Analysis of protease activity in live antigen-presenting cells shows regulation of the phagosomal proteolytic contents during dendritic cell activation

Journal of Experimental Medicine

Volumn 196, Issue 4, 2002, Pages 529-539

  Lennon Duménil, Ana Maria ^a   Bakker, Arnold H ^a   Maehr, René ^a   Fiebiger, Edda ^a   Overkleeft, Herman S ^a   Rosemblatt, Mario ^b   Ploegh, Hidde L ^a,c   Lagaudrière Gesbert, Cécile ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF CHILE   (Chile)

^c Building 2 ^*  (United States)

Author keywords

Active site directed probe; Antigen processing; Cathepsin; Phagocytosis; Phagosomal maturation

Indexed keywords

CATHEPSIN; CD11 ANTIGEN; CYSTEINE PROTEINASE; CYTOCHALASIN D; GAMMA INTERFERON; LIPOPOLYSACCHARIDE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; RECOMBINANT GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR;

ANIMAL CELL; ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; ARTICLE; CONTROLLED STUDY; DENDRITIC CELL; ENZYME ACTIVITY; MACROPHAGE; MOUSE; NONHUMAN; PHAGOCYTOSIS; PHAGOSOME; PRIORITY JOURNAL; PROTEIN DEGRADATION; T LYMPHOCYTE ACTIVATION;

ANIMALS; ANTIGEN PRESENTATION; BINDING SITES; CATHEPSIN B; CATHEPSINS; CELL LINE; CELLS, CULTURED; CYSTEINE ENDOPEPTIDASES; CYSTEINE PROTEINASE INHIBITORS; DENDRITIC CELLS; DOWN-REGULATION; LEUCINE; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PHAGOCYTOSIS; PHAGOSOMES;

EID: 0037136285     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20020327     Document Type: Article

References (33)

1. Capture and processing of exogenous antigens for presentation on MHC molecules
2. How MHC class II molecules acquire peptide cargo: Biosynthesis and trafficking through the endocytic pathway
3. Mechanisms of antigen uptake for presentation
4. Proteases involved in MHC class II antigen presentation
5. The role of lysosomal proteinases in MHC class II-mediated antigen processing and presentation
6. A closer look at proteolysis and MHC class II-restricted antigen presentation
7. Endosomal proteolysis and MHC class II function
8. Antigen processing in the endocytic compartment
9. Enzymatic reduction of disulfide bonds in lysosomes: Characterization of a gamma-interferon-inducible lysosomal thiol reductase (GILT)
10. Defective antigen processing in GILTfree mice
11. Antigen processing for amateurs and professionals
12. Phagosomes are fully competent antigen-processing organelles that mediate the formation of peptide:class II MHC complexes
13. Maturation of phagosomes is accompanied by changes in their fusion properties and size-selective acquisition of solute materials from endosomes
14. Different fates of phagocytosed particles after delivery into macrophage lysosomes
15. The phagosome proteome: Insight into phagosome functions
16. The p41 isoform of invariant chain is a chaperone for cathepsin L
17. Selective targeting of lysosomal cysteine proteases with radiolabeled electrophilic substrate analogs
18. Epoxide electrophiles as activity-dependent cysteine protease profiling and discovery tools
19. Individual cathepsins degrade immune complexes internalized by antigen-presenting cells via Fcγ receptors
20. Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor
21. Role for cathepsin F in invariant chain processing and major histocompatibility complex class II peptide loading by macrophages
22. Mechanistic studies on the inactivation of papain by epoxysuccinyl inhibitors
23. Deviant trafficking of I-Ad mutant molecules is reflected in their peptide binding properties
24. Procathepsins L and D are membrane-bound in acidic microsomal vesicles
25. Involvement of the vacuolar H(+)-ATPases in the secretory pathway of HepG2 cells
26. How MHC class II molecules reach the endocytic pathway
27. Invariant chain cleavage and peptide loading in major histocompatibility complex class II vesicles
28. Neutrophils process exogenous bacteria via an alternate class I MHC processing pathway for presentation of peptides to T lymphocytes
29. Developmental regulation of invariant chain proteolysis controls MHC class II trafficking in mouse dendritic cells
30. Lysosomal enzyme trafficking between phagosomes, endosomes, and lysosomes in J774 macrophages. Enrichment of cathepsin H in early endosomes
31. Essential role for cathepsin S in MHC class II-associated invariant chain processing and peptide loading
32. Transient accumulation of new class II MHC molecules in a novel endocytic compartment in B lymphocytes
33. Bm-CPI-2, a cystatin homolog secreted by the filarial parasite Brugia malayi, inhibits class II MHC-restricted antigen processing