메뉴 건너뛰기




Volumn 8, Issue 7-8, 1998, Pages 362-378

The generation of carbohydrate-based combinatorial libraries for drug discovery

Author keywords

[No Author keywords available]

Indexed keywords

BENZODIAZEPINE DERIVATIVE; BIPHENYL DERIVATIVE; CYCLO(PROLYLPHENYLALANYL DEXTRO TRYPTOPHYLLYSYLTHREONYLPHENYLALANYL); DISACCHARIDE; MONOSACCHARIDE; NEUROKININ 1 RECEPTOR ANTAGONIST; NEW DRUG; SOMATOSTATIN DERIVATIVE; STEROID;

EID: 0032439916     PISSN: 10542523     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper
Times cited : (37)

References (24)
  • 1
    • 0028243847 scopus 로고
    • Applications of combinatorial technologies to drug discovery. 1 Background and peptide combinatorial libraries
    • Gallop, M.A.; Barrett, R.W.; Dower, W.J.; Fodor, S.P.A.; Gordon, E.M. Applications of Combinatorial Technologies to Drug Discovery. 1 Background and Peptide Combinatorial Libraries. J. Med. Chem. 1994, 37, 1233-1251.
    • (1994) J. Med. Chem. , vol.37 , pp. 1233-1251
    • Gallop, M.A.1    Barrett, R.W.2    Dower, W.J.3    Fodor, S.P.A.4    Gordon, E.M.5
  • 2
    • 0028318863 scopus 로고
    • Applications of combinatorial technologies to drug discovery. 2. Combinatorial organic synthesis, library screening strategies and future directions
    • Gordon, E.M.; Barrett, R.W.; Dower, W.J.; Fodor, S.P.A.; Gallop, M.A. Applications of Combinatorial Technologies to Drug Discovery. 2. Combinatorial Organic Synthesis, Library Screening Strategies and Future Directions. J. Med. Chem. 1994, 37, 1385-1400.
    • (1994) J. Med. Chem. , vol.37 , pp. 1385-1400
    • Gordon, E.M.1    Barrett, R.W.2    Dower, W.J.3    Fodor, S.P.A.4    Gallop, M.A.5
  • 6
    • 0030932342 scopus 로고    scopus 로고
    • Solid phase synthesis of 1, 4-Benzodiazepine-2, 5-diones. Library preparation and demonstration of synthesis generality
    • Boojamra, C.G.; Burow, K.M.; Thompson, L.A.; Ellman, J.A. Solid Phase Synthesis of 1, 4-Benzodiazepine-2, 5-diones. Library Preparation and Demonstration of Synthesis Generality. J. Org. Chem. 1997, 62, 1240-1256.
    • (1997) J. Org. Chem. , vol.62 , pp. 1240-1256
    • Boojamra, C.G.1    Burow, K.M.2    Thompson, L.A.3    Ellman, J.A.4
  • 7
    • 0029146716 scopus 로고
    • Solid-phase synthesis of defined 1,4-benzodiazepine-2, 5-dione mixtures
    • Goff, D.A.; Zuckermann, R.N. Solid-Phase Synthesis of Defined 1,4-Benzodiazepine-2, 5-dione Mixtures. J. Org. Chem. 1995, 60, 5744-5745.
    • (1995) J. Org. Chem. , vol.60 , pp. 5744-5745
    • Goff, D.A.1    Zuckermann, R.N.2
  • 9
    • 0025997018 scopus 로고
    • Medicinal chemistry in the golden age of biology: Lessons from steroid and peptide research
    • Hirschmann, R. Medicinal Chemistry in the Golden Age of Biology: Lessons from Steroid and Peptide Research. Angew. Chem. Int. Ed. Engl. 1991, 30, 1278-1301.
    • (1991) Angew. Chem. Int. Ed. Engl. , vol.30 , pp. 1278-1301
    • Hirschmann, R.1
  • 10
    • 84982506235 scopus 로고
    • The first design and synthesis of a steroidal peptidomimetic. The potential value of peptideomimetics in elucidating the bioactive confirmation of peptide ligands
    • Hirschmann, R.; Sprengeler, P.A.; Kawasaki, T.; Leahy, J.W.; Shakespeare, W.C.; Smith III, A.B. The First Design and Synthesis of a Steroidal Peptidomimetic. The Potential Value of Peptideomimetics in Elucidating the Bioactive Confirmation of Peptide Ligands. J. Am. Chem. Soc. 1992, 114, 9699-9701.
    • (1992) J. Am. Chem. Soc. , vol.114 , pp. 9699-9701
    • Hirschmann, R.1    Sprengeler, P.A.2    Kawasaki, T.3    Leahy, J.W.4    Shakespeare, W.C.5    Smith A.B. III6
  • 14
    • 0021886542 scopus 로고
