메뉴 건너뛰기




Volumn 48, Issue 6, 2000, Pages 518-530

Signaling: Cellular insights into the pathophysiology of bipolar disorder

Author keywords

Bipolar disorder; G proteins; Grotein kinase A; Lithium; protein kinase C; Signal transduction

Indexed keywords

AMPHETAMINE; ANTIDEPRESSANT AGENT; BRAIN MONOAMINE; CARBAMAZEPINE; COCAINE; CYCLIC AMP; DEXAMETHASONE; G PROTEIN COUPLED RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; LITHIUM; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR;

EID: 0034666355     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3223(00)00929-X     Document Type: Review
Times cited : (182)

References (92)
  • 1
    • 0342445420 scopus 로고    scopus 로고
    • A preliminary investigation of a protein kinase C inhibitor (tamoxifen) in the treatment of acute mania
    • Bebchuk J.M., Arfken C.L., Dolan-Manji S., Murphy J., Manji H.K. A preliminary investigation of a protein kinase C inhibitor (tamoxifen) in the treatment of acute mania. Arch Gen Psychiatry. 57:2000;95-97.
    • (2000) Arch Gen Psychiatry , vol.57 , pp. 95-97
    • Bebchuk, J.M.1    Arfken, C.L.2    Dolan-Manji, S.3    Murphy, J.4    Manji, H.K.5
  • 2
    • 0034666043 scopus 로고    scopus 로고
    • Are schizophrenic and bipolar disorders related? A review of family and molecular studies
    • Berrettini W.H. Are schizophrenic and bipolar disorders related? A review of family and molecular studies. Biol Psychiatry. 48:2000;531-538.
    • (2000) Biol Psychiatry , vol.48 , pp. 531-538
    • Berrettini, W.H.1
  • 3
    • 0033555859 scopus 로고    scopus 로고
    • Emergent properties of networks of biological signaling pathways
    • Bhalla U.S., Iyengar R. Emergent properties of networks of biological signaling pathways. Science. 283:(5400):1999;381-387.
    • (1999) Science , vol.283 , Issue.5400 , pp. 381-387
    • Bhalla, U.S.1    Iyengar, R.2
  • 4
    • 0027351998 scopus 로고
    • Molecular machines integrate coincident synaptic signals
    • Bourne H.R., Nicoll R. Molecular machines integrate coincident synaptic signals. Cell. 72:(suppl):1993;65-75.
    • (1993) Cell , vol.72 , Issue.SUPPL , pp. 65-75
    • Bourne, H.R.1    Nicoll, R.2
  • 5
    • 0002437618 scopus 로고    scopus 로고
    • Toward an integrated biological model of bipolar disorder
    • L.T. Young, & R.T. Joffe. New York: Marcel Dekker
    • Bowden C.L. Toward an integrated biological model of bipolar disorder. Young L.T., Joffe R.T. Bipolar Disorder Biological Models and Their Clinical Application . 1997;235-254 Marcel Dekker, New York.
    • (1997) Bipolar Disorder: Biological Models and Their Clinical Application , pp. 235-254
    • Bowden, C.L.1
  • 6
    • 0033970107 scopus 로고    scopus 로고
    • Molecular clock genes in man and lower animals. Possible implications for circadian abnormalities in depression
    • Bunney W.E., Bunney B.G. Molecular clock genes in man and lower animals. Possible implications for circadian abnormalities in depression. Neuropsychopharmacology. 22:2000;335-345.
    • (2000) Neuropsychopharmacology , vol.22 , pp. 335-345
    • Bunney, W.E.1    Bunney, B.G.2
  • 7
    • 0032830190 scopus 로고    scopus 로고
    • Regulation of signal transduction pathways and gene expression by mood stabilizers and antidepressants
    • Chen G., Hasanat K.A., Bebchuk J.M., Moore G.J., Glitz D., Manji H.K. Regulation of signal transduction pathways and gene expression by mood stabilizers and antidepressants. Psychosom Med. 61:1999;599-617.
    • (1999) Psychosom Med , vol.61 , pp. 599-617
    • Chen, G.1    Hasanat, K.A.2    Bebchuk, J.M.3    Moore, G.J.4    Glitz, D.5    Manji, H.K.6
  • 8
    • 0029848644 scopus 로고    scopus 로고
    • Attenuation of adenylyl cyclases by carbamazepine in vitro
    • Chen G., Hawver D., Wright C., Potter W.Z., Manji H.K. Attenuation of adenylyl cyclases by carbamazepine in vitro. J Neurochem. 67:1996;2079-2086.
    • (1996) J Neurochem , vol.67 , pp. 2079-2086
    • Chen, G.1    Hawver, D.2    Wright, C.3    Potter, W.Z.4    Manji, H.K.5
  • 9
    • 0034280804 scopus 로고    scopus 로고
    • Lithium regulates PKC-mediated intracellular cross-talk and gene expression in the CNS in vivo
    • (in press):
    • Chen G, Masana M, Manji HK (in press): Lithium regulates PKC-mediated intracellular cross-talk and gene expression in the CNS in vivo. Bipolar Disord.
    • Bipolar Disord.
    • Chen, G.1    Masana, M.2    Manji, H.K.3
  • 11
    • 0025719210 scopus 로고
    • Chronic lithium regulates the expression of adenylate cyclase and Gi-protein alpha subunit in rat cerebral cortex
    • Colin S.F., Chang H.C., Mollner S., Pfeuffer T., Reed R.R., Duman R.S., Nestler E.J. Chronic lithium regulates the expression of adenylate cyclase and Gi-protein alpha subunit in rat cerebral cortex. Proc Natl Acad Sci U S A. 88:1991;10634-10637.
