Reversible Inhibition of Calcineurin by the Polyphenolic Aldehyde Gossypol

Journal of Biological Chemistry

Volumn 276, Issue 51, 2001, Pages 47914-47921

  Baumgrass, Ria ^a   Weiwad, Matthias ^a   Erdmann, Frank ^a   Liu, Jun O ^c   Wunderlich, Dirk ^b   Grabley, Susanne ^b   Fischer, Gunter ^a  

^a M P Res U Enzymol Protein F   (Germany)

^b HANS KNÖLL INSTITUTE   (Germany)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALDEHYDES; BIOASSAY; CELLS; ENZYME INHIBITION; GENES; ORGANIC POLYMERS;

BINDING SITE;

ENZYMES;

4 NITROPHENYL PHOSPHATE; CALCINEURIN; CALCINEURIN INHIBITOR; CYCLOPHILIN; CYCLOSPORIN A; GOSSYPOL; GOSSYPOL DERIVATIVE; GOSSYPOLONE; IMMUNOPHILIN; IONOMYCIN; LUCIFERASE; NUCLEAR FACTOR; PHORBOL 13 ACETATE 12 MYRISTATE; PHOSPHOPEPTIDE; POLYPHENOL DERIVATIVE; TACROLIMUS; TRANSCRIPTION FACTOR NFAT; UNCLASSIFIED DRUG; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASES; DNA BINDING PROTEIN; DNA BINDING PROTEINS; ENZYME INHIBITOR; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR NF AT; TRANSCRIPTION FACTOR NF-AT;

ARTICLE; BINDING SITE; CHEMICAL ANALYSIS; CYTOSOL; DRUG EFFECT; GENE ACTIVITY; HUMAN; HUMAN CELL; IC 50; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEPHOSPHORYLATION; RECEPTOR BINDING; REPORTER GENE; AMINO ACID SEQUENCE; ANIMAL; CATTLE; CELL CULTURE; CHEMISTRY; ENZYME SPECIFICITY; GENETICS; LYMPHOCYTE ACTIVATION; METABOLISM; MOLECULAR GENETICS; PHOSPHORYLATION; PROTEIN TRANSPORT; T LYMPHOCYTE;

AMINO ACID SEQUENCE; ANIMAL; CALCINEURIN; CATTLE; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DNA-BINDING PROTEINS; ENZYME INHIBITORS; GENES, REPORTER; GOSSYPOL; HUMAN; LUCIFERASE; LYMPHOCYTE ACTIVATION; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; PROTEIN TRANSPORT; SUBSTRATE SPECIFICITY; SUPPORT, NON-U.S. GOV'T; TRANSCRIPTION FACTORS;

EID: 0035930554     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M103273200     Document Type: Article

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