II. Glutamine and glutamate

Biomedicine and Pharmacotherapy

Volumn 56, Issue 9, 2002, Pages 446-457

  Tapiero, Haim ^a   Mathe G ^b   Couvreur, P ^a   Tew, K D ^c  

^a UNIV PARIS SUD   (France)

^b HÔPITAL PAUL BROUSSE   (France)

^c FOX CHASE CANCER CENTER   (United States)

Author keywords

Glutamate; Glutamine

Indexed keywords

2 OXOGLUTARIC ACID; 4 AMINOBUTYRIC ACID; ALPHA TOCOPHEROL; AMMONIA; ANTICONVULSIVE AGENT; ARGININE; CALCIUM ION; CARBOHYDRATE; CHANNEL SITE ANTAGONIST; CYCLOSERINE; ENDOTOXIN; ESSENTIAL AMINO ACID; FLAVORING AGENT; FOLIC ACID; GLUTAMATE RECEPTOR; GLUTAMIC ACID; GLUTAMINASE; GLUTAMINE; GLUTATHIONE; GLYCINE SITE ANTAGONIST; HISTIDINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; NEUROLEPTIC AGENT; NITROGEN; ORNITHINE; POLYAMINE SITE ANTAGONIST; PROLINE; SODIUM; TOPIRAMATE; UNCLASSIFIED DRUG; VEGETABLE PROTEIN;

ABDOMINAL PAIN; ACID BASE BALANCE; AMINO ACID BLOOD LEVEL; AMINO ACID BRAIN LEVEL; AMINO ACID METABOLISM; AMINO ACID SYNTHESIS; AMINO ACID TRANSPORT; AMMONIA FORMATION; AMNESIA; BONE MARROW TRANSPLANTATION; BURN; CALCIUM TRANSPORT; CANCER; CANCER CHEMOTHERAPY; CANCER THERAPY; CARBON METABOLISM; CELL GROWTH; CELL MIGRATION; CELL SURVIVAL; CITRIC ACID CYCLE; COLLAGEN SYNTHESIS; CONNECTIVE TISSUE; CYCLIZATION; CYTOSKELETON; DEAMINATION; DEGENERATIVE DISEASE; DIARRHEA; DIET SUPPLEMENTATION; DIETARY INTAKE; EPILEPSY; HUMAN; HYPERALGESIA; INTESTINE; KIDNEY; LEARNING; MAJOR SURGERY; MAMMAL; MEMORY; MOUTH INFLAMMATION; MUCOSA INFLAMMATION; NAUSEA; NERVE CELL DIFFERENTIATION; NEUROTOXICITY; NITROGEN BALANCE; NONHUMAN; PLASTICITY; PRIORITY JOURNAL; REVIEW; SCHIZOPHRENIA; SEPSIS; TASTE; THERMAL INJURY; VEIN OCCLUSION; VOMITING; ANIMAL; CHEMISTRY; GENERAL ASPECTS OF DISEASE; HEALTH; METABOLISM;

ANIMALS; DISEASE; GLUTAMIC ACID; GLUTAMINE; HEALTH; HUMANS;

EID: 0036864714     PISSN: 07533322     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0753-3322(02)00285-8     Document Type: Article

References (175)