    • (1991) Proc Natl Acad Sci U S a , vol.88 , pp. 10634-10637
    • Colin, S.F.1    Chang, H.C.2    Mollner, S.3    Pfeuffer, T.4    Reed, R.R.5    Duman, R.S.6    Nestler, E.J.7
  • 12
    • 0025869265 scopus 로고
    • Long-lasting change in the membrane-associated protein kinase C activity in the hippocampal kindled rat
    • Daigen A., Akiyama K., Otsuki S. Long-lasting change in the membrane-associated protein kinase C activity in the hippocampal kindled rat. Brain Res. 545:1991;131-136.
    • (1991) Brain Res , vol.545 , pp. 131-136
    • Daigen, A.1    Akiyama, K.2    Otsuki, S.3
  • 13
    • 0002999524 scopus 로고
    • A two-dimensional threshold model of seasonal bipolar affective disorder
    • D. Magnusson, & A. Ohman. Orlando, FL: Academic Press
    • Depue R.A., Karuss S.P., Spoont M.R. A two-dimensional threshold model of seasonal bipolar affective disorder. Magnusson D., Ohman A. Psychopathology An International Perspective . 1987;95-123 Academic Press, Orlando, FL.
    • (1987) Psychopathology: An International Perspective , pp. 95-123
    • Depue, R.A.1    Karuss, S.P.2    Spoont, M.R.3
  • 14
    • 0026065035 scopus 로고
    • Differential effect of lithium on fos protooncogene expression mediated by receptor and postreceptor activators of protein kinase C and cyclic adenosine monophosphate: Model for its antimanic action
    • Divish M.M., Sheftel G., Boyle A., Kalasapudi V.D., Papolos D.F., Lachman H.M. Differential effect of lithium on fos protooncogene expression mediated by receptor and postreceptor activators of protein kinase C and cyclic adenosine monophosphate model for its antimanic action . J Neurosci Res. 28:1991;40-48.
    • (1991) J Neurosci Res , vol.28 , pp. 40-48
    • Divish, M.M.1    Sheftel, G.2    Boyle, A.3    Kalasapudi, V.D.4    Papolos, D.F.5    Lachman, H.M.6
  • 15
    • 0032576396 scopus 로고    scopus 로고
    • Increased temporal cortex CREB concentrations and antidepressant treatment in major depression
    • Dowlatshahi D., MacQueen G.M., Wang J.F., Young L.T. Increased temporal cortex CREB concentrations and antidepressant treatment in major depression. Lancet. 2352:(9142):1998;1754-1755.
    • (1998) Lancet , vol.2352 , Issue.9142 , pp. 1754-1755
    • Dowlatshahi, D.1    MacQueen, G.M.2    Wang, J.F.3    Young, L.T.4
  • 17
    • 0026579550 scopus 로고
    • The calcium second messenger system in bipolar disorders: Data supporting new research directions
    • Dubovsky S., Murphy J., Christiano J., Lee C. The calcium second messenger system in bipolar disorders Data supporting new research directions . J Neuropsychiatry Clin Neurosci. 4:1992;3-14.
    • (1992) J Neuropsychiatry Clin Neurosci , vol.4 , pp. 3-14
    • Dubovsky, S.1    Murphy, J.2    Christiano, J.3    Lee, C.4
  • 19
    • 0022997635 scopus 로고
    • The cyclic AMP second messenger system in man: The effects of heredity, hormones, drugs, aluminum, age and disease on signal amplification
    • Ebstein R.P., Oppenheim G., Ebstein B.S., Amiri Z., Stessman J. The cyclic AMP second messenger system in man The effects of heredity, hormones, drugs, aluminum, age and disease on signal amplification . Prog Neuropsychopharmacol Biol Psychiatry. 10:1986;323-353.
    • (1986) Prog Neuropsychopharmacol Biol Psychiatry , vol.10 , pp. 323-353
    • Ebstein, R.P.1    Oppenheim, G.2    Ebstein, B.S.3    Amiri, Z.4    Stessman, J.5
  • 20
    • 0023680941 scopus 로고
    • Social zeitgebers and biological rhythms. A unified approach to understanding the etiology of depression
    • Ehlers C.L., Frank E., Kupfer D.J. Social zeitgebers and biological rhythms. A unified approach to understanding the etiology of depression. Arch Gen Psychiatry. 45:1988;948-952.
    • (1988) Arch Gen Psychiatry , vol.45 , pp. 948-952
    • Ehlers, C.L.1    Frank, E.2    Kupfer, D.J.3
  • 21
    • 0001926958 scopus 로고    scopus 로고
    • Animal models of bipolar disorder: From a single episode to progressive cycling models
    • (in press): In: Myslobodsky MS, Weiner I, editors. Boston: Kluwer Academic
    • Einat H, Kofman O, Belmaker RH (in press): Animal models of bipolar disorder: From a single episode to progressive cycling models. In: Myslobodsky MS, Weiner I, editors. Contemporary Issues in Modeling Psychopathology. Boston: Kluwer Academic.
    • Contemporary Issues in Modeling Psychopathology
    • Einat, H.1    Kofman, O.2    Belmaker, R.H.3
  • 22
    • 0025893280 scopus 로고
    • Receptor coupling to G proteins: Interactions not affected by lithium
    • Ellis J., Lenox R.H. Receptor coupling to G proteins Interactions not affected by lithium . Lithium. 2:1991;141-147.
