Transcription coupled repair and its impact on mutagenesis

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 400, Issue 1-2, 1998, Pages 135-142

  Vrieling, Harry ^a,b   Van Zeeland, Albert A ^a,b   Mullenders, Leon H F ^a,b  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b JA Cohen Institute Interuniversity Research Institute for Radiopathology and Radiation Protection   (Netherlands)

Author keywords

Alkylation damage; Bulky DNA lesion; Global genome repair; Mutagenesis; Transcription coupled repair

Indexed keywords

DNA; DNA POLYMERASE; MUTAGENIC AGENT; PROTEIN P53;

ANIMAL CELL; ARTICLE; CARCINOGENESIS; DNA ADDUCT; DNA DAMAGE; EXCISION REPAIR; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; MOUSE; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; RAT; ULTRAVIOLET RADIATION;

ANIMALS; DNA; DNA MUTATIONAL ANALYSIS; DNA REPAIR; DOSE-RESPONSE RELATIONSHIP, RADIATION; HUMANS; MUTAGENESIS; MUTAGENS; MUTATION; TRANSCRIPTION, GENETIC; TUMOR SUPPRESSOR PROTEIN P53; ULTRAVIOLET RAYS;

EID: 0032565507     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0027-5107(98)00064-5     Document Type: Article

References (57)

