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Volumn 55, Issue 3, 1998, Pages 233-254

Protease inhibitors for the treatment of human immunodeficiency virus infection

Author keywords

Antivirals; Compliance; Costs; Dosage; Drug administration; Drug interactions; Food; HIV infections; Human immunodeficiency virus; Indinavir sulfate; Mechanism of action; Nelfinavir mesylate; Patient information; Pharmacists; Pharmacokinetics; Resistance; ; Ritonavir; Saquinavir messyalte; Toxicity

Indexed keywords

ANTIFUNGAL AGENT; ANTIINFECTIVE AGENT; ANTIRETROVIRUS AGENT; INDINAVIR; LAMIVUDINE; NELFINAVIR; ORAL CONTRACEPTIVE AGENT; PROTEINASE INHIBITOR; RITONAVIR; RNA DIRECTED DNA POLYMERASE INHIBITOR; SAQUINAVIR; STAVUDINE; UNINDEXED DRUG; ZALCITABINE; ZIDOVUDINE;

EID: 0032007325     PISSN: 10792082     EISSN: None     Source Type: Journal    
DOI: 10.1093/ajhp/55.3.233     Document Type: Review
Times cited : (77)

References (127)
  • 1
    • 0022546859 scopus 로고
    • HTLV-III gag protein is processed in yeast cells by the virus pol-protease
    • Kramer RA, Schaber MD, Skalka AM et al. HTLV-III gag protein is processed in yeast cells by the virus pol-protease. Science. 1986; 231:1580-4.
    • (1986) Science , vol.231 , pp. 1580-1584
    • Kramer, R.A.1    Schaber, M.D.2    Skalka, A.M.3
  • 2
    • 0005241362 scopus 로고
    • Active human immunodeficiency virus protease is required for viral infectivity
    • Kohl NE, Emini EA, Schlief WA et al. Active human immunodeficiency virus protease is required for viral infectivity. Proc Natl Acad Sci U S A. 1988; 85:4686-90.
    • (1988) Proc Natl Acad Sci U S A , vol.85 , pp. 4686-4690
    • Kohl, N.E.1    Emini, E.A.2    Schlief, W.A.3
  • 3
    • 0342394457 scopus 로고
    • Role of capsid precursor processing and myrisoylation in morphogenesis and infectivity of human immunodeficiency virus type 1
    • Gottinger HG, Sodroski JG, Haseltine WA. Role of capsid precursor processing and myrisoylation in morphogenesis and infectivity of human immunodeficiency virus type 1. Proc Natl Acad Sci U S A. 1989; 86:5781-5.
    • (1989) Proc Natl Acad Sci U S A , vol.86 , pp. 5781-5785
    • Gottinger, H.G.1    Sodroski, J.G.2    Haseltine, W.A.3
  • 5
    • 1842494261 scopus 로고
    • Roche Invirase clears FDA in 97 days as first approved protease inhibitor; new formulation in study; international confirmatory trial; power increased
    • Roche Invirase clears FDA in 97 days as first approved protease inhibitor; new formulation in study; international confirmatory trial; power increased. FDC Rep. 1995; 57 (Dec 11):3-4.
    • (1995) FDC Rep. , vol.57 , Issue.DEC 11 , pp. 3-4
  • 6
    • 14444280858 scopus 로고    scopus 로고
    • Abbott Norvir for HIV reduces death risk 40%, reduces disease progression risk 56% in advanced HIV; FDA approves ritonavir March 1 in record 72 days
    • Abbott Norvir for HIV reduces death risk 40%, reduces disease progression risk 56% in advanced HIV; FDA approves ritonavir March 1 in record 72 days. FDC Rep. 1996; 58 (Mar 4):7-8.
    • (1996) FDC Rep. , vol.58 , Issue.MAR 4 , pp. 7-8
  • 7
    • 1842286377 scopus 로고    scopus 로고
    • Merck Crixivan temporary distribution to begin filling scripts March 25 through independent pharmacy service; scale-up facilities to be ready in six months
    • Merck Crixivan temporary distribution to begin filling scripts March 25 through independent pharmacy service; scale-up facilities to be ready in six months. FDC Rep, 1996; 58 (Mar 18):3-4.
    • (1996) FDC Rep , vol.58 , Issue.MAR 18 , pp. 3-4
  • 8
    • 14444268262 scopus 로고    scopus 로고
    • Agouron Viracept to be compared to Norvir in clinical end-point study
    • T&G 1.
    • Agouron Viracept to be compared to Norvir in clinical end-point study. FDC Rep. 1997; 59 (Mar 17):T&G 1.
    • (1997) FDC Rep. , vol.59 , Issue.MAR 17
  • 9
    • 14444276024 scopus 로고
    • Three-dimensional structure of aspartyl protease from human immunodeficiency virus HIV-1
    • Navia MA, Fitzgerald PMD, McKeever BM et al. Three-dimensional structure of aspartyl protease from human immunodeficiency virus HIV-1. Nature. 1989; 159:87-94.
    • (1989) Nature , vol.159 , pp. 87-94
    • Navia, M.A.1    Fitzgerald, P.M.D.2    McKeever, B.M.3
  • 10
    • 0029552583 scopus 로고
    • HIV-1 protease inhibitors: Their development, mechanism of action and clinical potential
    • Pillay D, Bryant M, Getman D et al. HIV-1 protease inhibitors: their development, mechanism of action and clinical potential. Rev Med Virol. 1995; 5:23-33.
    • (1995) Rev Med Virol. , vol.5 , pp. 23-33
    • Pillay, D.1    Bryant, M.2    Getman, D.3
  • 11
    • 0024344021 scopus 로고
    • Structure of complex of synthetic HIV-1 protease with a substrate-based inhibitor at 2.3 Å resolution
    • Miller M, Sathyanarayana BK, Toth MV et al. Structure of complex of synthetic HIV-1 protease with a substrate-based inhibitor at 2.3 Å resolution. Science. 1989; 246:1149-52.
    • (1989) Science , vol.246 , pp. 1149-1152
    • Miller, M.1    Sathyanarayana, B.K.2    Toth, M.V.3
  • 12
    • 0025268321 scopus 로고
    • Rational design of peptide-based HIV proteinase inhibitors
    • Roberts NA, Martin JA, Kinchington D et al. Rational design of peptide-based HIV proteinase inhibitors. Science. 1990; 248:358-61.
    • (1990) Science , vol.248 , pp. 358-361
    • Roberts, N.A.1    Martin, J.A.2    Kinchington, D.3
  • 13
    • 0024992935 scopus 로고
    • Design, activity, and 2.8 Å crystal structure of a C2 symmetric inhibitor complexed to HIV-1 protease
    • Erickson JR, Neidhart DJ, van Drie J et al. Design, activity, and 2.8 Å crystal structure of a C2 symmetric inhibitor complexed to HIV-1 protease. Science. 1990; 249:527-33.
    • (1990) Science , vol.249 , pp. 527-533
    • Erickson, J.R.1    Neidhart, D.J.2    Van Drie, J.3
  • 14
    • 0028057975 scopus 로고
    • Rational design of potent, bioavailable, nonpeptide cyclic ureas as HIV protease inhibitors
    • Lam PY, Jadhav PK, Eyermann CJ et al. Rational design of potent, bioavailable, nonpeptide cyclic ureas as HIV protease inhibitors. Science. 1994; 263:380-4.