    • (1991) Lithium , vol.2 , pp. 141-147
    • Ellis, J.1    Lenox, R.H.2
  • 23
    • 0030997903 scopus 로고    scopus 로고
    • High intracellular calcium concentrations in transformed lymphoblasts from subjects with bipolar I disorder
    • Emamghoreishi M., Schlichter L., Li P.P., Parikh S., Sen J., Kamble A., Warsh J.J. High intracellular calcium concentrations in transformed lymphoblasts from subjects with bipolar I disorder. Am J Psychiatry. 154:1997;976-982.
    • (1997) Am J Psychiatry , vol.154 , pp. 976-982
    • Emamghoreishi, M.1    Schlichter, L.2    Li, P.P.3    Parikh, S.4    Sen, J.5    Kamble, A.6    Warsh, J.J.7
  • 24
    • 0032844695 scopus 로고    scopus 로고
    • Increased cyclic AMP-dependent protein kinase activity in postmortem brain from patients with bipolar affective disorder
    • Fields A., Li P.P., Kish S.J., Warsh J.J. Increased cyclic AMP-dependent protein kinase activity in postmortem brain from patients with bipolar affective disorder. J Neurochem. 73:1999;1704-1710.
    • (1999) J Neurochem , vol.73 , pp. 1704-1710
    • Fields, A.1    Li, P.P.2    Kish, S.J.3    Warsh, J.J.4
  • 25
    • 0027278902 scopus 로고
    • Altered platelet protein kinase C activity in bipolar affective disorder, manic episode
    • Friedman E., Hoau Y.W., Levinson D., Connell T.A., Singh H. Altered platelet protein kinase C activity in bipolar affective disorder, manic episode. Biol Psychiatry. 33:1993;520-525.
    • (1993) Biol Psychiatry , vol.33 , pp. 520-525
    • Friedman, E.1    Hoau, Y.W.2    Levinson, D.3    Connell, T.A.4    Singh, H.5
  • 26
    • 0029796167 scopus 로고    scopus 로고
    • Receptor-mediated activation of G proteins is increased in postmortem brains of bipolar affective disorder subjects
    • Friedman E., Wang H.Y. Receptor-mediated activation of G proteins is increased in postmortem brains of bipolar affective disorder subjects. J Neurochem. 67:1996;1145-1152.
    • (1996) J Neurochem , vol.67 , pp. 1145-1152
    • Friedman, E.1    Wang, H.Y.2
  • 28
    • 0001970461 scopus 로고
    • Neuroendocrinology of mood disorders
    • F.E. Bloom, & D.J. Kupfer. New York: Raven
    • Holsboer F. Neuroendocrinology of mood disorders. Bloom F.E., Kupfer D.J. Psychopharmacology The Fourth Generation of Progress . 1995;957-969 Raven, New York.
    • (1995) Psychopharmacology: The Fourth Generation of Progress , pp. 957-969
    • Holsboer, F.1
  • 29
    • 0033031651 scopus 로고    scopus 로고
    • Elevated basal and thapsigargin stimulated intracellular calcium of platelets and lymphocytes from bipolar affective disorder patients measured by a fluorometric microassay
    • Hough C., Lu S.J., Davis C.L., Chuang D.M., Post R.M. Elevated basal and thapsigargin stimulated intracellular calcium of platelets and lymphocytes from bipolar affective disorder patients measured by a fluorometric microassay. Biol Psychiatry. 46:1999;247-255.
    • (1999) Biol Psychiatry , vol.46 , pp. 247-255
    • Hough, C.1    Lu, S.J.2    Davis, C.L.3    Chuang, D.M.4    Post, R.M.5
  • 30
    • 0032870743 scopus 로고    scopus 로고
    • Molecular mechanisms underlying mood-stabilization in manic-depressive illness: The phenotype challenge
    • Ikonomov O., Manji H.K. Molecular mechanisms underlying mood-stabilization in manic-depressive illness The phenotype challenge . Am J Psychiatry. 156:1999;1506-1514.
    • (1999) Am J Psychiatry , vol.156 , pp. 1506-1514
    • Ikonomov, O.1    Manji, H.K.2
  • 31
    • 0033999332 scopus 로고    scopus 로고
    • Increased adenylyl cyclase type 1 mRNA, but not adenylyl cyclase type 2 in the rat hippocampus following antidepressant treatment
    • Jensen J.B., Mikkelsen J.D., Mork A. Increased adenylyl cyclase type 1 mRNA, but not adenylyl cyclase type 2 in the rat hippocampus following antidepressant treatment. Eur Neuropsychopharmacol. 10:2000;105-111.
    • (2000) Eur Neuropsychopharmacol , vol.10 , pp. 105-111
    • Jensen, J.B.1    Mikkelsen, J.D.2    Mork, A.3
  • 32
    • 0032947795 scopus 로고    scopus 로고
    • Anti-bipolar therapy: Mechanism of action of lithium
    • Jope R.S. Anti-bipolar therapy Mechanism of action of lithium . Mol Psychiatry. 4:1999;117-128.
    • (1999) Mol Psychiatry , vol.4 , pp. 117-128
    • Jope, R.S.1
  • 33
    • 0033013011 scopus 로고    scopus 로고
    • A bimodal model of the mechanism of action of lithium
    • Jope R.S. A bimodal model of the mechanism of action of lithium. Mol Psychiatry. 4:1999;21-25.
