Molecular components of the circadian system in Drosophila

Annual Review of Physiology

Volumn 63, Issue , 2001, Pages 729-755

  Williams, J A ^a   Sehgal, A ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Clock; Locomotor activity; PDF; Period; Timeless

Indexed keywords

CRYPTOCHROME; CYCLIC AMP;

CHRONOBIOLOGY; CIRCADIAN RHYTHM; DROSOPHILA MELANOGASTER; FEEDBACK SYSTEM; GENETIC CODE; NONHUMAN; PERIODICITY; PHOTORECEPTOR; PRIORITY JOURNAL; REVIEW;

ANIMALS; CIRCADIAN RHYTHM; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; GENE EXPRESSION; INSECT PROTEINS; NUCLEAR PROTEINS; TRANSCRIPTION FACTORS;

EID: 0035052919     PISSN: 00664278     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.physiol.63.1.729     Document Type: Review

References (135)

1. Molecular bases for circadian biological clocks
2. Time flies for Drosophila
3. Perturbing the pacemaker in the chick pineal
4. Circadian rhythms and the circadian organization of living things
5. Circadian systems I. The driving oscillation and its assay in Drosophila pseudoobscura
6. Developmental state and the circadian clock interact to influence the timing of eclosion in Drosophila melanogaster
7. Behavior of period-altered circadian rhythm mutants of Drosophila in light:dark cycles (Diptera:Drosophilidae)
8. Circadian rhythms in olfactory responses of Drosophila melanogaster
9. Visual receptor cycle in normal and period mutant Drosophila: Microspectrophotometry, electrophysiology, and ultrastructural morphometry
10. Genetic analysis of the circadian oviposition rhythm in Drosophila melanogaster: Effects of drift in laboratory strains
11. Oviposition in the period genotypes of Drosophila melanogaster
12. Antibodies to the period gene product of Drosophila reveal diverse tissue distribution and rhythmic changes in the visual system
13. Regulation of the Drosophila protein timeless suggests a mechanism for resetting the circadian clock by light
14. Light-induced degradation of TIMELESS and entrainment of the Drosophila circadian clock
15. Response of the timeless protein to light correlates with behavioral entrainment and suggests a non-visual pathway for circadian photoreception
16. Clock mutants of Drosophila melanogaster
17. Loss of circadian behavioral rhythms and per RNA oscillations in the Drosophila mutant timeless
18. Characterization of Andante, a new Drosophila clock mutant, and its interactions with other clock mutants
19. Mutational analysis of the Drosophila miniature-dusky (m-dy) locus: Effects on cell size and circadian rhythms
20. The isolation of biological rhythm mutations in the autosomes of Drosophila melanogaster
21. Block in nuclear localization of period protein by a second clock mutation, timeless
22. rit Lengthens circadian period in a temperature-dependent manner through suppression of PERIOD protein cycling and nuclear localization
23. Molecular and behavioral analysis of four period mutants in Drosophila melanogaster encompassing extreme short, novel long, and unorthodox arrhythmic types
24. An ultrashort clock mutation at the period locus of Drosophila melanogaster that reveals some new features of the fly's circadian system
25. SL mutant of the Drosophila rhythm gene timeless manifests allele-specific interactions with period gene mutants
26. A TIMELESS-independent function for PERIOD proteins in the Drosophila clock
27. Isolation and analysis of six timeless alleles that cause short or long period circadian rhythms in Drosophila
28. Positional cloning and sequence analysis of the Drosophila clock gene, timeless
29. The Drosophila single-minded gene encodes a nuclear protein with sequence similarity to the per gene product
30. Remembrance of things PAS: Regulation of development by bHLH-PAS proteins
31. Post-transcriptional regulation contributes to Drosophila clock gene mRNA cycling
32. Feedback of the Drosophila period gene on circadian cycling of its messenger RNA levels
33. Rhythmic expression of timeless: A basis for promoting circadian cycles in period gene autoregulation
34. Temporal phosphorylation of the Drosophila period protein
35. A light entrainment mechanism for the Drosophila circadian clock
36. Suppression of PERIOD protein abundance and circadian cycling by the Drosophila clock mutation timeless
37. Double-time is a novel Drosophila clock gene that regulates PERIOD protein accumulation
38. Regulation of nuclear entry of the Drosophila clock proteins Period and Timeless
39. Multiple circadian-regulated elements contribute to cycling period gene expression in Drosophila
40. Alterations of per RNA in noncoding regions affect periodicity of circadian behavioral rhythms
41. TIMELESS-dependent positive and negative autoregulation in the Drosophila circadian clock
42. Isolation of timeless by PER protein interaction: Defective interaction between timeless protein and long-period mutant PERL