    • (1994) Science , vol.263 , pp. 380-384
    • Lam, P.Y.1    Jadhav, P.K.2    Eyermann, C.J.3
  • 15
    • 0028852105 scopus 로고
    • Design of VX-478, a potent inhibitor of HIV protease
    • Navia MA, Sato VL, Tung RD. Design of VX-478, a potent inhibitor of HIV protease. Int Antivir News. 1995; 9:143-5.
    • (1995) Int Antivir News , vol.9 , pp. 143-145
    • Navia, M.A.1    Sato, V.L.2    Tung, R.D.3
  • 16
    • 0028942590 scopus 로고
    • Saquinavir
    • Saquinavir. Drugs Future. 1995; 20:321-5.
    • (1995) Drugs Future , vol.20 , pp. 321-325
  • 20
    • 0024590979 scopus 로고
    • Mutational analysis of human immunodeficiency virus type 1 protease suggests functional homology with aspartic proteinases
    • Loeb DD, Hutchison CA III, Edgell MH et al. Mutational analysis of human immunodeficiency virus type 1 protease suggests functional homology with aspartic proteinases. J Virol. 1989; 63:111-21.
    • (1989) J Virol. , vol.63 , pp. 111-121
    • Loeb, D.D.1    Hutchison III, C.A.2    Edgell, M.H.3
  • 21
    • 0029865526 scopus 로고    scopus 로고
    • Perspectives in HIV protease inhibitors
    • Leonard JM. Perspectives in HIV protease inhibitors. Adv Exp Med Biol. 1996; 394:319-25.
    • (1996) Adv Exp Med Biol. , vol.394 , pp. 319-325
    • Leonard, J.M.1
  • 22
    • 0030895312 scopus 로고    scopus 로고
    • Protease inhibitors in patients with HIV disease
    • Barry M, Gibbons S, Back D et al. Protease inhibitors in patients with HIV disease. Clin Pharmacokinet. 1997; 32:194-209.
    • (1997) Clin Pharmacokinet , vol.32 , pp. 194-209
    • Barry, M.1    Gibbons, S.2    Back, D.3
  • 23
    • 0030993833 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 protease inhibitors
    • McDonald CK, Kuritzkes DR. Human immunodeficiency virus type 1 protease inhibitors. Arch Intern Med. 1997; 157:951-9.
    • (1997) Arch Intern Med. , vol.157 , pp. 951-959
    • McDonald, C.K.1    Kuritzkes, D.R.2
  • 25
    • 0028811974 scopus 로고
    • Viral dynamics in human immunodeficiency virus type 1 infection
    • Wei X, Ghosh SK, Taylor ME et al. Viral dynamics in human immunodeficiency virus type 1 infection. Nature. 1995; 373:117-22.
    • (1995) Nature , vol.373 , pp. 117-122
    • Wei, X.1    Ghosh, S.K.2    Taylor, M.E.3
  • 26
    • 0028952146 scopus 로고
    • HIV population dynamics in vivo: Implications for genetic variation, pathogenesis and therapy
    • Coffin JM. HIV population dynamics in vivo: implications for genetic variation, pathogenesis and therapy. Science. 1995; 267:483-9.
    • (1995) Science , vol.267 , pp. 483-489
    • Coffin, J.M.1
  • 27
    • 0028228751 scopus 로고
    • Human immunodeficiency virus type 1 variants with increased replicative capacity develop during the asymptomatic stage before disease progression
    • Connor RI, Ho DD. Human immunodeficiency virus type 1 variants with increased replicative capacity develop during the asymptomatic stage before disease progression. J Virol. 1994; 68:4400-8.
    • (1994) J Virol. , vol.68 , pp. 4400-4408
    • Connor, R.I.1    Ho, D.D.2
  • 28
    • 0027459081 scopus 로고
    • Quantitation of zidovudine-resistant human immunodeficiency virus type 1 in the blood of treated and untreated patients
    • Mohri H, Singh MK, Ching WTW et al. Quantitation of zidovudine-resistant human immunodeficiency virus type 1 in the blood of treated and untreated patients. Proc Natl Acad Sci U S A. 1993; 30:25-9.
    • (1993) Proc Natl Acad Sci U S A , vol.30 , pp. 25-29
    • Mohri, H.1    Singh, M.K.2    Ching, W.T.W.3
  • 29
    • 0028051329 scopus 로고
    • Natural occurrence of drug resistance mutations in the reverse transcriptase of human immunodeficiency virus type 1 isolates
    • Nájera I, Richman DD, Olivares I et al. Natural occurrence of drug resistance mutations in the reverse transcriptase of human immunodeficiency virus type 1 isolates. AIDS Res Hum Retroviruses. 1994; 10:1479-88.
    • (1994) AIDS Res Hum Retroviruses , vol.10 , pp. 1479-1488
    • Nájera, I.1    Richman, D.D.2    Olivares, I.3
  • 30
    • 0028988479 scopus 로고
    • Pol gene qua sispecies of human immunodeficiency virus: Mutations associated with drug resistance in virus from patients undergoing no drug therapy
    • Nájera I, Holgu'n A, Quinones-Mateu E et al. Pol gene qua sispecies of human immunodeficiency virus: mutations associated with drug resistance in virus from patients undergoing no drug therapy. J Virol. 1995; 69:23-31.
    • (1995) J Virol. , vol.69 , pp. 23-31
    • Nájera, I.1    Holgu'n, A.2    Quinones-Mateu, E.3
  • 31
    • 0028892434 scopus 로고
    • Clinical Isolates of HIV-1 contain few pre-existing proteinase inhibitor resistance-conferring mutations
    • Yamaguchi K, Byrn RA. Clinical Isolates of HIV-1 contain few pre-existing proteinase inhibitor resistance-conferring mutations. Biochim Biophys Acta. 1994; 1253:136-40.
    • (1994) Biochim Biophys Acta , vol.1253 , pp. 136-140
    • Yamaguchi, K.1    Byrn, R.A.2
  • 32
    • 0030469959 scopus 로고    scopus 로고
    • Patient compliance and drug failure in protease inhibitor monotherapy
    • Vanhove GF, Schapiro JM, Winters MA et al. Patient compliance and drug failure in protease inhibitor monotherapy. JAMA. 1996; 276:1955-6.
    • (1996) JAMA , vol.276 , pp. 1955-1956
    • Vanhove, G.F.1    Schapiro, J.M.2    Winters, M.A.3
  • 33
    • 0029824426 scopus 로고    scopus 로고
    • In vivo resistance to a human immunodeficiency virus type 1 proteinase inhibitor: Mutations, kinetics, and frequencies
    • Jacobsen H, Hönggi M, Ott M et al. In vivo resistance to a human immunodeficiency virus type 1 proteinase inhibitor: mutations, kinetics, and frequencies. J Infect Dis. 1996; 173:1379-87.
