Trifluoperazine and dibucaine-induced inhibition of glutamate-induced mitochondrial depolarization in rat cultured forebrain neurones

British Journal of Pharmacology

Volumn 122, Issue 5, 1997, Pages 803-808

  Hoyt, Kari R ^a   Sharma, Terre A ^a   Reynolds, Ian J ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

CGP 37157; Dibucaine; Glutamate; Indo; Intracellular free calcium; JC 1; Mitochondria; Permeability transition pore; Sodium calcium exchange; Trifluoperazine

Indexed keywords

CALCIUM ION; CINCHOCAINE; DIZOCILPINE; FLUORESCENT DYE; GLUTAMATE RECEPTOR; GLUTAMIC ACID; TRIFLUOPERAZINE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; EMBRYO; FOREBRAIN; MEMBRANE BINDING; MEMBRANE DEPOLARIZATION; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; NERVE CELL CULTURE; NONHUMAN; PRIORITY JOURNAL; RAT; SODIUM CALCIUM EXCHANGE;

ANIMALS; BENZIMIDAZOLES; CALCIUM; CARBOCYANINES; CELLS, CULTURED; CLONAZEPAM; DIBUCAINE; DIZOCILPINE MALEATE; FLUORESCENT DYES; FLUOROMETRY; GLUTAMIC ACID; MEMBRANE POTENTIALS; MITOCHONDRIA; NEURONS; PROSENCEPHALON; RATS; RATS, SPRAGUE-DAWLEY; SODIUM-CALCIUM EXCHANGER; THIAZEPINES; TRIFLUOPERAZINE;

EID: 0030729437     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0701442     Document Type: Article

References (39)

