Structural basis of RasGRP binding to high-affinity PKC ligands

Journal of Medicinal Chemistry

Volumn 45, Issue 4, 2002, Pages 853-860

  Rong, Suo Bao ^a   Enyedy, Istvan J ^a   Qiao, Lixin ^a,b   Zhao, Lianyun ^a   Ma, Dawei ^c   Pearce, Larry L ^d   Lorenzo, Patricia S ^d   Stone, James C ^e   Blumberg, Peter M ^d   Wang, Shaomeng ^a   Kozikowski, Alan P ^a  

^a GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

^b NeuroLogic Inc   (United States)

^c SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY   (China)

^d NATIONAL CANCER INSTITUTE   (United States)

^e UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

7 (N OCTYL)INDOLACTAM V; 7 METHOXY 8 (1 DECYNYL)BENZOLACTAM V; 8 (1 DECYNYL)BENZOLACTAM V; DIACYLGLYCEROL; DRUG RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; INDOLACTAM V; LACTAM DERIVATIVE; LEUCINE; LIGAND; PHENYLALANINE; PHORBOID RECEPTOR; PHORBOL 13 ACETATE 12 MYRISTATE; PHORBOL ESTER DERIVATIVE; PROTEIN KINASE C; RAS GUANYL RELEASING PROTEIN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; COMPUTER MODEL; DRUG PROTEIN BINDING; DRUG RECEPTOR BINDING; ENZYME REGULATION; HYDROGEN BOND; LIGAND BINDING; MOLECULAR INTERACTION; MOLECULAR MODEL; MOUSE; NANOTECHNOLOGY; NONHUMAN; PROTEIN FOLDING; PROTEIN STRUCTURE; RAT; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

EID: 0037075082     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm010422z     Document Type: Article

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