Design and synthesis of unsymmetrical peptidyl urea inhibitors of aspartic peptidases

Organic Letters

Volumn 3, Issue 15, 2001, Pages 2313-2316

  Dales, Natalie A ^a   Bohacek, Regine S ^b   Satyshur, Kenneth A ^a   Rich, Daniel H ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b ARIAD PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTIC PROTEINASE; DRUG DERIVATIVE; PEPSIN A; PEPTIDE; PROTEINASE INHIBITOR; RHIZOPUSPEPSIN; UREA;

ANIMAL; ARTICLE; CHEMISTRY; COMPUTER SIMULATION; DRUG ANTAGONISM; DRUG DESIGN; METABOLISM; PROTEIN CONFORMATION; STRUCTURE ACTIVITY RELATION; SWINE; SYNTHESIS; X RAY CRYSTALLOGRAPHY;

ANIMALS; ASPARTIC ENDOPEPTIDASES; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; PEPSIN A; PEPTIDES; PROTEASE INHIBITORS; PROTEIN CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP; SWINE; UREA;

EID: 0035954884     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol0160912     Document Type: Article

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