43. Temporally regulated nuclear entry of the Drosophila period protein contributes to the circadian clock
44. Effect of constant light and circadian entrainment of perS flies: Evidence for light-mediated delay of the negative feedback loop in Drosophila
45. A promoterless period gene mediates behavioral rhythmicity and cyclical per expression in a restricted subset of the Drosophila nervous system
46. Circadian rhythms in Drosophila can be driven by period expression in a restricted group of central brain cells
47. Drosophila photoreceptors contain an autonomous circadian oscillator that can function without period mRNA cycling
48. Circadian cycling of a period-lacZ fusion protein in Drosophila: Evidence for cyclic degradation
49. Effects of dosage alterations at the per locus on the period of the circadian clock of Drosophila
50. Changes in abundance or structure of the per gene product can alter periodicity of the Drosophila clock
51. Spatial and temporal expression of the period gene in Drosophila melanogaster
52. In situ localization of the per clock protein during development of Drosophila melanogaster
53. Circadian clock in Malphigian tubules
54. Rhythms of Drosophila period gene expression in culture
55. Expression of the period clock gene within different cell types in the brain of Drosophila adults and mosaic analysis of these cells' influence on circadian behavioral rhythms
56. Robust circadian rhythmicity of Drosophila melanogaster requires the presence of lateral neurons: A brain-behavioral study of disconnected mutants
57. The disconnected visual system mutations in Drosophila melanogaster drastically disrupt circadian rhythms
58. A pdf neuropeptide gene mutation and ablation of PDF neurons each cause severe abnormalities of behavioral circadian rhythms in Drosophila
59. Temporal and spatial expression patterns of transgenes containing increasing amounts of the Drosophila clock gene period and a lacZ reporter: Mapping elements of the PER protein involved in circadian cycling
60. Spatial and temporal expression of the period and timeless genes in the developing nervous system of Drosophila: Newly identified pacemaker candidates and novel features of clock gene product cycling
61. A lack of locomoter activity rhythms in Drosophila melanogaster larvae
62. Ontogeny of a biological clock in Drosophila melanogaster
63. short mutation on phase shifts induced by light pulses delivered to Drosophila larvae
64. Resetting the Drosophila clock by photic regulation of PER and a PER-TIM complex
65. Evidence that the TIM light response is relevant to light-induced phase shifts in Drosophila melanogaster
66. Altered entrainment and feedback loop function effected by a mutant period protein
67. A role for the proteasome in the light response of the timeless clock protein
68. b mutation identifies cryptochrome as a circadian photoreceptor in Drosophila
69. CRY, a Drosophila clock and light-regulated cryptochrome, is a major contributor to circadian rhythm resetting and photosensitivity
70. dCRY is a unique Drosophila circadian photoreceptor
71. Drosophila CRY is a deep brain ciracadian photoreceptor
72. Light-dependent sequestration of timeless by cryptochrome
73. The biology of vision in Drosophila
74. Behavior in light:dark cycles of Drosophila mutants that are arrhythmic, blind or both
75. Thermally regulated translational control of FRQ mediates aspects of temperature responses in the Neurospora circadian clock
76. Differential effects of light and heat on the Drosophila circadian clock proteins PER and TIM
77. How a circadian clock adapts to seasonal decreases in temperature and day length
78. Reciprocal behavior associated with altered homeostasis and photosensitivity of Drosophila clock mutants
79. PER protein interactions and temperature compensation of a circadian clock in Drosophila
80. Natural variation in a Drosophila clock gene and temperature compensation
81. Molecular coevolution within a Drosophila clock gene
82. Conserved regions of the timeless (tim) clock gene in Drosophila analyzed through phylogenetic and functional studies
83. Comparison of chromosomal DNA composing timeless in Drosophila melanogaster and D. virilis suggests a new conserved structure for the TIMELESS protein
84. Inter-specific comparison of the period gene of Drosophila reveals large blocks on nonconserved coding DNA
85. Cloning of a structural and functional homolog of the circadian clock gene period from the giant silkmoth Antheraea pernyi
86. The clock gene period of the housefly, Musca domestica, rescues behavioral rhythmicity in Drosophila melanogaster: Evidence for intermolecular coevolution
87. A TIMELES S-independent function for PERIOD proteins in the Drosophila clock
88. Requirement of circadian genes for cocaine sensitization in Drosophila
89. Genetic dissection of monoamine neurotransmitter synthesis in Drosophila