    • (1999) Mol Psychiatry , vol.4 , pp. 21-25
    • Jope, R.S.1
  • 34
    • 0028219225 scopus 로고
    • Lithium and brain signal transduction systems
    • Jope R.S., Williams M.B. Lithium and brain signal transduction systems. Biochem Pharmacol. 77:1994;429-441.
    • (1994) Biochem Pharmacol , vol.77 , pp. 429-441
    • Jope, R.S.1    Williams, M.B.2
  • 35
    • 0031933722 scopus 로고    scopus 로고
    • Protein kinase C inhibitors block amphetamine-mediated dopamine release in rat striatal slices
    • Kantor L., Gnegy M.E. Protein kinase C inhibitors block amphetamine-mediated dopamine release in rat striatal slices. J Pharmacol Exp Ther. 284:1998;592-598.
    • (1998) J Pharmacol Exp Ther , vol.284 , pp. 592-598
    • Kantor, L.1    Gnegy, M.E.2
  • 36
    • 0031973757 scopus 로고    scopus 로고
    • Lithium, but not carbamazepine, potentiates hyperactivity induced by intra-accumbens cholera toxin
    • Kofman O., Li P.P., Warsh J.J. Lithium, but not carbamazepine, potentiates hyperactivity induced by intra-accumbens cholera toxin. Pharmacol Biochem Behav. 59:1998;191-200.
    • (1998) Pharmacol Biochem Behav , vol.59 , pp. 191-200
    • Kofman, O.1    Li, P.P.2    Warsh, J.J.3
  • 37
    • 0023461332 scopus 로고
    • Role of receptor coupling to phosphoinositide metabolism in the therapeutic action of lithium
    • Lenox R.H. Role of receptor coupling to phosphoinositide metabolism in the therapeutic action of lithium. Adv Exp Med Biol. 221:1987;515-530.
    • (1987) Adv Exp Med Biol , vol.221 , pp. 515-530
    • Lenox, R.H.1
  • 39
    • 0028219446 scopus 로고
    • Lithium and the brain: A psychopharmacological strategy to a molecular basis for manic depressive illness
    • Lenox R.H., Watson D.G. Lithium and the brain A psychopharmacological strategy to a molecular basis for manic depressive illness . Clin Chem. 40:1994;309-314.
    • (1994) Clin Chem , vol.40 , pp. 309-314
    • Lenox, R.H.1    Watson, D.G.2
  • 40
    • 0026567408 scopus 로고
    • Chronic lithium administration alters a prominent PKC substrate in rat hippocampus
    • Lenox R.H., Watson D.G., Patel J., Ellis J. Chronic lithium administration alters a prominent PKC substrate in rat hippocampus. Brain Res. 570:1992;333-340.
    • (1992) Brain Res , vol.570 , pp. 333-340
    • Lenox, R.H.1    Watson, D.G.2    Patel, J.3    Ellis, J.4
  • 41
    • 0029045714 scopus 로고
    • Relationship between Rap1 protein phosphorylation and regulation of Ca2+ transport in platelets: A new approach
    • Magnier C., Corvazier E., Aumont M.C., Le Jemtel T.H., Enouf J. Relationship between Rap1 protein phosphorylation and regulation of Ca2+ transport in platelets A new approach . Biochem J. 310:1995;469-475.
    • (1995) Biochem J , vol.310 , pp. 469-475
    • Magnier, C.1    Corvazier, E.2    Aumont, M.C.3    Le Jemtel, T.H.4    Enouf, J.5
  • 42
    • 0002066894 scopus 로고
    • The stability of constrained randomness: Lithium prophylaxis at several neurobiological levels
    • R.M. Post, & J.C. Ballenger. Baltimore: Williams & Wilkins
    • Mandell A.J., Knapp S., Ehlers C., Russo P.V. The stability of constrained randomness Lithium prophylaxis at several neurobiological levels . Post R.M., Ballenger J.C. Neurobiology of Mood Disorders. 1984;744-776 Williams & Wilkins, Baltimore.
    • (1984) Neurobiology of Mood Disorders , pp. 744-776
    • Mandell, A.J.1    Knapp, S.2    Ehlers, C.3    Russo, P.V.4
  • 43
    • 0026623287 scopus 로고
    • G proteins: Implications for psychiatry
    • Manji H.K. G proteins Implications for psychiatry . Am J Psychiatry. 149:1992;746-760.
    • (1992) Am J Psychiatry , vol.149 , pp. 746-760
    • Manji, H.K.1
  • 44
    • 0001779170 scopus 로고    scopus 로고
    • Regulation of signal transduction pathways by mood stabilizing agents: Implications for the pathophysiology and treatment of bipolar affective disorder
    • H.K. Manji, C.L. Bowden, & R.H. Belmaker. Washington, DC: American Psychiatric Press
    • Manji H.K., Chen G., Hsiao J.K., Masana M.I., Moore G.J., Potter W.Z. Regulation of signal transduction pathways by mood stabilizing agents Implications for the pathophysiology and treatment of bipolar affective disorder . Manji H.K., Bowden C.L., Belmaker R.H. Bipolar Medications Mechanisms of Action . 2000;129-177 American Psychiatric Press, Washington, DC.
    • (2000) Bipolar Medications: Mechanisms of Action , pp. 129-177
    • Manji, H.K.1    Chen, G.2    Hsiao, J.K.3    Masana, M.I.4    Moore, G.J.5    Potter, W.Z.6
  • 45
    • 0033570745 scopus 로고    scopus 로고
    • Protein kinase C signaling in the brain: Molecular transduction of mood stabilization in the treatment of bipolar disorder
    • Manji H.K., Lenox R.H. Protein kinase C signaling in the brain Molecular transduction of mood stabilization in the treatment of bipolar disorder . Biol Psychiatry. 46:1999;1328-1351.
