The origin recognition complex: From simple origins to complex functions

Genes and Development

Volumn 16, Issue 6, 2002, Pages 659-672

  Bell, Stephen P ^a  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA BINDING; DNA REPLICATION; DNA SEQUENCE; GENE FUNCTION; MOLECULAR RECOGNITION; PRIORITY JOURNAL; PROMOTER REGION; REVIEW;

ADENOSINE TRIPHOSPHATASES; ADENOSINE TRIPHOSPHATE; ANIMALS; BINDING SITES; CELL CYCLE; CHROMATIN; DNA; DNA-BINDING PROTEINS; ESCHERICHIA COLI; MODELS, BIOLOGICAL; MUTATION; ORIGIN RECOGNITION COMPLEX; PHOSPHORYLATION; SACCHAROMYCES CEREVISIAE;

EID: 0037087587     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.969602     Document Type: Review

References (115)

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3. E2F mediates developmental and cell cycle regulation of ORC1 in Drosophila
4. Drosophila ORC specifically binds to ACE3, an origin of DNA replication control element
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6. Eukaryotic replicators and associated protein complexes
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11. Where it all starts: Eukaryotic origins of DNA replication
12. Origin recognition complex binding to a metazoan replication origin
13. Cohesins bind to preferential sites along yeast chromosome III, with differential regulation along arms versus the centric region
14. Replication origins in Xenopus egg extract are 5-15 kilobases apart and are activated in clusters that fire at different times
15. The units of DNA replication in Drosophila melanogaster chromosomes
16. DNA replication control through interaction of E2F-RB and the origin recognition complex
17. Intergenic DNA and the sequence requirements for replication initiation in eukaryotes
18. Replication factors MCM2 and ORC1 interact with the histone acetyltransferase HBO1
19. The BAH (bromo-adjacent homology) domain: A link between DNA methylation, replication, and transcriptional regulation
20. Role for a Xenopus Orc2-related protein in controlling DNA replication
21. Human DNA replication initiation factors, ORC and MCM, associate with oriP of Epstein-Barr virus
22. Assembly of functionally active Drosophila origin recognition complex from recombinant proteins
23. Functional analysis of mutant and wild-type Drosophila origin recognition complex
24. The fission yeast homologue of Orc4p binds to replication origin DNA via multiple AT-hooks
25. Control of elongation by RNA polymerase II
26. Regulation of eukaryotic DNA replication
27. Architecture of the human origin recognition complex
28. Replication from oriP of Epstein-Barr virus requires human ORC and is inhibited by geminin
29. Two steps in the assembly of complexes at yeast replication origins in vivo
30. Separable functions of ORC5 in replication initiation and silencing in Saccharomyces cerevisiae
31. Roles for ORC in M phase and S phase
32. Interaction of Dbf4, the Cdc7 protein kinase regulatory subunit, with yeast replication origins in vivo
33. Evidence suggesting that the ARS elements associated with silencers of the yeast mating-type locus HML do not function as chromosomal DNA replication origins
34. Initiation of DNA replication in eukaryotic cells
35. A role for the replication proteins PCNA, RF-C, polymerase epsilon and Cdc45 in transcriptional silencing in Saccharomyces cerevisiae
36. Opening of the clamp: An intimate view of an ATP-driven biological machine
37. Origin recognition complex (ORC) in transcriptional silencing and DNA replication in S. cerevisiae
38. The origin recognition complex has essential functions in transcriptional silencing and chromosomal replication
39. The origin recognition complex, SIR1, and the S phase requirement for silencing
40. Premature structural changes at replication origins in a yeast minichromosome maintenance (MCM) mutant
41. Making sense of eukaryotic DNA replication origins
42. The ORC1 homolog orp1 in fission yeast plays a key role in regulating onset of S phase
43. Identification of a preinitiation step in DNA replication that is independent of origin recognition complex and cdc6, but dependent on cdk2
44. A role for Cdk2 kinase in negatively regulating DNA replication during S phase of the cell cycle
45. Distinct cytoplasmic and nuclear fractions of Drosophila heterochromatin protein 1: Their phosphorylation levels and associations with origin recognition complex proteins
46. Transition in specification of embryonic metazoan DNA replication origins
47. Histone acetyltransferase HBO1 interacts with the ORC1 subunit of the human initiator protein
48. On the regulation of DNA replication in bacteria
49. DNA replication-independent silencing in S. cerevisiae
50. ATP bound to the origin recognition complex is important for preRC formation
51. Coordinate binding of ATP and origin DNA regulates the ATPase activity of the origin recognition complex
52. Site-specific DNA binding of the Schizosaccharomyces pombe origin recognition complex is determined by the Orc4 subunit
53. The human origin recognition complex protein 1 dissociates from chromatin during S phase in HeLa cells
54. Is the MCM2-7 complex the eukaryotic DNA replication fork helicase?
55. Chromosomal addresses of the cohesin component Mcd1p
56. The k43 gene, required for chorion gene amplification and diploid cell chromosome replication, encodes the Drosophila homolog of yeast origin recognition complex subunit 2
57. Architecture of the yeast origin recognition complex bound to origins of DNA replication
58. Regulation of origin recognition complex conformation and ATPase activity: Differential effects of single-stranded and double-stranded DNA binding
59. The Schizosaccharomyces pombe origin recognition complex interacts with multiple AT-rich regions of the replication origin DNA by means of the AT-hook domains of the spOrc4 protein