1. ANKARCRONA, M., DYPBUKT, J.M., ORRENIUS, S. & NICOTERA, P. (1996). Calcineurin and mitochondrial function in glutamate-induced neuronal cell death. FEBS Lett., 394, 321-324.
2. BERNARDI, P., BROEKEMEIER, K.M. & PFEIFFER, D.R. (1994). Recent progress on regulation of the mitochondrial permeability transition pore; a cyclosporin-sensitive pore in the inner mitochondrial membrane. J. Bioenerg. Biomemb., 26, 509-517.
3. BINDOKAS, V.P., JORDAN, J., LEE, C.C. & MILLER, R.J. (1996). Superoxide production in rat hippocampal neurons: selective imaging with hydroethidine. J. Neurosci., 16, 1324-1336.
4. 2+ in cultured cortical neurones. Neuron, 11, 751-757.
5. BROEKEMEIER, K.M., DEMPSEY, M.E. & PFEIFFER, D.R. (1989). Cyclosporin A is a potent inhibitor of the inner membrane permeability transition in liver mitochondria. J. Biol. Chem., 264, 7826-7830.
6. BROEKEMEIER, K.M. & PFEIFFER, D.R. (1995). Inhibition of the mitochondrial permeability transition by cyclosporin a during long time frame experiments - relationship between pore opening and the activity of mitochondrial phospholipases. Biochemistry, 34, 16440-16449.
7. 2+ release from mitochondria. J. Biol. Chem., 260, 105-113.
8. CHOI, D.W. (1988). Glutamate neurotoxicity and diseases of the nervous system. Neuron, 1, 623-634.
9. 2+ exchange of heart mitochondria by benzothiazepine CGP-37157. J. Cardiovasc. Pharmacol., 21, 595-599.
10. DAWSON, T.M., STEINER, J.P., DAWSON, V.L., DINERMAN, J.L., UHL, G.R. & SNYDER, S.H. (1993). Immunosuppressant FK 506 enhances phosphorylation of nitric oxide synthase and protects against glutamate neurotoxicity. Proc. Natl. Acad. Sci. U.S.A., 90, 9808-9812.
11. DAWSON, V.L., DAWSON, T.M., LONDON, E.D., BREDT, D.S. & SNYDER, S.H. (1991). Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures. Proc. Natl. Acad. Sci. U.S.A., 88, 6368-6371.
12. DUGAN, L.L., SENSI, S.L., CANZONIERO, L.M., HANDRAN, S.D., ROTHMAN, S.M., LIN, T.S., GOLDBERG, M.P. & CHOI, D.W. (1995). Mitochondrial production of reactive oxygen species in cortical neurons following exposure to N-methyl-D-aspartate. J. Neurosci., 15, 6377-6388.
13. GRIFFITHS, E.J. & HALESTRAP, A.P. (1995). Mitochondrial non-specific pores remain closed during cardiac ischaemia, but open upon reperfusion. Biochem. J., 307, 93-98.
14. GUNTER, T.E., GUNTER, K.K., SHEU, S.S. & GAVIN, C.E. (1994). Mitochondrial calcium transport: physiological and pathological relevance. Am. J. Physiol., 267, C313-C339.
15. 2+ accumulation in cortical cell culture correlates with subsequent neuronal degeneration. J. Neurosci., 13, 1993-2000.
16. 2+-free solutions in rat cortical neurons in vitro. J. Neurochem., 68, 1836-1845.
17. 2+ carrier in mitoplasts derived from heart mitochondria. FEBS Lett., 182, 281-286.
18. KHODOROV, B., PINELIS, V., VERGUN, O., STOROZHEVYKH, T. & VINSKAYA, N. (1996). Mitochondrial deenergization underlies neuronal calcium overload following a prolonged glutamate challenge. FEBS Lett., 397, 230-234.
19. KIEDROWSKI, L. & COSTA, E. (1995). Glutamate-induced destabilization of intracellular calcium concentration homeostasis in cultured cerebellar granule cells: role of mitochondria in calcium buffering. Mol. Pharmacol., 47, 140-147.
20. LEVIN, R.M. & WEISS, B. (1979). Selective binding of antipsychotics and other psychoactive agents to the calcium-dependent activator of cyclic nucleotide phosphodiesterase. J. Pharmacol. Exp. Ther., 208, 454-459.
21. LIU, J., FARMER, J.D. JR., LANE, W.S., FRIEDMAN, J., WEISSMAN, I. & SCHREIBER, S.L. (1991). Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell, 66, 807-815.
22. MICHAELS, R.L. & ROTHMAN, S.M. (1990). Glutamate neurotoxicity in vitro: antagonist pharmacology and intracellular calcium concentrations. J. Neurosci., 10, 283-292.
23. NIEMINEN, A.L., PETRIE, T.G., LEMASTERS, J.J. & SELMAN, W.R. (1996). Cyclosporin A delays mitochondrial depolarization induced by N-methyl-D-Aspartate in cortical neurons - evidence of the mitochondrial permeability transition. Neuroscience, 75, 993-997.
24. NIEMINEN, A.L., SAYLOR, A.K., TESFAI, S.A., HERMAN, B. & LEMASTERS, J.J. (1995). Contribution of the mitochondrial permeability transition to lethal injury after exposure of hepatocytes to t-butylhydroperoxide. Biochem. J., 307, 99- 106.
25. REERS, M., SMITH, T.W. & CHEN, L.B. (1991). J-aggregate formation of a carbocyanine as a quantitative fluorescent indicator of membrane potential. Biochemistry, 30, 4480-4486.
26. REYNOLDS, I.J. & HASTINGS, T.G. (1995). Glutamate induces the production of reactive oxygen species in cultured forebrain neurons following NMDA receptor activation. J. Neurosci., 15, 3318-3327.
27. REYNOLDS, I.J. & MILLER, R.J. (1988). Tricyclic antidepressants block N-methyl-D-aspartate receptors: similarities to the action of zinc. Br. J. Pharmacol., 95, 95-102.
28. 3H-labeled MK-801 binding to the excitatory amino acid receptor complex from rat brain is enhanced by glycine. Proc. Natl. Acad. Sci. U.S.A., 84, 7744-7748.
29. 3H]MK801 binding to rat brain N-methyl-D-aspartate receptors. J. Neurochem., 56, 1731-1740.
30. RITCHIE, J. & GREENE, N. (1990). Local Anesthetics. In Goodman and Gilman's The Pharmacological Basis of Therapeutics, ed. Gilman, A., Rall, T., Nies, A. & Taylor, P. pp. 311-331. New York, NY: Pergamon Press.
31. ROTHMAN, S.M., THURSTON, J.H. & HAUHART, R.E. (1987). Delayed neurotoxicity of excitatory amino acids in vitro. Neuroscience, 22, 471-480.
32. SAVAGE, M.K. & REED, D.J. (1994). Release of mitochondrial glutathione and calcium by a cyclosporin A-sensitive mechanism occurs without large amplitude swelling. Arch. Biochem. Biophys., 315, 142-152.
33. SCHINDER, A.F., OLSON, E.C., SPITZER, N.C. & MONTAL, M. (1996). Mitochondrial dysfunction is a primary event in glutamate neurotoxicity. J. Neurosci., 16, 6125-6133.
34. 2+ loads. J. Neurophysiol., 72, 2563-2569.
35. 2+ loads by mitochondria in cultured rat hippocampal neurons. J. Neurophysiol., 76, 1611-1621.
36. 2+ following intense glutamate stimulation of cultured rat forebrain neurons. J. Physiol., 498, 31-47.
37. 2+ exchange buffer glutamate-induced calcium loads in cultured cortical neurons. J. Neurosci., 15, 1318-1328.
38. WHITE, R.J & REYNOLDS, I.J. (1996). Mitochondrial depolarization in glulamate-stimulated neurons - an early signal specific to excitotoxin exposure. J. Neurosci., 16, 5688-5697.
39. ZORATTI, M. & SZABO, I. (1995). The mitochondrial permeability transition. Biochim. Biopshys. Acta, 1241, 139-176.