1. Darmaun D., Matthews D.E., Bier D.M. Glutamine and glutamate kinetic in humans. Am J Physiol. 251:1986;E117-E126.
2. Eagle H. Nutrition needs of mammalian cells in tissue culture. Science. 122:1955;501-504.
3. Cao Y., Feng Z., Hoos A., Klimberg V.S. Glutamine enhances gut glutathione production. J Parenter Enter Nutr. 22:1998;224-227.
4. Neu J., Shenoy V., Chakrabarti R. Glutamine nutrition and metabolism: where do we go from here? FASEB J. 10:1996;829-837.
5. Boelens P.G., Nijveldt R.J., Houdijk A.P.J., Meijer S., van Leeuwen P.A.M. Glutamine alimentation in catabolic state. J Nutr. 131:2001;2569S-2577S.
6. Windmueller H.G., Spaeth A.E. Source and fate of circulating citrulline. Am J Physiol. 241:1981;E473-480.
7. Houdijk A.P.J., van Leeuwen P.A.M., Teerlink T., et al. Glutamine enriched enteral diet increases renal arginine production. J Parenter Enter Nutr. 18:1994;422-426.
8. Halperin H.L., Kamel H.S., Ethier J.H. Biochemistry and physiology of ammonium excretion. Seldin D.W., Giebisch L. The kidney: physiology and pathology. 1992;2645-2680 Raven Press, New York, NY.
9. Satyal S.H., Schmidt E., Kitagawa K., et al. Polyglutamine aggregates alter protein folding homeostasis in Caenorhabditis elegans. Proc Natl Acad Sci USA. 97:2000;5750-5755.
10. Carmichael J., Chatellier J., Woolfson J.A., et al. Bacterial and yeast chaperones reduce both aggregate formation and cell death in mammalian cell models of Huntington's disease. Proc Natl Acad Sci USA. 97:2000;9701-9705.
11. Perutz M.F. Glutamine repeats and neurodegenerative diseases: molecular aspects. Trends Biochem Sci. 24:1999;58-63.
12. Paulson H., Bonini N.M., Roth K.A. Polyglutamine disease and neuronal death. Proc Natl Acad Sci USA. 97:2000;12957-12958.
13. Houdijk A.P.J., Rijnsburger E.R., Jansen J., et al. Randomized trial of glutamine-enriched enteral nutrition on infectious morbidity in patients with multiple trauma. Lancet. 352:1998;772-776.
14. Morlion B.J., Stehle P., Wachtler P., et al. Total parenteral nutrition with glutamine dipeptide after major abdominal surgery: a randomised, double blind controlled study. Ann Surg. 227:1998;302-308.
15. Jiang Z.M., Cao J.D., Zhu X.G., et al. The impact of alanyl-glutamine on clinical postoperative patients: a randomised double-blind controlled study of 120 patients. J Parenter Enter Nutr. 23:1999;S62-S66.
16. Shabert J.K., Winslow C., Lacey J.M., Wilmore D.W. Glutamine antioxidant supplementation increases body cell mass in AIDS patients with weight loss: a randomised double blind controlled trial. Nutrition. 15:1999;860-864.
17. Brown S.A., Goringe A., Fegan C., et al. Parenteral glutamine protects hepatic function during bone marrow transplantation. Bone Marrow Transplant. 22:1998;281-284.
18. Coghlin-Dickson D.T., Wong R.M., Offrin R.S., Shizuru J.A., et al. Effect of oral glutamine supplementation during bone marrow transplantation. J Parenter Enter Nutr. 24:2000;61-66.
19. Schloerb P.R., Skikne B.S. Oral and parenteral glutamine in bone marrow transplantation: a randomised double blind study. J Parenter Enter Nutr. 23:1999;117-122.
20. Bozzetti F., Biganzzoli L., Gavazzi C., et al. Glutamine supplementation in cancer patients receiving chemotherapy: a double blind randomised study. Nutrition. 13:1997;748-751.
21. Cao Y., Kennedy R., Klimberg V.S. Glutamine protects against doxorubicin-induced cardiotoxicity. J Surg Res. 85:1999;178-182.
22. Decker-Baumann C., Buhl K., Frohmuller S., Von Herbay A., Dueck M., Schlag P.M. Reduction of chemotherapy induced side-effects by parenteral glutamine supplementation in patients with metastatic colorectal cancer. Eur J Cancer. 35:1999;205-207.
23. Lacey J.M., Wilmore D.W. Is glutamine a conditionally essential amino acid? Nutr Rev. 48:1990;297-309.
24. Bode B.P. Recent Molecular advances in mammalian glutamine transport. J Nutr. 131:2001;2475S-2485S.
25. Christensen H.N., Liang M., Archer E.G. A distinct Na+-requiring transport system for alanine, serine, cysteine and similar amino acids. J Biol Chem. 242:1967;5237-5246.
