TrkA mediates developmental sympathetic neuron survival in vivo by silencing an ongoing p75NTR-mediated death signal

Journal of Cell Biology

Volumn 155, Issue 7, 2001, Pages 1275-1285

  Majdan, Marta ^a   Walsh, Gregory S ^a   Aloyz, Raquel ^a   Miller, Freda D ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

Developmental cell death; Neuronal apoptosis; Neurotrophin receptors; Neurotrophins; Trk signaling

Indexed keywords

BETA TUBULIN; NERVE GROWTH FACTOR RECEPTOR; NEUROTROPHIN 3; NEUROTROPHIN RECEPTOR; PROTEIN P75; TYROSINE 3 MONOOXYGENASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL FATE; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; GENE DOSAGE; IN VIVO STUDY; MOUSE; NERVE CELL; NERVE CELL DIFFERENTIATION; NERVE CELL NECROSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RECEPTOR DENSITY; REGULATORY MECHANISM; SIGNAL PROCESSING; SUPERIOR CERVICAL GANGLION; SYMPATHETIC NERVE; WESTERN BLOTTING;

ANIMALS; CELL SURVIVAL; CELLS, CULTURED; MICE; MICE, INBRED BALB C; NEURONS; ONCOGENE PROTEINS; RECEPTOR, NERVE GROWTH FACTOR; RECEPTORS, NERVE GROWTH FACTOR; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 0035945344     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.200110017     Document Type: Article

References (57)

1. Attenuation of a caspase-3 dependent cell death in NT4- and p75NTR-deficient sensory neurons
2. p53 is essential for developmental neuron death as regulated by the TrkA and p75NTR neurotrophin receptors
3. The p75NTR neurotrophin receptor mediates neuronal apoptosis and is essential for naturally occurring sympathetic neuron death
4. NGF and neurotrophin-3 both activate TrkA on sympathetic neurons but differentially regulate survival and neuritogenesis
5. Differential expression of nerve growth factor receptors leads to altered binding affinity and neurotrophin responsiveness
6. Biochemical and functional interactions between the neurotrophin receptors trk and p75NTR
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14. The trk tyrosine protein kinase mediates the mitogenic properties of nerve growth factor and neurotrophin-3
15. p75-deficient trigeminal sensory neurons have an altered response to NGF but not to other neurotrophins
16. TrkB signalling inhibits p75NTR-mediated apoptosis induced by nerve growth factor in embryonic proprioceptive neurons
17. Bax is required for neuronal death after trophic factor deprivation and during development
18. TrkA, but not TrkC, receptors are essential for survival of sympa thetic neurons in vivo
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55. Complete ablation of the neurotrophin receptor p75NTR causes defects both in the nervous and vascular system
56. p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities
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