The calmodulin antagonist trifluoperazine in transient focal brain ischemia in rats: Anti-ischemic effect and therapeutic window

Stroke

Volumn 28, Issue 12, 1997, Pages 2539-2544

  Kuroda, Satoshi ^a   Nakai, Akihito ^b   Kristían, Tibor ^c   Siesjö, Bo K ^d  

^a HOKKAIDO UNIVERSITY   (Japan)

^b NIPPON MEDICAL SCHOOL   (Japan)

^c INSTITUTE OF CHEMISTRY   (Slovakia)

^d NONE

Author keywords

Calcium; Calmodulin; Cerebral ischemia, focal; Middle cerebral artery occlusion; Rats

Indexed keywords

CALMODULIN INHIBITOR; TRIFLUOPERAZINE;

ANIMAL EXPERIMENT; ARTICLE; BRAIN BLOOD FLOW; DRUG EFFECT; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MIDDLE CEREBRAL ARTERY; NONHUMAN; PRIORITY JOURNAL; RAT; SCORING SYSTEM; TRANSIENT ISCHEMIC ATTACK;

EID: 0031439426     PISSN: 00392499     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.STR.28.12.2539     Document Type: Article

References (57)

1. Choi D. Calcium-mediated neurotoxicity: relationship to specific channel types and role in ischemic damage. Trends Neurosci. 1988; 11:465-469.
2. Choi D. Calcium: still center-stage in hypoxic-ischemic neuronal death. Trends Neurosci. 1995;18:58-60.
3. Siesjö BK. Mechanisms of ischemic brain damage. Crit Care Med. 1988;16:954-963.
4. Siesjö BK. The role of calcium in cell death. In: Price D, Thoenen H, Aguayo A, eds. Neurodegenerative Disorders: Mechanisms and Prospects for Therapy. New York, NY: John Wiley & Sons Ltd; 1991.
5. Tymianski M, Tator CH. Normal and abnormal calcium homeostasis in neurons: a basis for the pathophysiology of traumatic and ischemic central nervous system injury. Neurosurgery. 1996;38:1176-1195.
6. Beresewicz A. Anti-ischemic and membrane stabilizing activity of calmodulin inhibitors. Basic Res Cardiol. 1989;84:631-645.
7. Otani H, Engelman RM, Rousou JA, Breyer RH, Clement R, Prasad R, Klar J, Das DK. Improvement of myocardial function by trifluoperazine, a calmodulin antagonist, after acute coronary artery occlusion and coronary revascularization. J Thorac Cardiovasc Surg. 1992;97:267-74.
8. Sargent CA, Sleph PG, Dzwonczyk S, Smith MA, Grover GJ. Effect of calmodulin and protein kinase C inhibitors on globally ischemic rat hearts. J Cardiovasc Pharmacol. 1992;20:251-260.
9. Gabauer I, Slezak J, Styk J, Ziegelhoffer A. Protective effect of calmodulin inhibitors on reperfusion injury. Bratisl Lek Listy. 1991; 92:184-194.
10. Kimura Y, Engelman RM, Rousou J, Flack J, Iyengar J, Das DK. Moderation of myocardial ischemia reperfusion injury by calcium channel and calmodulin receptor inhibition. Heart Vessels. 1992;7: 189-195.
11. Nedergaard M, Hansen A. Characterization of cortical depolarizations evoked in focal cerebral ischemia. J Cereb Blood Flow Metab. 1993;13:568-574.
12. Gill R, Andine O, Hillered L, Persson L, Hagberg H. The effect of MK-801 on cortical spreading depression in the penumbra zone following focal ischemia in the rat. J Cereb Blood Flow Metab. 1992;12:371-379.
13. Back T, Kohno K, Hossmann K-A. Cortical negative DC deflections following middle cerebral artery occlusion and KCl-induced spreading depression: effect on blood flow, tissue oxygenation and electroencephalogram. J Cereb Blood Flow Metab. 1994; 14:12-19.
14. Kristián T, Siesjö BK. Calcium-related damage in ischemia. Life Sci. 1996;59:357-367.
15. Kristián T, Gidö G, Kuroda S, Schutz A, Siesjö BK. Calcium metabolism of focal and penumbral tissues in rats subjected to transient middle cerebral artery occlusion. Exp Brain Res. In press.
16. Greenberg JH, Uematsu D, Araki N, Hickey WF, Reivich M. Cytosolic free calcium during focal cerebral ischemia and the effects of nimodipine on calcium and histologic damage. Stroke. 1990; 21(suppl IV):IV-72-IV-77.