    • A diastereospecific, non-racemic synthesis of a novel β-hydroxy-δ-lactone hmg-coa reductase inhibitor
    • Sletzinger, M.; Verhoeven, T.R.; Volante, R.P.; McNamara, J.M.; Corley, E.G.; Liu, T.M.H. A Diastereospecific, Non-Racemic Synthesis of a Novel β-Hydroxy-δ-Lactone HMG-CoA Reductase Inhibitor. Tet. Lett. 1985, 26, 2951-2954.
    • (1985) Tet. Lett. , vol.26 , pp. 2951-2954
    • Sletzinger, M.1    Verhoeven, T.R.2    Volante, R.P.3    McNamara, J.M.4    Corley, E.G.5    Liu, T.M.H.6
  • 15
    • 0025165652 scopus 로고
    • Phosphorus-containing inhibitors of HMG-CoA reductase. 1. 4-[(2-arylethyl) hydroxy phosphinyl] -3-hydroxybutanoic acids: A new class of cell-selective inhibitors of cholesterol biosynthesis
    • Karanewsky, D.S.; Badia, M.C.; Ciosek, C.P.; Robl, J.A.; Sofia, M.J.; Simpkins, L.M.; DeLange, B.; Harrity, T.W.; Biller, S.A.; Gordon, E.M. Phosphorus-Containing Inhibitors of HMG-CoA Reductase. 1. 4-[(2-Arylethyl) hydroxy phosphinyl] -3-hydroxybutanoic Acids: A New Class of Cell-Selective Inhibitors of Cholesterol Biosynthesis. J. Med. Chem. 1990, 33, 2952-2956.
    • (1990) J. Med. Chem. , vol.33 , pp. 2952-2956
    • Karanewsky, D.S.1    Badia, M.C.2    Ciosek, C.P.3    Robl, J.A.4    Sofia, M.J.5    Simpkins, L.M.6    Delange, B.7    Harrity, T.W.8    Biller, S.A.9    Gordon, E.M.10
  • 19
    • 0026470597 scopus 로고
    • Nonpeptidal peptidomimetics with a β-d-glucose scaffolding
    • A Partial Somatostatin Agonist Bearing a Close Structural Relationship to a Potent, Selective Substance P Antagonist
    • Hirschmann, R.; Nicolaou, K.C.; Pietranico, S.; Salvino, J.; Leahy, E.M.; Sprengler, P.A.; Furst, G.; Smith III, A.B. NonPeptidal Peptidomimetics with a β-D-Glucose Scaffolding. A Partial Somatostatin Agonist Bearing a Close Structural Relationship to a Potent, Selective Substance P Antagonist. J. Am. Chem. Soc. 1992, 114, 9218-9220.
    • (1992) J. Am. Chem. Soc. , vol.114 , pp. 9218-9220
    • Hirschmann, R.1    Nicolaou, K.C.2    Pietranico, S.3    Salvino, J.4    Leahy, E.M.5    Sprengler, P.A.6    Furst, G.7    Smith A.B. III8
  • 21
    • 15844372436 scopus 로고    scopus 로고
    • Synthesis of potent cyclic hexapeptide NK-1 antagonists. Use of a minilibrary in transforming a peptidal somatostatin receptor ligand into an NK-1 receptor ligand via a polyvalent peptidomimetic
    • Hirschmann, R.; Yao, W.; Cascieri, M.A.; Strader, C.D.; Maechler, L.; Cichy-Knight, M.A.; Hynes, Jr., J.; van Rijn, R.D.; Sprengler, P.A.; Smith III, A.B. Synthesis of Potent Cyclic Hexapeptide NK-1 Antagonists. Use of a Minilibrary in Transforming a Peptidal Somatostatin Receptor Ligand into an NK-1 Receptor Ligand via a Polyvalent Peptidomimetic. J. Med. Chem. 1996, 39, 2441-2448.
    • (1996) J. Med. Chem. , vol.39 , pp. 2441-2448
    • Hirschmann, R.1    Yao, W.2    Cascieri, M.A.3    Strader, C.D.4    Maechler, L.5    Cichy-Knight, M.A.6    Hynes J., Jr.7    Van Rijn, R.D.8    Sprengler, P.A.9    Smith A.B. III10
  • 22
    • 0000845917 scopus 로고    scopus 로고
    • Carbohydrate-based small-molecule scaffolds for the construction of universal pharmacophore mapping libraries
    • Sofia, M.J.; Hunter, R.; Chan, T.Y.; Vaughan, A.; Dulina, R.; Wang, H.; Gange, D. Carbohydrate-Based Small-Molecule Scaffolds for the Construction of Universal Pharmacophore Mapping Libraries. J. Org. Chem. 1998, 63, 2802-2803.
    • (1998) J. Org. Chem. , vol.63 , pp. 2802-2803
    • Sofia, M.J.1    Hunter, R.2    Chan, T.Y.3    Vaughan, A.4    Dulina, R.5    Wang, H.6    Gange, D.7
  • 24
    • 0344715722 scopus 로고    scopus 로고
    • Unpublished results from these laboratories
    • Unpublished results from these laboratories.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.