The effect of inhibitor binding on the structural stability and cooperativity of the HIV-1 protease

Proteins: Structure, Function and Genetics

Volumn 36, Issue 2, 1999, Pages 147-156

  Todd, Matthew J ^a   Freire, Ernesto ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

Calorimetry; Cooperative interactions; HIV; Protease

Indexed keywords

N ACETYLPEPSTATIN; PROTEINASE; PROTEINASE INHIBITOR;

ALGORITHM; ARTICLE; BINDING AFFINITY; BINDING SITE; CONFORMATIONAL TRANSITION; DIFFERENTIAL SCANNING CALORIMETRY; DIMERIZATION; DRUG PROTEIN BINDING; ENTHALPY; ENTROPY; ENZYME BINDING; ENZYME DENATURATION; ENZYME INHIBITION; ENZYME STABILITY; ENZYME STRUCTURE; HIGH TEMPERATURE; HUMAN IMMUNODEFICIENCY VIRUS 1; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

ALGORITHMS; BINDING SITES; CALORIMETRY; CALORIMETRY, DIFFERENTIAL SCANNING; COMPUTER SIMULATION; ENZYME STABILITY; HIV PROTEASE; HIV PROTEASE INHIBITORS; HIV-1; HYDROGEN-ION CONCENTRATION; LIGANDS; MODELS, MOLECULAR; PEPSTATINS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DENATURATION; TEMPERATURE; THERMODYNAMICS; TITRIMETRY;

EID: 0033181015     PISSN: 08873585     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0134(19990801)36:2<147::AID-PROT2>3.0.CO;2-3     Document Type: Article

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