26. Souba W.W., Pan M., Stevens B.R. Kinetics of the sodium-dependent glutamine transporter in human intestinal cell confluent monolayers. Biochem Biophys Res Commun. 188:1992;746-753.
27. +-dependent neutral amino acid transporter. J Biol Chem. 271:1996;14883-14890.
28. Bröer A., Brookes N., Ganapathy V., et al. The astroglial ASCT2 amino acid transporter as a mediator of glutamine efflux. J Neurochem. 73:1999;2184-2194.
29. + exchange and a substrate gated anion conductance. Biochem J. 346:2000;705-710.
30. +-dependent neutral amino acid transporter B. Am J Physiol. 272:1997;G1463-1472.
31. Kilberg M.S., Handlogten M.E., Christensen H.N. Characteristics of an amino acid transport system in rat liver for glutamine, asparagine, histidine and closely related analogs. J Biol Chem. 255:1980;4011-4019.
32. Hundal H.S., Rennie M.J., Watt P.W. Characteristics of L-glutamine transport in perfused rat skeletal muscle. J Physiol. 393:1987;283-305.
33. +-dependent glutamine transport activity in rat brain neurons. J Neurochem. 68:1997;954-960.
34. Nakanishi T., Sugawara M., Huang W., et al. Structure, function and tissue expression pattern of human SN2, a subtype of the amino acid transport system N. Biochem Biophys Res Commun. 281:2001;1343-1348.
35. Chaudhry F.A., Reimer R.J., Krizaj D., et al. Molecular analysis of system N suggests novel physiological roles in nitrogen metabolism and synaptic transmission. Cell. 99:1999;769-780.
36. Gu S., Roderick H.L., Camacho P., Jiang J.X. Identification and characterization of an amino acid transporter expressed differentially in liver. Proc Natl Acad Sci USA. 97:2000;3230-3235.
37. +-coupled glutamine transporter. J Biol Chem. 275:2000;23707-23717.
38. Jamshidi M.B., Kaye P.L. Glutamine transport by mouse inner cell masses. J Reprod Fertil. 104:1995;91-97.
39. +-dependent transport of basic zwitterionic and bicyclic amino acids by a broad scope system in mouse blastocysts. J Biol Chem. 260:1985;12118-12123.
40. (°+). J Biol Chem. 274:1999;23740-23745.
41. Christensen H.N., Oxender D.L., Liang M., Vatz K.A. The use of N-methylation to direct the route of mediated transport of amino acids. J Biol Chem. 240:1965;3609-3616.
42. Bode B.P., Kaminski D.L., Souba W.W., Li A.P. Glutamine transport in isolated human hepatocytes and transformed liver cells. Hepatology. 21:1995;511-520.
43. Sugawara M., Nakanishi T., Fei Y.J., et al. Structure and function of ATA3, a new subtype of amino acid transport system A, primarily expressed in the liver and skeletal muscle. Biochim Biophys Acta. 1509:2000;7-13.
44. Deves R., Chavez P., Boyd C.A. Identification of a new transport system (y+L) in human erythrocytes that recognises lysine and leucine with high affinity. J Physiol. 454:1992;491-501.
45. Oxender D., Christensen H. Distinct mediating systems for the transport of neutral amino acids by the Ehrlich cells. J Biol Chem. 238:1963;3686-3699.
46. Taylor P.M., Egan C.J., Rennie M.J. Transport of glutamine across blood facing membranes of perfused rat jejunum. Am J Physiol. 256:1989;E550-558.
47. Bussolati O., Sala R., Astorri A., et al. Characterization of amino acid transport in human endothelial cells. Am J Physiol. 265:1993;C1006-1014.
48. +-independent transport of basic and zwitterionic amino acids in mouse blastocyts by a shared system and by processes which distinguish between these substrates. J Biol Chem. 263:1988;3150-3163.
49. Bode B.P., Recent M. olecular advances in mammalian glutamine transport. J Nutr. 131:2001;2475S-2485S.
50. Indiveri C., Abruzzo G., Stipani I., Palmieri F. Identification and purification of the reconstitutively active glutamine carrier from rat kidney mitochondria. Biochem J. 333:1998;285-290.
51. Molina M., Segura J.A., Aledo J.C., et al. Glutamine transport by vesicles isolated from tumour cell mitochondrial inner membrane. Biochem J. 308:1995;629-633.
52. Inoue Y., Pacitti A.J., Souba W.W. Endotoxin increases hepatic glutamine transport activity. J Surg Res. 54:1993;393-400.
53. Fischer C.P., Bode B.P., Souba W.W. Starvation and endotoxin act independently and synergistically to coordinate hepatic glutamine transport. J Trauma. 40:1996;688-693.
