell epitopes containing two cysteine residues from hen egg-white lysozyme (HEL74-90)
5. Distinct antigen MHC class II complexes generated by separate processing pathways
6. Antigen unfolding and disulfide reduction in antigen presenting cells
7. Proteolysis in MHC class II antigen presentation: Who's in charge?
8. Cathepsins and compartmentalization in antigen presentation
9. Impaired invariant chain degradation and antigen presentation and diminished collagen-induced arthritis in cathepsin S null mice
10. Cathepsin L: Critical role in li degradation and CD4 T cell selection in the thymus
11. Cathepsin S required for normal MHC class II peptide loading and germinal center development
12. Cathepsins B and D are dispensable for major histocompatibility complex class II-mediated antigen presentation
13. Individual cathepsins degrade immune complexes internalized by antigen-presenting cells via Fcγ receptors
14. Control of antigen presentation by a single protease cleavage site
15. The disulfide bridges of hen's egg-white lysozyme
16. Reduction of disulfide bonds within lysosomes is a key step in antigen processing
17. Emerging roles for cysteine proteases in human biology
18. Crystal structure of anti-Hen egg white lysozyme antibody (HyHEL-10) Fv-antigen complex. Local structural changes in the protein antigen and water-mediated interactions of Fv-antigen and light chain-heavy chain interfaces
19. Altered immunoglobulin expression and functional silencing of self-ractive B lymphocytes in transgenic mice
20. Structure of an antibody-antigen complex: Crystal structure of the HyHEL-10 Fab-lysozyme complex
21. MHC class II antigen processing in B cells: Accelerated intracellular targeting of antigens
22. An asparaginyl endopeptidase processes a microbial antigen for class II MHC presentation
23. Immunodominance is independent of structural constraints: Each region within hen eggwhite lysozyme is potentially available upon processing of native antigen
24. Presentation of antigens internalized through the B cell receptor requires newly synthesized MHC class II molecules
25. The lysosomal cysteine proteases
26. Early endosomes and a late endocytic compartment generate different peptide-class II MHC complexes via distinct processing mechanisms
27. Early endosomal maturation of MHC class II molecules independently of cysteine proteases and H-2DM
28. Antigen processing and class II MHC peptide-loading compartments in human B-lymphoblastoid cells
29. Large protein fragments as substrates for endocytic antigen capture by MHC class II molecules
30. Vinyl sulfones as mechanism-based cysteine protease inhibitors
31. Preparation of microsomal membranes for cotranslational protein translocation
32. An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone arrow
33. Cathepsin S controls the trafficking and maturation of MHC class II molecules in dendritic cells
34. A convenient protein substrate for the determination of protease specificity: Reduced and S-3-(trimethyladed amino)propylated lysozyme
35. Submit and disulfide structure of monomeric and dimeric forms of detergent-soluble HLA antigens