    • (1996) J Infect Dis. , vol.173 , pp. 1379-1387
    • Jacobsen, H.1    Hönggi, M.2    Ott, M.3
  • 34
    • 0028843163 scopus 로고
    • Characterization of human immunodeficiency virus type 1 mutants with decreased sensitivity to proteinase Inhibitor Ro 31-8959
    • Jacobsen H, Yasargil K, Winslow DL et al. Characterization of human immunodeficiency virus type 1 mutants with decreased sensitivity to proteinase Inhibitor Ro 31-8959. Virology. 1995; 206:527-34.
    • (1995) Virology , vol.206 , pp. 527-534
    • Jacobsen, H.1    Yasargil, K.2    Winslow, D.L.3
  • 35
    • 0028943992 scopus 로고
    • In vivo emergence of HIV-1 variants resistant to multiple protease inhibitors
    • Condra JH, Schleif WA, Blahy OM et al. In vivo emergence of HIV-1 variants resistant to multiple protease inhibitors. Nature. 1995; 374:569-71.
    • (1995) Nature , vol.374 , pp. 569-571
    • Condra, J.H.1    Schleif, W.A.2    Blahy, O.M.3
  • 36
    • 15444377672 scopus 로고    scopus 로고
    • Ordered accumulation of mutations in HIV protease confers resistance to ritonavir
    • Molla A, Korneyeva M, Gao Q et al. Ordered accumulation of mutations in HIV protease confers resistance to ritonavir. Nature Med. 1996; 2:760-6.
    • (1996) Nature Med. , vol.2 , pp. 760-766
    • Molla, A.1    Korneyeva, M.2    Gao, Q.3
  • 37
    • 0028854676 scopus 로고
    • Selection and analysis of human immunodeficiency virus type 1 variants with increased resistance to ABT-538, a novel protease inhibitor
    • Markowitz M, Mo H, Kempf DJ et al. Selection and analysis of human immunodeficiency virus type 1 variants with increased resistance to ABT-538, a novel protease inhibitor. J Virol. 1995; 69:701-6.
    • (1995) J Virol. , vol.69 , pp. 701-706
    • Markowitz, M.1    Mo, H.2    Kempf, D.J.3
  • 38
    • 1842284096 scopus 로고    scopus 로고
    • Clinical and virological responses to ritonavir, an inhibitor of HIV protease
    • Vancouver, Canada; Jul 10
    • Korneyeva M, Molla A, Kempf D et al. Clinical and virological responses to ritonavir, an inhibitor of HIV protease. Paper presented at 11th International Conference on AIDS. Vancouver, Canada; 1996 Jul 10.
    • (1996) 11th International Conference on AIDS
    • Korneyeva, M.1    Molla, A.2    Kempf, D.3
  • 39
    • 0028013171 scopus 로고
    • Generation and characterization of a human immunodeficiency virus type 1 (HIV-1) mutant resistant to an HIV-1 protease inhibitor
    • El-Farrash MA, Kuroda MJ, Kitazaki T et al. Generation and characterization of a human immunodeficiency virus type 1 (HIV-1) mutant resistant to an HIV-1 protease inhibitor. J Virol. 1994; 68:233-9.
    • (1994) J Virol. , vol.68 , pp. 233-239
    • El-Farrash, M.A.1    Kuroda, M.J.2    Kitazaki, T.3
  • 40
    • 0028014288 scopus 로고
    • Characterization of human immunodeficiency virus type 1 variants with increased resistance to a C-2 symmetric protease inhibitor
    • Ho DD, Toyoshima T, Mo H et al. Characterization of human immunodeficiency virus type 1 variants with increased resistance to a C-2 symmetric protease inhibitor. J Virol. 1994; 68:2016-20.
    • (1994) J Virol. , vol.68 , pp. 2016-2020
    • Ho, D.D.1    Toyoshima, T.2    Mo, H.3
  • 41
    • 12644277366 scopus 로고    scopus 로고
    • Genotypic analysis of HIV-1 variants isolated from patients treated with the protease inhibitor nelfinavir, alone or in combination with d4T or AZT and 3TC
    • Washington, DC; Jan 23
    • Patick AK, Duran M, Cao Y. Genotypic analysis of HIV-1 variants isolated from patients treated with the protease inhibitor nelfinavir, alone or in combination with d4T or AZT and 3TC. Paper presented at Fourth Conference on Retroviruses and Opportunistic Infections. Washington, DC; 1997 Jan 23.
    • (1997) Fourth Conference on Retroviruses and Opportunistic Infections
    • Patick, A.K.1    Duran, M.2    Cao, Y.3
  • 42
    • 13344275873 scopus 로고    scopus 로고
    • Antiviral and resistance studies of AG1343, an orally bioavailable inhibitor of human immunodeficiency virus protease
    • Patick AK, Mo H, Markowitz M et al. Antiviral and resistance studies of AG1343, an orally bioavailable inhibitor of human immunodeficiency virus protease. Antimicrob Agents Chemother. 1996; 40:292-7.
    • (1996) Antimicrob Agents Chemother. , vol.40 , pp. 292-297
    • Patick, A.K.1    Mo, H.2    Markowitz, M.3
  • 43
    • 0013471965 scopus 로고    scopus 로고
    • Ritonavir-saquinavir combination treatment in protease inhibitor experienced patients with advanced HIV disease
    • Toronto, Canada; Sep 29
    • Sampson M, Torres RA, Stein AJ et al. Ritonavir-saquinavir combination treatment in protease inhibitor experienced patients with advanced HIV disease. Paper presented at 37th Interscience Conference on Antimicrobial Agents and Chemotherapy. Toronto, Canada; 1997 Sep 29.
    • (1997) 37th Interscience Conference on Antimicrobial Agents and Chemotherapy
    • Sampson, M.1    Torres, R.A.2    Stein, A.J.3
  • 44
    • 0028806725 scopus 로고
    • A preliminary study of ritonavir, an inhibitor of HIV-1 protease, to treat HIV-1 infection
    • Markowitz M, Saag M, Powderly W et al. A preliminary study of ritonavir, an inhibitor of HIV-1 protease, to treat HIV-1 infection. N Engl J Med. 1995; 333:1534-9.
    • (1995) N Engl J Med. , vol.333 , pp. 1534-1539
    • Markowitz, M.1    Saag, M.2    Powderly, W.3
  • 45
    • 0029872589 scopus 로고    scopus 로고
    • A 24-week open-label Phase I/II evaluation of the HIV protease inhibitor MK-639 (indinavir)
    • Stein DS, Fish DG, Bilello JA et al. A 24-week open-label Phase I/II evaluation of the HIV protease inhibitor MK-639 (indinavir).AIDS. 1996; 10:485-92.
    • (1996) AIDS , vol.10 , pp. 485-492
    • Stein, D.S.1    Fish, D.G.2    Bilello, J.A.3
  • 46
    • 14444275266 scopus 로고    scopus 로고
    • La Jolla, CA: Agouron Pharmaceuticals; Mar.
    • Nelfinavir package insert. La Jolla, CA: Agouron Pharmaceuticals; 1997 Mar.
    • (1997) Nelfinavir Package Insert
  • 47
    • 14444288508 scopus 로고    scopus 로고
    • Nutley, NJ: Roche Laboratories; Jun
    • Saquinavir package Insert. Nutley, NJ: Roche Laboratories; 1996 Jun.