60. Mammalian Orc1 protein is selectively released from chromatin and ubiquitinated during the S-to-M transition in the cell division cycle
61. Isolation of ORC6, a component of the yeast origin recognition complex by a one-hybrid system
62. Establishment of transcriptional silencing in the absence of DNA replication
63. Persistent initiation of DNA replication and chromatin-bound MCM proteins during the cell cycle in cdc6 mutants
64. ORC and Cdc6p interact and determine the frequency of initiation of DNA replication in the genome
65. Nucleosomes positioned by ORC facilitate the initiation of DNA replication
66. Structure and function of Cdc6/Cdc18: Implications for origin recognition and checkpoint control
67. Aberrant replication timing induces defective chromosome condensation in Drosophila ORC2 mutants
68. XCDT1 is required for the assembly of pre-replicative complexes in Xenopus laevis
69. The ins and outs of nucleosome assembly
70. Yeast origin recognition complex is involved in DNA replication and transcriptional silencing
71. Role of DNA replication in the repression of silent mating type loci in yeast
72. Cdc6p modulates the structure and DNA binding activity of the origin recognition complex in vitro
73. Identification and reconstitution of the origin recognition complex from Schizosaccharomyces pombe
74. Orp1, a member of the Cdc18/Cdc6 family of S-phase regulators, is homologous to a component of the origin recognition complex
75. Selective instability of Orc1 protein accounts for the absence of functional origin recognition complexes during the M-G(1) transition in mammals
76. The structure and function of yeast ARS elements
77. Cyclin-dependent kinases prevent DNA re-replication through multiple mechanisms
78. The Cdt1 protein is required to license DNA for replication in fission yeast
79. A tale of toroids in DNA metabolism
80. Association of fission yeast Orp1 and Mcm6 proteins with chromosomal replication origins
81. Expression of the HsOrc1 gene, a human ORC1 homolog, is regulated by cell proliferation via the E2F transcription factor
82. Stability, chromatin association, and functional activity of mammalian pre-replication complex proteins during the cell cycle
83. Association of the origin recognition complex with heterochromatin and HP1 in higher eukaryotes
84. A role for the Cdc7 kinase regulatory subunit Dbf4p in the formation of initiation-competent origins of replication
85. Nucleotide-dependent prereplicative complex assembly by Cdc6p, a homolog of eukaryotic and prokaryotic clamp-loaders
86. Orc mutants arrest in metaphase with abnormally condensed chromosomes
87. Latheo encodes a subunit of the origin recognition complex and disrupts neuronal proliferation and adult olfactory memory when mutant
88. Replication dynamics of the yeast genome
89. The origin recognition complex interacts with a bipartite DNA binding site within yeast replicators
90. HMGI/Y proteins: Flexible regulators of transcription and chromatin structure
91. The Xenopus origin recognition complex is essential for DNA replication and MCM binding to chromatin
92. Interaction between the origin recognition complex and the replication licensing system in Xenopus
93. Changes in association of the Xenopus origin recognition complex with chromatin on licensing of replication origins
94. Initiation complex assembly at budding yeast replication origins begins with the recognition of a bipartite sequence by limiting amounts of the initiator, ORC
95. ORC localization in Drosophila follicle cells and the effects of mutations in dE2F and dDP
96. Human CDC6/Cdc 18 associates with Orc1 and cyclin-cdk and is selectively eliminated from the nucleus at the onset of S phase
97. ORC- and Cdc6-dependent complexes at active and inactive chromosomal replication origins in Saccharomyces cerevisiae
98. Specification of regions of DNA replication initiation during embryogenesis in the 65-kilobase DNApolcα-dE2F locus of Drosophila melanogaster
99. Human origin recognition complex binds to the region of the latent origin of DNA replication of Epstein-Barr virus
100. Stepwise assembly of initiation proteins at budding yeast replication origins in vitro
101. Transcriptional silencing: Replication redux
102. Nucleosome positioning can affect the function of a cis-acting DNA element in vivo
103. Sister chromatid cohesion is required for postreplicative double-strand break repair in Saccharomyces cerevisiae
104. Holding your own: Establishing sister chromatid cohesion
105. Loading of an Mcm protein onto DNA replication origins is regulated by Cdc6p and CDKs
106. Association of human origin recognition complex 1 with chromatin DNA and nuclease-resistant nuclear structures
107. Subsets of human origin recognition complex (ORC) subunits are expressed in non-proliferating cells and associate with non-ORC proteins
108. Role of interactions between the origin recognition complex and SIR1 in transcriptional silencing
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110. Assembly of the human origin recognition complex
111. Initiation of eukaryotic DNA replication: Origin unwinding and sequential chromatin association of Cdc45, RPA, and DNA polymerase alpha
112. The Bfa1/Bub2 GAP complex comprises a universal checkpoint required to prevent mitotic exit
113. Pre-meiotic S phase is linked to reductional chromosome segregation and recombination
114. The B2 element of the Saccharomyces cerevisiae ARS1 origin of replication requires specific sequences to facilitate pre-RC formation
115. Genome-wide distribution of ORC and MCM proteins in S. cerevisiae: High-resolution mapping of replication origins