    • (1999) Biol Psychiatry , vol.46 , pp. 1328-1351
    • Manji, H.K.1    Lenox, R.H.2
  • 46
    • 0032827466 scopus 로고    scopus 로고
    • Lithium at 50: Have the neuroprotective effects of this unique cation been overlooked?
    • Manji H.K., Moore G.J., Chen G. Lithium at 50 Have the neuroprotective effects of this unique cation been overlooked? Biol Psychiatry. 46:1999;929-940.
    • (1999) Biol Psychiatry , vol.46 , pp. 929-940
    • Manji, H.K.1    Moore, G.J.2    Chen, G.3
  • 47
    • 0034667299 scopus 로고    scopus 로고
    • Clinical and preclinical evidence for the neurotrophic effects of mood-stabilizing agents: Implications for the pathophysiology and treatment of manic-depressive illness
    • (in press):
    • Manji HK, Moore GJ, Chen G (in press): Clinical and preclinical evidence for the neurotrophic effects of mood-stabilizing agents: Implications for the pathophysiology and treatment of manic-depressive illness. Biol Psychiatry.
    • Biol Psychiatry
    • Manji, H.K.1    Moore, G.J.2    Chen, G.3
  • 49
    • 0026703789 scopus 로고
    • In vivo evidence that lithium inactivates Gi modulation of adenylate cyclase in brain
    • Masana M.I., Bitran J.A., Hsiao J.K., Potter W.Z. In vivo evidence that lithium inactivates Gi modulation of adenylate cyclase in brain. J Neurochem. 59:1992;200-205.
    • (1992) J Neurochem , vol.59 , pp. 200-205
    • Masana, M.I.1    Bitran, J.A.2    Hsiao, J.K.3    Potter, W.Z.4
  • 50
    • 0030992613 scopus 로고    scopus 로고
    • Increased G alpha q/11 immunoreactivity in postmortem occipital cortex from patients with bipolar affective disorder
    • Mathews R., Li P.P., Young L.T., Kish S.J., Warsh J.J. Increased G alpha q/11 immunoreactivity in postmortem occipital cortex from patients with bipolar affective disorder. Biol Psychiatry. 41:1997;649-656.
    • (1997) Biol Psychiatry , vol.41 , pp. 649-656
    • Mathews, R.1    Li, P.P.2    Young, L.T.3    Kish, S.J.4    Warsh, J.J.5
  • 52
    • 0032523206 scopus 로고    scopus 로고
    • Signal transduction by platelet adenylate cyclase: Alterations in depressed patients may reflect impairment in the coordinated integration of cellular signals (coincidence detection)
    • Mooney J.J., Samson J.A., McHale N.L., Colodzin R., Alpert J., Koutsos M., Schildkraut J.J. Signal transduction by platelet adenylate cyclase Alterations in depressed patients may reflect impairment in the coordinated integration of cellular signals (coincidence detection) . Biol Psychiatry. 43:1998;574-583.
    • (1998) Biol Psychiatry , vol.43 , pp. 574-583
    • Mooney, J.J.1    Samson, J.A.2    McHale, N.L.3    Colodzin, R.4    Alpert, J.5    Koutsos, M.6    Schildkraut, J.J.7
  • 53
    • 0032744013 scopus 로고    scopus 로고
    • Temporal dissociation between lithium-induced CNS myo-inositol changes and clinical response in manic-depressive illness
    • Moore G.J., Bebchuk J.M., Parrish J.K., Faulk M.W., Arfken C.L., Strahl-Bevacqua J., Manji H.K. Temporal dissociation between lithium-induced CNS myo-inositol changes and clinical response in manic-depressive illness. Am J Psychiatry. 156:1999;1902-1908.
    • (1999) Am J Psychiatry , vol.156 , pp. 1902-1908
    • Moore, G.J.1    Bebchuk, J.M.2    Parrish, J.K.3    Faulk, M.W.4    Arfken, C.L.5    Strahl-Bevacqua, J.6    Manji, H.K.7
  • 55
    • 0024504074 scopus 로고
    • The effects of lithium in vitro and ex vivo on adenylate cyclase in brain are exerted by distinct mechanisms
    • Mork A., Geisler A. The effects of lithium in vitro and ex vivo on adenylate cyclase in brain are exerted by distinct mechanisms. Neuropharmacology. 28:1989;307-311.
    • (1989) Neuropharmacology , vol.28 , pp. 307-311
    • Mork, A.1    Geisler, A.2
  • 56
    • 0027007777 scopus 로고
    • Effects of lithium on second messenger systems in the brain
    • Mork A., Geisler A., Hollund P. Effects of lithium on second messenger systems in the brain. Pharmacol Toxicol. 71:(suppl 1):1992;4-17.
    • (1992) Pharmacol Toxicol , vol.71 , Issue.SUPPL. 1 , pp. 4-17
    • Mork, A.1    Geisler, A.2    Hollund, P.3
  • 57
    • 0024465747 scopus 로고
    • Chronic antidepressant administration alters the subcellular distribution of cyclic AMP-dependent protein kinase in rat frontal cortex
    • Nestler E.J., Terwilliger R.Z., Duman R.S. Chronic antidepressant administration alters the subcellular distribution of cyclic AMP-dependent protein kinase in rat frontal cortex. J Neurochem. 53:1989;1644-1647.
