Effects of immunosuppressants, calcineurin inhibition, and blockade of endoplasmic reticulum calcium channels on free fatty acid efflux from the ischemic/reperfused rat cerebral cortex

Brain Research

Volumn 957, Issue 1, 2002, Pages 12-24

  Phillis, J W ^a   Diaz, F G ^b   O'Regan, M H ^c   Pilitsis, J G ^a,b  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WAYNE STATE UNIVERSITY   (United States)

^c UNIVERSITY OF DETROIT MERCY   (United States)

Author keywords

Calcineurin; Cerebral ischemia; Endoplasmic reticulum; Free fatty acid; Immunosuppressant; Mitochondria; Phospholipase

Indexed keywords

ARACHIDONIC ACID; CALCINEURIN INHIBITOR; CALCIUM; CYCLOSPORIN A; DANTROLENE; DOCOSAHEXAENOIC ACID; FATTY ACID; GOSSYPOL; IMMUNOSUPPRESSIVE AGENT; INOSITOL TRISPHOSPHATE; LINOLEIC ACID; MYRISTIC ACID; OLEIC ACID; PALMITIC ACID; PHOSPHOLIPASE; RAPAMYCIN; RYANODINE RECEPTOR; TACROLIMUS; TRIFLUOPERAZINE; UNCLASSIFIED DRUG; XESTOSPONGIN C;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL OCCLUSION; BRAIN CORTEX; BRAIN ISCHEMIA; BRAIN PERFUSION; CALCIUM TRANSPORT; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; DRUG INHIBITION; DRUG MECHANISM; ENDOPLASMIC RETICULUM; EXTRACELLULAR SPACE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; CALCINEURIN; CALCIUM CHANNELS; CEREBRAL CORTEX; CYCLOSPORINE; DANTROLENE; ENDOPLASMIC RETICULUM; ENZYME INHIBITORS; FATTY ACIDS, NONESTERIFIED; GOSSYPOL; IMMUNOSUPPRESSIVE AGENTS; MACROCYCLIC COMPOUNDS; MALE; OXAZOLES; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; RYANODINE; SIROLIMUS; TACROLIMUS; THAPSIGARGIN; TRIFLUOPERAZINE;

EID: 0037032669     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(02)03578-3     Document Type: Article

References (71)