17. Memezawa H, Zhao Q, Smith M-L, Siesjö BK. Hyperthermia nullifies the ameliorating effect of dizocilpine maleate (MK-801) in focal cerebral ischemia. Brain Res. 1995;670:48-52.
18. Margaill I, Parmentier S, Callebert J, Allix M, Boulu R, Plotkine M. Short therapeutic window for MK-801 in transient focal cerebral ischemia in normotensive rats. J Cereb Blood Flow Metab. 1996;16: 107-113.
19. Zhao Q, Pahlmark K, Smith M-L, Siesjö BK. Delayed treatment with the spin trap α-phenyl-N-tert-butyl nitrone (PBN) reduced infarct size following transient middle cerebral artery occlusion in rats. Acta Physiol Scand. 1994;152:349-350.
20. Folbergrová J, Zhao Q, Katsura K, Siesjö BK. N-tert-Butyl-α-phenylnitrone improves recovery of brain energy state in rats following transient focal ischemia. Proc Natl Acad Sci U S A. 1995;92: 5057-5061.
21. Siesjö BK, Katsura K, Zhao Q, Folbergrova J, Pahlmark K, Siesjö P, Smith M. Mechanisms of secondary brain damages in global and focal ischemia: a speculative synthesis. J Neurotrauma. 1995;12: 943-956.
22. Siesjö BK, Siesjö P. Mechanisms of secondary brain injury. Eur J Anaesthesiol. 1996;13:247-268.
23. Kuroda S, Siesjö BK. Postischemic administration of FK506 reduced infarct volume following transient focal brain ischemia. Neurosci Res Com. 1996;19:83-90.
24. Kuroda S, Katsura K, Hillered L, Bates TE, Siesjö BK. Delayed treatment with α-phenyl-N-tert-butyl nitrone (PBN) attenuates secondary mitochondrial dysfunction after transient focal cerebral ischemia in the rat. Neurobiol Dis. 1996;3:149-157.
25. Nakai A, Kuroda S, Kristián T, Siesjö BK. The immunosuppressant FK506 ameliorates secondary mitochondrial failure following transient focal cerebral ischemia in the rat. Neurobiol Dis. In press.
26. Koizumi J, Yoshida Y, Nakazawa T, Ooneda G. Experimental studies of ischemic brain edema. I: a new experimental model of cerebral embolism in rats in which recirculation can be introduced in the ischemic area. Jpn J Stroke. 1986;8:1-8.
27. Memezawa H, Minamisawa H, Smith M-L, Siesjö BK. Ischemic penumbra in a model of reversible middle cerebral artery occlusion in the rat. Exp Brain Res. 1992;89:67-78.
28. Zhao Q, Memezawa H, Smith M-L, Siesjö BK. Hyperthermia complicates middle cerebral artery occlusion induced by an intraluminal filament. Brain Res. 1994;649:253-259.
29. Bederson J, Pitts L, Tsuji M, Nishimura M, Davis R, Bartkowski H. Rat middle cerebral artery occlusion: evaluation of the model and development of a neurological examination. Stroke. 1986;17:472-476.
30. 2 activity in the brain of rats. Eur Arch Psychiatry Clin Neurosci. 1995;245:179-182.
31. Swanson RA, Morton MT, Tsao-Wu G, Savalos RA, Davidson C, Sharp FR. A semiautomated method for measuring brain infarct volume. J Cereb Blood Flow Metab. 1990;10:290-293.
32. Kohno K, Back T, Hoehn-Berlage M, Hossmann K-A. A modified rat model of middle cerebral artery thread occlusion under electrophysiological control for magnetic resonance investigations. Magn Reson Imaging. 1995;13:65-71.
33. Röther J, de Crespigny A, D'Arceuil H, Moseley M. MR detection of cortical spreading depression immediately after focal ischemia in rats. J Cereb Blood Flow Metab. 1996;16:214-220.
34. Siesjö B, Bengtsson F. Calcium fluxes, calcium antagonists, and calcium-related pathology in brain ischemia, hypoglycemia, and spreading depression: a unifying hypothesis. J Cereb Blood Flow Metab. 1989;9:127-140.
35. Hossmann KA, Ophoff BG, Schmidt-Kastner R, Oschlies U. Mitochondrial calcium sequestration in cortical and hippocampal neurons after prolonged ischemia of the cat brain. Acta Neuropathol (Berl). 1985;68:230-238.
36. Zaidan E, Sims N. The calcium content of mitochondria from brain subrogions following short-term forebrain ischemia and recirculation in the rat. J Neurochem. 1994;63:1812-1819.