54. Inoue Y., Bode B.P., Souba W.W. Antibody to TNF-alpha blocks LPS-stimulated hepatic amino acid transport. Surgery. 116:1994;356-366.
55. Austgen T.R., Chakrabarti R., Chen M.K., Souba W.W. Adaptive regulation in skeletal muscle glutamine metabolism in endotoxin-treated rats. J Trauma. 32:1992;600-607.
56. Welbourne T.C. Interorgan glutamine flow in metabolic acidosis. Am J Physiol. 253:1987;F1069-1076.
57. Lukaszewicz G., Abcouwer S., Labow B., Souba W.W. Glutamine synthetase gene expression in the lungs of endotoxin-treated and adrenalectomized rats. Am J Physiol. 273:1997;L1182-1190.
58. Brand K., Leibold W., Luppa P., Schoerner C., Schulz A. Metabolic alterations associated with proliferation of mitogen activated lymphocytes and of lymphoblastoid cell lines: evaluation of glucose and glutamine metabolism. Immunobiology. 173:1986;23-24.
59. Souba W.W., Herskoowitz K., Klimberg V.S., et al. The effects of sepsis and endotoxemia on gut glutamine metabolism. Ann Surg. 211:1990;543-549.
60. Austgen T.R., Chen M.K., Dudrick P.S., Copeland E.M., Souba W.W. Cytokine regulation of intestinal glutamine utilization. Am J Surg. 163:1991;174-180.
61. Brosnan J.T., Vinay P., Gougoux A., Halperin M.L. Renal ammonia production and its implications for acid base balance. Häussinger D. pH homeostasis - mechanism and control. 1988;281-304 Academic Press, New York, NY.
62. Austgen T.R., Chen M.K., Moore W., Souba W.W. Endotoxin and renal glutamine metabolism. Arc. Surg. 126:1991;23-27.
63. Gerich J.E., Meyer C., Stumvoll M.W. Hormonal control of renal and systemic glutamine metabolism. J Nutr. 130:2000;995S-1001S.
64. Stumvoll M., Meyer C., Perriello G., et al. Human kidney and liver gluconeogenesis evidence for organ substrate selectivity. Am J Physiol. 274:1998;E817-826.
65. Stumvoll M., Perriello G., Meyer C., Gerich J. Role of glutamine in human carbohydrate metabolism in kidney and other tissues. Kidney Int. 55:1999;778-779.
66. Garlick P., Wernerman J. Protein metabolism in injury. Cooper G.J., Dudley H.A.F., Gann D.S., Little R.A., Maynard R.L. Scientific foundation of trauma. 1997;690-728 Butterworth Heineman, Oxford, UK.
67. Wilmore D.W. Metabolic response to severe surgical illness: overview. World J Surg. 24:2000;705-711.
68. Brooks D.C., Bessey P.Q., Black P.R., Aoki T.T., Wilmore D.W. Insulin stimulates branched chain amino acid uptake and diminishes nitrogen flux from skeletal muscle of injured patients. J Surg Res. 40:1986;395.
69. Ross R.J.M., Chew S.L. Acquired growth hormone resistance. Eur J Endocrinol. 132:1995;655-660.
70. Max S.R., Mill J., Mearow K., et al. Dexamethazone regulates glutamine synthetase expression in skeletal muscles. Am J Physiol. 255:1988;E397-402.
71. Krishna M.G., Coker R.H., Lacy D.B., et al. Glucagon response to exercise is critical for accelerated hepatic glutamine metabolism and nitrogen disposal. Am J Physiol. 279:2000;E638-645.
72. O'Riordain M.G., Fearon K.C.H., Ross J.A., et al. Glutamine-supplemented total parenteral nutrition enhances T-lymphocytes response in surgical patients undergoing colorectal resection. Ann Surg. 220:1994;212-221.
73. Parry-Billings M., Evans J., Calder P.C., Newsholme E.A. Does glutamine contribute to immunosuppression after major burns? Lancet. 336:1990;523-525.
74. Espat N.J., Bode B.P., Lind D.S., Copeland E.M., Souba W.W. Normalization of tumor-induced increases in hepatic amino acid transport after surgical resection. Ann Surg. 221:1995;50-58.
75. Gomez-Fabre P.M., Aledo J.C., Del Castillo-Olivares A., et al. Molecular cloning sequencing and expression studies of the human breast cancer cell glutaminase. Biochem J. 345:2000;365-375.
76. Imbert G., Saudou F., Yvert G., et al. Cloning of the gene for spinocerebeller ataxia 2 reveals a locus with high sensitivity to expanded GAG/glutamine repeats. Nat Genet. 14:1996;285-291.
77. Elgadi K.M., Meguid R.A., Qian M., Souba W.W., Abcouwer S.F. Cloning and analysis of unique human glutaminase isoforms generated by tissue-specific alternative splicing. Physiol Genomics. 1:1999;51-62.