1. Al-Nasser I.A. In vivo prevention of adriamycin cardiotoxicity by cyclosporin A or FK506. Toxicology. 131:1998;175-181.
2. Ankarcrona M., Dypbukt J.M., Bonfoco E., Zhivotovsky B., Orrenius S., Lipton S.A., Nicotera P. Glutamate-induced neuronal death: a succession of necrosis or apoptosis depending on mitochondrial function. Neuron. 15:1995;951-973.
3. Ankarcrona M., Dypbukt J.M., Orrenius S., Nicoterra P.L. Calcineurin and mitochondrial function in glutamate-induced neuronal cell death. FEBS Lett. 394:1996;321-324.
4. Arber S., Krause K.H., Caroni P. s-Cyclophilin is retained intracellularly via a unique COOH-terminal sequence and colocalizes with the calcium storage protein calreticulin. J. Cell Biol. 116:1992;113-125.
5. 2+ to the endoplasmic reticulum and prevent the depletion of neighboring endoplasmic reticulum regions. J. Biol. Chem. 276:2001;29430-29439.
6. 2+ release channels in rat heart. Biochem. J. 352:2000;61-70.
7. Baumgrass R., Weiwad M., Erdmann F., Liu J.O., Wunderlich D., Grabley S., Fischer G. Reversible inhibition of calcineurin by the polyphenolic aldehyde gossypol. J. Biol. Chem. 276:2001;47914-47921.
8. Bernardi P. The permeability transition pore. Control points of a cyclosporin A-sensitive mitochondrial channel involved in cell death. Biochim. Biophys. Acta. 1275:1996;5-9.
9. Bochelen D., Rudin M., Sauter A. Calcineurin inhibitors FK506 and SDZ ASM981 alleviate the outcome of focal cerebral ischemic/reperfusion injury. J. Pharmacol. Exp. Ther. 288:1999;653-659.
10. 2. Nature. 390:1997;622-625.
11. Brillantes A.M., Ondrias K., Scott A., Kobrinsky E., Ondriasova E., Moschella M.C., Jayraman T., Landers M., Ehrlich B.E., Marks A.R. Stabilization of calcium release channel (ryanodine receptor) function by FK506-binding protein. Cell. 77:1994;513-523.
12. Broekemeier K.M., Pfeiffer D.R. Cyclosporin A-sensitive and insensitive mechanisms produce the permeability transition in mitochondria. Biochem. Biophys. Res. Commun. 163:1989;561-566.
13. Butcher S.P., Henshall D.C., Teramura Y., Iwasaki K., Sharkey J. Neuroprotective actions of FK506 in experimental stroke: in vivo evidence against an antiexcitotoxic mechanism. J. Neurosci. 17:1997;6939-6946.
14. 2+ flux. Cell. 83:1995;463-472.
15. Cameron A.M., Steiner J.P., Sabatini D.M., Kaplin A.I., Walensky L.D., Snyder S.H. Immunophilin FK506 binding protein associated with inositol 1,4,5-triphosphate receptor modulates calcium flux. Proc. Natl. Acad. Sci. USA. 92:1995;1784-1788.
16. Connern C.P., Halestrap A.P. Recruitment of mitochondrial cyclophilin to the mitochondrial inner membrane under conditions of oxidative stress that enhance the opening of a calcium-sensitive non-specific channel. Biochem. J. 302:1994;321-324.
17. Dawson T.M., Steiner J.P., Dawson V.L., Dinerman J.L., Uhl G.R., Snyder S.H. Immunosuppressant FK506 enhances phosphorylation of nitric oxide synthase and protects against glutamate neurotoxicity. Proc. Natl. Acad. Sci. USA. 90:1993;9808-9812.
18. Drake M., Friberg H., Boris-Moller F., Sakata K., Wieloch T. The immunosuppressant FK506 ameliorates ischaemic damage in the rat brain. Acta Physiol. Scand. 158:1996;155-159.
19. 2+ depletion. Proc. Natl. Acad. Sci. USA. 98:2001;13625-13630.
20. 2 inhibitor, quinacrine, reduces infarct size in rats after transient middle cerebral artery occlusion. Brain Res. 752:1997;203-208.
21. 2 translocation to internal membranes. J. Biol. Chem. 276:2001;30150-30160.
22. Fiskum G., Murphy A.N., Beal M.F. Mitochondria in neurodegeneration: acute ischemia and chronic neurodegenerative diseases. J. Cereb. Blood Flow Metab. 19:1999;351-369.
23. Frandsen A., Schousboe A. Dantrolene prevents glutamate cytotoxicity and calcium release from intracellular stores in cultured cerebral cortical neurons. J. Neurochem. 56:1991;1075-1078.