37. Grotta JC, Picone CM, Dedman JR, Rhoades HM, Strong RA, Earls RM, Yao LP. Neuronal protection correlates with prevention of calcium-calmodulin binding in rats. Stroke. 1990;21 (suppl III): III-28-III-31.
38. Dienel GA. Regional accumulation of calcium in postischemic rat brain. J Neurochem. 1984;43:913-925.
39. Deshpande JK, Siesjö BK, Wieloch T. Calcium accumulation and neuronal damage in the rat hippocampus following cerebral ischemia. J Cereb Blood Flow Metab. 1987;7:89-95.
40. Dux E, Mies G, Hossmann K-A, Siklos L. Calcium in the mitochondria following brief ischemia of gerbil brain. Neurosci Lett. 1987;78:295-300.
41. Rappaport ZH, Young W, Flamm ES. Regional brain calcium changes in the rat middle cerebral artery occlusion model of ischemia. Stroke. 1987;18:760-764.
42. Shirotani T, Shiama K, Iwata M, Kita H, Chigasaki H. Calcium accumulation following middle cerebral artery occlusion in stroke-prone spontaneously hypertensive rats. J Cereb Blood Flow Metab. 1994;14:831-836.
43. Chien KR, Abrams J, Pfau RG, Farber JL. Prevention by chlorpromazine of ischemic liver cell death. Am J Pathol. 1977;88:539-558.
44. Zivin JA, Kochhar A, Saitoh T. Phenothiazines reduce ischemic damage to the central nervous system. Brain Res. 1989;482:189-193.
45. Yu MJ, McCowan JR, Smalstig EB, Bennett DR, Roush ME, Clemens JA. Phenothiazine derivative reduced rat brain damage after global or focal ischemia. Stroke. 1992;23:1287-1291.
46. Beresewicz A, Wasilewska A, Herbaczynskacedro K. Calmodulin antagonist reduced release of malondialdehyde from isolated ischemic/reperfused rat heart. Acta Physiol Pol. 1988;39:442-449.
47. Chien KR, Pfau RG, Farber JL. Ischemic myocardial cell injury. Am J Pathol. 1979;97:505-530.
48. Otani H, Prasad MR, Jones RM, Das DK. Mechanism of membrane phospholipid degradation in ischemic-reperfused rat hearts. Am J Physiol. 1989;257:H252-H258.
49. Smith DS, Rehncrona S, Siesjö BK. Inhibitory effects of different barbiturates on lipid peroxidation in brain tissue in vitro: comparison with the effects of promethazine and chlorpromazine. Anesthesiology. 1980;53:186-194.
50. Janero DR, Burghardt B. Prevention of oxidative injury to cardiac phospholipid by membrane-active 'stabilizing agents.' Res Commun Chem Pathol Pharmacol. 1989;63:163-173.
51. 2) activity in gerbil brain: enhanced activities of cytosolic, mitochondrial, and microsomal forms after ischemia and reperfusion. J Neurosci. 1991;11:1829-1836.
52. Balestrino M, Somjen GG. Chlorpromazine protects brain tissue in hypoxia by delaying spreading depression-mediated calcium influx. Brain Res. 1986;385:219-226.
53. Hiestand DM, Haley BE, Kindy MS. Role of calcium in inactivation of calcium/calmodulin dependent protein kinase II after cerebral ischemia. J Neurol Sci. 1992;113:31-37.
54. Matsuo Y, Kihara T, Ikeda M, Ninomiya M, Onodera H, Kogure K. Role of neutrophils in radical production during ischemia and reperfusion of the rat brain: effect of neutrophil depletion on extracellular ascorbyl radical formation. J Cereb Blood Flow Metab. 1995;15:941-947.
55. Dirnagl U, Lindauer U, Them A, Schreiber S, Pfister H-W, Koedel U, Reszka R, Freyer D, Villringer A. Global cerebral ischemia in the rat: online monitoring of oxygen free radical production using chemiluminescence in vivo. J Cereb Blood Flow Metab. 1995;15:929-940.
56. Floyd R. Role of oxygen free radicals in carcinogenesis and brain ischemia. FASEB J. 1990;4:2587-2597.
57. Dawson T, Steiner J, Dawson V, Dinerman J, Uhl G, Snyder S. Immunosuppressant FK506 enhances phosphorylation of nitric oxide synthase and protects against glutamate neurotoxicity. Proc Natl Acad Sci U S A. 1993;90:9808-9812.