    • (1996) Saquinavir Package Insert
  • 48
    • 0345083342 scopus 로고    scopus 로고
    • West Point, PA: Merck & Co.; Mar
    • Indinavir package insert. West Point, PA: Merck & Co.; 1996 Mar.
    • (1996) Indinavir Package Insert
  • 49
    • 0004592712 scopus 로고    scopus 로고
    • North Chicago, IL: Abbott Laboratories; May
    • Ritonavir package insert. North Chicago, IL: Abbott Laboratories; 1996 May.
    • (1996) Ritonavir Package Insert
  • 50
    • 0031588522 scopus 로고    scopus 로고
    • Indinavir in cerebrospinal fluid of HIV-1 infected patients
    • Letter
    • Stahle L, Martin C, Svensson J-O et al. Indinavir in cerebrospinal fluid of HIV-1 infected patients. Lancet. 1997; 350:1823. Letter.
    • (1997) Lancet , vol.350 , pp. 1823
    • Stahle, L.1    Martin, C.2    Svensson, J.-O.3
  • 51
    • 4243957546 scopus 로고    scopus 로고
    • Kalamazoo, MI: Pharmacia & Upjohn; Apr
    • Delavirdine package insert. Kalamazoo, MI: Pharmacia & Upjohn; 1997 Apr.
    • (1997) Delavirdine Package Insert
  • 52
    • 0343323330 scopus 로고    scopus 로고
    • Saquinavir vs Hivid vs combination as treatment for advanced HIV infection in patients discontinuing/unable to take Retrovir
    • Vancouver, Canada; Jul 8
    • Salgo M, Beattie D, Bragman K et al. Saquinavir vs Hivid vs combination as treatment for advanced HIV infection in patients discontinuing/unable to take Retrovir. Paper presented at 11th International Conference on AIDS. Vancouver, Canada; 1996 Jul 8.
    • (1996) 11th International Conference on AIDS
    • Salgo, M.1    Beattie, D.2    Bragman, K.3
  • 53
    • 2442723342 scopus 로고    scopus 로고
    • Treatment of human immunodeficiency virus infection with saquinavir, zidovudine, and zalcitabine
    • Collier AC, Coombs RW, Schoenfeld DA et al. Treatment of human immunodeficiency virus infection with saquinavir, zidovudine, and zalcitabine. N Engl J Med. 1996; 334:1011-7.
    • (1996) N Engl J Med. , vol.334 , pp. 1011-1017
    • Collier, A.C.1    Coombs, R.W.2    Schoenfeld, D.A.3
  • 54
    • 0003204379 scopus 로고    scopus 로고
    • Prolongation of life and prevention of AIDS complications in advanced HIV immunodeficiency with ritonavir
    • Vancouver, Canada; Jul 7-12
    • Cameron DW, Heath-Chiozzi M, Kravcik S. Prolongation of life and prevention of AIDS complications in advanced HIV immunodeficiency with ritonavir: update. Paper presented at 11th International Conference on AIDS. Vancouver, Canada; 1996 Jul 7-12.
    • (1996) 11th International Conference on AIDS
    • Cameron, D.W.1    Heath-Chiozzi, M.2    Kravcik, S.3
  • 55
    • 14444282847 scopus 로고    scopus 로고
    • Abbott Norvir for HIV reduces death risk 40%; reduces disease progression risk 55% in advanced HIV
    • Abbott Norvir for HIV reduces death risk 40%; reduces disease progression risk 55% in advanced HIV. FDC Rep. 1996; 58 (Mar 4):7-8.
    • (1996) FDC Rep. , vol.58 , Issue.MAR 4 , pp. 7-8
  • 56
    • 0008913115 scopus 로고    scopus 로고
    • A triple combination of ritonavir+AZT+DDC as first line treatment of patients with AIDS: Update
    • Vancouver, Canada; Jul 8
    • Mathez D, Bagnarelli P, De Truchis P et al. A triple combination of ritonavir+AZT+DDC as first line treatment of patients with AIDS: update. Paper presented at 11th International Conference on AIDS. Vancouver, Canada; 1996 Jul 8.
    • (1996) 11th International Conference on AIDS
    • Mathez, D.1    Bagnarelli, P.2    De Truchis, P.3
  • 58
    • 0003059230 scopus 로고    scopus 로고
    • Potent and sustained antiretroviral activity of indinavir (IDV), zidovudine (ZDV) and lamivudine (3TC)
    • Vancouver, Canada; Jul 10
    • Gulick RM, Mellors J, Havlir D et al. Potent and sustained antiretroviral activity of indinavir (IDV), zidovudine (ZDV) and lamivudine (3TC). Paper presented at 11th International Conference on AIDS. Vancouver, Canada; 1996 Jul 10.
    • (1996) 11th International Conference on AIDS
    • Gulick, R.M.1    Mellors, J.2    Havlir, D.3
  • 59
    • 0005514294 scopus 로고    scopus 로고
    • The efficacy of Viracept (nelfinavir mesylate, NFV) in pivotal Phase II/III double-blind randomized controlled trials as monotherapy and in combination with d4T or AZT/3TC
    • Washington, DC; Jan 22-27
    • Powderly W, Sension M, Conant M et al. The efficacy of Viracept (nelfinavir mesylate, NFV) in pivotal Phase II/III double-blind randomized controlled trials as monotherapy and in combination with d4T or AZT/3TC. Paper presented at Fourth Conference on Retroviruses and Opportunistic Infections. Washington, DC; 1997 Jan 22-27.
    • (1997) Fourth Conference on Retroviruses and Opportunistic Infections
    • Powderly, W.1    Sension, M.2    Conant, M.3
  • 60
    • 0003244062 scopus 로고    scopus 로고
    • The safety of Viracept (nelfinavir mesylate, NFV) in pivotal Phase II/III double-blind randomized controlled trials as monotherapy and in combination with d4T or AZT/3TC
    • Washington, DC; Jan 23
    • Henry K, Lamarca A, Myers R et al. The safety of Viracept (nelfinavir mesylate, NFV) in pivotal Phase II/III double-blind randomized controlled trials as monotherapy and in combination with d4T or AZT/3TC. Paper presented at Fourth Conference on Retroviruses and Opportunistic Infections. Washington, DC; 1997 Jan 23.
    • (1997) Fourth Conference on Retroviruses and Opportunistic Infections
    • Henry, K.1    Lamarca, A.2    Myers, R.3
  • 62
    • 0345285361 scopus 로고    scopus 로고
    • Causes of long term efficacy and/or drug failure in protease (PR) inhibitor monotherapy
    • Vancouver, Canada; Jul 8
    • Schapiro JM, Winters MA, Vierra M et al. Causes of long term efficacy and/or drug failure in protease (PR) inhibitor monotherapy. Paper presented at 11th International Conference on AIDS. Vancouver, Canada; 1996 Jul 8.
    • (1996) 11th International Conference on AIDS
    • Schapiro, J.M.1    Winters, M.A.2    Vierra, M.3
  • 63
    • 0030052964 scopus 로고    scopus 로고
    • Alteration in the immune response of human immunodeficiency virus (HIV) infected subjects treated with an HIV-specific protease inhibitor, ritonavir
    • Kelleher AD, Carr A, Zaunders J et al. Alteration in the immune response of human immunodeficiency virus (HIV) infected subjects treated with an HIV-specific protease inhibitor, ritonavir. J Infect Dis. 1996; 173:321-9.
