Human origin recognition complex binds to the region of the latent origin of DNA replication of Epstein-Barr virus

EMBO Journal

Volumn 20, Issue 16, 2001, Pages 4588-4602

  Schepers, Aloys ^a   Ritzi, Marion ^a   Bousset, Kristine ^a   Kremmer, Elisabeth ^a   Yates, John L ^b   Harwood, Janet ^c,d   Diffley, John F X ^c   Hammerschmidt, Wolfgang ^a  

^a National Research Center for Environment and Health   (Germany)

^b Roswell Park Cancer ^*  (United States)

^c IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^d GLAXOSMITHKLINE   (United Kingdom)

Author keywords

DNA replication; EBNA1; Epstein Barr virus; ORC; OriP

Indexed keywords

ARTICLE; B LYMPHOCYTE; BINDING SITE; CELL IMMORTALIZATION; CHROMOSOME REPLICATION; DNA REPLICATION; EPSTEIN BARR VIRUS; GENOME; NONHUMAN; PRIORITY JOURNAL; TRANSACTIVATION; VIRUS REPLICATION;

ANIMALS; B-LYMPHOCYTES; BINDING SITES; DNA REPLICATION; DNA, VIRAL; DNA-BINDING PROTEINS; EPSTEIN-BARR VIRUS NUCLEAR ANTIGENS; HERPESVIRUS 4, HUMAN; HUMANS; ORIGIN RECOGNITION COMPLEX; RATS; REPLICATION ORIGIN; VIRUS LATENCY; VIRUS REPLICATION;

HUMAN HERPESVIRUS 4; PROKARYOTA;

EID: 0035881485     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/20.16.4588     Document Type: Article

References (70)