24. Friberg H., Ferrand Drake M., Bengtsson F., Halestrap A.P., Wieloch T. Cyclosporin A, but not FK506, protects mitochondria and neurons against hypoglycemic damage and implicates the mitochondrial permeability transition in cell death. J. Neurosci. 18:1998;5151-5159.
25. Fruman D.A., Burakoff S.J., Bierer B.E. Immunophilins in protein folding and immunosuppression. FASEB J. 8:1994;391-400.
26. Gafni J., Munsch J.A., Lam T.H., Catlin M.C., Costa L.G., Molinski T.F., Pessah I.N. Xestospongins: potent membrane permeable blockers of the inositol 1,4,5-triphosphate receptor. Neuron. 19:1997;723-733.
27. Garaschuk O., Yaari Y., Konnerth A. Release and sequestration of calcium by ryanodine-sensitive stores in rat hippocampal neurons. J. Physiol. (Lond.). 502:1997;13-30.
28. Gepdiremen A., Duzenli S., Hacimuftuoglu A., Suleyman H., Oztas S. The effects of dantrolene alone or in combination with nimodipine in glutamate-induced neurotoxicity in cerebellar granular cell cultures in rat pups. Pharmacol. Res. 43:2001;241-244.
29. Griffiths E.J., Halestrap A.P. Further evidence that cyclosporin A protects mitochondria from calcium overload by inhibiting a matrix peptidylprolyl cis-trans isomerase. Implications for the immunosuppressive and toxic effects of cyclosporin. Biochem. J. 274:1991;611-614.
30. Hamilton G.S., Steiner J.P. Immunophilins: beyond immunosuppression. J. Med. Chem. 41:1998;5119-5143.
31. 3-sensitive stores. J. Neurosci. Res. 59:2000;276-282.
32. Hoyt K.R., Sharma T.A., Reynolds I.J. Trifluoperazine and dibucaine-induced inhibition of glutamate-induced mitochondrial depolarization in rat cultured forebrain neurons. Br. J. Pharmacol. 122:1997;803-808.
33. Ide T., Morikawa E., Kirino T. An immunosuppressant, FK506, protects hippocampal neurons from forebrain ischemia in the Mongolian gerbil. Neurosci. Lett. 204:1996;157-160.
34. Imberti R., Nieminen A.-L., Herman B., Lemasters J.J. Mitochondrial and glycolytic dysfunction in lethal injury to hepatocytes by t-butylhydroperoxide: protection by fructose, cyclosporin A and trifluoperazine. J. Pharmacol. Exp. Ther. 265:1993;392-400.
35. Jeremic A., Jeftinija K., Stevanovic J., Glavaski A., Jeftinija S. ATP stimulates calcium-dependent glutamate release from cultured astrocytes. J. Neurochem. 77:2001;664-675.
36. Kuroda S., Janelidze S., Siesjo B.K. The immunosuppressants cyclosporin A and FK506 equally ameliorate brain damage due to 30-min middle cerebral artery occlusion in hyperglycemic rats. Brain Res. 835:1999;148-153.
37. Kuroda S., Nakai A., Kristian T., Siesjo B.K. The calmodulin antagonist trifluoperazine in transient focal brain ischemia in rats. Anti-ischemic effect and therapeutic window. Stroke. 28:1997;2539-2544.
38. Le Hir M., Su Q., Weber L., Woerly G., Granelli-Piperno A., Ryffel B. In situ detection of cyclosporin A: evidence for nuclear localization of cyclosporin and cyclophilins. Lab. Invest. 73:1995;727-733.
39. Lipton P. Ischemic cell death in brain neurons. Physiol. Rev. 79:1999;1431-1568.
40. Liu J., Farmer J.D., Lane W.S., Friedman J., Weissman I., Schreiber S.L. Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell. 66:1991;807-815.
41. Matsumoto S., Friberg H., Ferrand-Drake M., Wieloch T. Blockade of the mitochondrial permeability transition pore diminishes infarct size in the rat after transient middle cerebral artery occlusion. J. Cereb. Blood Flow Metab. 19:1999;736-741.
42. Mattson M.P., Zhu H., Yu J., Kindy M.S. Presenilin-1 mutation increases neuronal vulnerability to focal ischemia in vivo and to hypoxia and glucose deprivation in cell culture: involvement of perturbed calcium homeostasis. J. Neurosci. 20:2000;1358-1364.
43. 2+ transients that modulate secretion. Nat. Cell Biol. 2:2000;57-61.
44. Morioka M., Hamada J.I., Ushio Y., Miyamoto E. Potential role of calcineurin for brain ischemia and traumatic injury. Prog. Neurobiol. 58:1999;1-30.
