Stoichiometric Phosphorylation of Human p53 at Ser315 Stimulates p53-dependent Transcription

Journal of Biological Chemistry

Volumn 276, Issue 7, 2001, Pages 4699-4708

  Blaydes, Jeremy P ^a   Luciani, M Gloria ^a   Pospisilova, Sarka ^a   Ball, Helen Mei Ling ^a   Vojtesek, Borek ^b   Hupp, Ted R ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b MASARYK MEMORIAL CANCER INSTITUTE   (Czech Republic)

Author keywords

[No Author keywords available]

Indexed keywords

ASSAYS; ENZYMES; GENES; MONOCLONAL ANTIBODIES; PHOSPHATES; PROTEINS; STOICHIOMETRY;

IRRADIATED CELLS;

BIOCHEMISTRY;

ALANINE; CYCLIN DEPENDENT KINASE; IMMUNOGLOBULIN G; MONOCLONAL ANTIBODY; PHOSPHATE; PROTEIN KINASE INHIBITOR; PROTEIN P53; ROSCOVITINE; SERINE; TETRAMER; TRANSCRIPTION FACTOR; DNA; ENZYME INHIBITOR; PHOSPHOSERINE; PURINE DERIVATIVE;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; GENE EXPRESSION; GENE MUTATION; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; QUANTITATIVE ANALYSIS; RADIATION INJURY; STEADY STATE; STOICHIOMETRY; ULTRAVIOLET IRRADIATION; CELL CULTURE; GENETICS; IMMUNOLOGY; METABOLISM; PHOSPHORYLATION; POINT MUTATION; TRANSACTIVATION; ULTRAVIOLET RADIATION;

ANTIBODIES, MONOCLONAL; DNA; ENZYME INHIBITORS; HUMANS; PHOSPHORYLATION; PHOSPHOSERINE; POINT MUTATION; PURINES; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53; ULTRAVIOLET RAYS;

EID: 0035895904     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M003485200     Document Type: Article

References (80)