78. Lobo C., Ruiz-Bellido M.A., Aledo J.C., Marquez Jnunez de Castro I., Alonso F.J. Inhibition of glutaminase expression by antisense mRNA decreases growth and tumourigenicity of tumor cells. Biochem J. 348:2000;257-261.
79. Ziegler T.R., Bye R.L., Persinger R.L., Young L.S., Antin J.H., Wilmore D.W. Effects of glutamine supplementation in circulating lymphocytes after bone marrow transplantation. A pilot study. Am J Med Sci. 315:1998;4-10.
80. Griffiths R.D. Glutamine: establishing clinical indications. Curr Opin Clin Nutr Metab Care. 2:1999;177-182.
81. Ziegler T.R., Daignault N.M. Glutamine regulation in human immune cell function. Nutrition. 16:2000;458-459.
82. Slavin S. New strategies for bone marrow transplantation. Curr Opin Immunol. 12:2000;542-551.
83. Blijlevens N.M., Donnelly J.P., DePauw B.E. Mucosal barrier injury: biology, pathology, clinical counterparts and consequences of intensive treatment for haematological malignancy: an overview. Bone Marrow Transplant. 25:2000;1269-1278.
84. Brown S.A., Goringe A., Fegan C., et al. Parenteral glutamine protects hepatic function during bone marrow transplantation. Bone Marrow Transplant. 22:1998;281-284.
85. Nattakom T.U., Charlton A., Wilmore D.W. Use of vitamin E and glutamine in the successful treatment of severe occlusive disease following bone marrow transplantation. Nutr Clin Pract. 10:1995;16-18.
86. Goringe A.D., Brown S., O'Callaghan V.O., et al. Glutamine and vitamin E in the treatment of hepatic veno-occlusive disease following high dose chemotherapy. Bone Marrow Transplant. 21:1998;829-832.
87. Darmaun D. Role of glutamine depletion in severe illness. Diabetes Nutr Metab. 13:2000;25-30.
88. Ziegler T.R., Bazargan N., Leader L.M., Martindale R.G. Glutamine and the intestinal tract. Curr Opin Clin Nutr Metab Care. 3:2000;355-362.
89. Giacometti T. Free and bound glutamate in natural products. Filer L.J., Garattini S., Kare M.R., Reynolds W.A., Wurtman R.L. Glutamic acid: advances in biochemistry and physiology. 1979;25-34 Raven Press, New York, NY.
90. Meister A. Biochemistry of glutamate, glutamine and glutathione. Filer L.J., Garattini S., Kare M.R., Reynolds W.A., Wurtman R.J. Glutamic acid: advances in biochemistry. 1979;69-84 Raven Press, New York, NY.
91. Ghezzi P., Garattini S., Caccia S., Salmona M., Zanini M.G. Plasma pyroglutamic acid levels after oral administration of monosodium glutamate to human volunteers. Toxicol Lett. 15:1983;123-129.
92. Stegink L.D., Filer J.L. Jr, Baker G.L., et al. Factors affecting plasma glutamate levels in normal adult subjects. Filer L.J., Garattini S., Kare M.R., Reynolds W.A., Wurtman R.L. Glutamic acid: advances in biochemistry. 1979;333-351 Raven Press, New York, NY.
93. Yano S., Tokumitsu H., Soderling T.R. Calcium promotes cell survival through CaM-k kinase activation of the protein-kinase-B pathway. Nature (Lond). 396:1998;584-587.
94. Watkins J.C., Evans R.H. Excitatory amino acids transmitters. Annu Rev Pharmacol Toxicol. 21:1981;165-204.
95. McDonald J.W., Johnston M.V. Physiological and pathophysiological roles of excitatory amino acids during central nervous system development. Brain Res. 15:1990;41-70.
96. Cleland T.A. Inhibitory glutamate receptor channels. Mol Neurobiol. 13:1996;97-136.
97. Fiorillo C.D., Williams J.T. Glutamate mediates an inhibitory postsynaptic potential in dopamine neurons. Nature (Lond). 394:1998;78-82.
98. MacRae T.H. Tubulin post-translational modifications: enzymes and their mechanisms of action. Eur J Biochem. 244:1997;265-278.
99. Bolinnec Y., Moudjou M., Fougult J.P., et al. Glutamylation of centreole and cytoplasmic tubulin in proliferating non-neuronal cells. Cell Motil Cytoskeleton. 39:1998;223-232.
100. Shane B. Folypolyglutamate synthesis and role in the regulation of one carbon metabolism. Vit Horm. 45:1989;263-335.
101. +-dependent glutamate uptake. J Neurosci. 19:1998;9620-9628.