1. [1] V.A. Bohr, C.A. Smith, D.S. Okumoto, P.C. Hanawalt, DNA repair in an active gene: removal of pyrimidine dimers from the DHFR gene of CHO cells is much more efficient than in the genome overall, Cell 40 (1985) 359-369.
2. [2] I. Mellon, G. Spivak, P.C. Hanawalt, Selective removal of transcription-blocking DNA damage from the transcribed strand of the mammalian DHFR gene, Cell 51 (1987) 241-249.
3. [3] D. Bootsma, J.H. Hoeijmakers, DNA repair. Engagement with transcription, Nature 363 (1993) 114-115, news; comment.
4. [4] I. Mellon, P.C. Hanawalt, Induction of the Escherichia coli lactose operon selectively increases repair of its transcribed DNA strand, Nature 342 (1989) 95-98.
5. [5] A. van Hoffen, J. Venema, R. Meschini, A.A. van Zeeland, L.H. Mullenders, Transcription-coupled repair removes both cyclobutane pyrimidine dimers and 6-4 photoproducts with equal efficiency and in a sequential way from transcribed DNA in xeroderma pigmentosum group C fibroblasts, EMBO J. 14 (1995) 360-367.
6. [6] C. Petitfrere, P.H. Clingen, C.F. Arlett, M.H.L. Green, Inhibition of RNA and DNA synthesis in UV-irradiated normal human fibroblasts is correlated with pyrimidine (6-4) pyrimidone photoproduct formation, Mutation Res-Fundam. Mol. Mech. Mut. 354 (1996) 87-94.
7. [7] S. Takeda, S. Naruse, R. Yatani, Effects of ultraviolet microbeam irradiation of various sites in HeLa cells on the synthesis of RNA, DNA and protein, Nature (1967) 696-697.
8. [8] B.S. Tung, W.G. McGregor, Y.C. Wang, V.M. Maher, J.J. McCormick, Comparison of the rate of excision of major UV photoproducts in the strands of the human HPRT gene of normal and xeroderma pigmentosum variant cells, Mutation Res. 362 (1996) 65-74.
9. [9] M.F. van Oosterwijk, A. Versteeg, R. Filon, A.A. van Zeeland, L.H.F. Mullenders, The sensitivity of Cockayne's syndrome cells to DNA-damaging agents is not due to defective transcription-coupled repair of active genes, Mol. Cell. Biol. 16 (1996) 4436-4444.
10. [10] W.G. McGregor, M.C. Mah, R.H. Chen, V.M. Maher, J.J. McCormick, Lack of correlation between degree of interference with transcription and rate of strand specific repair in the HPRT gene of diploid human fibroblasts, J. Biol. Chem. 270 (1995) 27222-27227.
11. [11] M.F. van Oosterwijk, R. Filon, A.A. van Zeeland, L.H.F. Mullenders, Lack of transcription-coupled repair of dG-CG-AAF adducts in human fibroblasts contrast the efficient inhibition of transcription, J. Biol. Chem., in press.
12. [12] B.A. Donahue, R.P.P. Fuchs, D. Reines, P.C. Hanawalt, Effects of aminofluorene and acetylaminofluorene DNA adducts on transcriptional elongation by RNA polymerase II, J. Biol. Chem. 271 (1996) 10588-10594.
13. [13] M.F. van Oosterwijk, R. Filon, W.H. Kalle, L.H.F. Mullenders, A.A. van Zeeland, The sensitivity of human fibroblasts to N-acetoxy-2-acetylaminofluorene is determined by the extent of transcription-coupled repair, and/or their capability to counteract RNA synthesis inhibition, Nucleic Acids. Res. 24 (1996) 4653-4659.
14. [14] C. Chalut, V. Moncollin, J.M. Egly, Transcription by RNA polymerase: II. A process linked to DNA repair, Bioassays 16 (1994) 651-655.
15. [15] A.M. Carothers, W. Zhen, J. Mucha, Y.J. Zhang, R.M. Santella, D. Grunberger, V.A. Bohr, DNA strand-specific repair of (±)-3 alpha,4 beta-dihydroxy-1 alpha,2 alpha-epoxy-1,2,3,4-tetrahydrobenzo[c]phenanthrene adducts in the hamster dihydrofolate reductase gene, Proc. Natl. Acad. Sci. U.S.A. 89 (1992) 11925-11929.
16. [16] M.P. Vreeswijk, A. van Hoffen, B.E. Westland, H. Vrieling, A.A. van Zeeland, L.H. Mullenders, Analysis of repair of cyclobutane pyrimidine dimers and pyrimidine 6-4 pyrimidone photoproducts in transcriptionally active and inactive genes in Chinese hamster cells, J. Biol. Chem. 269 (1994) 31858-31863.
17. [17] M.S. Tang, A. Pao, X.S. Zhang, Repair of benzo(a)pyrene diol epoxide-and UV-induced DNA damage in dihydrofolate reductase and adenine phosphoribosyltransferase genes of CHO cells, J. Biol. Chem. 269 (1994) 12749-12754.
18. [18] E.G. Snyderwine, V.A. Bohr, Gene-and strand-specific damage and repair in Chinese hamster ovary cells treated with 4-nitroquinoline 1-oxide, Cancer Res. 52 (1992) 4183-4189.
19. [19] D.A. Scicchitano, P.C. Hanawalt, Repair of N-methylpurines in specific DNA sequences in Chinese hamster ovary cells: absence of strand specificity in the dihydrofolate reductase gene, Proc. Natl. Acad. Sci. U.S.A. 86 (1989) 3050-3054.
20. [20] A. May, R.S. Nairn, D.S. Okumoto, K. Wassermann, T. Stevnsner, J.C. Jones, V.A. Bohr, Repair of individual DNA strands in the hamster dihydrofolate reductase gene after treatment with ultraviolet light, alkylating agents, and cisplatin, J. Biol. Chem. 268 (1993) 1650-1657.
