MAST/Orbit has a role in microtubule-kinetochore attachment and is essential for chromosome alignment and maintenance of spindle bipolarity

Journal of Cell Biology

Volumn 157, Issue 5, 2002, Pages 749-760

  Maiato, Helder ^a,b   Sampaio, Paula ^a   Lemos, Catarina L ^a   Findlay, John ^c   Carmena, Mar ^b   Earnshaw, William C ^b   Sunkel, Claudio E ^a  

^a UNIVERSITY OF PORTO   (Portugal)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

^c UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Drosophila; Kinetochores; MAST; Microtubules; Spindle

Indexed keywords

CELL PROTEIN; DOUBLE STRANDED RNA; DYNEIN ADENOSINE TRIPHOSPHATASE; MAST PROTEIN; ORBIT PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CELL ADHESION; CELLULAR DISTRIBUTION; CENTROMERE; CHROMOSOMAL PARAMETERS; CHROMOSOME STRUCTURE; CONTROLLED STUDY; DROSOPHILA; EMBRYO; IN VIVO STUDY; METAPHASE; MICROTUBULE; MITOSIS SPINDLE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FAMILY; PROTEIN LOCALIZATION;

ALLELES; ANIMALS; CELL CYCLE PROTEINS; CELLS, CULTURED; CHROMOSOMES; DROSOPHILA; DROSOPHILA PROTEINS; DYNEIN ATPASE; INSECT PROTEINS; KINETOCHORES; MICROSCOPY, ELECTRON; MICROTUBULE-ASSOCIATED PROTEINS; MICROTUBULES; MITOSIS; MITOTIC SPINDLE APPARATUS; MUTATION; PHENOTYPE; RNA, DOUBLE-STRANDED;

ASTER;

EID: 0037182592     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.200201101     Document Type: Article

References (43)

1. Essential roles of Drosophila inner cenrromere protein (INCENP) and aurora B in histone H3 phosphorylation, metaphase chromosome alignment, kinetochore disjunction, and chromosome segregation
2. CLASPs are CLIP-115 and -170 associating proteins involved in the regional regulation of microtubule dynamics in motile fibroblasts
3. CLIP170-like rip1p spatially organizes microtubular dynamics in fission yeast
4. Use of double-stranded RNA interference in Drosophila cell lines to dissect signal transduction pathways
5. Localization of CENP-E in the fibrous corona and outer plate of mammalian kinetochores from prometaphase through anaphase
6. Evidence for a role of CLIP-170 in the establishment of metaphase chromosome alignment
7. Fission yeast ch-TOG/XMAP215 homologue Alp14 connect mitotic spindles with the kinetochore and is a component of the Mad2-dependent spindle checkpoint
8. Drosophila aurora B kinase is required for histone H3 phosphorylation and condensin recruitment during chromosome condensation and to organize the central spindle during cytokinesis
9. NDC10: A gene involved in chromosome segregation in Saccharomyces cerevisiae
10. Techniques for studying mitosis in Drosophila
11. Molecular analysis of kinetochore-microtubule attachment in budding yeast
12. The kinesin-like protein KLP61F is essential for mitosis in Drosophila
13. Heterochromatic deposition of centromeric histone H3-like proteins
14. The Drosophila homeotic target gene centrosomin (cnn) encodes a novel centrosomal protein with leucine zippers and maps to a genomic region required for midgut morphogenesis
15. Genetic analysis of the mitotic spindle
16. Orbit, a novel microtubule-associated protein essential for mitosis in Drosophila melanogaster
17. Probing spindle-assembly mechanisms with monastrol, a small molecule inhibitor of the mitotic kinesin Eg5
18. Dynein is transient kinetochore component whose binding is regulated by microtubule attachment, not tension
19. A class VI unconventional myosin is associated with a homologue of a microtubule-binding protein, cytoplasmic linker protein-170, in neurons and at the posterior pole of Drosophila embryos
20. MAST, a conserved microtubule-associated protein required for bipolar mitotic spindle organization
21. Polyploids require Bik1 for kinetochore-microtubule attachment
22. CENP-E is essential for reliable bioriented spindle attachment, but chromosome alignment can be achieved via redundant mechanisms in mammalian cells
23. The microtubule motor cytoplasmic dynein is required for spindle orientation during germline cell divisions and oocyte differentiation in Drosophila
24. Sites of microtubule assembly and disassembly in the mitotic spindle
25. In vivo localisation of the mitotic POLO kinase shows a highly dynamic association with the mitotic apparatus during early embryogenesis in Drosophila
26. M phase-specific kinetochore proteins in fission yeast. Microtubule-associating Dis1 and Mtc1 display rapid separation and segregation during anaphase
27. Cell division: Mitotic kinases as regulators of cell division and its checkpoints
28. Dis1/TOG universal microtubule adaptors-one MAP for all?
29. STU1, a supressor of a β-tubulin mutation, encodes a novel and essential component of the yeast mitotic spindle
30. CLIP-170 links endocytic vesicles to microtubules
31. Cytoplasmic dynein is localized to kinetochores during mitosis
32. Correlative light and electron microscopy of mitotic cells in monolayer cultures
33. Kinetochores are transported poleward along a single astral microtubule during chromosome attachment to the spindle in newt lung cells
34. Mitotic spindle function in Saccharomyces cerevisiae requires a balance between different types of kinesin-related motors
35. Kinesin-related proteins required for structural integrity of the mitotic spindle
36. Waiting for anaphase: Mad2 and the spindle assembly checkpoint
37. Functional coordination of three mitotic motors in Drosophila embryos
38. Microtubule motors in mitosis
39. Cytoplasmic dynein is required for poleward chromosome movement during mitosis in Drosophila embryos
40. Cloning of a gene encoding an antigene associated with the centrosome in Drosophila
41. The Drosophila l(2)zw10 gene product, required for accurate mitotic chromosome segregation, is redistributed at anaphase onset
42. CENP-E is a plus end-directed kinetochore motor required for metaphase chromosome alignment
43. CENP-E forms a link between attachment of spindle microtubules to kinetochores and the mitotic checkpoint