Probing the binding of indolactam-V to protein kinase C through site- directed mutagenesis and computational docking simulations

Journal of Medicinal Chemistry

Volumn 42, Issue 18, 1999, Pages 3436-3446

  Wang, Shaomeng ^a   Liu, Ming ^a   Lewin, Nancy E ^b   Lorenzo, Patricia S ^b   Bhattacharrya, Dipak ^b   Qiao, Lixin ^a   Kozikowski, Alan P ^a   Blumberg, Peter M ^b  

^a GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIACYLGLYCEROL; INDOLACTAM V; PROTEIN KINASE C; TELEOCIDIN;

ARTICLE; BINDING AFFINITY; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG STRUCTURE; ENZYME ACTIVITY; SITE DIRECTED MUTAGENESIS;

ANIMALS; BINDING SITES; COMPUTER SIMULATION; DRUG DESIGN; HYDROGEN BONDING; INDOLES; LACTAMS; LYNGBYA TOXINS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MUTAGENESIS, SITE-DIRECTED; PHORBOL ESTERS; PROTEIN BINDING; PROTEIN KINASE C; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0033539133     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm990129n     Document Type: Article

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