    • (1996) J Infect Dis. , vol.173 , pp. 321-329
    • Kelleher, A.D.1    Carr, A.2    Zaunders, J.3
  • 64
    • 3643059022 scopus 로고    scopus 로고
    • Antiviral activity of indinavir plus zidovudine compared to indinavir or zidovudine alone in antiretroviral naive patients
    • New Orleans, LA; Sep 16
    • Leavitt R, Massari F, Nessly M et al. Antiviral activity of indinavir plus zidovudine compared to indinavir or zidovudine alone in antiretroviral naive patients. Paper presented at 36th Interscience Conference on Antimicrobial Agents and Chemotherapy. New Orleans, LA; 1996 Sep 16.
    • (1996) 36th Interscience Conference on Antimicrobial Agents and Chemotherapy
    • Leavitt, R.1    Massari, F.2    Nessly, M.3
  • 65
    • 0343964167 scopus 로고    scopus 로고
    • Stavudine (d4T), didanosine (ddI), and nelfinavir combination therapy in HIV-infected subjects: Antiviral effect and safety in an ongoing pilot study
    • Washington, DC; Jan 23
    • Pedneault L, Ellion R, Adler M et al. Stavudine (d4T), didanosine (ddI), and nelfinavir combination therapy in HIV-infected subjects: antiviral effect and safety in an ongoing pilot study. Paper presented at Fourth Conference on Retroviruses and Opportunistic Infections. Washington, DC; 1997 Jan 23.
    • (1997) Fourth Conference on Retroviruses and Opportunistic Infections
    • Pedneault, L.1    Ellion, R.2    Adler, M.3
  • 66
    • 14444279175 scopus 로고    scopus 로고
    • Glaxo/Vertex HIV protease inhibitor 141W94 shows 99% reduction in viral load
    • Glaxo/Vertex HIV protease inhibitor 141W94 shows 99% reduction in viral load. FDC Rep. 1996; 58 (Sep 23):9-10.
    • (1996) FDC Rep. , vol.58 , Issue.SEP 23 , pp. 9-10
  • 68
    • 0031035968 scopus 로고    scopus 로고
    • Pharmacokinetic en hancement of inhibitors of the human immunodeficiency virus protease by coadministration with ritonavir
    • Kempf DJ, Marsh KG, Kumar G et al. Pharmacokinetic en hancement of inhibitors of the human immunodeficiency virus protease by coadministration with ritonavir. Antimicrob Agents Chemother. 1997; 41:654-60.
    • (1997) Antimicrob Agents Chemother. , vol.41 , pp. 654-660
    • Kempf, D.J.1    Marsh, K.G.2    Kumar, G.3
  • 70
    • 0003217559 scopus 로고    scopus 로고
    • Nelfinavir mesylate (NFV) increases saquinavir soft-gel capsule (SQV-SGC) exposure in HIV+ patients
    • Washington, DC; Jan 23
    • Kravcik S, Sahai J, Kerr B et al. Nelfinavir mesylate (NFV) increases saquinavir soft-gel capsule (SQV-SGC) exposure in HIV+ patients. Paper presented at Fourth Conference on Retroviruses and Opportunistic Infections. Washington, DC; 1997 Jan 23.
    • (1997) Fourth Conference on Retroviruses and Opportunistic Infections
    • Kravcik, S.1    Sahai, J.2    Kerr, B.3
  • 71
    • 0345333788 scopus 로고    scopus 로고
    • A Phase I/II study of the protease inhibitor ritonavir (ABT-538) in children with HIV infection
    • Vancouver, Canada; Jul 10
    • Mueller BU, Zuckerman J, Nelson RP Jr et al. A Phase I/II study of the protease inhibitor ritonavir (ABT-538) in children with HIV infection. Paper presented at 11th International Conference on AIDS. Vancouver, Canada; 1996 Jul 10.
    • (1996) 11th International Conference on AIDS
    • Mueller, B.U.1    Zuckerman, J.2    Nelson Jr., R.P.3
  • 73
    • 0030573421 scopus 로고    scopus 로고
    • Update: Provisional Public Health Service recommendations for chemoprophylaxis after occupational exposure to HIV
    • Centers for Disease Control and Prevention. Update: provisional Public Health Service recommendations for chemoprophylaxis after occupational exposure to HIV. MMWR. 1996; 45:468-72.
    • (1996) MMWR , vol.45 , pp. 468-472
  • 74
    • 0029650657 scopus 로고
    • Case-control study of HIV seroconversion in health care workers after percutaneous exposure to HIV infected blood-France, United Kingdom, and United States, January 1988-August 1994
    • Centers for Disease Control and Prevention. Case-control study of HIV seroconversion in health care workers after percutaneous exposure to HIV infected blood-France, United Kingdom, and United States, January 1988-August 1994. MMWR. 1995; 44:929-33.
    • (1995) MMWR , vol.44 , pp. 929-933
  • 75
    • 0028507333 scopus 로고
    • HIV therapy advances: Update on a proteinase inhibitor
    • Vella S. HIV therapy advances: update on a proteinase inhibitor. AIDS. 1994; 8(suppl 3):S25-9.
    • (1994) AIDS , vol.8 , Issue.SUPPL. 3
    • Vella, S.1
  • 76
    • 0028846165 scopus 로고
    • A short-term study of the safety, pharmacokinetics, and efficacy of ritonavir, an inhibitor of HIV-1 protease
    • Danner SA, Carr A, Leonard JM et al. A short-term study of the safety, pharmacokinetics, and efficacy of ritonavir, an inhibitor of HIV-1 protease. N Engl J Med. 1995; 333:1528-33.
    • (1995) N Engl J Med. , vol.333 , pp. 1528-1533
    • Danner, S.A.1    Carr, A.2    Leonard, J.M.3
  • 77
    • 0029790554 scopus 로고    scopus 로고
    • Renal failure after treatment with ritonavir
    • Letter
    • Duong M, Sgro C, Grappin M et al. Renal failure after treatment with ritonavir. Lancet. 1996; 348:693. Letter.
    • (1996) Lancet , vol.348 , pp. 693
    • Duong, M.1    Sgro, C.2    Grappin, M.3
  • 78
    • 0343471516 scopus 로고    scopus 로고
    • Urinary stones in HIV-1-positive patients treated with indinavir
    • Daudon M, Estépa L, Viard JP et al. Urinary stones in HIV-1-positive patients treated with indinavir. Lancet, 1997; 349:1294-5.
    • (1997) Lancet , vol.349 , pp. 1294-1295
    • Daudon, M.1    Estépa, L.2    Viard, J.P.3
  • 79
    • 0342618506 scopus 로고    scopus 로고
    • Severe hepatitis in three AIDS patients treated with indinavir
    • Letter
    • Bräu N, Leaf HL, Wieczorek RL et al. Severe hepatitis in three AIDS patients treated with indinavir. Lancet. 1997; 349:924-5. Letter.
    • (1997) Lancet , vol.349 , pp. 924-925
    • Bräu, N.1    Leaf, H.L.2    Wieczorek, R.L.3
  • 80
    • 0029872589 scopus 로고    scopus 로고
    • A 24-week open label Phase I/II evaluation of the HIV protease inhibitor MK-639 (indinavir)
    • Stein DS, Fish DG, Bilello JA et al. A 24-week open label Phase I/II evaluation of the HIV protease inhibitor MK-639 (indinavir). AIDS. 1996; 10:485-92.
