Inactivation of the retinoblastoma tumor suppressor induces apoptosis protease-activating factor-1 dependent and independent apoptotic pathways during embryogenesis

Cancer Research

Volumn 61, Issue 23, 2001, Pages 8395-8400

  Guo, Zhong ^a   Yikang, Shi ^a   Zacksenhaus, Eldad ^a   Yoshida, Hiroki ^b   Mak, Tak W ^b  

^a UNIVERSITY HEALTH NETWORK   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOTIC PROTEASE ACTIVATING FACTOR 1; DNA; ENZYME ACTIVATOR; PROTEIN P53; RETINOBLASTOMA PROTEIN; RNA; TRANSCRIPTION FACTOR E2F; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; GENOTYPE; HISTOPATHOLOGY; HYPOPHYSIS TUMOR; IN SITU HYBRIDIZATION; LENS; MOUSE; MUSCLE DEVELOPMENT; NERVOUS SYSTEM DEVELOPMENT; NICK END LABELING; NONHUMAN; PERIPHERAL NERVOUS SYSTEM; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SKELETAL MUSCLE; TUMOR SUPPRESSOR GENE;

ANIMALS; APOPTOSIS; APOPTOTIC PROTEASE-ACTIVATING FACTOR 1; CELL CYCLE PROTEINS; DNA-BINDING PROTEINS; E2F TRANSCRIPTION FACTORS; E2F1 TRANSCRIPTION FACTOR; EMBRYONIC AND FETAL DEVELOPMENT; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE SILENCING; GENES, RETINOBLASTOMA; LENS, CRYSTALLINE; MALE; MICE; MUSCLE, SKELETAL; PITUITARY NEOPLASMS; PREGNANCY; PROTEINS; TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0035576791     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. pRb and E2f-1 in mouse development and tumorigenesis
2. The retinoblastoma protein and the cell cycle
3. Developmental defects and tumor predisposition in Rb mutant mice
4. The retinoblastoma gene family is differentially expressed during embryogenesis
5. The Pezcoller lecture: Cancer cell cycles revisited
6. Cooperative tumorigenic effects of germline mutations in Rb and p53
7. p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens
8. Loss of Rb activates both p53-dependent and independent cell death pathways in the developing mouse nervous system
9. E2F1 and p53 are dispensable whereas p21Waf1/Cip1 cooperates with Rb to restrict endoreduplication and apoptosis during skeletal myogenesis
10. Mutation of E2f-1 suppresses apoptosis and inappropriate S phase entry and extends survival of Rb-deficient mouse embryos
11. E2F1 mediates ectopic proliferation and stage-specific p53-dependent apoptosis but not aberrant differentiation in the ocular lens of Rb deficient fetuses
12. Biochemical pathways of caspase activation during apoptosis
13. Apoptotic pathways: Paper wraps stone blunts scissors
14. Executionary pathway for apoptosis: Lessons from mutant mice
15. Apaf1 is required for mitochondrial pathways of apoptosis and brain development
16. Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development
17. Adult Apaf-1-deficient mice exhibit male infertility
18. pRb controls cell proliferation, differentiation and death of skeletal muscle cells and other lineages during embryogenesis
19. Apaf-1 and caspase-9 in p53-dependent apoptosis and tumor inhibition
20. Inactivation of the apoptosis effector Apaf-1 in malignant melanoma
21. Effects of an Rb mutation in the mouse
22. Dual roles of the retinoblastoma protein in cell cycle regulation and neuron differentiation
23. Retinoblastoma gene promoter directs transgene expression exclusively to the nervous system
24. E2Fs regulate the expression of genes involved in differentiation, development, proliferation, and apoptosis
25. Interdigital cell death can occur through a necrotic and caspase-independent pathway
26. Apoptotic protease activating factor (Apaf-1)-independent cell death suppression by Bcl-2
27. Early loss of the retinoblastoma gene is associated with impaired growth inhibitory innervation during melanotroph carcinogenesis in Rb+/-mice
28. Differential requirement for caspase 9 in apoptotic pathways in vivo
29. Dealing the CARDs between life and death
30. Human nod1 confers responsiveness to bacterial lipopolysaccharides
31. A novel enhancer of the Apaf1 apoptosome involved in cytochrome c-dependent caspase activation and apoptosis
32. Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death
33. E2F-I potentiates cell death by blocking antiapoptotic signaling pathways