1. Kastan, M. B., Onyekwere, O., Sidransky, D., Vogelstein, B., and Craig, R. W. (1991) Cancer Res. 51, 6304-6311
2. Lu, X., and Lane, D. P. (1993) Cell 75, 765-778
3. Bunz, F., Hwang, P. M., Torrance, C., Waldman, T., Zhang, Y., Dillehay, L., Williams, J., Lengauer, C., Kinzler, K. W., and Vogelstein, B. (1999) J. Clin. Invest. 104, 263-269
4. Linke, S. P., Clarkin, K. C., Di Leonardo, A., Tsou, A., and Wahl, G. M. (1996) Genes Dev. 10, 934-947
5. Nitta, M., Okamura, H., Aizawa, S., and Yamaizumi, M. (1997) Oncogene 15, 561-568
6. Graeber, T. G., Osmanian, C., Jacks, T., Housman, D. E., Koch, C. J., Lowe, S. W., and Giaccia, A. J. (1996) Nature 379, 88-91
7. Williams, A. C., Collard, T. J., and Paraskeva, C. (1999) Oncogene 18, 3199-3204
8. el-Deiry, W. S., Kern, S. E., Pietenpol, J. A., Kinzler, K. W., and Vogelstein, B. (1992) Nat. Genet. 1, 45-49
9. Pietenpol, J. A., Tokino, T., Thiagalingam, S., el-Deiry, W. S., Kinzler, K. W., and Vogelstein, B. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 1998-2002
10. Avantaggiati, M. L., Ogryzko, V., Gardner, K., Giordano, A., Levine, A. S., and Kelly, K. (1997) Cell 89, 1175-1184
11. Lee, C. W., Sorensen, T. S., Shikama, N., and La Thangue, N. B. (1998) Oncogene 16, 2695-2710
12. Cho, Y., Gorina, S., Jeffrey, P. D., and Pavletich, N. P. (1994) Science 265, 346-355
13. Clore, G. M., Ernst, J., Clubb, R., Omichinski, J. G., Kennedy, W. M., Sakaguchi, K., Appella, E., and Gronenborn, A. M. (1995) Nat. Struct. Biol. 2, 321-333
14. Hupp, T. R., Sparks, A., and Lane, D. P. (1995) Cell 83, 237-245
15. Gu, W., and Roeder, R. G. (1997) Cell 90, 595-606
16. Sakaguchi, K., Herrera, J. E., Saito, S., Miki, T., Bustin, M., Vassilev, A., Anderson, C. W., and Appella, E. (1998) Genes Dev. 12, 2831-2841
17. Gostissa, M., Hengstermann, A., Fogal, V., Sandy, P., Schwarz, S. E., Scheffner, M., and Del Sal, G. (1999) EMBO J. 18, 6462-6471
18. Rodriguez, M. S., Desterro, J. M., Lain, S., Midgley, C. A., Lane, D. P., and Hay, R. T. (1999) EMBO J. 18, 6455-6461
19. Liu, L., Scolnick, D. M., Trievel, R. C., Zhang, H. B., Marmorstein, R., Halazonetis, T. D., and Berger, S. L. (1999) Mol. Cell. Biol. 19, 1202-1209
20. Venkatachalam, S., Shi, Y. P., Jones, S. N., Vogel, H., Bradley, A., Pinkel, D., and Donehower, L. A. (1998) EMBO J. 17, 4657-4667
21. Tyner, S. D., Choi, J., Laucirica, R., Ford, R. J., and Donehower, L. A. (1999) Mol. Carcinog. 24, 197-208
22. Hupp, T. R., Lane, D. P., and Ball, K. L. (2000) Biochem. J., 352, 1-17
23. Lambert, P. F., Kashanchi, F., Radonovich, M. F., Shiekhattar, R., and Brady, J. N. (1998) J. Biol. Chem. 273, 33048-33053
24. Dumaz, N., and Meek, D. W. (1999) EMBO J. 18, 7002-7010
25. Fiscella, M., Ullrich, S. J., Zambrano, N., Shields, M. T., Lin, D., Lees-Miller, S. P., Anderson, C. W., Mercer, W. E., and Appella, E. (1993) Oncogene 8, 1519-1528
26. Unger, T., Sionov, R. V., Moallem, E., Yee, C. L., Howley, P. M., Oren, M., and Haupt, Y. (1999) Oncogene 18, 3205-3212
27. Webley, K., Bond, J. A., Jones, C. J., Blaydes, J. P., Craig, A., Hupp, T., and Wynford-Thomas, D. (2000) Mol. Cell. Biol. 20, 2803-2808
28. Banin, S., Moyal, L., Shieh, S., Taya, Y., Anderson, C. W., Chessa, L., Smorodinsky, N. I., Prives, C., Reiss, Y., Shiloh, Y., and Ziv, Y. (1998) Science 281, 1674-1677
29. Tibbetts, R. S., Brumbaugh, K. M., Williams, J. M., Sarkaria, J. N., Cliby, W. A., Shieh, S. Y., Taya, Y., Prives, C., and Abraham, R. T. (1999) Genes Dev. 13, 152-157
30. Lakin, N. D., Hann, B. C., and Jackson, S. P. (1999) Oncogene 18, 3989-3995
31. Craig, A. L., Burch, L., Vojtesek, B., Mikutowska, J., Thompson, A., and Hupp, T. R. (1999) Biochem. J. 342, 133-141
32. Unger, T., Juven-Gershon, T., Moallem, E., Berger, M., Vogt Sionov, R., Lozano, G., Oren, M., and Haupt, Y. (1999) EMBO J. 18, 1805-1814
33. Sakaguchi, K., Saito, S., Higashimoto, Y., Roy, S., Anderson, C. W., and Appella, E. (2000) J. Biol. Chem. 275, 9278-9283
34. Li, L., Ljungman, M., and Dixon, J. E. (2000) J. Biol. Chem. 275, 2410-2414
35. Bond, J. A., Webley, K., Wyllie, F. S., Jones, C. J., Craig, A., Hupp, T., and Wynford-Thomas, D. (1999) Oncogene 18, 3788-3792
36. Craig, A. L., Blaydes, J. P., Burch, L. R., Thompson, A. M., and Hupp, T. R. (1999) Oncogene 18, 6305-6312
37. Tang, H. Y., Zhao, K., Pizzolato, J. F., Fonarev, M., Langer, J. C., and Manfredi, J. J. (1998) J. Biol. Chem. 273, 29156-29163