1. Cell cycle modulation of protein - DNA interactions at a human replication origin
2. Start sites of bidirectional DNA synthesis at the human lamin B2 origin
3. Replication of latent Epstein-Barr virus genomes in Raji cells
4. The plasmid replicon of EBV consists of multiple cis-acting elements that facilitate DNA synthesis by the cell and a viral maintenance element
5. Genetic dissection of a mammalian replicator in the human β-globin locus
6. Definition of the sequence requirements for binding of the EBNA-1 protein to its palindromic target sites in Epstein-Barr virus DNA
7. E2F mediates developmental and cell cycle regulation of ORC1 in Drosophila
8. Drosophila ORC specifically binds to ACE3, an origin of DNA replication control element
9. Nucleotide dependent recognition of chromosomal origins of DNA replication by a multi-protein complex
10. Discrete start sites for DNA synthesis in the yeast ARS1 origin
11. Chromosomal ARS1 has a single leading strand start site
12. Where it all starts: Eukaryotic origins of DNA replication
13. Initiation of eukaryotic DNA replication: Conservative or liberal?
14. A first-generation packaging cell line for Epstein-Barr virus-derived vectors
15. Identification and characterization of the human ORC6 homolog
16. Eukaryotic DNA replication
17. Two steps in the assembly of complexes at yeast replication origins in vivo
18. Overproduction, purification and characterization of EBNA1, the origin binding protein of Epstein-Barr virus
19. The Epstein-Barr virus origin of plasmid replication, oriP, contains both the initiation and termination sites of DNA replication
20. Conserved initiator proteins in eukaryotes
21. The scaffold/matrix attachment region binding protein hnRNP-U (SAF-A) is directly bound to chromosomal DNA in vivo: A chemical cross-linking study
22. Organization of DNA replication origins in the fission yeast genome
23. Monoclonal antibodies directed against the Epstein-Barr virus-encoded nuclear antigen 1 (EBNA1): Immunohistologic detection of EBNA1 in the malignant cells of Hodgkin's disease
24. Sequence requirements of the Epstein-Barr virus latent origin of DNA replication
25. Constitutive binding of EBNA1 protein to the Epstein-Barr virus replication origin, oriP, with distortion of DNA structure during latent infection
26. Distinct cytoplasmic and nuclear fractions of Drosophila heterochromatin protein 1: Their phosphorylation levels and associations with origin recognition complex proteins
27. The budding yeast homolog of the human EBNA1-binding protein 2 (Ebp2p) is an essential nucleolar protein required for pre- rRNA processing
28. Histone acetyltransferase HBO1 interacts with the ORC1 subunit of the human initiator protein
29. Reconstitution of Epstein-Barr virus-based plasmid partitioning in budding yeast
30. Regulation of chromosome replication
31. Immortalization of human primary B lymphocytes in vitro with DNA
32. Immortalization of human B lymphocytes by a plasmid containing 71 kilobase pairs of Epstein-Barr virus DNA
33. Epstein-Barr virus-mediated B-cell proliferation is dependent upon latent membrane protein 1, which simulates an activated CD40 receptor
34. Expression of mucin (MUC-1) from a mini-Epstein-Barr virus in immortalized B-cells to generate tumor antigen specific cytotoxic T cells
35. Rep*: A viral element that can partially replace the origin of plasmid DNA synthesis of Epstein-Barr virus
36. The human origin recognition complex protein 1 dissociates from chromatin during S phase in HeLa cells
37. Interaction of Cdc2 and Cdc 18 with a fission yeast ORC2-like protein
38. Architecture of the yeast origin recognition complex bound to origins of DNA replication
39. Initiation of latent DNA replication in the Epstein-Barr virus genome can occur at sites other than the genetically defined origin
40. EBNA1 can link the enhancer element to the initiator element of the Epstein-Barr virus plasmid origin of DNA replication
41. 1 transition in mammals
42. Nucleoprotein complexes and DNA 5′-ends at oriP of Epstein-Barr virus
43. Initiation of DNA replication within oriP is dispensable for stable replication of the latent Epstein-Barr virus chromosome after infection of established cell lines
44. Construction of large DNA segments in Escherichia coli
45. Association of the origin recognition complex with heterochromatin and HP1 in higher eukaryotes
46. Plasmid-like replicative intermediates of the Epstein-Barr virus lytic origin of DNA replication
47. Identification of HsORC4, a member of the human origin of the replication recognition complex
48. Orc51, a new member of the human-origin recognition complex, is deleted in uterine leiomyomas and malignant myeloid diseases
49. The origin recognition complex interacts with a bipartite DNA binding site within yeast replicators
50. Functional conservation of multiple elements in yeast chromosomal replicators
51. Sequence-specific DNA binding of the Epstein-Barr virus nuclear antigen (EBNA-1) to clustered sites in the plasmid maintenance region
52. A putative origin of replication of plasmids derived from Epstein-Barr virus is composed of two cis-acting components
53. Interaction of Xenopus Cdc2·cyclin A1 with the origin recognition complex
54. Initiation complex assembly at budding yeast replication origins begins with the recognition of a bipartite sequence by limiting amounts of the initiator
55. Identification of minimal oriP of Epstein-Barr virus required for DNA replication
56. Requirement of replication licensing for the dyad symmetry element-dependent replication of the Epstein-Barr virus oriP minichromosome
57. EBP2, a human protein that interacts with sequences of the Epstein-Barr virus nuclear antigen 1 important for plasmid maintenance
58. Association of human origin recognition complex 1 with chromatin DNA and nuclease-resistant nuclear structures
59. Subsets of human origin recognition complex (ORC) subunits are expressed in non-proliferating cells and associate with non-ORC proteins
60. Replication origins of mammalian chromosomes: The happy few
61. Role of interactions between the origin recognition complex and SIR1 in transcriptional silencing
62. The ORC4 and ORC5 subunits of the Xenopus and human origin recognition complex are related to ORC1 and Cdc6
63. Assembly of the human origin recognition complex
64. P32/TAP, a cellular protein that interacts with EBNA-1 of Epstein-Barr virus
65. Multiple EBNA1-binding sites are required to form an EBNA1-dependent enhancer and to activate a minimal replicative origin within oriP of Epstein-Barr virus
66. A cis-acting element from the Epstein-Barr viral genome that permits stable replication of recombinant plasmids in latently infected cells
67. Epstein-Barr virus DNA replication
68. Epstein-Barr virus-derived plasmids replicate only once per cell cycle and are not amplified after entry into cells
69. The minimal replicator of Epstein-Barr virus oriP
70. Rapid proliferation of B cells from adenoids in response to Epstein-Barr virus infection