    • (1989) J Neurochem , vol.53 , pp. 1644-1647
    • Nestler, E.J.1    Terwilliger, R.Z.2    Duman, R.S.3
  • 58
    • 0028934406 scopus 로고
    • Regulation of endogenous ADP-ribosylation by acute and chronic lithium in rat brain
    • Nestler E.J., Terwilliger R.Z., Duman R.S. Regulation of endogenous ADP-ribosylation by acute and chronic lithium in rat brain. J Neurochem. 64:1995;2319-2324.
    • (1995) J Neurochem , vol.64 , pp. 2319-2324
    • Nestler, E.J.1    Terwilliger, R.Z.2    Duman, R.S.3
  • 59
    • 0025038304 scopus 로고
    • Chronic cocaine treatment decreases levels of the G protein subunits Gi alpha and Go alpha in discrete regions of rat brain
    • Nestler E.J., Terwilliger R.Z., Walker J.R., Sevarino K.A., Duman R.S. Chronic cocaine treatment decreases levels of the G protein subunits Gi alpha and Go alpha in discrete regions of rat brain. J Neurochem. 55:1990;1079-1082.
    • (1990) J Neurochem , vol.55 , pp. 1079-1082
    • Nestler, E.J.1    Terwilliger, R.Z.2    Walker, J.R.3    Sevarino, K.A.4    Duman, R.S.5
  • 60
    • 0023093402 scopus 로고
    • Effects of lithium in vitro and ex vivo on components of the adenylate cyclase system in membranes from the cerebral cortex of the rat
    • Newman M.E., Belmaker R.H. Effects of lithium in vitro and ex vivo on components of the adenylate cyclase system in membranes from the cerebral cortex of the rat. Neuropharmacology. 26:1987;211-217.
    • (1987) Neuropharmacology , vol.26 , pp. 211-217
    • Newman, M.E.1    Belmaker, R.H.2
  • 61
    • 0030723121 scopus 로고    scopus 로고
    • Effect of lithium on transcription factor binding in cultured cerebellar granule cells and the brain of rats
    • Ozaki N., Chuang D.-M. Effect of lithium on transcription factor binding in cultured cerebellar granule cells and the brain of rats. J Neurochem. 69:1997;2336-2344.
    • (1997) J Neurochem , vol.69 , pp. 2336-2344
    • Ozaki, N.1    Chuang, D.-M.2
  • 62
    • 0030911906 scopus 로고    scopus 로고
    • A naturally occurring amino acid substitution of the human serotonin (5-HT) 2A receptor influences amplitude and timing of intracellular calcium mobilization
    • Ozaki N., Manji H.K., Luiberman V., Lu S., Rosenthal N., Goldman D. A naturally occurring amino acid substitution of the human serotonin (5-HT) 2A receptor influences amplitude and timing of intracellular calcium mobilization. J Neurochem. 68:1997;2186-2193.
    • (1997) J Neurochem , vol.68 , pp. 2186-2193
    • Ozaki, N.1    Manji, H.K.2    Luiberman, V.3    Lu, S.4    Rosenthal, N.5    Goldman, D.6
  • 63
    • 0034158322 scopus 로고    scopus 로고
    • Abnormalities of cAMP signaling in affective disorders: Implications for pathophysiology and treatment
    • Perez J., Tardito D., Mori S., Racagni G., Smeraldi E., Zanardi R. Abnormalities of cAMP signaling in affective disorders Implications for pathophysiology and treatment . Bipolar Disord. 2:2000;27-36.
    • (2000) Bipolar Disord , vol.2 , pp. 27-36
    • Perez, J.1    Tardito, D.2    Mori, S.3    Racagni, G.4    Smeraldi, E.5    Zanardi, R.6
  • 64
    • 0034162071 scopus 로고    scopus 로고
    • Altered Rap1 endogenous phosphorylation and levels in platelets from patients with bipolar disorder
    • Perez J., Tardito D., Mori S., Racagni G., Smeraldi E., Zanardi R. Altered Rap1 endogenous phosphorylation and levels in platelets from patients with bipolar disorder. J Psychiatr Res. 34:2000;99-104.
    • (2000) J Psychiatr Res , vol.34 , pp. 99-104
    • Perez, J.1    Tardito, D.2    Mori, S.3    Racagni, G.4    Smeraldi, E.5    Zanardi, R.6
  • 65
    • 0033957413 scopus 로고    scopus 로고
    • Second messenger-regulated protein kinases in the brain: Their functional role and the action of antidepressant drugs
    • Popoli M., Brunello N., Perez J., Racagni G. Second messenger-regulated protein kinases in the brain Their functional role and the action of antidepressant drugs . J Neurochem. 74:2000;21-33.
    • (2000) J Neurochem , vol.74 , pp. 21-33
    • Popoli, M.1    Brunello, N.2    Perez, J.3    Racagni, G.4
  • 66
    • 0013625267 scopus 로고
    • Mechanism of action of lithium: Comparison and contrast with carbamazepine
    • N.J. Birch. London: Academic Press
    • Post R.M., Chuang D.-M. Mechanism of action of lithium Comparison and contrast with carbamazepine . Birch N.J. Lithium and the Cell Pharmacology and Biochemistry . 1991;199-241 Academic Press, London.
    • (1991) Lithium and the Cell: Pharmacology and Biochemistry , pp. 199-241
    • Post, R.M.1    Chuang, D.-M.2
  • 67
    • 0002928254 scopus 로고    scopus 로고
    • Neurobiological models of recurrence in mood disorder
    • D.S. Charney, E.J. Nester, & B.S. Bunney. New York: Oxford University Press
    • Post R.M., Weiss S.R.B. Neurobiological models of recurrence in mood disorder. Charney D.S., Nester E.J., Bunney B.S. Neurobiology of Mental Illness. 1999;365-384 Oxford University Press, New York.
