A mouse kidney cell line with a G:C → C:G transversion mutator phenotype

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 503, Issue 1-2, 2002, Pages 69-76

  Shin, Chi Y ^a,b   Ponomareva, Olga N ^a   Connolly, Lanelle ^a   Turker, Mitchell S ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b OREGON STATE UNIVERSITY   (United States)

Author keywords

DNA mismatch repair; Drug resistance; Mutator phenotype; Transversion mutation

Indexed keywords

CISPLATIN; HYDROGEN PEROXIDE; MISMATCH REPAIR PROTEIN PMS2; MUTAGENIC AGENT; PROTEIN; PROTEIN MLH1; TIOGUANINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL LINE; CONTROLLED STUDY; DRUG CYTOTOXICITY; EPITHELIUM CELL; GENE LOCUS; GENE MUTATION; GENOTOXICITY; IONIZING RADIATION; KIDNEY CELL; KIDNEY EPITHELIUM; MISMATCH REPAIR; MOUSE; NONHUMAN; NUCLEIC ACID BASE SUBSTITUTION; PHENOTYPE; PRIORITY JOURNAL; ULTRAVIOLET RADIATION;

ANIMALS; BASE PAIR MISMATCH; CELL LINE; CISPLATIN; DNA REPAIR; KIDNEY; METHYLNITRONITROSOGUANIDINE; MICE; MICROSATELLITE REPEATS; MUTATION; PHENOTYPE; THIOGUANINE; ULTRAVIOLET RAYS;

EID: 0037134761     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0027-5107(02)00073-8     Document Type: Article

References (37)

1. DNA replication fidelity
2. Mammalian DNA mismatch repair
3. Involvement of DNA methylation in human carcinogenesis
4. Multiple mutations are common at mouse Aprt in genotoxin-exposed mismatch repair deficient cells
5. Elevated mutant frequencies and increased C: G→T: A transitions in Mlh1-/-versus Pms2-/-murine small intestinal epithelial cells
6. Spontaneous mutation, oxidative DNA damage, and the roles of base and nucleotide excision repair in the yeast Saccharomyces cerevisiae
7. Spontaneously immortalized cell lines obtained from adult Atm null mice retain sensitivity to ionizing radiation and exhibit a mutational pattern suggestive of oxidative stress
8. A novel signature mutation for oxidative damage resembles a mutational pattern found commonly in human cancers
9. Tissue-specific deletion and discontinuous loss of heterozygosity are signatures for the mutagenic effects of ionizing radiation in solid tissues
10. Mutations of bacteria from virus sensitivity to virus resistance
11. Spontaneous and ionizing radiation induced mutations involve large events when selecting for loss of an autosomal locus
12. A cell line selected for resistance to ionizing radiation exhibits cross resistance to other genotoxic agents and a mutator phenotype for loss of heterozygosity events
13. A role for certain mouse Aprt sequences in resistance to toxic adenine analogs
14. Molecular evidence for the induction of large interstitial deletions on mouse chromosome 8 by ionizing radiation
15. Spontaneous and ionizing radiation induced mutations involve large events when selecting for loss of an autosomal locus
16. Enhanced UV-induced mutagenesis in the UV61 cell line, the Chinese hamster homologue of Cockayne's syndrome B, is associated with defective transcription coupled repair of cyclobutane pyrimidine dimers
17. Transcription coupled repair and its impact on mutagenesis
18. Escherichia coli MutY protein has a guanine-DNA glycosylase that acts on 7,8-dihydro-8-oxoguanine:Guanine mispair to prevent spontaneous G:C → C:G transversions
19. DNA sequence analysis of spontaneous mutagenesis in Saccharomyces cerevisiae
20. Increased transversions in a novel mutator colon cancer cell line
21. Mitotic recombination produces the majority of recessive fibroblast variants in heterozygous mice
22. Biallelic methylation and silencing of mouse Aprt in normal kidney cells
23. Molecular analysis of APRT deficiency in the mouse P19 teratocarcinoma stem cell line
24. Tissue specificity of spontaneous point mutations in lambda supF transgenic mice
25. Mutagenesis in PMS2- and MSH2-deficient mice indicates differential protection from transversions and frameshifts
26. Loss of heterozygosity and base substition at the APRT locus in mismatch-repair-proficient and -deficient colorectal carcinoma cell lines
27. Mismatch repair deficient human cells: Spontaneous and MNNG-induced mutational spectra in the HPRT gene
28. Specificity of mutations in the PMS2-deficient human tumor cell line HEC-1-A
29. The specificity of UV-induced mutations at an endogenous locus in mammalian cells
30. Involvement of the DNA mismatch repair system in antineoplastic drug resistance
31. Retroviral coexpression of two different types of drug resistance genes to protect normal cells from combination chemotherapy
32. Protective effect of O6-methylguanine-DNA methyltransferase (MGMT) on the cytotoxic and recombinogenic activity of different antineoplastic drugs
33. Toxicity, mutation frequency and mutation spectrum induced by dacarbazine in CHO cells expressing different levels of O(6)-methylguanine-DNA methyltransferase
34. 6-methylguanine-DNA methyltransferase by promoter hypermethylation is associated with G to A mutations in K-ras in colorectal tumorigenesis
35. Promoter hypermethylation of the DNA repair gene O(6)-methylguanine-DNA methyltransferase is associated with the presence of G:C to A:T transition mutations in p53 in human colorectal tumorigenesis
36. Nearest neighbor influences on DNA polymerase insertion fidelity
37. Defective transcription-coupled repair of oxidative base damage in Cockayne syndrome patients from XP group G