90. Rest in Drosophila is a sleep-like state
91. Circadian rhythm mutations in Drosophila melanogaster affect short-term fluctuations in the male's courtship song
92. Neuroanatomy of cells expressing clock genes in Drosophila: Transgenic manipulation of the period and timeless genes to mark the perikarya of circadian pacemaker neurons and their projections
93. Molecular analysis of mammalian circadian rhythms
94. A mutant Drosophila homolog of mammalian Clock disrupts circadian rhythms and transcription of period and timeless
95. CYCLE is a second bHLH-PAS clock protein essential for circadian rhythmicity and transcription of Drosophila period and timeless
96. Closing the circadian loop: Clock-induced transcription of its own inhibitors per and tim
97. Circadian regulation of a Drosophila homolog of the mammalian Clock gene: PER and TIM function as positive regulators
98. PER and TIM inhibit the DNA binding activity of a Drosophila CLOCK-CYC/dBMAL1. Heterodimer without disrupting formation of the heterodimer: A basis for circadian transcription
99. The Drosophila CLOCK protein undergoes daily rhythms in abundance, phosphorylation and interactions with the PER-TIM complex
100. dCLOCK is present in limiting amounts and likely mediates daily interactions between the dCLOCK-CYC transcription factor and the PER-TIM complex
101. Interlocked feedback loops within the Drosophila circadian oscillator
102. Cycling vrille expression is required for a functional Drosophila clock
103. The Drosophila clock gene double-time encodes a protein closely related to human casein kinase I
104. Double-time is identical to discs overgrown, which is required for cell survival, proliferation and growth arrest in Drosophila imaginal discs
105. The vrille gene of Drosophila is a maternal enhancer of decapentaplegic and encodes a new member of the bZIP family of transcription factors
106. Pigmentdispersing hormones
107. The period clock gene is expressed in central nervous system neurons which also produce a neuropeptide that reveals the projections of circadian pacemaker cells within the brain of Drosophila melanogaster
108. Isolation and chronobiological analysis of a neuropeptide pigment-dispersing factor gene in Drosophila melanogaster
109. Differential regulation of circadian pacemaker output by separate clock genes in Drosophila
110. Ectopic expression of the neuropeptide pigment-dispersing factor alters behavioral rhythms in Drosophila melanogaster
111. Transplantation of a circadian pacemaker in Drosophila
112. Independent photoreceptive circadian clocks throughout Drosophila
113. Multi-tissue circadian expression of Rat period homolog (rPer2) mRNA is governed by the mammalian circadian clock, the suprachiasmatic nucleus in the brain
114. Resetting central and peripheral circadian oscillators in transgenic rats
115. Transplanted Drosophila excretory tubules maintain circadian clock cycling out of phase with the host
116. Extent and character of circadian gene expression in Drosophila melanogaster: Identification of twenty oscillating mRNAs in the fly head
117. A novel circadianly expressed Drosophila melanogaster gene dependent on the period gene for its rhythmic expression
118. A new gene encoding a putative transcription factor regulated by the Drosophila circadian clock
119. The Drosophila takeout gene is a novel molecular link between circadian rhythms and feeding behavior
120. Drosophila ebony mutants have altered circadian activity rhythms but normal eclosion rhythm
121. A new biological rhythm mutant of Drosophila melanogaster that identifies a gene with an essential embryonic function
122. Maternal function of a retroviral-type zinc-finger protein is essential for Drosophila development
123. Regulation of a specific circadian clock output pathway by lark, a putative RNA-binding protein with repressor activity
124. A molecular rhythm mediating circadian clock output in Drosophila
125. Peptidergic regulation of behavior: An identified neuron approach
126. Altered circadian pacemaker functions and cyclic AMP rhythms in the Drosophila learning mutant dunce
127. Drosophila melanogaster deficient in protein kinase A manifests behavior-specific arrhythmia but normal clock function
128. The Drosophila dCREB2 gene affects the circadian clock
129. Genetic and developmental analysis of polytene section 17 of the X chromosome of Drosophila melanogaster
130. Functional co-assembly among subunits of cyclic-nucleotide-activated, nonselective cation channels, and across species from nematode to human
131. Epac is a Rap1 guanine-nucleotideexchange factor directly activated by cyclic AMP
132. The Drosophila roughened mutation: Activation of a Rap homolog disrupts eye development and interferes with cell determination
133. Correlates of sleep and waking in Drosophila melanogaster
134. Identification and physiology of circadian pacemakers