    • (1999) Neurobiology of Mental Illness , pp. 365-384
    • Post, R.M.1    Weiss, S.R.B.2
  • 68
    • 0002710089 scopus 로고    scopus 로고
    • Lithium, carbamazepine and valproate in affective illness: Biochemical and neurobiological mechanisms
    • H.K. Manji, C.L. Bowden, & R.H. Belmaker. Washington, DC: American Psychiatric Press
    • Post R.M., Weiss S.R.B., Clark M., Chuang D.M., Hough C., He L. Lithium, carbamazepine and valproate in affective illness Biochemical and neurobiological mechanisms . Manji H.K., Bowden C.L., Belmaker R.H. Bipolar Medications Mechanisms of Action . 2000;219-248 American Psychiatric Press, Washington, DC.
    • (2000) Bipolar Medications: Mechanisms of Action , pp. 219-248
    • Post, R.M.1    Weiss, S.R.B.2    Clark, M.3    Chuang, D.M.4    Hough, C.5    He, L.6
  • 69
    • 0030614785 scopus 로고    scopus 로고
    • Reduced [3H] cyclic AMP binding in postmortem brain from subjects with bipolar affective disorder
    • Rahman S., Li P.P., Young L.T., Kofman O., Kish S.J., Warsh J.J. Reduced [3H] cyclic AMP binding in postmortem brain from subjects with bipolar affective disorder. J Neurochem. 68:1997;297-304.
    • (1997) J Neurochem , vol.68 , pp. 297-304
    • Rahman, S.1    Li, P.P.2    Young, L.T.3    Kofman, O.4    Kish, S.J.5    Warsh, J.J.6
  • 71
    • 0012210332 scopus 로고    scopus 로고
    • Effects of antidepressant treatments on the G protein-adenylyl cyclase axis as the possible basis of therapeutic action
    • H.K. Manji, C.L. Bowden, & R.H. Belmaker. Washington, DC: American Psychiatric Press
    • Rasenick M.M., Chen J., Ozawa H. Effects of antidepressant treatments on the G protein-adenylyl cyclase axis as the possible basis of therapeutic action. Manji H.K., Bowden C.L., Belmaker R.H. Bipolar Medications Mechanisms of Action . 2000;87-108 American Psychiatric Press, Washington, DC.
    • (2000) Bipolar Medications: Mechanisms of Action , pp. 87-108
    • Rasenick, M.M.1    Chen, J.2    Ozawa, H.3
  • 73
    • 0029666245 scopus 로고    scopus 로고
    • Ca2+ entry induced by calcium influx factor and its regulation by protein kinase C in rabbit neutrophils
    • Shibata K., Morita K., Kitayama S., Okamoto H., Dohi T. Ca2+ entry induced by calcium influx factor and its regulation by protein kinase C in rabbit neutrophils. Biochem Pharmacol. 52:1996;167-171.
    • (1996) Biochem Pharmacol , vol.52 , pp. 167-171
    • Shibata, K.1    Morita, K.2    Kitayama, S.3    Okamoto, H.4    Dohi, T.5
  • 74
    • 0030048270 scopus 로고    scopus 로고
    • The phospholipase C/protein kinase C pathway is involved in cathepsin G-induced human platelet activation: Comparison with thrombin
    • Si-Tahar M., Renesto P., Falet H., Rendu F., Chignard M. The phospholipase C/protein kinase C pathway is involved in cathepsin G-induced human platelet activation comparison with thrombin . Biochem J. 313:1996;401-408.
    • (1996) Biochem J , vol.313 , pp. 401-408
    • Si-Tahar, M.1    Renesto, P.2    Falet, H.3    Rendu, F.4    Chignard, M.5
  • 77
    • 0026341781 scopus 로고
    • Sensitization to psychostimulants and stress after injection of pertussis toxin into the A10 dopamine region
    • Steketee J.D., Kalivas P.W. Sensitization to psychostimulants and stress after injection of pertussis toxin into the A10 dopamine region. J Pharmacol Exp Ther. 259:1991;916-924.
    • (1991) J Pharmacol Exp Ther , vol.259 , pp. 916-924
    • Steketee, J.D.1    Kalivas, P.W.2
  • 78
    • 0030273260 scopus 로고    scopus 로고
    • Enhanced protein kinase C activity and translocation in bipolar affective disorder brains
    • Wang H.Y., Friedman E. Enhanced protein kinase C activity and translocation in bipolar affective disorder brains. Biol Psychiatry. 40:1996;568-575.
    • (1996) Biol Psychiatry , vol.40 , pp. 568-575
    • Wang, H.Y.1    Friedman, E.2
  • 79
    • 0033019216 scopus 로고    scopus 로고
    • Effects of lithium on receptor-mediated activation of G proteins in rat brain cortical membranes
    • Wang H.Y., Friedman E. Effects of lithium on receptor-mediated activation of G proteins in rat brain cortical membranes. Neuropharmacology. 38:1999;403-414.
