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Bioorganic and Medicinal Chemistry Letters

Volumn 12, Issue 13, 2002, Pages 1763-1766

Structure-based design and synthesis of HIV-1 protease inhibitors employing β-D-mannopyranoside scaffolds

(4) Murphy, Paul V a O'Brien, Julie L a Gorey Feret, Lorraine J b Smith III, Amos B c

a UNIVERSITY COLLEGE DUBLIN (Ireland)

b BRISTOL MYERS SQUIBB (United States)

c UNIVERSITY OF PENNSYLVANIA (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEINASE INHIBITOR; ASPARTIC PROTEINASE; DRUG DERIVATIVE; MANNOSE;

ARTICLE; DRUG DESIGN; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; IC 50; STEREOSPECIFICITY; BINDING SITE; CHEMISTRY; CONFORMATION; DRUG EFFECT; ENZYMOLOGY; HUMAN IMMUNODEFICIENCY VIRUS 1; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ASPARTIC ENDOPEPTIDASES; BINDING SITES; DRUG DESIGN; HIV PROTEASE INHIBITORS; HIV-1; INHIBITORY CONCENTRATION 50; MANNOSE; MOLECULAR CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP; SUPPORT, NON-U.S. GOV'T;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0037042775 PISSN: 0960894X EISSN: None Source Type: Journal
DOI: 10.1016/S0960-894X(02)00220-2 Document Type: Article

Times cited : (27)

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