Molecular modeling and site-directed mutagenesis studies of a phorbol ester-binding site in protein kinase C

Journal of Medicinal Chemistry

Volumn 39, Issue 13, 1996, Pages 2541-2553

  Wang, Shaomeng ^a   Kazanietz, Marcelo G ^a   Blumberg, Peter M ^a   Marquez, Victor E ^a   Milne, G W A ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PHORBOL ESTER; PROTEIN KINASE C;

ARTICLE; BINDING AFFINITY; COMPETITIVE INHIBITION; DRUG BINDING SITE; ENZYME ACTIVATION; ENZYME BINDING; HYDROGEN BOND; LIGAND BINDING; MOLECULAR MODEL; NONHUMAN; PROTEIN DOMAIN; PROTEIN STRUCTURE; SITE DIRECTED MUTAGENESIS;

AMINO ACID SEQUENCE; BINDING SITES; COMPUTER GRAPHICS; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; DIGLYCERIDES; HYDROGEN BONDING; ISOENZYMES; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; MUTAGENESIS, SITE-DIRECTED; PHORBOL 12,13-DIBUTYRATE; PROTEIN KINASE C;

EID: 0029973374     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm950403n     Document Type: Article

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