    • (1996) AIDS , vol.10 , pp. 485-492
    • Stein, D.S.1    Fish, D.G.2    Bilello, J.A.3
  • 82
    • 14444270829 scopus 로고    scopus 로고
    • FDA protease inhibitor letter urges monitoring of hemophiliacs
    • T&G 3.
    • FDA protease inhibitor letter urges monitoring of hemophiliacs. FDC Rep. 1996; 57:T&G 3.
    • (1996) FDC Rep. , vol.57
  • 83
    • 0031026640 scopus 로고    scopus 로고
    • Unusual occurrence of spontaneous hematomas in three asymptomatic HIV-infected haemophilia patients a few days after the onset of ritonavir treatment
    • Ginsburg C, Salmon-Ceron D, Vassilief D et al. Unusual occurrence of spontaneous hematomas in three asymptomatic HIV-infected haemophilia patients a few days after the onset of ritonavir treatment. AIDS. 1997; 11:388-9.
    • (1997) AIDS , vol.11 , pp. 388-389
    • Ginsburg, C.1    Salmon-Ceron, D.2    Vassilief, D.3
  • 84
    • 0031556850 scopus 로고    scopus 로고
    • Benign symmetric lipomatosis associated with protease inhibitors
    • Letter
    • Hengel RL, Watts NB, Lennox JL. Benign symmetric lipomatosis associated with protease inhibitors. Lancet. 1997; 350:1596. Letter.
    • (1997) Lancet , vol.350 , pp. 1596
    • Hengel, R.L.1    Watts, N.B.2    Lennox, J.L.3
  • 85
    • 0030763107 scopus 로고    scopus 로고
    • Hypertrophy of the breasts in a patient treated with indinavir
    • Herry I, Bernard L, de Truchis P et al. Hypertrophy of the breasts in a patient treated with indinavir. Clin Infect Dis. 1997; 25:937-8.
    • (1997) Clin Infect Dis. , vol.25 , pp. 937-938
    • Herry, I.1    Bernard, L.2    De Truchis, P.3
  • 86
    • 0030430035 scopus 로고    scopus 로고
    • Cytochrome P450-mediated metabolism of the HIV-1 protease inhibitor ritonavir (ABT-538) in human liver microsomes
    • Kumar GN, Rodrigues AD, Buko AM et al. Cytochrome P450-mediated metabolism of the HIV-1 protease inhibitor ritonavir (ABT-538) in human liver microsomes. J Pharmacol Exp Ther. 1996; 277:423-31.
    • (1996) J Pharmacol Exp Ther. , vol.277 , pp. 423-431
    • Kumar, G.N.1    Rodrigues, A.D.2    Buko, A.M.3
  • 87
    • 0001864447 scopus 로고    scopus 로고
    • Overview of in vitro and in vivo, drug interaction studies of nelfinavir, a new HIV-1 protease inhibitor
    • Washington, DC; Jan 23
    • Kerr B, Lee C, Yuen G et al. Overview of in vitro and in vivo, drug interaction studies of nelfinavir, a new HIV-1 protease inhibitor. Paper presented at Fourth Conference on Retroviruses and Opportunistic Infections. Washington, DC; 1997 Jan 23.
    • (1997) Fourth Conference on Retroviruses and Opportunistic Infections
    • Kerr, B.1    Lee, C.2    Yuen, G.3
  • 88
    • 0031024382 scopus 로고    scopus 로고
    • Selective biotransformation of the human immunodeficiency virus protease Inhibitor saquinavir by human small-intestinal cytochrome P4503A4: Potential contribution to high first-pass metabolism
    • Fitzsimmons ME, Collins JM. Selective biotransformation of the human immunodeficiency virus protease Inhibitor saquinavir by human small-intestinal cytochrome P4503A4: potential contribution to high first-pass metabolism. Drug Metab Dispos. 1997; 25:256-66.
    • (1997) Drug Metab Dispos. , vol.25 , pp. 256-266
    • Fitzsimmons, M.E.1    Collins, J.M.2
  • 89
    • 0029872126 scopus 로고    scopus 로고
    • Role of cytochrome P450 3A4 in human metabolism of MK-639, a potent human immunodeficiency virus protease inhibitor
    • Chiba M, Hensleigh M, Nishime JA et al. Role of cytochrome P450 3A4 in human metabolism of MK-639, a potent human immunodeficiency virus protease inhibitor. Drug Metab Dispos. 1996; 24:307-14.
    • (1996) Drug Metab Dispos. , vol.24 , pp. 307-314
    • Chiba, M.1    Hensleigh, M.2    Nishime, J.A.3
  • 90
    • 0003031788 scopus 로고    scopus 로고
    • Concurrent ritonavir and rifabutin increases the risk of rifabutin-associated adverse effects
    • Vancouver, Canada; Jul 8
    • Sun E, Heath-Chiozzi M, Cameron DW et al. Concurrent ritonavir and rifabutin increases the risk of rifabutin-associated adverse effects. Paper presented at 11th International Conference on AIDS. Vancouver, Canada; 1996 Jul 8.
    • (1996) 11th International Conference on AIDS
    • Sun, E.1    Heath-Chiozzi, M.2    Cameron, D.W.3
  • 91
    • 0009872253 scopus 로고    scopus 로고
    • Assessment of multiple doses of ritonavir on the pharmacokinetics of theophylline
    • Vancouver, Canada; Jul 8
    • Hsu A, Granneman GR, Witt G et al. Assessment of multiple doses of ritonavir on the pharmacokinetics of theophylline. Paper presented at 11th International Conference on AIDS. Vancouver, Canada; 1996 Jul 8.
    • (1996) 11th International Conference on AIDS
    • Hsu, A.1    Granneman, G.R.2    Witt, G.3
  • 92
    • 1842275677 scopus 로고    scopus 로고
    • Effect of ritonavir on the pharmacokinetics of ethinyl estradiol in healthy female volunteers
    • Vancouver, Canada; Jul 8
    • Quellet D, Hsu A, Qian J et al. Effect of ritonavir on the pharmacokinetics of ethinyl estradiol in healthy female volunteers. Paper presented at 11th International Conference on AIDS. Vancouver, Canada; 1996 Jul 8.
    • (1996) 11th International Conference on AIDS
    • Quellet, D.1    Hsu, A.2    Qian, J.3
  • 93
    • 0030952933 scopus 로고    scopus 로고
    • Ergotism related to concurrent administration of ergotamine tartrate and ritonavir in an AIDS patient
    • Letter
    • Caballero-Granado FJ, Viciana P, Cordero E et al. Ergotism related to concurrent administration of ergotamine tartrate and ritonavir in an AIDS patient. Antimicrob Agents Chemother, 1997; 41:1207. Letter.
    • (1997) Antimicrob Agents Chemother , vol.41 , pp. 1207
    • Caballero-Granado, F.J.1    Viciana, P.2    Cordero, E.3
  • 94
    • 0030601568 scopus 로고    scopus 로고
    • Clinical update: Impact of HIV protease inhibitors on the treatment of HIV-infected tuberculosis patients with rifampin
    • Centers for Disease Control and Prevention. Clinical update: impact of HIV protease inhibitors on the treatment of HIV-infected tuberculosis patients with rifampin. MMWR. 1996; 45:921-5.
