Monte Carlo simulations of the peptide recognition at the consensus binding site of the constant fragment of human immunoglobulin G: The energy landscape analysis of a hot spot at the intermolecular interface

Proteins: Structure, Function and Genetics

Volumn 48, Issue 3, 2002, Pages 539-557

  Verkhivker, Gennady M ^a,b   Bouzida, Djamal ^a   Gehlhaar, Daniel K ^a   Rejto, Paul A ^a   Freer, Stephan T ^a   Rose, Peter W ^a  

^a AGOURON PHARMACEUTICALS INC   (United States)

^b PFIZER INC   (United States)

Author keywords

Alanine scanning; Consensus binding site; Energy landscapes; Hot spot; Molecular recognition; Monte Carlo simulations

Indexed keywords

ALANINE; ASPARAGINE; IMMUNOGLOBULIN FC FRAGMENT; IMMUNOGLOBULIN G; SERINE PROTEINASE; TYROSINE;

ARTICLE; BINDING AFFINITY; BINDING SITE; CALCULATION; COMPLEX FORMATION; CRYSTALLOGRAPHY; ENERGY; HYDROPHOBICITY; MOLECULAR RECOGNITION; MOLECULAR STABILITY; MONTE CARLO METHOD; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN INTERACTION; SIMULATION; THERMODYNAMICS;

ALANINE; BINDING SITES; COMPUTER SIMULATION; CONSENSUS SEQUENCE; HUMANS; IMMUNOGLOBULIN CONSTANT REGIONS; IMMUNOGLOBULIN FC FRAGMENTS; IMMUNOGLOBULIN G; MODELS, MOLECULAR; MONTE CARLO METHOD; PEPTIDES; PEPTIDES, CYCLIC; PROTEIN BINDING; PROTEIN CONFORMATION; THERMODYNAMICS;

EID: 0037102958     PISSN: 08873585     EISSN: None     Source Type: Journal    
DOI: 10.1002/prot.10164     Document Type: Article

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