Requirements for effective inhibition of immunostimulatory CpG motifs by neutralizing motifs

Antisense and Nucleic Acid Drug Development

Volumn 10, Issue 5, 2000, Pages 381-389

  Zhao, H ^a   Cheng, S H ^a   Yew, N S ^a  

^a GENZYME CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL DNA; DINUCLEOTIDE; INTERLEUKIN 12; OLIGODEOXYNUCLEOTIDE DERIVATIVE;

5' UNTRANSLATED REGION; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CPG ISLAND; FEMALE; GENE CLUSTER; GENE INDUCTION; GENE SEQUENCE; IMMUNOCOMPETENT CELL; IMMUNOSTIMULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALIA; BACTERIA (MICROORGANISMS); VERTEBRATA;

EID: 0033762213     PISSN: 10872906     EISSN: None     Source Type: Journal    
DOI: 10.1089/oli.1.2000.10.381     Document Type: Article

References (28)

1. Induction of NK activity in murine and human cells by CpG motifs in oligodeoxynucleotides and bacterial DNA
2. Functions for DNA methylation in vertebrates
3. Bacterial DNA induces NK cells to produce IFN-gamma in vivo and increases the toxicity of lipopolysaccharides
4. DNA vaccines for viral diseases
5. Cationic lipids enhance cytokine and cell influx levels in the lung following administration of plasmid: Cationic lipid complexes
6. Immunoadjuvant action of plasmid DNA in liposomes
7. Bacterial DNA induces murine interferon-gamma production by stimulation of interleukin-12 and tumor necrosis factor-alpha
8. Mechanism and function of a newly identified CpG DNA motif in human primary B cells
9. Delineation of a CpG phosphorothioate oligodeoxynucleotide for activating primate immune responses in vitro and in vivo
10. Why is CpG suppressed in the genomes of virtually all small eukaryotic viruses but not in those of large eukaryotic viruses?
11. CpG motifs as immune adjuvants
12. CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma
13. Sequence motifs in adenoviral DNA block immune activation by stimulatory CpG motifs
14. Mechanisms and therapeutic applications of immune stimulatory CpG DNA
15. CpG motifs in bacterial DNA trigger direct B-cell activation
16. In vivo gene transfer via intravenous administration of cationic lipid-protamine-DNA (LPD) complexes
17. Effect of immune response on gene transfer to the lung via systemic administration of cationic lipidic vectors
18. CpG DNA is a potent enhancer of systemic and mucosal immune responses against hepatitis B surface antigen with intranasal administration to mice
19. Inflammatory responses following direct injection of plasmid DNA into skeletal muscle
20. The influence of base sequence on the immunostimulatory properties of DNA
21. Basis of pulmonary toxicity associated with cationic lipid-mediated gene transfer to the mammalian lung
22. CpG motifs in bacterial DNA cause inflammation in the lower respiratory tract
23. The actions of bacterial DNA on routine macrophages
24. Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activation of murine dendritic cells
25. Macrophages sense pathogens via DNA motifs: Induction of tumor necrosis facor-alpha-mediated shock
26. The inhibitory role of CpG immunostimulatory motifs in cationic lipid vector-mediated transgene expression in vivo
27. Contribution of plasmid DNA to inflammation in the lung after administration of cationic lipid:pDNA complexes
28. Reduced inflammatory response to plasmid DNA vectors by elimination and inhibition of immunostimulatory CpG motifs