    • (1996) MMWR , vol.45 , pp. 921-925
  • 95
    • 3543099979 scopus 로고    scopus 로고
    • Name confusion with new protease inhibitors
    • Cohen MR. Name confusion with new protease inhibitors. Hosp Pharm. 1996; 31(8):930-4.
    • (1996) Hosp Pharm. , vol.31 , Issue.8 , pp. 930-934
    • Cohen, M.R.1
  • 96
    • 0027235750 scopus 로고
    • The lifetime cost of treating a person with HIV
    • Hellinger FJ. The lifetime cost of treating a person with HIV. JAMA, 1993; 270:474-8.
    • (1993) JAMA , vol.270 , pp. 474-478
    • Hellinger, F.J.1
  • 97
    • 0345334246 scopus 로고    scopus 로고
    • Antiretroviral therapy for HIV infection
    • Carpenter CJ, Fischl MA, Hammer SM et al. Antiretroviral therapy for HIV infection. JAMA. 1996; 276:146-54.
    • (1996) JAMA , vol.276 , pp. 146-154
    • Carpenter, C.J.1    Fischl, M.A.2    Hammer, S.M.3
  • 98
    • 0003707380 scopus 로고    scopus 로고
    • Montvale, NJ: Medical Economics
    • Doherty MC, ed. Red book. Montvale, NJ: Medical Economics; 1997.
    • (1997) Red Book
    • Doherty, M.C.1
  • 99
    • 0028785597 scopus 로고
    • Pharmacists as HIV/AIDS information resources: Survey of Alabama pharmacists
    • Binkley D, Waller L, Potts L et al. Pharmacists as HIV/AIDS information resources: survey of Alabama pharmacists. AIDS Educ Prev. 1995; 7:455-66.
    • (1995) AIDS Educ Prev. , vol.7 , pp. 455-466
    • Binkley, D.1    Waller, L.2    Potts, L.3
  • 100
    • 0030010146 scopus 로고    scopus 로고
    • Pharmacist's provision of continuity of care to patients with human immunodeficiency virus infection
    • Foisy MM, Tseng A, Blaikie N. Pharmacist's provision of continuity of care to patients with human immunodeficiency virus infection. Am J Health-Syst Pharm. 1996; 53:1013-7.
    • (1996) Am J Health-Syst Pharm. , vol.53 , pp. 1013-1017
    • Foisy, M.M.1    Tseng, A.2    Blaikie, N.3
  • 101
    • 14444283348 scopus 로고    scopus 로고
    • A continuity of care, pharmaceutical care model for HIV patients
    • Devine B, Chow VC. A continuity of care, pharmaceutical care model for HIV patients. Calif J Health-Syst Pharm. 1996; Jan/Feb:6-8.
    • (1996) Calif J Health-Syst Pharm. , vol.JAN-FEB , pp. 6-8
    • Devine, B.1    Chow, V.C.2
  • 102
  • 103
    • 0028302687 scopus 로고
    • Competitive inhibition of HIV-1 protease by warfarin derivatives
    • Tummino PJ, Ferguson D, Hupe D. Competitive inhibition of HIV-1 protease by warfarin derivatives. Biochem Biophys Res Commun. 1994; 201:290-4.
    • (1994) Biochem Biophys Res Commun. , vol.201 , pp. 290-294
    • Tummino, P.J.1    Ferguson, D.2    Hupe, D.3
  • 104
    • 0028028221 scopus 로고
    • Structure-based design of HIV protease inhibitors: 4-hydroxycoumarins and 4-hydroxy-2-pyrones as non-peptidie inhibitors
    • Thairsrivongs S, Tomich PK, Watenpaugh KD et al. Structure-based design of HIV protease inhibitors: 4-hydroxycoumarins and 4-hydroxy-2-pyrones as non-peptidie inhibitors. J Med Chem. 1994; 37:3200-4.
    • (1994) J Med Chem. , vol.37 , pp. 3200-3204
    • Thairsrivongs, S.1    Tomich, P.K.2    Watenpaugh, K.D.3
  • 105
    • 0030895692 scopus 로고    scopus 로고
    • Antiviral activity of the dihydropyrone PNU-140690, a new nonpeptidic human immunodeficiency virus protease inhibitor
    • Poppe SM, Slade DE, Chong KT et al. Antiviral activity of the dihydropyrone PNU-140690, a new nonpeptidic human immunodeficiency virus protease inhibitor. Antimicrob Agents Chemother. 1997; 41:1058-63.
    • (1997) Antimicrob Agents Chemother. , vol.41 , pp. 1058-1063
    • Poppe, S.M.1    Slade, D.E.2    Chong, K.T.3
  • 106
    • 14444271777 scopus 로고    scopus 로고
    • HIV-1 resistant to multiple peptidemimetic protease inhibitors lack significant cross-resistance to the dihydropyrone inhibitors
    • Vancouver, Canada; Jul 11
    • Poppe SM, Slade D, Chong K et al. HIV-1 resistant to multiple peptidemimetic protease inhibitors lack significant cross-resistance to the dihydropyrone inhibitors. Paper presented at 11th International Conference on AIDS. Vancouver, Canada; 1996 Jul 11.
    • (1996) 11th International Conference on AIDS
    • Poppe, S.M.1    Slade, D.2    Chong, K.3
  • 107
    • 0028077638 scopus 로고
    • Structure-assisted design of nonpeptide human immunodeficiency virus-1 protease inhibitors
    • Rosé JR, Craik CS. Structure-assisted design of nonpeptide human immunodeficiency virus-1 protease inhibitors. Am J Respir Crit Care Med. 1994; 150:5176-82.
    • (1994) Am J Respir Crit Care Med. , vol.150 , pp. 5176-5182
    • Rosé, J.R.1    Craik, C.S.2
  • 108
    • 0029984203 scopus 로고    scopus 로고
    • Discovery of novel, nonpeptide HIV-1 protease inhibitors by pharmacophore searching
    • Wang S, Milne GWA, Van X et al. Discovery of novel, nonpeptide HIV-1 protease inhibitors by pharmacophore searching. J Med Chem. 1996; 39:2047-54.
    • (1996) J Med Chem. , vol.39 , pp. 2047-2054
    • Wang, S.1    Milne, G.W.A.2    Van, X.3
  • 110
    • 0030610689 scopus 로고    scopus 로고
    • 1-acid glycoprotein on the anti-human immunodeficiency virus (HIV) activity of the protease inhibitor CGP 61755: A comparative study with other relevant HIV protease inhibitors
    • 1-acid glycoprotein on the anti-human immunodeficiency virus (HIV) activity of the protease inhibitor CGP 61755: a comparative study with other relevant HIV protease inhibitors. J Infect Dis. 1997; 175:1063-70.
