Toxicity, mutation frequency and mutation spectrum induced by dacarbazine in CHO cells expressing different levels of O6-methylguanine-DNA methyltransferase

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 447, Issue 2, 2000, Pages 257-265

  Psaroudi, Maria C ^a   Kyrtopoulos, Soterios A ^a  

^a INSTITUTE OF BIOLOGY   (Greece)

Author keywords

Alkylating agent; Chemotherapy; Cytostatic drug; DNA methylation; Second cancer

Indexed keywords

6 O METHYLGUANINE; DACARBAZINE; DNA; METALLOTHIONEIN; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE;

ANIMAL CELL; ARTICLE; CHO CELL; CONTROLLED STUDY; CYTOTOXICITY; GENE; GENE MUTATION; MUTAGENICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TOXICITY;

AMINO ACID SUBSTITUTION; ANIMALS; CHO CELLS; CRICETINAE; DACARBAZINE; DNA METHYLATION; DNA MUTATIONAL ANALYSIS; ENZYME INDUCTION; GUANINE; HUMANS; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; LIVER EXTRACTS; MALE; METHYLNITROSOUREA; MUTATION; O(6)-METHYLGUANINE-DNA METHYLTRANSFERASE; POINT MUTATION; RATS; RATS, SPRAGUE-DAWLEY;

ANIMALIA;

EID: 0034646126     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0027-5107(99)00220-1     Document Type: Article

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