38. Lane, D. P. (1999) Br. J. Cancer 80, (Suppl. 1) 1-5
39. Hirao, A., Kong, Y. Y., Matsuoka, S., Wakeham, A., Ruland, J., Yoshida, H., Liu, D., Elledge, S. J., and Mak, T. W. (2000) Science 287, 1824-1827
40. Shieh, S. Y., Ahn, J., Tamai, K., Taya, Y., and Prives, C. (2000) Genes Dev. 14, 289-300
41. Chehab, N. H., Malikzay, A., Appel, M., and Halazonetis, T. D. (2000) Genes Dev. 14, 278-288
42. Blaydes, J. P., Craig, A. L., Wallace, M., Ball, M. L., Traynor, N., Gibbs, N., and Hupp, T. R. (2000) Oncogene 19, 3829-3839
43. Blaydes, J. P., and Hupp, T. R. (1998) Oncogene 17, 1045-1052
44. Cuddihy, A. R., Wong, A. H., Tam, N. W., Li, S., and Koromilas, A. E. (1999) Oncogene 18, 2690-2702
45. Cuddihy, A. R., Li, S., Tam, N. W., Wong, A. H., Taya, Y., Abraham, N., Bell, J. C., and Koromilas, A. E. (1999) Mol. Cell. Biol. 19, 2475-2484
46. Abarzua, P., LoSardo, J. E., Gubler, M. L., and Neri, A. (1995) Cancer Res. 55, 3490-3494
47. Abarzua, P., LoSardo, J. E., Gubler, M. L., Spathis, R., Lu, Y. A., Felix, A., and Neri, A. (1996) Oncogene 13, 2477-2482
48. Caron de Fromentel, C., Gruel, N., Venot, C., Debussche, L., Conseiller, E., Dureuil, C., Teillaud, J. L., Tocque, B., and Bracco, L. (1999) Oncogene 18, 551-557
49. Bischoff, J. R., Friedman, P. N., Marshak, D. R., Prives, C., and Beach, D. (1990) Proc. Natl. Acad. Sci. U. S. A. 87, 4766-4770
50. Wang, Y., and Prives, C. (1995) Nature 376, 88-91
51. Fuchs, B., Hecker, D., and Scheidtmann, K. H. (1995) Eur. J. Biochem. 228, 625-639
52. Hansen, S., Midgley, C. A., Lane, D. P., Freeman, B. C., Morimoto, R. I., and Hupp, T. R. (1996) J. Biol. Chem. 271, 30922-30928
53. Hecker, D., Page, G., Lohrum, M., Weiland, S., and Scheidtmann, K. H. (1996) Oncogene 12, 953-961
54. Sakaguchi, K., Sakamoto, H., Lewis, M. S., Anderson, C. W., Erickson, J. W., Appella, E., and Xie, D. (1997) Biochemistry 36, 10117-10124
55. Lohrum, M., and Scheidtmann, K. H. (1996) Oncogene 13, 2527-2539
56. Pospisilova, S., Brazda, V., Amrichova, J., Kamermeierova, R., Palecek, E., and Vojtesek, B. (2000) J. Immunol. Methods 237, 51-64
57. Harlow, E., and Lane, D. (1988) Antibodies: A Laboratory Manual, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
58. Luciani, G., Hutchins, J., Zheleva, D., and Hupp, T. (2000) J. Mol. Biol. 300, 503-518
59. Hupp, T. R., and Lane, D. P. (1994) Curr. Biol. 4, 865-875
60. Blaydes, J. P., Gire, V., Rowson, J. M., and Wynford-Thomas, D. (1997) Oncogene 14, 1859-1868
61. Hsieh, J. K., Chan, F. S., O'Connor, D. J., Mittnacht, S., Zhong, S., and Lu, X. (1999) Mol. Cell 3, 181-193
62. Hupp, T. R., Meek, D. W., Midgley, C. A., and Lane, D. P. (1992) Cell 71, 875-886
63. Wellerson, R., and Kaplan, P. (1986) Hybridoma 5, 199-213
64. Thompson, R. J., and Jackson, A. P. (1985) Trends Biochem. Sci 9, 1-3
65. Hupp, T. R., and Lane, D. P. (1995) J. Biol. Chem. 270, 18165-18174
66. Blaydes, J. P., and Wynford-Thomas, D. (1998) Oncogene 16, 3317-3322
67. Abraham, J., Kelly, J., Thibault, P., and Benchimol, S. (2000) J. Mol. Biol. 295, 853-864
68. Thiagalingam, S., Kinzler, K. W., and Vogelstein, B. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 6062-6066
69. Tarunina, M., and Jenkins, J. R. (1993) Oncogene 8, 3165-3173
70. Milne, D. M., Palmer, R. H., and Meek, D. W. (1992) Nucleic Acids Res. 20, 5565-5570
71. Hall, S. R., Campbell, L. E., and Meek, D. W. (1996) Nucleic Acids Res. 24, 1119-1126
72. Hao, M., Lowy, A. M., Kapoor, M., Deffie, A., Liu, G., and Lozano, G. (1996) J. Biol. Chem. 271, 29380-29385
73. Mundt, M., Hupp, T., Fritsche, M., Merkle, C., Hansen, S., Lane, D., and Groner, B. (1997) Oncogene 15, 237-244
74. Baldin, V., Cans, C., Knibiehler, M., and Ducommun, B. (1997) J. Biol. Chem. 272, 32731-32734
75. Okano-Uchida, T., Sekiai, T., Lee, K., Okumura, E., Tachibana, K., and Kishimoto, T. (1998) Dev. Biol. 197, 39-53
76. Hayashi, S., and Yamaguchi, M. (1999) Genes Cells 4, 111-122
77. Romanowski, P., Marr, J., Madine, M. A., Rowles, A., Blow, J. J., Gautier, J., and Laskey, R. A. (2000) J. Biol. Chem. 275, 4239-4243
78. Anderson, J. A., Lewellyn, A. L., and Maller, J. L. (1997) Mol. Biol. Cell 8, 1195-1206
79. Gil-Gomez, G., Berns, A., and Brady, H. J. (1998) EMBO J. 17, 7209-7218
80. Jaspersen, S. L., Charles, J. F., and Morgan, D. O. (1999) Curr. Biol. 9, 227-236