102. Obrenovitch T.P., Urenjak J. Altered glutamatergic transmission in neurological disorders: from high extracellular glutamate to excessive synaptic efficacy. Prog Neurobiol. 51:1997;39-87.
103. McGehee D.S., Role L.W. Presynaptic ionotropic receptors. Curr Opin Neurobiol. 6:1996;342-349.
104. Meldrum B.S. The glutamate synapse as a therapeutic target: perspective for the future. Ottersen O.P., Langmoen I.A., Gjerstad L. Progress in brain research. vol. 116:1998;413-430 Elsevier Science BV, Amsterdam, The Netherlands.
105. Laube B., Kuhse J., Betz H. Evidence for tetrameric structure of recombinant NMDA receptors. J Neurosci. 18:1998;2954-2961.
106. Cotman C.W., Kahle J.S., Miller S.E., Ulas J., Bridges R.J. Excitatory amino acid neurotransmission. Bloom F.E., Kupfer D.J. Psychopharmacology: the fourth generation of progress. 1995;75-85 Raven Press, New York, NY.
107. Tang C.M., Shi Q.Y., Katchman A., Lynch G. Modulation of the time course of fast EPSCs and glutamate channel kinetics by aniracetam. Science (Washington). 254:1991;288-290.
108. Hayashi T., Umemori H., Mishina M., Yamamoto T., The A.M. PA receptor interacts with and signals through the protein tyrosine kinase lyn. Nature (Lond). 397:1999;72-76.
109. Nakanishi S., Masu M. Molecular diversity and functions of glutamate receptors. Annu Rev Biophys Biomol Struct. 23:1994;319-348.
110. Conn P.J., Pin J.P. Pharmacology and functions of metabotropic glutamate receptors. Annu Rev Pharmacol Toxicol. 37:1997;205-237.
111. Winder D.G., Conn P.J. Activation of metabotropic glutamate receptors increases camp accumulation in hippocampus by potentiating responses to endogenous adenosine. J Neurosci. 13:1993;38-44.
112. +-dependent glutamate/aspartate transporter from rat brain. Proc Natl Acad Sci USA. 89:1992;10955-10959.
113. Lehre K.P., Danbolt N.C. The number of glutamate transporter subtype molecules at glutamatergic synapses: chemical and stereological quantification in young adult rat brain. J Neurosci. 18:1998;8751-8757.
114. Pines G., Danbolt N.C., Bjoras M., Zhang Y., Bendahan A., et al. Cloning and expression of a rat brain L-glutamate transporter. Nature (Lond). 360:1992;464-467.
115. Kanai Y., Hediger M.A. Primary structure and functional characterization of a high-affinity glutamate transporter. Nature (Lond). 360:1992;467-471.
116. Fairman W.A., Vandenberg R.J., Arriza J.L., Kavanaugh M.P., Amara S.G. An excitatory amino acid transporter with properties of a ligand-gated chloride channel. Nature (Lond). 375:1995;599-603.
117. Seal R.P., Amara S.G. Excitatory amino acid transporters: a family in flux. Annu Rev Pharmacol Toxicol. 39:1999;431-456.
118. Kataoka Y., Morii H., Watanabe Y., Ohmori H. A postsynaptic excitatory amino acid transporter with chloride conductance functionally regulated by neuronal activity in cerebellar Purkinje cells. J Neurosci. 17:1997;7017-7024.
119. Massieu L., Morales-Villagran A., Tapia R. Accumulation of extracellular glutamate by inhibition of its uptake is not sufficient for inducing neuronal damage: an in vivo microdialysis study. J Neurochem. 64:1995;2262-2272.
120. Rawls S.M., McGinty J.F. L-trans-Pyrrolidine-2,4-icarboxylic acid evoked striatal glutamate levels are attenuated by calcium reduction, tetrodotoxin and glutamate receptor blockade. J Neurochem. 68:1997;1553-1563.
121. Peghini P., Janzen J., Stoffel W. Glutamate transporter EAAC-1-deficient mice develop dicarboxylic aminoaciduria and behavioural abnormalities but no degeneration. EMBO J. 16:1997;3822-3832.
122. 3H]-glutamate uptake with different potencies in rodent central nervous system regions expressing different transporter subtypes. Pharmacol Res. 35:1997;149-151.
123. 3H]-glutamate binding by serotonin in the rat hippocampus: an autoradiographic study. Life Sci. 49:1991;283-292.
124. Mascarucci P., Perego G., Terrazino S., DeSimoni M.G. Glutamate release in the nucleus tractus solitarius induced by peripheral lipopolysaccharide and interleukin-1β Neuroscience. 86:1998;1285-1290.
125. Schwarzer C., Sperk G., Samarin R., et al. Neuropeptides-immunoreactivity and their mRNA expression in kindling: functional implications for limbic epileptogenesis. Brain Res Rev. 22:1996;27-50.