21. [21] W. Wang, A. Sitaram, D.A. Scicchitano, 3-Methyladenine and 7-methylguanine exhibit no preferential removal from the transcribed strand of the dihydrofolate reductase gene in Chinese hamster ovary B11 cells, Biochemistry 34 (1995) 1798-1804.
22. [22] A. Sitaram, G. Plitas, W. Wang, D.A. Scicchitano, Functional nucleotide excision repair is required for the preferential removal of N-ethylpurines from the transcribed strand of the dihydrofolate reductase gene of Chinese hamster ovary cells, Mol. Cell Biol. 17 (1997) 564-570.
23. [23] S.A. Leadon, P.K. Cooper, Preferential repair of ionizing radiation-induced damage in the transcribed strand of an active human gene is defective in Cockayne syndrome, Proc. Natl. Acad. Sci. U.S.A. 90 (1993) 10499-10503.
24. 6-alkylguanines in the nuclear DNA of human lymphocytes and leukaemic cells: analysis at the single-cell level, Br. J. Cancer 69 (1994) 698-705.
25. 6-methylguanine in transcribed genes prevents mutation of H-ras in rat mammary tumorigenesis induced by ethylnitrosourea in place of methylnitrosourea, Proc. Natl. Acad. Sci. U.S.A. 95 (1998) 1635-1640.
26. [26] H. Vrieling, M.L. van Rooijen, N.A. Groen, M.Z. Zdzienicka, J.W. Simons, P.M. Lohman, A.A. van Zeeland, DNA strand specificity for UV-induced mutations in mammalian cells, Mol. Cell Biol. 9 (1989) 1277-1283.
27. [27] P. Menichini, H. Vrieling, A.A. van Zeeland, Strand-specific mutation spectra in repair-proficient and repair-deficient hamster cells, Mutation Res. 251 (1991) 143-155.
28. [28] H. Vrieling, J. Venema, M.L. van Rooyen, A. van Hoffen, P. Menichini, M.Z. Zdzienicka, J.W. Simons, L.H. Mullenders, A.A. van Zeeland, Strand specificity for UV-induced DNA repair and mutations in the Chinese hamster HPRT gene, Nucleic Acids. Res. 19 (1991) 2411-2415.
29. [29] R.H. Chen, V.M. Maher, J. Brouwer, P. van de Putte, J.J. McCormick, Preferential repair and strand-specific repair of benzo[a]pyrene diol epoxide adducts in the HPRT gene of diploid human fibroblasts, Proc. Natl. Acad. Sci. U.S.A. 89 (1992) 5413-5417.
30. [30] R.H. Chen, V.M. Maher, J.J. McCormick, Effect of excision repair by diploid human fibroblasts on the kinds and locations of mutations induced by (±)-7 beta,8 alpha-dihydroxy-9 alpha,10 alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene in the coding region of the HPRT gene, Proc. Natl. Acad. Sci. U.S.A. 87 (1990) 8680-8684.
31. [31] W.G. McGregor, R.H. Chen, L. Lukash, V.M. Maher, J.J. McCormick, Cell cycle-dependent strand bias for UV-induced mutations in the transcribed strand of excision repair-proficient human fibroblasts but not in repair-deficient cells, Mol. Cell Biol. 11 (1991) 1927-1934.
32. [32] R.H. Chen, V.M. Maher, J.J. McCormick, Lack of a cell cycle-dependent strand bias for mutations induced in the HPRT gene by (±)-7 beta,8 alpha-dihydroxy-9 alpha, 10 alpha-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene in excision repair-deficient human cells, Cancer Res. 51 (1991) 2587-2592.
33. [33] E. Sage, B. Lamolet, E. Brulay, E. Moustacchi, A. Chateauneuf, E.A. Drobetsky, Mutagenic specificity of solar UV light in nucleotide excision repair-deficient rodent cells, Proc. Natl. Acad. Sci. U.S.A. 93 (1) (1996) 176-180.
34. [34] B. Andersson, S. Fait, B. Lambert, Strand specificity for mutations induced by (+)-anti BPDE in the hprt gene in human T-lymphocytes, Mutation Res. 269 (1992) 129-140.
35. [35] S.J. Wei, R.L. Chang, N. Bhachech, X.X. Cui, K.A. Merkler, C.Q. Wong, E. Hennig, H. Yagi, D.M. Jerina, A.H. Conney, Dose-dependent differences in the profile of mutations induced by (+)-7R,8S-dihydroxy-9S,10R-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene in the coding region of the hypoxanthine (guanine) phosphoribosyltransferase gene in Chinese hamster V-79 cells, Cancer Res. 53 (1993) 3294-3301.
36. [36] S.J. Wei, R.L. Chang, E. Hennig, X.X. Cui, K.A. Merkler, C.Q. Wong, H. Yagi, D.M. Jerina, A.H. Conney, Mutagenic selectivity at the HPRT locus in V-79 cells: comparison of mutations caused by bay-region benzo[a]pyrene 7,8-diol-9,-10-epoxide enantiomers with high and low carcinogenic activity, Carcinogenesis 15 (1994) 1729-1735.
37. [37] D.J. Zhan, R.H. Heflich, P.P. Fu, Molecular characterization of mutation and comparison of mutation profiles in the hprt gene of Chinese hamster ovary cells treated with benzo[a]pyrene trans-7,8-diol-anti-9,10-epoxide, 1-nitrobenzo[a]pyrene trans-7,8-diol-anti-9,10-epoxide, and 3-nitrobenzo[a]pyrene trans-7,8-diol-anti-9,10-epoxide, Environ. Mol. Mutagen. 27 (1996) 19-29.