    • (1997) J Infect Dis. , vol.175 , pp. 1063-1070
    • Lazdins, J.K.1    Mestan, J.2    Goutte, G.3
  • 111
    • 0029962749 scopus 로고    scopus 로고
    • PH-sensitive nanoparticles: An effective means to improve the oral delivery of HIV-1 protease inhibitors in dogs
    • Leroux J-C, Cozens RM, Roesel JL et al. pH-sensitive nanoparticles: an effective means to improve the oral delivery of HIV-1 protease inhibitors in dogs. Pharm Res. 1996; 13:485-7.
    • (1996) Pharm Res. , vol.13 , pp. 485-487
    • Leroux, J.-C.1    Cozens, R.M.2    Roesel, J.L.3
  • 112
    • 14444272737 scopus 로고    scopus 로고
    • Nanoparticles as drug carrier for antiviral agents against HIV
    • Vancouver, Canada; Jul 8
    • Bender A, Immelmann A, Kreuter J et al. Nanoparticles as drug carrier for antiviral agents against HIV. Paper presented at 11th International Conference on AIDS. Vancouver, Canada; 1996 Jul 8.
    • (1996) 11th International Conference on AIDS
    • Bender, A.1    Immelmann, A.2    Kreuter, J.3
  • 114
    • 14444268964 scopus 로고    scopus 로고
    • Design, synthesis and biological properties of ABT-378, a highly potent HIV protease inhibitor
    • Washington, DC; Jan 24
    • Sham H, Kempf D, Molla A et al. Design, synthesis and biological properties of ABT-378, a highly potent HIV protease inhibitor. Paper presented at Fourth Conference on Retroviruses and Opportunistic Infections. Washington, DC; 1997 Jan 24.
    • (1997) Fourth Conference on Retroviruses and Opportunistic Infections
    • Sham, H.1    Kempf, D.2    Molla, A.3
  • 115
    • 0027521133 scopus 로고
    • CGP 53437, an orally bioavailable inhibitor of human immunodeficiency virus type 1 protease with potent antiviral activity
    • Alteri E, Bold G, Cozens R et al. CGP 53437, an orally bioavailable inhibitor of human immunodeficiency virus type 1 protease with potent antiviral activity. Antimicrob Agents Chemother. 1993; 37:2087-92.
    • (1993) Antimicrob Agents Chemother. , vol.37 , pp. 2087-2092
    • Alteri, E.1    Bold, G.2    Cozens, R.3
  • 117
    • 14444280857 scopus 로고    scopus 로고
    • Biological characterization of a novel HIV-protease inhibitor, CGP 70726, a representative of a new structural class
    • New Orleans, LA; Sep 15
    • Cozens RM. Biological characterization of a novel HIV-protease inhibitor, CGP 70726, a representative of a new structural class. Paper presented at 36th Interscience Conference on Antimicrobial Agents and Chemotherapy. New Orleans, LA; 1996 Sep 15.
    • (1996) 36th Interscience Conference on Antimicrobial Agents and Chemotherapy
    • Cozens, R.M.1
  • 118
    • 0030113025 scopus 로고    scopus 로고
    • Improved cyclic urea inhibitors of the HIV-1 protease: Synthesis, potency, resistance profile, human pharmacokinetics and x-ray crystal structure of DMP 450
    • Hodge CN, Aldrich PE, Bacheler LT et al. Improved cyclic urea inhibitors of the HIV-1 protease: synthesis, potency, resistance profile, human pharmacokinetics and x-ray crystal structure of DMP 450. Chem Biol. 1996; 3:301-14.
    • (1996) Chem Biol. , vol.3 , pp. 301-314
    • Hodge, C.N.1    Aldrich, P.E.2    Bacheler, L.T.3
  • 119
    • 14444282407 scopus 로고    scopus 로고
    • Discovery of potent, orally bioavailable, non-peptidic, cyclic sulfones as HIV protease inhibitors
    • Vancouver, Canada; Jul 8
    • Kim CU, McGee L, Krawczyk S et al. Discovery of potent, orally bioavailable, non-peptidic, cyclic sulfones as HIV protease inhibitors. Paper presented at 11th International Conference on AIDS. Vancouver, Canada; 1996 Jul 8.
    • (1996) 11th International Conference on AIDS
    • Kim, C.U.1    McGee, L.2    Krawczyk, S.3
  • 120
    • 0345400589 scopus 로고    scopus 로고
    • A Phase I trial of HIV protease inhibitor KNI-272 in patients with AIDS or symptomatic HIV infection
    • Vancouver, Canada; Jul 10
    • Humphrey RW, Nguyen B-Y, Wyvill KM et al. A Phase I trial of HIV protease inhibitor KNI-272 in patients with AIDS or symptomatic HIV infection. Paper presented at 11th International Conference on AIDS. Vancouver, Canada; 1996 Jul 10.
    • (1996) 11th International Conference on AIDS
    • Humphrey, R.W.1    Nguyen, B.-Y.2    Wyvill, K.M.3
  • 121
    • 14444287245 scopus 로고    scopus 로고
    • Analysis of HIV-1 variants resistant to irreversible protease inhibitors, LB71148 and LB71262
    • Vancouver, Canada; Jul 8
    • Lee TG, Kwon YD, Choi HI et al. Analysis of HIV-1 variants resistant to irreversible protease inhibitors, LB71148 and LB71262. Paper presented at 11th International Conference on AIDS. Vancouver, Canada; 1996 Jul 8.
    • (1996) 11th International Conference on AIDS
    • Lee, T.G.1    Kwon, Y.D.2    Choi, H.I.3
  • 122
    • 0029944321 scopus 로고    scopus 로고
    • Inhibitors of human immunodeficiency virus type 1 protease containing 2-aminobenzyl-substituted 4-amino-3-hydroxy-5-phenylpentanoic acid: Synthesis, activity, and oral bioavailability
    • Lehr P, Billich A, Charpiot B et al. Inhibitors of human immunodeficiency virus type 1 protease containing 2-aminobenzyl-substituted 4-amino-3-hydroxy-5-phenylpentanoic acid: synthesis, activity, and oral bioavailability. J Med Chem. 1996; 39:2060-7.
    • (1996) J Med Chem. , vol.39 , pp. 2060-2067
    • Lehr, P.1    Billich, A.2    Charpiot, B.3
  • 123
    • 0030902238 scopus 로고    scopus 로고
    • Antiviral properties of palinavir, a potent inhibitor of the human immunodeficiency virus type 1 protease
    • Lamarre D, Croteau G, Wardrop E et al. Antiviral properties of palinavir, a potent inhibitor of the human immunodeficiency virus type 1 protease. Antimicrob Agents Chemother. 1997; 41:965-71.
    • (1997) Antimicrob Agents Chemother. , vol.41 , pp. 965-971
    • Lamarre, D.1    Croteau, G.2    Wardrop, E.3
  • 124
    • 2642705996 scopus 로고    scopus 로고
    • The dihydropyrones: Third-generation, non-peptidic HIV protease inhibitor development candidates
    • Vancouver, Canada; Jul 9
    • Thaisrivongs S, Aristoff PA, Tarpley WG et al. The dihydropyrones: third-generation, non-peptidic HIV protease inhibitor development candidates. Paper presented at 11th International Conference on AIDS. Vancouver, Canada; 1996 Jul 9.
    • (1996) 11th International Conference on AIDS
    • Thaisrivongs, S.1    Aristoff, P.A.2    Tarpley, W.G.3


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