126. Cagan R.H., Torii K., Kare M.R. Biochemical studies of glutamate taste receptors: the synaptic taste effect of L-glutamate and 5′-ribonucleotides. Filer L.J., Garattini S., Kare M.R., Reynolds W.A., Wurtman R.L. Glutamic acid: advances in biochemistry. 1979;1-9 Raven Press, New York, NY.
127. Halpern B.P. Psychophysics of taste. Beauchamp G.K., Bartoshuk L.M. Tasting and smelling handbook of perception and cognition. 2nd: 1997;77-123 Academic Press, San Diego, CA.
128. Yamaguchi S., Ninomiya K. What is umami? Food Rev Int. 14:1998;123-138.
129. Yamaguchi S., Kimizuka A. Psychometric studies on the taste of monosodium glutamate. Filer L.J., Garattini S., Kare M.R., Reynolds W.A., Wurtman R.L. Glutamic acid: advances in biochemistry. 1979;35-54 Raven Press, New York, NY.
130. Ninomiya K. Natural occurrence. Food Rev Int. 14:1998;177-211.
131. Tseng Y.-H., Mau J.L. Contents of sugars, free amino acids and 5′-nucleotides in mushrooms, Agaricus bisporus, during post harvest storage. Annual Meeting of Institute of Food Technologists, Orlando, FL. 1997;. paper 23D-17 (abs).
132. Yamaguchi S. Basic properties of umami and its effects on food flavor. Food Rev Int. 14:1998;139-176.
133. Yoshida Y. Umami taste and traditional seasonings. Food Rev Int. 14:1998;213-246.
134. Kinnamon S.C., Margolskee R.F. Mechanisms of taste transduction. Curr Opin Neurobiol. 6:1996;506-513.
135. Brand J.G. Receptor and transduction processes for umami taste. J Nutr. 130:2000;942S-945S.
136. Nishijo H., Ono T., Uwano T., Kondoh T., Torii K. Hypothalamic and amygdalar neuronal responses to various tastant solutions during ingestive behavior in rats. J Nutr. 130:2000;954S-959S.
137. Roper S.D., Hampson D.R., Chaudhari N. Mice lacking the metabotropic glutamate receptor 4 show altered taste preference. Soc Neurosci Abst. 23:1997;1037. [Abst]
138. Dingledine R., Conn J.P. Peripheral glutamate receptors: molecular biology and role in taste sensation. J Nutr. 130:2000;1039S-1042S.
139. Olney J.W. Brain lesions, obesity and other disturbances in mice treated with monosodium glutamate. Science (Washington, DC). 164:1969;719-721.
140. Reynolds W.A., Lemkey-Johnston N., Stegink L.D. Morphology of the fetal monkey hypothalamus after in utero exposure to monosodium glutamate. Filer L.J., Garattini S., Kare M.R., Reynolds W.A., Wurtman R.J. Glutamic acid: advances in biochemistry. 1979;217-229 Raven Press, New York, NY.
141. Choi D.W. Glutamate neurotoxicity and diseases of the nervous system. Neuron. 1:1988;623-634.
142. Lipton S.A., Rosenberg P.A. Excitatory amino acids as a final common pathway for neurologic disorders. New Engl J M. 330:1994;613-622.
143. Nicholls D., Attwell D. The release and uptake of excitatory amino acids. Trends Pharmacol Sci. 11:1990;462-468.
144. Sohn S., Kim E., Gwag B.J. Glutamate neurotoxicity in mouse cortical neurons: atypical necrosis with DNA ladders and chromatin condensation. Neurosci Lett. 240:1998;147-150.
145. Du Y., Bales K.R., Dodel R.C., Hamilton-Byrd E., et al. Activation of a caspase 3-related cysteine protease is required for glutamate-mediated apoptosis of cultured cerebellar granule neurons. Proc Natl Acad Sci USA. 94:1997;11657-11662.
146. Cik M., Chazot P.L., Stephenson F.A. Optimal expression of cloned NMDAR1/NMDAR2A heteromeric glutamate receptors: a biochemical characterization. Biochem J. 296:1993;877-883.
147. Teitelbaum J.S., Zatorre R.J., Carpenter S., et al. Neurologic sequelae of domoic acid intoxication due to the ingestion of contaminated mussels. New Engl J M. 322:1990;1781-1787.
148. Rothstein J.D., Kuncl R.W. Neuroprotective strategies in a model of chronic glutamate-mediated motor neuron toxicity. J Neurochem. 65:1995;643-651.
149. Meldrum B. Protection against ischaemic neuronal damage by drugs acting on excitatory transmission Cerebrovasc. Brain Metab Rev. 2:1990;27-57.
150. Leigh P.N., Meldrum B.S. Excitotoxicity in amyotrophic lateral sclerosis. Neurology. 47:1996;S221-227.