45. Nicholls D.G., Budd S.L. Mitochondria and neuronal survival. Physiol. Rev. 80:2000;315-360.
46. Nieminen A.L., Petrie T.G., Lemasters J.J., Selman W.R. Cyclosporin delays mitochondrial depolarization induced by N-methyl-D-aspartate in cortical neurons: evidence of mitochondrial permeability transition. Neuroscience. 75:1996;993-997.
47. 2+ marks: miniature calcium signals in single mitochondria driven by ryanodine receptors. Proc. Natl. Acad. Sci. USA. 99:2002;2380-2385.
48. Paschen W., Doutheil J. Disturbances of the functioning of endoplasmic reticulum: a key mechanism underlying neuronal cell injury? J. Cereb. Blood Flow Metab. 19:1999;1-18.
49. Phillis J.W. Cerebroprotective action of the phospholipase inhibitor quinacrine in the ischemia/reperfused gerbil hippocampus. Life Sci. 58:1996;PL97-PL101.
50. Phillis J.W., O'Regan M.H. Mechanisms of glutamate and aspartate release in the ischemic rat cerebral cortex. Brain Res. 730:1996;150-164.
51. 2+ exchange by 7-chloro-5-(2-chlorophenyl)-5,1-dihydro-4,1-benzothiazepin-2(3H)-one attenuates free fatty acid efflux in rat cerebral cortex during ischemia-reperfusion injury. Neurosci. Lett. 321:2002;1-4.
52. Pilitsis J.G., Diaz F.G., O'Regan M.H., Phillis J.W. Differential effects of phospholipase inhibitors on free fatty acid efflux in rat cerebral cortex during ischemia-reperfusion injury. Brain Res. 951:2002;96-106.
53. 2+ sequestration. Ann. NY Acad. Sci. 853:1998;341-344.
54. Reddy P.A., Atreya C.D. Identification of simian cyclophilin A as a calreticulin-binding protein in yeast two-hybrid screen and demonstration of cyclophilin A interaction with calreticulin. Int. J. Biol. Macromol. 25:1999;345-351.
55. 2+ responses. Science. 280:1998;1763-1766.
56. 2 activity in gerbil brain: enhanced activities of cytosolic, mitochondrial and microsomal forms after ischemia and reperfusion. J. Neurosci. 11:1991;1829-1836.
57. 2, PKC and ERKs in the rat cerebral cortex during ischemia/reperfusion. Neurochem. Res. 24:1999;669-677.
58. Sharkey J., Butcher S.P. Immunophilins mediate the neuroprotective effects of FK506 in focal cerebral ischemia. Nature. 371:1994;336-339.
59. 2+ uptake into the endoplasmic reticulum and mitochondria. J. Biol. Chem. 276:2001;23329-23340.
60. Snyder S.H., Lai M.M., Burnett P.E. Immunophilins in the nervous system. Neuron. 21:1998;283-294.
61. Sung X., Shin C., Windebank A.J. Calmodulin in ischemic neurotoxicity of rat hippocampus in vitro. Neuroreport. 8:1997;415-418.
62. 2+-ATPase. Proc. Natl. Acad. Sci. USA. 87:1990;2466-2470.
63. Tokime T., Nozaki K., Kikuchi H. Neuroprotective effect of FK506, an immunosuppressant, on transient global ischemia in gerbil. Neurosci. Lett. 206:1996;81-84.
64. Uchino H., Elmer E., Uchino K., Lindvall O., Siesjo B.K. Cyclosporin A dramatically ameliorates CA1 hippocampal damage following transient forebrain ischemia in the rat. Acta Physiol. Scand. 155:1995;469-471.
65. Uchino H., Elmer E., Uchino K., Li P.A., He Q.P., Smith M.L., Siesjo B.K. Amelioration by cyclosporin A of brain damage in transient forebrain ischemia in the rat. Brain Res. 812:1998;216-226.
66. Wei H., Perry D.C. Dantrolene is cytoprotective in two models of neuronal cell death. J. Neurochem. 67:1996;2390-2398.
67. 2+ store depletion. J. Biol. Chem. 275:2000;36676-36682.
68. Yagita Y., Kitagawa K., Matsushita K., Taguchi A., Mabuchi T., Ohtsuki T., Yanagihara T., Matsumoto M. Effect of immunosuppressant FK506 on ischemia-induced degeneration of hippocampal neurons in gerbils. Life Sci. 59:1996;1643-1650.
69. Yoshimoto T., Siesjo B.K. Post-treatment with the immunosuppressant cyclosporin A in transient focal ischemia. Brain Res. 839:1999;283-291.
70. 2+ release from mitochondria. J. Neurosci. 19:1999;3307-3315.
71. Zivin J.A., Kochhar A., Saitoh T. Phenothiazines reduce ischemic damage to the central nervous system. Brain Res. 482:1989;189-193.