38. [38] R.H. Heflich, R.A. Mittelstaedt, M.G. Manjanatha, L.E. Lyncook, A. Aidoo, DNA sequence analysis of hprt mutations in lymphocytes from Sprague-Dawley rots treated with 7,12-dimethylbenz[a]anthracene, Environ. Mol. Mutagen. 28 (1996) 5-12.
39. [39] T.R. Skopek, V.E. Walker, J.E. Cochrane, T.R. Craft, N.F. Cariello, Mutational spectrum at the Hprt locus in splenic T cells of B6C3F1 mice exposed to N-ethyl-N-nitrosourea, Proc. Natl. Acad. Sci. U.S.A. 89 (1992) 7866-7870.
40. [40] J.L. Yang, P.C. Lee, S.R. Lin, J.G. Lin, Comparison of mutation spectra induced by N-ethyl-N-nitrosourea in the hprt gene of Mer+ and Mer-diploid human fibroblasts, Carcinogenesis 15 (1994) 939-945.
41. [41] J.G. Jansen, C.M. van Teijlingen, G.R. Mohn, A.A. van Zeeland, H. Vrieling, AT base pairs are the main target for mutations at the hprt locus of rat skin fibroblasts exposed in vitro to the monofunctional alkylating agent N-ethyl-N-nitrosourea, Mutagenesis 9 (1994) 417-421.
42. 6-alkylguanine in hprt mutagenesis in T-lymphocytes of rats exposed in vivo to ethylmethanesulfonate, N-(2-hydroxyethyl)-N-nitrosourea, or N-ethyl-N-nitrosourea, Cancer Res. 55 (1995) 1875-1882.
43. [43] M.G. Manjanatha, R.K. Newton, R.A. Mittelstaedt, G.R. Villani, K.B. Declos, R.H. Heflich, Molecular analysis of DNA adducts and hprt mutations produced by 6-nitrosochrysene in Chinese hamster ovary cells, Carcinogenesis 14 (1993) 1863-1870.
44. [44] E.E. Li, R.H. Heflich, K.B. Delclos, Trans-1,2-dihydro-1,2-dihydroxy-6-aminochrysene is metabolized to form a major adduct with deoxyguanosine and produces mutations in the hprt gene of Chinese hamster ovary cells at G:C basepairs, Carcinogenesis 14 (1993) 2109-2114.
45. [45] A. Inga, R. Iannone, P. Degan, P. Campomenosi, G. Fronza, A. Abbondandolo, P. Menichini, Analysis of 4-nitroquinoline-1-oxide induced mutations at the hprt locus in mammalian cells: possible involvement of preferential DNA repair, Mutagenesis 9 (1994) 67-72.
46. [46] M. Yadollahi-Farsani, N.J. Gooderham, D.S. Davies, A.R. Boobis, Mutational spectra of the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine(PhIP) at the Chinese hamsters hprt locus, Carcinogenesis 17 (1996) 617-624.
47. [47] P.M. Morgenthaler, D. Holzhauser, Analysis of mutations induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in human lymphoblastoid cells, Carcinogenesis 16 (1995) 713-718.
48. [48] C.C. Chiou, J.L. Yang, Mutagenicity and specific mutation spectrum induced by 8-methoxypsoralen plus a low dose of UVA in the hprt gene in diploid human fibroblasts, Carcinogenesis 16 (1995) 1357-1362.
49. [49] C. Guillouf, A. Laquerbe, E. Moustacchi, D. Papadopoulo, Mutagenic processing of psoralen monoadducts differ in normal and Fanconi anemia cells, Mutagenesis 8 (1993) 355-361.
50. [50] S.C. Yang, J.G. Lin, C.C. Chiou, L.Y. Chen, J.L. Yang, Mutation specificity of 8-methoxypsoralen plus two doses of UVA irradiation in the hprt gene in diploid human fibroblasts, Carcinogenesis 15 (1994) 201-207.
51. [51] D. Papadopoulo, A. Laquerbe, C. Guillouf, E. Moustacchi, Molecular spectrum of mutations induced at the HPRT locus by a crosslinking agent in human cell lines with different repair capacities, Mutation Res. 294 (1993) 167-177.
52. [52] A.J. Nataraj, J.C. TrentII, H.N. Ananthaswamy, p53 gene mutations and photocarcinogenesis, Photochem. Photobiol. 62 (1995) 218-230.
53. [53] N. Dumaz, A. Stary, T. Soussi, L. Daya-Grosjean, A. Sarasin, Can we predict solar ultraviolet radiation as the causal event in human tumours by analysing the mutation spectra of the p53 gene?, Mutat. Res. 307 (1994) 375-386.
54. [54] L. Daya-Grosjean, N. Dumaz, A. Sarasin, The specificity of p53 mutation spectra in sunlight-induced human cancers, J. Photochem. Photobiol. 28 (1995) 115-124.
55. [55] H.J. van Kranen, F.R. de Gruijl, A. de Vries, Y. Sontag, P.W. Wester, H.C. Senden, E. Rozemuller, C.F. van Kreijl, Frequent p53 alterations but low incidence of ras mutations in UV-B-induced skin tumors of hairless mice, Carcinogenesis 16 (1995) 1141-1147.
56. [56] N. Dumaz, H.J. van Kranen, A. de Vries, R.J. Berg, P.W. Wester, C.F. van Kreijl, A. Sarasin, L. Daya-Grosjean, F.R. de Gruijl, The role of UV-B light in skin carcinogenesis through the analysis of p53 mutations in squamous cell carcinomas of hairless mice, Carcinogenesis 18 (1997) 897-904.
57. [57] N. Dumaz, C. Drougard, A. Sarasin, L. Daya-Grosjean, Specific UV-induced mutation spectrum in the p53 gene of skin tumors from DNA-repair-deficient xeroderma pigmentosum patients, Proc. Natl. Acad. Sci. U.S.A. 90 (1993) 10529-10533.