151. Ludolph A.C., Meyer T., Riepe M.W., Völkel H. Amyotrophic lateral sclerosis and glutamate. Restor Neurol Neurosci. 13:1998;59-67.
152. Hirata A., Nakamura R., Kwak S., Nagata N., Kamakura K. AMPA receptor-mediated slow neuronal death in the rat spinal cord induced by long-term blockade of glutamate transporters with THA. Brain Res. 771:1997;37-44.
153. Iacopino A., Christakos S., German D., Sonsalla P.K., Altar C.A. Calbindin-D28K-containing neurons in animal models of neurodegeneration: possible protection from excitotoxicity. Brain Res Mol Brain Res. 13:1992;251-261.
154. Lacommblez L., Bensimon G., Leigh P.N., Guillet P., Meininger V. Dose ranging study of riluzole in amyotrophic lateral sclerosis. Lancet. 347:1996;1425-1431.
155. Roy J., Minotti S., Dong L., Figlewicz D.A., Durham H.D. Glutamate potentiates the toxicity of mutant Cu/Zn superoxide dismutase in motor neurons by postsynaptic calcium-dependent mechanisms. J Neurosci. 18:1998;9673-9684.
156. Bate L., Gardiner M. Genetics of inherited epilepsies. Epileptic Disord. 1:1999;7-19.
157. Burgess D.L., Noebels J.L. Single gene defects in mice: the role of voltage dependent calcium channels in absence models. Epilepsy Res. 36:1999;111-122.
158. Ghaury M., Chapman A.G., Meldrum B.S. Convulsant and anticonvulsant actions of agonists and antagonists of group III mGluRs. NeuroReport. 7:1996;1469-1474.
159. Meldrum B.S., Chapman A.G. Excitatory amino acid receptors and antiepileptic drug development. Delgado-Escueta A.V., Wilson W.A., Olsen R.W., Porter R.J. Advances in neurology. vol. 79:1999;965-978 Lippincott Wiliams & Wilkins, Philadelphia, USA.
160. Chapman A.G., Naran K., Yip P., Meldrum B.S. Anticonvulsant activity of a metabotropic glutamate receptor 8 preferential agonist, (R,S)-4-phosphonophenylglycine. Eur J Pharmacol. 383:1999;23-27.
161. Chapman A.G., Yip P.K., Yap J.S., et al. Anticonvulsant action of two antagonists at mGluR1: LY367385 ((+)-2-methyl-4-carboxyphenylglycine) and (RS)-1-aminoindan-1,5-dicarboxylic acid (AIDA). Eur J Pharmacol. 368:1999;17-24.
162. Chapman A.G. Glutamate and epilepsy. 130:2000;1043S-1045S.
163. Mukhin A., Fan L., Faden A.I. Activation of metabotropic glutamate receptor subtype mGluR1 contributes to post-traumatic neuronal injury. J Neurosci. 16:1996;6012-6020.
164. Lynch G., Granger R., Ambros-Ingerson J., et al. Evidence that a positive modulator of AMPA-type glutamate receptors improves delayed recall in aged humans. Exp Neurol. 145:1997;89-92.
165. Gill R. The pharmacology of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA)/kainate antagonists and their role in cerebral ischemia. Cerebrovasc Brain Metab. 6:1994;225-256.
166. Tanaka K., Watase K., Manabe T., et al. Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT1. Science (Washington, DC). 276:1997;1699-1702.
167. Rothstein J.D., DykesHoberg M., Pardo C.A., et al. Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate. Neuron. 16:1996;675-686.
168. Sonnewald U., Westergaard N., Schousboe A. Glutamate transport and metabolism in astrocytes. Glia. 21:1997;56-63.
169. Kanner B.I. Glutamate transporters from brain. A novel neurotransmitter transporter family. FEBS Lett. 325:1993;95-99.
170. Szatkowski M., Barbour B., Attwell D. Non-vesicular release of glutamate from glial cells by reversed electrogenic glutamate uptake. Nature (Lond). 348:1990;443-446.
171. Longuemare M.C., Swanson R.A. Excitatory amino acids release from astrocytes during energy failure by reversal of sodium-dependent uptake. J Neurosci Res. 40:1995;379-386.
172. Ye Z- C., Sontheimer H. Glioma cells release excitotoxic concentrations of glutamate. Cancer Res. 59:1999;4383-4391.
173. Jarrard L.E., Meldrum B.S. Selective excitotoxic pathology in the rat hippocampus. Neuropathol Appl Neurobiol. 19:1993;381-389.
174. Goff D.C., Wine L. Glutamate in schizophrenia: clinical and research implications. Schizophr Res. 27:1997;157-168.
175. Banerjee S.P., Zuck L.G., Yablonsky-Alter E., Lidsky T.I. Glutamate agonist activity: implications for antipsychotic drug action and schizophrenia. NeuroReport. 6:1995;2500-2504.