    • (1999) Neuropharmacology , vol.38 , pp. 403-414
    • Wang, H.Y.1    Friedman, E.2
  • 80
    • 0032953393 scopus 로고    scopus 로고
    • Cyclic AMP responsive element binding protein phosphorylation and DNA binding is decreased by chronic lithium but not valproate treatment of SH-SY5Y neuroblastoma cells
    • Wang J.F., Asghari V., Rockel C., Young L.T. Cyclic AMP responsive element binding protein phosphorylation and DNA binding is decreased by chronic lithium but not valproate treatment of SH-SY5Y neuroblastoma cells. Neuroscience. 91:1999;771-776.
    • (1999) Neuroscience , vol.91 , pp. 771-776
    • Wang, J.F.1    Asghari, V.2    Rockel, C.3    Young, L.T.4
  • 82
    • 0002570996 scopus 로고    scopus 로고
    • Guanine nucleotide binding (G) protein disturbances in bipolar affective disorder
    • H.K. Manji, C.L. Bowden, & R.H. Belmaker. Washington, DC: American Psychiatric Press
    • Warsh J.J., Young L.T., Li P.P. Guanine nucleotide binding (G) protein disturbances in bipolar affective disorder. Manji H.K., Bowden C.L., Belmaker R.H. Bipolar Medications Mechanisms of Action . 2000;299-329 American Psychiatric Press, Washington, DC.
    • (2000) Bipolar Medications: Mechanisms of Action , pp. 299-329
    • Warsh, J.J.1    Young, L.T.2    Li, P.P.3
  • 83
    • 0030036555 scopus 로고    scopus 로고
    • Chronic lithium-induced down-regulation of MARCKS in immortalized hippocampal cells: Potentiation by muscarinic receptor activation
    • Watson D.G., Lenox R.H. Chronic lithium-induced down-regulation of MARCKS in immortalized hippocampal cells Potentiation by muscarinic receptor activation . J Neurochem. 67:1996;767-777.
    • (1996) J Neurochem , vol.67 , pp. 767-777
    • Watson, D.G.1    Lenox, R.H.2
  • 84
    • 0031981038 scopus 로고    scopus 로고
    • Sodium valproate down-regulates the myristoylated alanine-rich C kinase substrate (MARCKS) in immortalized hippocampal cells. A property of protein kinase C-mediated mood stabilizers
    • Watson D.G., Watterson J.M., Lenox R.H. Sodium valproate down-regulates the myristoylated alanine-rich C kinase substrate (MARCKS) in immortalized hippocampal cells. A property of protein kinase C-mediated mood stabilizers. J Pharmacol Exp Ther. 285:1998;307-316.
    • (1998) J Pharmacol Exp Ther , vol.285 , pp. 307-316
    • Watson, D.G.1    Watterson, J.M.2    Lenox, R.H.3
  • 85
    • 0001925817 scopus 로고
    • Biological rhythms in manic-depressive illness
    • T.A. Wehr, & F.K. Goodwin. Pacific Grove, CA: Boxwood Press
    • Wehr T.A., Goodwin F.K. Biological rhythms in manic-depressive illness. Wehr T.A., Goodwin F.K. Circadian Rhythms in Psychiatry. 1983;129-184 Boxwood Press, Pacific Grove, CA.
    • (1983) Circadian Rhythms in Psychiatry , pp. 129-184
    • Wehr, T.A.1    Goodwin, F.K.2
  • 86
    • 0023499777 scopus 로고
    • Can antidepressants cause mania and worsen the course of affective illness?
    • Wehr T.A., Goodwin F.K. Can antidepressants cause mania and worsen the course of affective illness? Am J Psychiatry. 144:1987;1403-1411.
    • (1987) Am J Psychiatry , vol.144 , pp. 1403-1411
    • Wehr, T.A.1    Goodwin, F.K.2
  • 88
    • 0033515888 scopus 로고    scopus 로고
    • Complexity in biological signaling systems
    • Weng G., Bhalla U.S., Iyengar R. Complexity in biological signaling systems. Science. 284:(5411):1999;92-96.
    • (1999) Science , vol.284 , Issue.5411 , pp. 92-96
    • Weng, G.1    Bhalla, U.S.2    Iyengar, R.3
  • 89
    • 0033056561 scopus 로고    scopus 로고
    • Region-selective effects of long-term lithium and carbamazepine administration on cyclic AMP levels in rat brain
    • Wiborg O., Kruger T., Jakobsen S.N. Region-selective effects of long-term lithium and carbamazepine administration on cyclic AMP levels in rat brain. Pharmacol Toxicol. 84:1999;88-93.
    • (1999) Pharmacol Toxicol , vol.84 , pp. 88-93
    • Wiborg, O.1    Kruger, T.2    Jakobsen, S.N.3
  • 90
    • 0021637266 scopus 로고
    • Beta-adrenoceptor binding defects in cell lines from families with manic-depressive disorder
    • Wright A.F., Crichton D.N., Loudon J.B., Morten J.E., Steel C.M. Beta-adrenoceptor binding defects in cell lines from families with manic-depressive disorder. Ann Hum Genet. 48:1984;201-214.
    • (1984) Ann Hum Genet , vol.48 , pp. 201-214
    • Wright, A.F.1    Crichton, D.N.2    Loudon, J.B.3    Morten, J.E.4    Steel, C.M.5
  • 92
    • 0030575523 scopus 로고    scopus 로고
    • Mood stabilizers have differential effects on endogenous ADP ribosylation in C6 glioma cells
    • Young L.T., Woods C.M. Mood stabilizers have differential effects on endogenous ADP ribosylation in C6 glioma cells. Eur J Pharmacol. 309:1996;215-218.
    • (1996) Eur J Pharmacol , vol.309 , pp. 215-218
    • Young, L.T.1    Woods, C.M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.